GREMLIN Database
TB2_DP1_HVA22 - TB2/DP1, HVA22 family
PFAM: PF03134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (86)
Sequences: 3107 (2218)
Seq/√Len: 239.2
META: 0.519

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_W78_G4.8191.00
16_S37_W2.6531.00
11_Y15_A2.5281.00
12_P36_Y2.3731.00
81_Y85_K2.3561.00
24_S30_D2.3371.00
47_E64_K2.2001.00
32_Q77_R2.0971.00
21_E88_R2.0121.00
24_S29_D1.9601.00
60_Y64_K1.9381.00
80_T84_E1.8331.00
77_R80_T1.7151.00
33_W36_Y1.6621.00
73_L76_T1.5961.00
70_W81_Y1.5631.00
14_Y18_K1.5461.00
25_K30_D1.5201.00
47_E60_Y1.5001.00
5_N9_F1.4901.00
16_S34_L1.4311.00
8_G68_L1.4131.00
15_A18_K1.3281.00
43_F68_L1.3211.00
9_F40_F1.3161.00
4_C65_L1.3071.00
17_F21_E1.3071.00
69_L73_L1.2441.00
51_D56_W1.2341.00
27_K31_T1.2291.00
21_E83_Y1.1841.00
64_K68_L1.1761.00
36_Y40_F1.1551.00
32_Q79_A1.1461.00
51_D55_S1.1421.00
51_D54_L1.1281.00
26_D31_T1.1241.00
68_L71_L1.1191.00
32_Q80_T1.0891.00
30_D34_L1.0841.00
37_W40_F1.0781.00
52_F55_S1.0711.00
25_K28_D1.0481.00
26_D29_D1.0441.00
68_L72_V1.0021.00
35_T79_A0.9971.00
38_V41_G0.9891.00
32_Q35_T0.9881.00
67_F71_L0.9881.00
49_F52_F0.9651.00
24_S27_K0.9381.00
25_K29_D0.9311.00
48_S51_D0.9271.00
19_A33_W0.9061.00
70_W76_T0.9041.00
81_Y86_F0.8911.00
25_K31_T0.8870.99
46_V50_L0.8840.99
8_G12_P0.8840.99
11_Y33_W0.8730.99
28_D31_T0.8690.99
9_F13_A0.8690.99
2_L5_N0.8620.99
69_L72_V0.8530.99
47_E56_W0.8400.99
84_E88_R0.8300.99
50_L53_L0.8090.99
76_T79_A0.7840.99
31_T84_E0.7690.99
7_V65_L0.7610.98
73_L77_R0.7540.98
8_G40_F0.7460.98
62_E66_A0.7220.98
35_T84_E0.7200.98
35_T38_V0.7150.98
15_A75_Q0.7060.97
16_S74_P0.7000.97
39_V42_L0.6960.97
13_A21_E0.6900.97
61_Y64_K0.6850.97
86_F89_P0.6780.97
27_K30_D0.6710.97
13_A71_L0.6590.96
42_L46_V0.6550.96
51_D59_F0.6510.96
6_L10_L0.6420.96
5_N48_S0.6410.96
51_D63_L0.6390.95
20_L40_F0.6380.95
39_V64_K0.6310.95
41_G44_T0.6300.95
26_D77_R0.6300.95
83_Y88_R0.6210.95
9_F44_T0.6170.95
47_E51_D0.6160.94
28_D80_T0.6130.94
43_F47_E0.6130.94
33_W37_W0.6070.94
19_A30_D0.6070.94
5_N8_G0.5940.93
3_L15_A0.5930.93
46_V84_E0.5890.93
56_W59_F0.5640.91
40_F68_L0.5560.91
63_L67_F0.5530.91
85_K89_P0.5480.90
80_T86_F0.5480.90
43_F51_D0.5470.90
56_W62_E0.5450.90
2_L51_D0.5430.90
2_L48_S0.5420.90
45_L50_L0.5420.90
9_F41_G0.5420.90
46_V52_F0.5380.89
39_V87_L0.5380.89
74_P78_G0.5380.89
42_L55_S0.5350.89
17_F74_P0.5330.89
30_D40_F0.5300.89
43_F55_S0.5260.88
32_Q41_G0.5250.88
46_V55_S0.5250.88
69_L74_P0.5230.88
26_D30_D0.5210.88
76_T80_T0.5180.88
42_L80_T0.5170.88
36_Y74_P0.5120.87
72_V76_T0.5060.86
65_L72_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b1eA 1 0.5333 1.5 0.913 Contact Map
1z96A 1 0.3889 1.3 0.917 Contact Map
2micA 2 0.2778 1.1 0.919 Contact Map
4i5sA 2 0.1556 1 0.921 Contact Map
2vdwB 1 0.3889 1 0.922 Contact Map
2a8eA 1 0.2333 1 0.923 Contact Map
3qnqA 2 0.3667 0.8 0.926 Contact Map
2oniA 4 0.3222 0.7 0.929 Contact Map
3froA 3 0.3333 0.7 0.931 Contact Map
4l6vi 1 0.3 0.6 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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