EXS - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

EXS - EXS family

PFAM:	PF03124	Sequences: LFPLYRGFFLIVLHLLLWGLNLYVWRRYRINYVFIFEFDPRTELSYRQVFELATFLTVLLLLSLLLFLNLTSGDLSPGDPKLVDLIPLILLLLLLLILFYRSSRFWFLRTLFRILLAPFYPVEFRDFFLADQLTSLVKVLRDLEFFICYYFYSVLVPIVAALPYWIRFLQCLRRYRDFPHLANALKYSSAIPVVILSALYRDKSNPLFVLWIVFSVINSLYSFYWDVVMDWGLKNPFLRDKLPKWVYYFAIVLNLVLRFAWILTVLSPHLGQHSELLVFLLALLEVIRRGIWNFFRLENEHL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	302 (301)
Sequences:	1184 (853)
Seq/√Len:	49.2
META:	0.197

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_Q	293_N	4.752	1.00
5_Y	63_S	4.677	1.00
223_F	255_L	4.670	1.00
111_L	133_L	4.441	1.00
16_L	57_T	4.300	1.00
168_F	184_A	4.171	1.00
253_L	291_I	3.856	1.00
113_R	126_D	3.431	1.00
238_L	248_Y	3.424	1.00
162_L	166_I	3.349	1.00
257_L	284_L	3.157	1.00
250_A	295_F	3.097	1.00
173_R	177_D	3.079	1.00
6_R	142_D	3.052	1.00
246_V	295_F	3.032	1.00
167_R	170_Q	3.015	1.00
231_W	250_A	2.838	1.00
249_F	253_L	2.777	1.00
24_V	294_F	2.715	1.00
218_N	222_S	2.431	1.00
227_V	251_I	2.356	1.00
16_L	53_A	2.313	1.00
178_F	182_A	2.308	1.00
21_N	294_F	2.276	1.00
167_R	187_Y	2.262	1.00
5_Y	86_I	2.243	1.00
14_H	136_L	2.160	1.00
183_N	186_K	2.136	1.00
116_L	120_Y	2.134	1.00
182_A	185_L	2.122	1.00
232_G	299_N	2.045	1.00
183_N	187_Y	2.043	1.00
175_Y	181_L	2.023	1.00
115_L	166_I	1.997	1.00
167_R	171_C	1.927	0.99
296_R	300_E	1.924	0.99
287_I	291_I	1.917	0.99
131_D	187_Y	1.910	0.99
101_R	105_F	1.905	0.99
167_R	296_R	1.900	0.99
285_E	288_R	1.867	0.99
224_Y	228_V	1.852	0.99
219_S	259_F	1.839	0.99
124_F	296_R	1.835	0.99
53_A	57_T	1.810	0.99
290_G	294_F	1.782	0.99
254_N	291_I	1.748	0.99
114_I	130_A	1.740	0.99
22_L	49_V	1.732	0.99
19_G	50_F	1.696	0.98
185_L	221_Y	1.691	0.98
288_R	292_W	1.616	0.98
114_I	166_I	1.598	0.98
165_W	169_L	1.566	0.97
258_R	261_W	1.565	0.97
31_N	34_F	1.563	0.97
289_R	292_W	1.562	0.97
253_L	257_L	1.560	0.97
131_D	135_S	1.533	0.97
145_F	149_Y	1.530	0.97
12_V	60_L	1.494	0.96
179_P	229_M	1.489	0.96
171_C	187_Y	1.474	0.96
187_Y	296_R	1.467	0.96
224_Y	229_M	1.465	0.96
174_R	180_H	1.451	0.96
174_R	301_H	1.438	0.95
250_A	291_I	1.424	0.95
285_E	289_R	1.415	0.95
223_F	227_V	1.414	0.95
131_D	225_W	1.381	0.94
195_I	199_L	1.381	0.94
128_F	293_N	1.350	0.94
167_R	183_N	1.332	0.93
235_N	240_D	1.325	0.93
128_F	132_Q	1.316	0.93
186_K	225_W	1.314	0.93
249_F	291_I	1.290	0.92
266_L	270_L	1.286	0.92
220_L	281_L	1.281	0.92
134_T	164_Y	1.278	0.92
248_Y	251_I	1.274	0.91
9_F	57_T	1.271	0.91
215_S	262_I	1.266	0.91
12_V	56_L	1.260	0.91
185_L	189_S	1.258	0.91
172_L	184_A	1.255	0.91
60_L	90_L	1.241	0.90
14_H	293_N	1.224	0.90
136_L	139_V	1.217	0.89
126_D	180_H	1.212	0.89
117_A	122_V	1.208	0.89
24_V	30_I	1.204	0.89
190_A	222_S	1.197	0.89
238_L	251_I	1.197	0.89
143_L	217_I	1.194	0.88
21_N	25_W	1.194	0.88
44_L	103_S	1.187	0.88
187_Y	292_W	1.187	0.88
276_L	280_L	1.185	0.88
13_L	287_I	1.175	0.88
131_D	183_N	1.171	0.87
235_N	244_K	1.168	0.87
127_F	174_R	1.164	0.87
154_V	157_P	1.157	0.87
266_L	269_H	1.135	0.86
31_N	174_R	1.128	0.85
57_T	95_L	1.125	0.85
257_L	261_W	1.114	0.85
5_Y	302_L	1.106	0.84
193_V	260_A	1.106	0.84
25_W	297_L	1.094	0.84
226_D	230_D	1.094	0.84
89_I	96_L	1.081	0.83
169_L	173_R	1.076	0.83
199_L	207_L	1.071	0.82
34_F	174_R	1.070	0.82
164_Y	194_V	1.066	0.82
170_Q	187_Y	1.064	0.82
166_I	169_L	1.062	0.82
92_L	96_L	1.040	0.80
13_L	283_L	1.031	0.80
133_L	140_L	1.027	0.80
140_L	159_V	1.027	0.80
168_F	191_I	1.026	0.79
125_R	128_F	1.026	0.79
216_V	252_V	1.023	0.79
186_K	221_Y	1.021	0.79
138_K	142_D	1.011	0.78
132_Q	138_K	1.010	0.78
95_L	252_V	1.007	0.78
193_V	215_S	1.004	0.78
246_V	250_A	1.004	0.78
220_L	224_Y	1.004	0.78
187_Y	221_Y	0.998	0.78
189_S	221_Y	0.993	0.77
140_L	161_A	0.992	0.77
164_Y	190_A	0.989	0.77
251_I	254_N	0.986	0.77
246_V	249_F	0.982	0.76
267_S	270_L	0.976	0.76
209_V	213_V	0.962	0.75
225_W	230_D	0.961	0.75
87_P	104_R	0.960	0.75
24_V	28_Y	0.958	0.75
187_Y	225_W	0.954	0.74
105_F	108_L	0.953	0.74
118_P	232_G	0.953	0.74
157_P	161_A	0.950	0.74
142_D	145_F	0.948	0.74
105_F	109_R	0.948	0.74
35_I	297_L	0.946	0.74
17_L	290_G	0.940	0.73
102_S	244_K	0.937	0.73
226_D	258_R	0.935	0.73
284_L	294_F	0.932	0.73
281_L	284_L	0.931	0.72
25_W	128_F	0.924	0.72
24_V	93_L	0.919	0.72
147_I	281_L	0.914	0.71
178_F	254_N	0.912	0.71
171_C	296_R	0.911	0.71
21_N	290_G	0.911	0.71
144_E	156_V	0.909	0.71
183_N	225_W	0.908	0.71
126_D	129_L	0.901	0.70
154_V	158_I	0.899	0.70
131_D	296_R	0.892	0.69
264_T	277_L	0.892	0.69
26_R	46_Y	0.890	0.69
60_L	64_L	0.889	0.69
144_E	148_C	0.889	0.69
228_V	232_G	0.885	0.69
122_V	296_R	0.880	0.68
33_V	38_F	0.879	0.68
227_V	254_N	0.875	0.68
197_S	262_I	0.867	0.67
299_N	302_L	0.866	0.67
131_D	186_K	0.866	0.67
104_R	108_L	0.865	0.67
115_L	118_P	0.860	0.66
63_S	86_I	0.857	0.66
18_W	138_K	0.855	0.66
91_L	287_I	0.850	0.65
108_L	150_Y	0.850	0.65
291_I	295_F	0.848	0.65
161_A	210_L	0.846	0.65
292_W	298_E	0.845	0.65
23_Y	50_F	0.843	0.65
89_I	95_L	0.842	0.65
168_F	172_L	0.839	0.64
66_L	70_L	0.833	0.64
112_F	120_Y	0.832	0.64
14_H	139_V	0.832	0.64
39_D	45_S	0.831	0.64
110_T	125_R	0.830	0.64
220_L	280_L	0.826	0.63
5_Y	211_W	0.822	0.63
183_N	296_R	0.821	0.63
141_R	160_A	0.818	0.62
25_W	36_F	0.812	0.62
196_L	210_L	0.806	0.61
172_L	181_L	0.805	0.61
221_Y	225_W	0.800	0.61
124_F	300_E	0.796	0.60
70_L	86_I	0.796	0.60
35_I	299_N	0.792	0.60
196_L	208_F	0.789	0.60
239_R	247_Y	0.787	0.59
117_A	165_W	0.786	0.59
163_P	170_Q	0.786	0.59
3_P	145_F	0.784	0.59
247_Y	250_A	0.779	0.59
292_W	296_R	0.776	0.58
95_L	249_F	0.774	0.58
42_T	115_L	0.772	0.58
14_H	132_Q	0.770	0.58
110_T	129_L	0.770	0.58
270_L	275_E	0.767	0.57
196_L	199_L	0.767	0.57
134_T	222_S	0.766	0.57
152_Y	156_V	0.764	0.57
171_C	175_Y	0.764	0.57
151_F	227_V	0.763	0.57
30_I	81_K	0.762	0.57
116_L	241_K	0.759	0.57
10_L	18_W	0.755	0.56
107_F	190_A	0.753	0.56
9_F	60_L	0.752	0.56
111_L	147_I	0.752	0.56
5_Y	8_F	0.751	0.56
35_I	39_D	0.746	0.55
247_Y	261_W	0.746	0.55
139_V	222_S	0.744	0.55
263_L	277_L	0.743	0.55
134_T	190_A	0.742	0.55
100_Y	234_K	0.742	0.55
163_P	167_R	0.740	0.55
254_N	275_E	0.740	0.55
134_T	138_K	0.739	0.55
233_L	238_L	0.732	0.54
197_S	200_Y	0.730	0.54
93_L	97_I	0.729	0.54
115_L	240_D	0.728	0.54
104_R	107_F	0.725	0.53
6_R	275_E	0.724	0.53
95_L	143_L	0.719	0.53
181_L	185_L	0.719	0.53
197_S	263_L	0.716	0.52
18_W	49_V	0.715	0.52
156_V	160_A	0.712	0.52
44_L	48_Q	0.711	0.52
210_L	241_K	0.708	0.52
7_G	25_W	0.708	0.52
20_L	24_V	0.707	0.51
188_S	191_I	0.707	0.51
10_L	44_L	0.703	0.51
5_Y	90_L	0.703	0.51
57_T	259_F	0.701	0.51
122_V	127_F	0.699	0.51
200_Y	208_F	0.694	0.50
35_I	193_V	0.693	0.50
137_V	264_T	0.693	0.50
25_W	87_P	0.692	0.50
36_F	103_S	0.691	0.50
118_P	165_W	0.691	0.50
186_K	254_N	0.690	0.50
254_N	258_R	0.690	0.50
21_N	293_N	0.689	0.50
50_F	57_T	0.688	0.50
17_L	287_I	0.687	0.49
133_L	295_F	0.683	0.49
248_Y	299_N	0.682	0.49
197_S	269_H	0.682	0.49
46_Y	50_F	0.680	0.49
130_A	189_S	0.679	0.49
107_F	228_V	0.677	0.48
25_W	32_Y	0.672	0.48
30_I	224_Y	0.671	0.48
158_I	177_D	0.671	0.48
137_V	164_Y	0.670	0.48
264_T	267_S	0.668	0.47
101_R	129_L	0.667	0.47
171_C	225_W	0.665	0.47
205_N	208_F	0.665	0.47
250_A	255_L	0.664	0.47
29_R	34_F	0.663	0.47
131_D	167_R	0.662	0.47
260_A	284_L	0.659	0.47
80_P	83_V	0.656	0.46
43_E	47_R	0.656	0.46
55_F	92_L	0.656	0.46
159_V	284_L	0.652	0.46
85_L	89_I	0.652	0.46
164_Y	267_S	0.651	0.46
221_Y	229_M	0.651	0.46
117_A	173_R	0.651	0.46
98_L	210_L	0.649	0.46
40_P	240_D	0.647	0.45
34_F	301_H	0.646	0.45
77_P	80_P	0.644	0.45
189_S	217_I	0.644	0.45
149_Y	218_N	0.644	0.45
193_V	211_W	0.642	0.45
237_F	248_Y	0.642	0.45
162_L	222_S	0.635	0.44
182_A	224_Y	0.635	0.44
134_T	163_P	0.634	0.44
131_D	171_C	0.631	0.44
275_E	278_V	0.630	0.44
160_A	281_L	0.627	0.43
62_L	99_F	0.626	0.43
111_L	185_L	0.625	0.43
197_S	270_L	0.624	0.43
225_W	292_W	0.622	0.43
227_V	255_L	0.622	0.43
19_G	39_D	0.621	0.43
10_L	19_G	0.620	0.43
17_L	154_V	0.619	0.43
55_F	93_L	0.619	0.43
48_Q	143_L	0.618	0.42
140_L	203_K	0.615	0.42
2_F	11_I	0.614	0.42
129_L	180_H	0.614	0.42
221_Y	287_I	0.613	0.42
36_F	128_F	0.612	0.42
216_V	220_L	0.611	0.42
133_L	137_V	0.610	0.42
188_S	210_L	0.607	0.41
286_V	291_I	0.605	0.41
215_S	260_A	0.604	0.41
126_D	218_N	0.604	0.41
196_L	207_L	0.603	0.41
99_F	243_P	0.602	0.41
37_E	40_P	0.602	0.41
173_R	186_K	0.601	0.41
138_K	218_N	0.601	0.41
3_P	6_R	0.601	0.41
213_V	255_L	0.599	0.41
52_L	182_A	0.599	0.41
95_L	185_L	0.599	0.41
104_R	297_L	0.597	0.40
285_E	292_W	0.597	0.40
31_N	48_Q	0.596	0.40
98_L	108_L	0.595	0.40
41_R	51_E	0.595	0.40
185_L	246_V	0.595	0.40
239_R	258_R	0.594	0.40
45_S	53_A	0.592	0.40
227_V	233_L	0.592	0.40
33_V	41_R	0.590	0.40
67_F	211_W	0.589	0.40
137_V	161_A	0.588	0.40
9_F	147_I	0.588	0.40
248_Y	252_V	0.587	0.39
19_G	49_V	0.583	0.39
122_V	174_R	0.581	0.39
19_G	53_A	0.580	0.39
5_Y	67_F	0.578	0.39
157_P	194_V	0.578	0.39
59_L	93_L	0.578	0.39
127_F	296_R	0.577	0.38
231_W	295_F	0.577	0.38
172_L	188_S	0.575	0.38
251_I	255_L	0.575	0.38
111_L	227_V	0.573	0.38
129_L	238_L	0.572	0.38
116_L	256_V	0.571	0.38
134_T	194_V	0.571	0.38
4_L	7_G	0.571	0.38
260_A	264_T	0.571	0.38
204_S	220_L	0.570	0.38
47_R	249_F	0.570	0.38
187_Y	289_R	0.567	0.37
36_F	301_H	0.566	0.37
23_Y	48_Q	0.565	0.37
104_R	296_R	0.565	0.37
185_L	217_I	0.563	0.37
219_S	222_S	0.562	0.37
89_I	109_R	0.562	0.37
293_N	302_L	0.561	0.37
29_R	85_L	0.561	0.37
96_L	244_K	0.558	0.37
127_F	180_H	0.558	0.37
99_F	172_L	0.557	0.37
298_E	302_L	0.557	0.37
66_L	85_L	0.557	0.37
183_N	288_R	0.557	0.37
180_H	188_S	0.554	0.36
137_V	145_F	0.554	0.36
183_N	292_W	0.554	0.36
30_I	168_F	0.553	0.36
135_S	288_R	0.553	0.36
252_V	256_V	0.553	0.36
35_I	118_P	0.552	0.36
79_D	213_V	0.550	0.36
25_W	28_Y	0.550	0.36
48_Q	56_L	0.549	0.36
127_F	282_A	0.549	0.36
97_I	202_D	0.549	0.36
99_F	212_I	0.542	0.35
112_F	220_L	0.541	0.35
93_L	121_P	0.540	0.35
204_S	271_G	0.539	0.35
91_L	94_L	0.535	0.34
86_I	252_V	0.535	0.34
15_L	29_R	0.534	0.34
35_I	132_Q	0.533	0.34
143_L	159_V	0.533	0.34
242_L	249_F	0.533	0.34
127_F	299_N	0.533	0.34
21_N	30_I	0.532	0.34
64_L	72_S	0.532	0.34
118_P	169_L	0.532	0.34
226_D	292_W	0.531	0.34
82_L	216_V	0.530	0.34
182_A	190_A	0.529	0.34
30_I	216_V	0.527	0.34
248_Y	261_W	0.526	0.34
3_P	18_W	0.526	0.34
19_G	287_I	0.526	0.34
191_I	223_F	0.526	0.34
111_L	115_L	0.524	0.33
117_A	166_I	0.524	0.33
250_A	287_I	0.523	0.33
9_F	72_S	0.523	0.33
172_L	210_L	0.522	0.33
197_S	211_W	0.520	0.33
247_Y	251_I	0.518	0.33
22_L	26_R	0.518	0.33
218_N	264_T	0.518	0.33
48_Q	103_S	0.517	0.33
25_W	293_N	0.516	0.33
11_I	16_L	0.515	0.33
125_R	297_L	0.514	0.33
66_L	69_N	0.511	0.32
49_V	52_L	0.510	0.32
73_G	93_L	0.509	0.32
93_L	96_L	0.509	0.32
38_F	42_T	0.509	0.32
7_G	164_Y	0.507	0.32
194_V	223_F	0.506	0.32
238_L	247_Y	0.505	0.32
10_L	286_V	0.505	0.32
4_L	8_F	0.503	0.32
182_A	229_M	0.503	0.32
125_R	132_Q	0.503	0.32
8_F	138_K	0.503	0.32
185_L	234_K	0.501	0.31
50_F	53_A	0.500	0.31
41_R	128_F	0.500	0.31
214_F	255_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rddB	1	0.1225	1	0.981	Contact Map
2gwwB	1	0.0662	1	0.981	Contact Map
2m5zA	1	0.1391	0.9	0.981	Contact Map
4g35B	1	0.043	0.9	0.982	Contact Map
2knuA	1	0.096	0.8	0.982	Contact Map
2ymyA	2	0.053	0.7	0.983	Contact Map
4xk8J	1	0.1291	0.6	0.983	Contact Map
1tifA	1	0.0828	0.6	0.984	Contact Map
3tx3A	2	0.2914	0.6	0.984	Contact Map
4n6hA	1	0.3675	0.6	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.