GREMLIN Database
Mlo - Mlo family
PFAM: PF03094 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 479 (463)
Sequences: 636 (386)
Seq/√Len: 18.0
META: 0.009

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_R119_L5.9151.00
116_R120_A5.8301.00
104_R107_L4.1801.00
34_G46_F3.7991.00
387_V391_I3.6051.00
117_R120_A3.4471.00
158_Y221_C3.0830.99
78_I82_V2.9260.99
142_H145_H2.8470.98
142_H146_I2.7740.98
22_I69_G2.6400.97
170_I233_S2.6330.97
147_F393_R2.6270.97
280_F358_F2.6110.97
459_S462_P2.6080.97
393_R401_Q2.6000.97
31_H61_F2.5970.97
69_G199_Q2.4840.96
103_R107_L2.3680.95
289_V299_S2.3270.94
38_K46_F2.3010.94
203_V207_L2.2410.93
136_L140_G2.2390.93
317_I401_Q2.2070.93
147_F339_P2.1980.92
42_K167_R2.1800.92
83_A228_G2.1630.92
67_T374_W2.1440.91
139_E358_F2.1420.91
103_R108_S2.1330.91
376_E393_R2.1140.91
458_S464_T2.1070.91
55_E145_H2.1000.91
78_I85_T2.0570.90
172_R282_V2.0560.90
265_D308_L2.0130.89
381_S393_R2.0080.88
75_K126_Y2.0060.88
311_T386_N1.9860.88
201_S206_H1.9820.88
366_E393_R1.9760.88
305_L359_I1.9480.87
187_F366_E1.9050.86
118_L121_A1.8990.85
105_R108_S1.8920.85
34_G264_E1.8840.85
219_I223_F1.8550.84
281_V405_S1.8320.83
106_L118_L1.8230.83
299_S422_M1.8190.83
79_P303_L1.8040.82
362_Q374_W1.7790.81
460_S464_T1.7600.81
299_S389_L1.7380.80
317_I442_A1.7120.79
56_L149_F1.7080.78
143_Q165_L1.6970.78
461_R464_T1.6880.78
144_L267_F1.6770.77
317_I393_R1.6730.77
78_I265_D1.6720.77
400_V409_L1.6490.76
30_L447_K1.6490.76
33_L338_Q1.6450.76
127_C130_K1.6350.75
166_G263_L1.6300.75
17_F78_I1.6290.75
131_G402_F1.6280.75
426_I435_L1.6270.75
70_Q148_I1.6270.75
161_L376_E1.6260.75
280_F374_W1.6020.74
425_A428_D1.5960.73
79_P82_V1.5890.73
298_L380_K1.5860.73
376_E401_Q1.5850.73
166_G409_L1.5840.73
159_S445_K1.5720.72
83_A159_S1.5720.72
218_W339_P1.5710.72
70_Q263_L1.5680.72
18_V206_H1.5560.72
443_K447_K1.5520.71
158_Y343_L1.5480.71
104_R118_L1.5310.70
55_E65_L1.5170.70
190_D193_R1.5160.69
425_A443_K1.5000.69
103_R106_L1.4900.68
291_G296_F1.4890.68
62_I314_Q1.4890.68
40_K340_S1.4800.68
179_E232_K1.4800.68
246_H274_S1.4770.67
221_C416_T1.4760.67
170_I245_A1.4700.67
26_I190_D1.4640.67
86_M367_L1.4580.66
74_S338_Q1.4520.66
160_V279_F1.4520.66
97_E120_A1.4510.66
195_R335_P1.4500.66
12_V427_F1.4460.66
29_L90_K1.4320.65
46_F301_I1.4290.65
193_R330_V1.4250.65
418_M423_K1.4230.64
365_F372_W1.4210.64
284_F288_N1.4060.63
150_V339_P1.3960.63
459_S463_T1.3900.63
86_M139_E1.3890.62
324_I335_P1.3850.62
5_E368_A1.3820.62
17_F21_L1.3780.62
66_L166_G1.3770.62
156_V264_E1.3720.61
282_V373_I1.3640.61
11_A200_T1.3640.61
370_F384_H1.3520.60
156_V373_I1.3500.60
159_S279_F1.3470.60
147_F319_K1.3440.60
193_R200_T1.3350.59
109_F112_S1.3310.59
181_K186_Q1.3270.59
37_L394_L1.3260.59
289_V321_A1.3260.59
348_R424_K1.3250.59
173_W176_W1.3210.58
180_T366_E1.3190.58
250_N314_Q1.3160.58
25_L107_L1.3150.58
149_F361_F1.3020.57
247_L320_L1.2940.57
215_I322_L1.2820.56
40_K136_L1.2820.56
27_E31_H1.2790.56
228_G231_T1.2780.56
150_V218_W1.2650.55
88_P307_L1.2610.55
379_F387_V1.2600.55
246_H361_F1.2570.55
59_L358_F1.2560.55
171_R256_H1.2480.54
449_G455_S1.2420.54
153_V391_I1.2400.54
301_I342_D1.2360.53
237_T425_A1.2340.53
147_F317_I1.2220.52
3_S338_Q1.2210.52
287_L374_W1.2180.52
118_L394_L1.2170.52
37_L238_L1.2140.52
279_F414_L1.2130.52
286_L292_W1.2100.52
159_S364_A1.2070.52
155_H435_L1.2060.51
457_P460_S1.2050.51
311_T326_E1.1890.50
150_V368_A1.1880.50
15_V78_I1.1840.50
180_T185_Y1.1820.50
74_S238_L1.1750.50
371_F374_W1.1740.50
435_L438_W1.1680.49
138_L283_I1.1680.49
427_F438_W1.1620.49
425_A445_K1.1590.49
165_L376_E1.1540.48
4_L13_A1.1510.48
6_E90_K1.1480.48
198_R201_S1.1480.48
414_L431_V1.1430.48
190_D194_F1.1420.48
245_A332_K1.1420.48
106_L121_A1.1400.47
3_S464_T1.1400.47
139_E238_L1.1370.47
55_E142_H1.1360.47
15_V56_L1.1360.47
337_V390_I1.1330.47
330_V333_G1.1320.47
157_L183_L1.1320.47
209_F316_I1.1180.46
220_V317_I1.1170.46
14_V228_G1.1070.45
458_S463_T1.1020.45
287_L294_T1.1020.45
343_L373_I1.1020.45
412_Y415_V1.0980.45
442_A445_K1.0970.45
101_E130_K1.0960.45
423_K445_K1.0940.45
9_T12_V1.0930.45
281_V401_Q1.0910.44
55_E133_V1.0890.44
75_K443_K1.0890.44
52_I402_F1.0880.44
175_A232_K1.0860.44
218_W368_A1.0850.44
76_I425_A1.0830.44
3_S30_L1.0820.44
166_G266_D1.0780.44
37_L431_V1.0770.44
180_T205_R1.0760.44
198_R217_L1.0740.43
30_L323_E1.0730.43
165_L375_Y1.0710.43
147_F286_L1.0700.43
16_C27_E1.0680.43
18_V53_K1.0650.43
104_R114_S1.0620.43
100_E301_I1.0610.43
78_I435_L1.0550.42
425_A435_L1.0540.42
76_I238_L1.0530.42
33_L165_L1.0490.42
410_P417_Q1.0460.42
316_I403_L1.0430.42
59_L292_W1.0410.41
105_R118_L1.0380.41
422_M435_L1.0360.41
52_I161_L1.0330.41
76_I229_S1.0320.41
351_L445_K1.0300.41
305_L324_I1.0270.41
161_L425_A1.0260.41
59_L66_L1.0230.40
163_M378_G1.0210.40
197_T330_V1.0190.40
152_A434_A1.0160.40
135_L232_K1.0160.40
3_S139_E1.0160.40
237_T270_V1.0130.40
157_L352_V1.0100.40
215_I237_T1.0080.39
86_M294_T1.0010.39
47_E67_T1.0010.39
196_F200_T1.0000.39
295_Y300_F0.9990.39
136_L288_N0.9980.39
99_E102_H0.9970.39
299_S321_A0.9960.39
386_N394_L0.9950.39
81_S208_G0.9920.39
170_I205_R0.9910.38
58_L359_I0.9890.38
262_S269_V0.9860.38
304_I316_I0.9860.38
240_H316_I0.9850.38
147_F401_Q0.9770.38
295_Y366_E0.9760.38
25_L29_L0.9730.37
171_R337_V0.9670.37
156_V338_Q0.9610.37
182_T221_C0.9580.37
73_I132_K0.9570.37
30_L340_S0.9550.36
267_F271_V0.9540.36
351_L444_K0.9530.36
22_I65_L0.9500.36
165_L399_I0.9500.36
270_V290_H0.9500.36
99_E395_V0.9480.36
395_V416_T0.9480.36
78_I130_K0.9470.36
116_R121_A0.9460.36
147_F158_Y0.9460.36
289_V371_F0.9450.36
8_P381_S0.9410.36
241_G420_S0.9410.36
74_S315_H0.9410.36
14_V386_N0.9400.36
209_F304_I0.9380.35
78_I230_V0.9370.35
35_K339_P0.9370.35
259_I414_L0.9330.35
169_K435_L0.9320.35
273_I393_R0.9320.35
193_R232_K0.9290.35
456_T461_R0.9290.35
17_F265_D0.9280.35
88_P412_Y0.9280.35
340_S343_L0.9280.35
383_F389_L0.9250.35
106_L111_D0.9250.35
262_S413_A0.9240.35
91_K265_D0.9230.35
326_E426_I0.9230.35
75_K161_L0.9220.35
22_I285_L0.9220.35
448_H451_S0.9210.35
179_E194_F0.9200.34
11_A224_R0.9160.34
10_W15_V0.9160.34
376_E402_F0.9160.34
12_V49_L0.9130.34
282_V288_N0.9120.34
320_L325_A0.9070.34
147_F231_T0.9060.34
436_K439_H0.9030.34
171_R227_Y0.9020.33
367_L371_F0.8980.33
335_P434_A0.8970.33
158_Y392_I0.8950.33
277_L299_S0.8910.33
103_R109_F0.8910.33
206_H364_A0.8900.33
314_Q341_D0.8880.33
409_L413_A0.8850.33
141_L145_H0.8820.32
260_K269_V0.8810.32
264_E301_I0.8800.32
164_A380_K0.8800.32
305_L398_V0.8790.32
82_V452_S0.8740.32
78_I269_V0.8730.32
422_M427_F0.8720.32
425_A446_K0.8720.32
28_R58_L0.8710.32
28_R68_V0.8710.32
3_S74_S0.8660.32
217_L315_H0.8660.32
130_K367_L0.8650.31
153_V364_A0.8650.31
24_L27_E0.8640.31
31_H67_T0.8630.31
15_V27_E0.8610.31
104_R108_S0.8610.31
339_P401_Q0.8580.31
299_S366_E0.8560.31
259_I320_L0.8500.31
115_G119_L0.8490.31
459_S464_T0.8470.31
260_K305_L0.8460.30
319_K352_V0.8450.30
45_L53_K0.8450.30
311_T331_V0.8450.30
2_R206_H0.8420.30
306_L376_E0.8420.30
54_E296_F0.8420.30
410_P414_L0.8420.30
158_Y306_L0.8400.30
449_G452_S0.8400.30
134_P326_E0.8380.30
321_A364_A0.8350.30
23_S62_I0.8340.30
367_L409_L0.8330.30
94_E398_V0.8320.30
68_V368_A0.8260.29
207_L210_W0.8260.29
389_L395_V0.8240.29
149_F246_H0.8230.29
374_W399_I0.8220.29
80_E301_I0.8180.29
390_I402_F0.8180.29
169_K396_L0.8180.29
457_P462_P0.8170.29
67_T271_V0.8170.29
155_H362_Q0.8160.29
357_H361_F0.8160.29
200_T206_H0.8150.29
32_R54_E0.8140.29
195_R200_T0.8140.29
258_Y264_E0.8130.29
43_K311_T0.8090.29
165_L200_T0.8050.28
410_P415_V0.8050.28
114_S118_L0.8040.28
226_F229_S0.8000.28
151_L257_K0.7990.28
265_D425_A0.7990.28
358_F374_W0.7990.28
224_R439_H0.7990.28
248_A320_L0.7970.28
358_F403_L0.7950.28
414_L417_Q0.7910.28
419_G427_F0.7910.28
26_I83_A0.7900.28
34_G142_H0.7890.28
85_T407_S0.7890.28
252_K426_I0.7880.28
157_L402_F0.7870.27
26_I316_I0.7850.27
62_I142_H0.7850.27
30_L131_G0.7840.27
308_L362_Q0.7840.27
216_L351_L0.7830.27
125_D153_V0.7820.27
12_V16_C0.7820.27
179_E206_H0.7820.27
446_K449_G0.7800.27
96_K283_I0.7790.27
10_W16_C0.7780.27
330_V336_V0.7780.27
339_P393_R0.7770.27
136_L227_Y0.7730.27
185_Y193_R0.7730.27
3_S342_D0.7730.27
213_S431_V0.7710.27
71_G139_E0.7680.27
85_T179_E0.7670.27
87_L373_I0.7650.26
25_L392_I0.7640.26
13_A58_L0.7620.26
221_C322_L0.7610.26
206_H216_L0.7580.26
237_T336_V0.7580.26
259_I315_H0.7560.26
165_L303_L0.7550.26
314_Q319_K0.7520.26
427_F434_A0.7510.26
4_L12_V0.7510.26
104_R113_G0.7500.26
201_S217_L0.7500.26
62_I147_F0.7500.26
80_E84_S0.7500.26
323_E397_G0.7480.26
9_T13_A0.7480.26
342_D350_R0.7450.25
39_K319_K0.7450.25
452_S455_S0.7440.25
301_I362_Q0.7430.25
246_H258_Y0.7410.25
358_F378_G0.7390.25
87_L135_L0.7390.25
153_V316_I0.7390.25
421_S442_A0.7380.25
309_V385_E0.7360.25
82_V130_K0.7340.25
281_V298_L0.7310.25
110_S115_G0.7310.25
254_D270_V0.7310.25
58_L149_F0.7280.25
24_L34_G0.7280.25
129_K283_I0.7250.25
171_R263_L0.7240.25
75_K215_I0.7230.24
414_L420_S0.7210.24
145_H361_F0.7210.24
185_Y366_E0.7160.24
421_S433_K0.7160.24
206_H414_L0.7160.24
383_F397_G0.7120.24
418_M438_W0.7100.24
28_R32_R0.7100.24
135_L174_K0.7090.24
163_M358_F0.7080.24
58_L361_F0.7070.24
170_I184_E0.7070.24
250_N256_H0.7070.24
133_V331_V0.7060.24
99_E120_A0.7040.24
143_Q200_T0.7030.24
342_D430_Q0.7020.24
8_P267_F0.7010.23
32_R354_F0.7000.23
161_L165_L0.6980.23
36_W143_Q0.6970.23
12_V264_E0.6950.23
11_A50_E0.6950.23
30_L307_L0.6930.23
71_G265_D0.6910.23
359_I431_V0.6910.23
143_Q217_L0.6900.23
96_K108_S0.6900.23
207_L254_D0.6880.23
86_M358_F0.6880.23
36_W50_E0.6860.23
289_V445_K0.6850.23
137_S147_F0.6850.23
17_F394_L0.6850.23
288_N383_F0.6830.23
343_L393_R0.6830.23
145_H364_A0.6820.23
87_L357_H0.6810.23
54_E384_H0.6810.23
186_Q254_D0.6790.23
250_N334_A0.6780.22
73_I454_S0.6770.22
317_I339_P0.6770.22
20_V366_E0.6770.22
225_Q229_S0.6770.22
56_L246_H0.6750.22
179_E190_D0.6750.22
175_A347_G0.6750.22
199_Q232_K0.6740.22
400_V420_S0.6730.22
308_L328_H0.6720.22
7_T16_C0.6720.22
165_L353_L0.6700.22
241_G282_V0.6690.22
143_Q191_P0.6660.22
174_K377_F0.6650.22
180_T200_T0.6620.22
254_D352_V0.6610.22
307_L409_L0.6600.22
273_I401_Q0.6600.22
65_L69_G0.6590.22
37_L291_G0.6590.22
184_E358_F0.6580.22
298_L393_R0.6570.22
443_K458_S0.6560.22
408_T416_T0.6560.22
115_G118_L0.6550.22
306_L314_Q0.6540.21
139_E369_F0.6530.21
23_S31_H0.6520.21
311_T429_E0.6520.21
57_M63_S0.6520.21
236_L379_F0.6510.21
45_L238_L0.6490.21
210_W220_V0.6470.21
174_K253_F0.6460.21
262_S425_A0.6460.21
374_W384_H0.6460.21
94_E102_H0.6450.21
174_K338_Q0.6440.21
19_I352_V0.6440.21
86_M373_I0.6440.21
158_Y237_T0.6430.21
230_V357_H0.6430.21
177_E261_R0.6420.21
39_K358_F0.6400.21
245_A348_R0.6400.21
147_F343_L0.6400.21
283_I289_V0.6390.21
219_I335_P0.6380.21
5_E10_W0.6370.21
71_G116_R0.6360.21
81_S431_V0.6350.21
78_I456_T0.6340.21
219_I371_F0.6330.21
275_P286_L0.6330.21
238_L319_K0.6320.21
59_L62_I0.6320.21
203_V277_L0.6310.21
82_V398_V0.6310.21
101_E106_L0.6300.20
82_V273_I0.6280.20
223_F447_K0.6270.20
280_F362_Q0.6260.20
214_P221_C0.6250.20
230_V263_L0.6240.20
300_F445_K0.6240.20
282_V338_Q0.6230.20
424_K434_A0.6230.20
139_E287_L0.6220.20
113_G254_D0.6210.20
22_I62_I0.6200.20
218_W315_H0.6190.20
65_L169_K0.6180.20
143_Q423_K0.6160.20
183_L371_F0.6150.20
30_L49_L0.6140.20
21_L342_D0.6110.20
216_L393_R0.6110.20
71_G215_I0.6100.20
47_E268_K0.6070.20
396_L413_A0.6050.20
78_I254_D0.6030.19
356_I359_I0.6030.19
18_V285_L0.6020.19
306_L400_V0.6010.19
218_W314_Q0.6010.19
286_L357_H0.6010.19
410_P413_A0.6000.19
68_V150_V0.6000.19
60_G63_S0.5980.19
124_S134_P0.5980.19
428_D447_K0.5960.19
299_S386_N0.5950.19
327_R331_V0.5940.19
107_L110_S0.5930.19
29_L414_L0.5920.19
23_S27_E0.5920.19
5_E396_L0.5920.19
21_L136_L0.5920.19
272_G362_Q0.5910.19
14_V364_A0.5910.19
219_I299_S0.5910.19
216_L347_G0.5900.19
401_Q405_S0.5900.19
272_G357_H0.5900.19
230_V416_T0.5890.19
19_I138_L0.5880.19
161_L435_L0.5870.19
369_F393_R0.5860.19
348_R386_N0.5860.19
145_H149_F0.5860.19
155_H354_F0.5860.19
28_R368_A0.5850.19
198_R340_S0.5840.19
105_R316_I0.5840.19
33_L314_Q0.5820.19
460_S463_T0.5810.19
79_P126_Y0.5800.19
286_L373_I0.5790.19
163_M375_Y0.5780.18
334_A368_A0.5770.18
299_S371_F0.5770.18
24_L182_T0.5770.18
339_P368_A0.5760.18
311_T416_T0.5750.18
34_G49_L0.5740.18
14_V445_K0.5730.18
101_E104_R0.5710.18
17_F159_S0.5710.18
240_H333_G0.5710.18
56_L361_F0.5710.18
202_F246_H0.5700.18
276_Y426_I0.5680.18
60_G77_C0.5650.18
256_H336_V0.5620.18
178_D267_F0.5620.18
70_Q142_H0.5620.18
414_L434_A0.5610.18
328_H331_V0.5590.18
404_C408_T0.5590.18
105_R115_G0.5590.18
188_S288_N0.5570.18
67_T267_F0.5570.18
82_V254_D0.5570.18
86_M138_L0.5560.18
323_E424_K0.5540.18
143_Q377_F0.5530.18
150_V295_Y0.5520.18
58_L320_L0.5510.18
213_S400_V0.5510.18
386_N402_F0.5490.17
296_F299_S0.5490.17
243_I420_S0.5480.17
110_S117_R0.5470.17
71_G358_F0.5470.17
33_L78_I0.5450.17
18_V301_I0.5450.17
196_F416_T0.5450.17
171_R253_F0.5440.17
142_H361_F0.5440.17
133_V369_F0.5420.17
199_Q328_H0.5420.17
374_W379_F0.5410.17
6_E26_I0.5410.17
108_S115_G0.5400.17
86_M167_R0.5400.17
189_N193_R0.5380.17
428_D432_A0.5380.17
260_K320_L0.5370.17
456_T460_S0.5370.17
73_I91_K0.5370.17
424_K448_H0.5350.17
281_V339_P0.5350.17
281_V317_I0.5340.17
323_E340_S0.5340.17
135_L340_S0.5330.17
218_W295_Y0.5330.17
154_F159_S0.5330.17
78_I83_A0.5320.17
218_W334_A0.5320.17
98_E169_K0.5310.17
55_E362_Q0.5300.17
456_T462_P0.5300.17
145_H405_S0.5280.17
348_R448_H0.5270.17
281_V357_H0.5270.17
180_T206_H0.5260.17
30_L41_H0.5250.17
67_T360_L0.5250.17
406_Y413_A0.5250.17
312_K316_I0.5250.17
220_V414_L0.5230.17
197_T335_P0.5190.16
161_L400_V0.5190.16
215_I318_T0.5180.16
318_T409_L0.5140.16
125_D314_Q0.5130.16
41_H105_R0.5120.16
408_T412_Y0.5120.16
108_S124_S0.5120.16
136_L306_L0.5110.16
284_F287_L0.5110.16
103_R113_G0.5100.16
16_C263_L0.5100.16
56_L202_F0.5080.16
117_R121_A0.5080.16
183_L351_L0.5070.16
300_F392_I0.5070.16
275_P282_V0.5060.16
224_R314_Q0.5050.16
155_H210_W0.5030.16
347_G452_S0.5030.16
33_L163_M0.5000.16
96_K311_T0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m3eA 1 0.0939 46.1 0.984 Contact Map
2kncA 1 0.1023 22.7 0.987 Contact Map
2k1aA 1 0.0814 14 0.988 Contact Map
4k0jA 3 0.1879 13.7 0.988 Contact Map
4b19A 1 0.0626 13.6 0.988 Contact Map
2l8sA 1 0.0898 10.1 0.989 Contact Map
3alzB 1 0.1378 9.8 0.989 Contact Map
4mt1A 3 0.2025 7.1 0.989 Contact Map
1vqsA 6 0.2213 7.1 0.989 Contact Map
3aqpA 1 0.1712 5.6 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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