GREMLIN Database
EXS - EXS family
PFAM: PF03124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 302 (301)
Sequences: 1184 (853)
Seq/√Len: 49.2
META: 0.197

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_Q293_N4.7521.00
5_Y63_S4.6771.00
223_F255_L4.6701.00
111_L133_L4.4411.00
16_L57_T4.3001.00
168_F184_A4.1711.00
253_L291_I3.8561.00
113_R126_D3.4311.00
238_L248_Y3.4241.00
162_L166_I3.3491.00
257_L284_L3.1571.00
250_A295_F3.0971.00
173_R177_D3.0791.00
6_R142_D3.0521.00
246_V295_F3.0321.00
167_R170_Q3.0151.00
231_W250_A2.8381.00
249_F253_L2.7771.00
24_V294_F2.7151.00
218_N222_S2.4311.00
227_V251_I2.3561.00
16_L53_A2.3131.00
178_F182_A2.3081.00
21_N294_F2.2761.00
167_R187_Y2.2621.00
5_Y86_I2.2431.00
14_H136_L2.1601.00
183_N186_K2.1361.00
116_L120_Y2.1341.00
182_A185_L2.1221.00
232_G299_N2.0451.00
183_N187_Y2.0431.00
175_Y181_L2.0231.00
115_L166_I1.9971.00
167_R171_C1.9270.99
296_R300_E1.9240.99
287_I291_I1.9170.99
131_D187_Y1.9100.99
101_R105_F1.9050.99
167_R296_R1.9000.99
285_E288_R1.8670.99
224_Y228_V1.8520.99
219_S259_F1.8390.99
124_F296_R1.8350.99
53_A57_T1.8100.99
290_G294_F1.7820.99
254_N291_I1.7480.99
114_I130_A1.7400.99
22_L49_V1.7320.99
19_G50_F1.6960.98
185_L221_Y1.6910.98
288_R292_W1.6160.98
114_I166_I1.5980.98
165_W169_L1.5660.97
258_R261_W1.5650.97
31_N34_F1.5630.97
289_R292_W1.5620.97
253_L257_L1.5600.97
131_D135_S1.5330.97
145_F149_Y1.5300.97
12_V60_L1.4940.96
179_P229_M1.4890.96
171_C187_Y1.4740.96
187_Y296_R1.4670.96
224_Y229_M1.4650.96
174_R180_H1.4510.96
174_R301_H1.4380.95
250_A291_I1.4240.95
285_E289_R1.4150.95
223_F227_V1.4140.95
131_D225_W1.3810.94
195_I199_L1.3810.94
128_F293_N1.3500.94
167_R183_N1.3320.93
235_N240_D1.3250.93
128_F132_Q1.3160.93
186_K225_W1.3140.93
249_F291_I1.2900.92
266_L270_L1.2860.92
220_L281_L1.2810.92
134_T164_Y1.2780.92
248_Y251_I1.2740.91
9_F57_T1.2710.91
215_S262_I1.2660.91
12_V56_L1.2600.91
185_L189_S1.2580.91
172_L184_A1.2550.91
60_L90_L1.2410.90
14_H293_N1.2240.90
136_L139_V1.2170.89
126_D180_H1.2120.89
117_A122_V1.2080.89
24_V30_I1.2040.89
190_A222_S1.1970.89
238_L251_I1.1970.89
143_L217_I1.1940.88
21_N25_W1.1940.88
44_L103_S1.1870.88
187_Y292_W1.1870.88
276_L280_L1.1850.88
13_L287_I1.1750.88
131_D183_N1.1710.87
235_N244_K1.1680.87
127_F174_R1.1640.87
154_V157_P1.1570.87
266_L269_H1.1350.86
31_N174_R1.1280.85
57_T95_L1.1250.85
257_L261_W1.1140.85
5_Y302_L1.1060.84
193_V260_A1.1060.84
25_W297_L1.0940.84
226_D230_D1.0940.84
89_I96_L1.0810.83
169_L173_R1.0760.83
199_L207_L1.0710.82
34_F174_R1.0700.82
164_Y194_V1.0660.82
170_Q187_Y1.0640.82
166_I169_L1.0620.82
92_L96_L1.0400.80
13_L283_L1.0310.80
133_L140_L1.0270.80
140_L159_V1.0270.80
168_F191_I1.0260.79
125_R128_F1.0260.79
216_V252_V1.0230.79
186_K221_Y1.0210.79
138_K142_D1.0110.78
132_Q138_K1.0100.78
95_L252_V1.0070.78
193_V215_S1.0040.78
246_V250_A1.0040.78
220_L224_Y1.0040.78
187_Y221_Y0.9980.78
189_S221_Y0.9930.77
140_L161_A0.9920.77
164_Y190_A0.9890.77
251_I254_N0.9860.77
246_V249_F0.9820.76
267_S270_L0.9760.76
209_V213_V0.9620.75
225_W230_D0.9610.75
87_P104_R0.9600.75
24_V28_Y0.9580.75
187_Y225_W0.9540.74
105_F108_L0.9530.74
118_P232_G0.9530.74
157_P161_A0.9500.74
142_D145_F0.9480.74
105_F109_R0.9480.74
35_I297_L0.9460.74
17_L290_G0.9400.73
102_S244_K0.9370.73
226_D258_R0.9350.73
284_L294_F0.9320.73
281_L284_L0.9310.72
25_W128_F0.9240.72
24_V93_L0.9190.72
147_I281_L0.9140.71
178_F254_N0.9120.71
171_C296_R0.9110.71
21_N290_G0.9110.71
144_E156_V0.9090.71
183_N225_W0.9080.71
126_D129_L0.9010.70
154_V158_I0.8990.70
131_D296_R0.8920.69
264_T277_L0.8920.69
26_R46_Y0.8900.69
60_L64_L0.8890.69
144_E148_C0.8890.69
228_V232_G0.8850.69
122_V296_R0.8800.68
33_V38_F0.8790.68
227_V254_N0.8750.68
197_S262_I0.8670.67
299_N302_L0.8660.67
131_D186_K0.8660.67
104_R108_L0.8650.67
115_L118_P0.8600.66
63_S86_I0.8570.66
18_W138_K0.8550.66
91_L287_I0.8500.65
108_L150_Y0.8500.65
291_I295_F0.8480.65
161_A210_L0.8460.65
292_W298_E0.8450.65
23_Y50_F0.8430.65
89_I95_L0.8420.65
168_F172_L0.8390.64
66_L70_L0.8330.64
112_F120_Y0.8320.64
14_H139_V0.8320.64
39_D45_S0.8310.64
110_T125_R0.8300.64
220_L280_L0.8260.63
5_Y211_W0.8220.63
183_N296_R0.8210.63
141_R160_A0.8180.62
25_W36_F0.8120.62
196_L210_L0.8060.61
172_L181_L0.8050.61
221_Y225_W0.8000.61
124_F300_E0.7960.60
70_L86_I0.7960.60
35_I299_N0.7920.60
196_L208_F0.7890.60
239_R247_Y0.7870.59
117_A165_W0.7860.59
163_P170_Q0.7860.59
3_P145_F0.7840.59
247_Y250_A0.7790.59
292_W296_R0.7760.58
95_L249_F0.7740.58
42_T115_L0.7720.58
14_H132_Q0.7700.58
110_T129_L0.7700.58
270_L275_E0.7670.57
196_L199_L0.7670.57
134_T222_S0.7660.57
152_Y156_V0.7640.57
171_C175_Y0.7640.57
151_F227_V0.7630.57
30_I81_K0.7620.57
116_L241_K0.7590.57
10_L18_W0.7550.56
107_F190_A0.7530.56
9_F60_L0.7520.56
111_L147_I0.7520.56
5_Y8_F0.7510.56
35_I39_D0.7460.55
247_Y261_W0.7460.55
139_V222_S0.7440.55
263_L277_L0.7430.55
134_T190_A0.7420.55
100_Y234_K0.7420.55
163_P167_R0.7400.55
254_N275_E0.7400.55
134_T138_K0.7390.55
233_L238_L0.7320.54
197_S200_Y0.7300.54
93_L97_I0.7290.54
115_L240_D0.7280.54
104_R107_F0.7250.53
6_R275_E0.7240.53
95_L143_L0.7190.53
181_L185_L0.7190.53
197_S263_L0.7160.52
18_W49_V0.7150.52
156_V160_A0.7120.52
44_L48_Q0.7110.52
210_L241_K0.7080.52
7_G25_W0.7080.52
20_L24_V0.7070.51
188_S191_I0.7070.51
10_L44_L0.7030.51
5_Y90_L0.7030.51
57_T259_F0.7010.51
122_V127_F0.6990.51
200_Y208_F0.6940.50
35_I193_V0.6930.50
137_V264_T0.6930.50
25_W87_P0.6920.50
36_F103_S0.6910.50
118_P165_W0.6910.50
186_K254_N0.6900.50
254_N258_R0.6900.50
21_N293_N0.6890.50
50_F57_T0.6880.50
17_L287_I0.6870.49
133_L295_F0.6830.49
248_Y299_N0.6820.49
197_S269_H0.6820.49
46_Y50_F0.6800.49
130_A189_S0.6790.49
107_F228_V0.6770.48
25_W32_Y0.6720.48
30_I224_Y0.6710.48
158_I177_D0.6710.48
137_V164_Y0.6700.48
264_T267_S0.6680.47
101_R129_L0.6670.47
171_C225_W0.6650.47
205_N208_F0.6650.47
250_A255_L0.6640.47
29_R34_F0.6630.47
131_D167_R0.6620.47
260_A284_L0.6590.47
80_P83_V0.6560.46
43_E47_R0.6560.46
55_F92_L0.6560.46
159_V284_L0.6520.46
85_L89_I0.6520.46
164_Y267_S0.6510.46
221_Y229_M0.6510.46
117_A173_R0.6510.46
98_L210_L0.6490.46
40_P240_D0.6470.45
34_F301_H0.6460.45
77_P80_P0.6440.45
189_S217_I0.6440.45
149_Y218_N0.6440.45
193_V211_W0.6420.45
237_F248_Y0.6420.45
162_L222_S0.6350.44
182_A224_Y0.6350.44
134_T163_P0.6340.44
131_D171_C0.6310.44
275_E278_V0.6300.44
160_A281_L0.6270.43
62_L99_F0.6260.43
111_L185_L0.6250.43
197_S270_L0.6240.43
225_W292_W0.6220.43
227_V255_L0.6220.43
19_G39_D0.6210.43
10_L19_G0.6200.43
17_L154_V0.6190.43
55_F93_L0.6190.43
48_Q143_L0.6180.42
140_L203_K0.6150.42
2_F11_I0.6140.42
129_L180_H0.6140.42
221_Y287_I0.6130.42
36_F128_F0.6120.42
216_V220_L0.6110.42
133_L137_V0.6100.42
188_S210_L0.6070.41
286_V291_I0.6050.41
215_S260_A0.6040.41
126_D218_N0.6040.41
196_L207_L0.6030.41
99_F243_P0.6020.41
37_E40_P0.6020.41
173_R186_K0.6010.41
138_K218_N0.6010.41
3_P6_R0.6010.41
213_V255_L0.5990.41
52_L182_A0.5990.41
95_L185_L0.5990.41
104_R297_L0.5970.40
285_E292_W0.5970.40
31_N48_Q0.5960.40
98_L108_L0.5950.40
41_R51_E0.5950.40
185_L246_V0.5950.40
239_R258_R0.5940.40
45_S53_A0.5920.40
227_V233_L0.5920.40
33_V41_R0.5900.40
67_F211_W0.5890.40
137_V161_A0.5880.40
9_F147_I0.5880.40
248_Y252_V0.5870.39
19_G49_V0.5830.39
122_V174_R0.5810.39
19_G53_A0.5800.39
5_Y67_F0.5780.39
157_P194_V0.5780.39
59_L93_L0.5780.39
127_F296_R0.5770.38
231_W295_F0.5770.38
172_L188_S0.5750.38
251_I255_L0.5750.38
111_L227_V0.5730.38
129_L238_L0.5720.38
116_L256_V0.5710.38
134_T194_V0.5710.38
4_L7_G0.5710.38
260_A264_T0.5710.38
204_S220_L0.5700.38
47_R249_F0.5700.38
187_Y289_R0.5670.37
36_F301_H0.5660.37
23_Y48_Q0.5650.37
104_R296_R0.5650.37
185_L217_I0.5630.37
219_S222_S0.5620.37
89_I109_R0.5620.37
293_N302_L0.5610.37
29_R85_L0.5610.37
96_L244_K0.5580.37
127_F180_H0.5580.37
99_F172_L0.5570.37
298_E302_L0.5570.37
66_L85_L0.5570.37
183_N288_R0.5570.37
180_H188_S0.5540.36
137_V145_F0.5540.36
183_N292_W0.5540.36
30_I168_F0.5530.36
135_S288_R0.5530.36
252_V256_V0.5530.36
35_I118_P0.5520.36
79_D213_V0.5500.36
25_W28_Y0.5500.36
48_Q56_L0.5490.36
127_F282_A0.5490.36
97_I202_D0.5490.36
99_F212_I0.5420.35
112_F220_L0.5410.35
93_L121_P0.5400.35
204_S271_G0.5390.35
91_L94_L0.5350.34
86_I252_V0.5350.34
15_L29_R0.5340.34
35_I132_Q0.5330.34
143_L159_V0.5330.34
242_L249_F0.5330.34
127_F299_N0.5330.34
21_N30_I0.5320.34
64_L72_S0.5320.34
118_P169_L0.5320.34
226_D292_W0.5310.34
82_L216_V0.5300.34
182_A190_A0.5290.34
30_I216_V0.5270.34
248_Y261_W0.5260.34
3_P18_W0.5260.34
19_G287_I0.5260.34
191_I223_F0.5260.34
111_L115_L0.5240.33
117_A166_I0.5240.33
250_A287_I0.5230.33
9_F72_S0.5230.33
172_L210_L0.5220.33
197_S211_W0.5200.33
247_Y251_I0.5180.33
22_L26_R0.5180.33
218_N264_T0.5180.33
48_Q103_S0.5170.33
25_W293_N0.5160.33
11_I16_L0.5150.33
125_R297_L0.5140.33
66_L69_N0.5110.32
49_V52_L0.5100.32
73_G93_L0.5090.32
93_L96_L0.5090.32
38_F42_T0.5090.32
7_G164_Y0.5070.32
194_V223_F0.5060.32
238_L247_Y0.5050.32
10_L286_V0.5050.32
4_L8_F0.5030.32
182_A229_M0.5030.32
125_R132_Q0.5030.32
8_F138_K0.5030.32
185_L234_K0.5010.31
50_F53_A0.5000.31
41_R128_F0.5000.31
214_F255_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rddB 1 0.1225 1 0.981 Contact Map
2gwwB 1 0.0662 1 0.981 Contact Map
2m5zA 1 0.1391 0.9 0.981 Contact Map
4g35B 1 0.043 0.9 0.982 Contact Map
2knuA 1 0.096 0.8 0.982 Contact Map
2ymyA 2 0.053 0.7 0.983 Contact Map
4xk8J 1 0.1291 0.6 0.983 Contact Map
1tifA 1 0.0828 0.6 0.984 Contact Map
3tx3A 2 0.2914 0.6 0.984 Contact Map
4n6hA 1 0.3675 0.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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