GREMLIN Database
DUF241 - Arabidopsis protein of unknown function
PFAM: PF03087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 234 (233)
Sequences: 1063 (677)
Seq/√Len: 44.4
META: 0.041

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_R232_L4.4141.00
12_I130_A3.6501.00
229_V233_N3.5841.00
222_R231_L2.7631.00
9_Y44_L2.6441.00
81_V84_Y2.5141.00
3_S7_D2.3981.00
97_K210_I2.3621.00
229_V232_L2.2901.00
84_Y88_R2.2181.00
191_K194_K2.2161.00
114_L165_M2.0950.99
65_L234_I2.0920.99
109_S112_S2.0770.99
83_S98_L2.0520.99
176_E180_V1.9990.99
214_E222_R1.9650.99
67_S71_R1.9580.99
159_S162_S1.8670.99
82_A90_K1.8530.99
109_S113_S1.8360.99
228_R233_N1.8330.99
16_L227_T1.8020.98
22_Q234_I1.7910.98
177_F180_V1.7890.98
140_S160_L1.7870.98
81_V128_R1.7690.98
230_S233_N1.7590.98
66_Q225_I1.7270.98
4_G15_L1.7250.98
25_L38_L1.7230.98
26_S56_L1.7120.98
176_E179_K1.7090.98
169_E172_E1.7000.98
9_Y21_T1.6760.97
39_D138_F1.6730.97
162_S203_L1.6720.97
41_S89_K1.6720.97
218_E231_L1.6610.97
110_S113_S1.6470.97
175_N179_K1.6380.97
14_E201_E1.6260.97
228_R231_L1.5950.97
183_A200_Q1.5930.97
67_S70_R1.5870.96
172_E184_L1.5740.96
6_G14_E1.5630.96
83_S90_K1.5520.96
221_F228_R1.5120.95
88_R181_D1.5070.95
122_A221_F1.4930.95
184_L187_L1.4830.95
69_L143_S1.4760.95
123_V225_I1.4670.94
70_R93_K1.4430.94
7_D49_G1.4370.94
68_A225_I1.4200.93
84_Y89_K1.4190.93
150_A199_A1.4120.93
172_E175_N1.3860.93
155_S160_L1.3650.92
58_L83_S1.3620.92
224_L228_R1.3620.92
171_E174_I1.3350.91
42_L216_G1.3340.91
123_V127_L1.3260.91
78_E81_V1.3130.90
221_F232_L1.3130.90
144_F175_N1.3080.90
95_I98_L1.3050.90
9_Y14_E1.2750.89
129_E213_L1.2730.89
161_V165_M1.2710.89
50_T76_E1.2690.89
73_D190_S1.2670.89
210_I218_E1.2620.89
30_Q132_E1.2400.88
187_L190_S1.2380.88
57_Q226_K1.2340.87
25_L44_L1.2280.87
177_F181_D1.2200.87
4_G8_L1.2160.87
138_F141_L1.2120.86
6_G44_L1.2030.86
76_E124_V1.1960.86
175_N181_D1.1920.86
32_K39_D1.1780.85
44_L50_T1.1750.85
59_K93_K1.1740.85
22_Q27_Q1.1720.85
34_V38_L1.1580.84
182_A195_K1.1570.84
64_E141_L1.1540.84
208_S211_E1.1500.83
205_A223_R1.1430.83
35_E213_L1.1380.83
40_G226_K1.1290.82
175_N178_E1.1100.81
38_L71_R1.1050.81
18_L73_D1.1030.81
147_G153_K1.1030.81
37_L227_T1.1010.81
158_W225_I1.0970.80
16_L82_A1.0970.80
65_L125_R1.0900.80
130_A225_I1.0880.80
118_Q137_V1.0850.80
52_R225_I1.0730.79
218_E224_L1.0710.79
147_G215_E1.0700.79
62_V203_L1.0660.78
18_L206_L1.0590.78
141_L148_P1.0510.77
213_L220_L1.0490.77
59_K210_I1.0400.77
1_G6_G1.0280.76
96_K229_V1.0250.76
35_E129_E1.0250.76
71_R93_K1.0210.75
65_L211_E1.0200.75
100_K204_E1.0180.75
59_K218_E1.0170.75
140_S230_S1.0170.75
7_D13_D1.0160.75
8_L118_Q1.0100.75
185_Q190_S1.0040.74
92_K130_A1.0020.74
5_L11_C0.9990.74
59_K62_V0.9940.73
158_W161_V0.9890.73
164_L167_K0.9820.72
211_E215_E0.9780.72
153_K168_K0.9770.72
15_L38_L0.9730.72
12_I234_I0.9650.71
19_P24_A0.9630.71
60_E118_Q0.9610.71
6_G9_Y0.9610.71
94_E98_L0.9580.71
158_W163_K0.9580.71
200_Q212_D0.9580.71
198_C201_E0.9540.70
132_E174_I0.9510.70
123_V134_T0.9490.70
66_Q180_V0.9470.70
218_E222_R0.9420.69
17_Q52_R0.9410.69
127_L151_K0.9350.69
31_R35_E0.9300.68
161_V166_Q0.9300.68
98_L101_S0.9290.68
164_L181_D0.9270.68
213_L224_L0.9240.68
176_E181_D0.9240.68
19_P58_L0.9210.68
95_I229_V0.9150.67
41_S48_C0.9120.67
5_L21_T0.9050.66
14_E51_A0.8890.65
42_L207_E0.8880.65
93_K163_K0.8790.64
88_R103_K0.8650.63
11_C31_R0.8580.62
14_E83_S0.8550.62
161_V220_L0.8500.61
189_S192_K0.8480.61
186_S190_S0.8470.61
55_L213_L0.8460.61
181_D184_L0.8450.61
137_V169_E0.8440.61
104_S177_F0.8440.61
20_S96_K0.8380.60
180_V183_A0.8370.60
220_L225_I0.8350.60
84_Y227_T0.8350.60
141_L196_V0.8340.60
160_L167_K0.8330.60
110_S114_L0.8310.59
51_A92_K0.8310.59
63_Q221_F0.8290.59
165_M219_C0.8230.59
69_L217_L0.8230.59
48_C53_D0.8200.58
39_D173_E0.8190.58
178_E209_S0.8190.58
73_D80_E0.8160.58
197_Q202_Q0.8160.58
23_Q26_S0.8150.58
200_Q225_I0.8140.58
225_I228_R0.8130.58
52_R65_L0.8120.58
11_C144_F0.8100.58
177_F225_I0.8080.57
26_S121_C0.8070.57
144_F148_P0.8040.57
52_R58_L0.8030.57
79_A127_L0.8000.57
65_L203_L0.7980.56
187_L193_K0.7960.56
172_E182_A0.7900.56
42_L230_S0.7880.55
81_V141_L0.7870.55
20_S58_L0.7850.55
153_K178_E0.7830.55
180_V193_K0.7760.54
15_L21_T0.7730.54
192_K195_K0.7670.53
105_M108_K0.7670.53
36_E71_R0.7670.53
1_G64_E0.7640.53
4_G16_L0.7640.53
35_E38_L0.7630.53
4_G7_D0.7620.53
104_S167_K0.7590.53
225_I232_L0.7590.53
73_D106_E0.7580.53
42_L135_V0.7520.52
42_L95_I0.7500.52
180_V206_L0.7480.52
78_E168_K0.7470.51
23_Q57_Q0.7440.51
42_L46_D0.7440.51
16_L23_Q0.7430.51
7_D14_E0.7430.51
174_I194_K0.7410.51
29_Q77_L0.7360.50
1_G14_E0.7360.50
38_L44_L0.7360.50
171_E175_N0.7350.50
100_K220_L0.7330.50
85_L205_A0.7330.50
183_A212_D0.7280.50
195_K199_A0.7280.50
6_G10_D0.7230.49
21_T140_S0.7220.49
142_L151_K0.7170.49
14_E62_V0.7090.48
27_Q66_Q0.7070.48
9_Y39_D0.7050.47
99_L103_K0.7050.47
210_I222_R0.7040.47
89_K231_L0.7020.47
118_Q165_M0.7010.47
9_Y141_L0.7000.47
127_L203_L0.6990.47
3_S21_T0.6950.46
47_L54_A0.6920.46
121_C124_V0.6900.46
93_K155_S0.6880.46
80_E139_E0.6820.45
231_L234_I0.6810.45
18_L134_T0.6700.44
92_K98_L0.6690.44
117_D122_A0.6650.44
3_S13_D0.6650.44
7_D41_S0.6640.44
157_K198_C0.6630.43
5_L48_C0.6620.43
59_K136_S0.6620.43
27_Q146_S0.6610.43
26_S229_V0.6530.42
88_R176_E0.6510.42
104_S120_L0.6510.42
168_K198_C0.6500.42
117_D120_L0.6440.42
61_S91_A0.6440.42
15_L199_A0.6410.41
178_E182_A0.6380.41
14_E148_P0.6280.40
174_I180_V0.6230.40
107_N163_K0.6200.39
24_A229_V0.6140.39
160_L222_R0.6130.39
117_D123_V0.6070.38
106_E139_E0.6070.38
5_L52_R0.6050.38
40_G44_L0.6000.38
158_W216_G0.5990.37
19_P33_W0.5990.37
175_N186_S0.5980.37
25_L50_T0.5950.37
18_L202_Q0.5930.37
188_L192_K0.5910.37
190_S194_K0.5910.37
173_E193_K0.5900.37
132_E200_Q0.5900.37
34_V110_S0.5880.36
9_Y12_I0.5870.36
69_L98_L0.5860.36
9_Y87_S0.5840.36
37_L98_L0.5830.36
49_G52_R0.5810.36
33_W43_R0.5810.36
48_C138_F0.5790.36
36_E137_V0.5780.36
107_N111_S0.5750.35
175_N193_K0.5710.35
8_L37_L0.5710.35
18_L87_S0.5700.35
12_I82_A0.5670.35
67_S102_L0.5630.34
9_Y132_E0.5620.34
104_S180_V0.5610.34
199_A211_E0.5600.34
52_R71_R0.5600.34
183_A207_E0.5580.34
135_V198_C0.5580.34
123_V126_V0.5570.34
209_S217_L0.5540.33
167_K178_E0.5510.33
198_C205_A0.5510.33
52_R61_S0.5510.33
112_S115_D0.5500.33
46_D160_L0.5500.33
21_T202_Q0.5480.33
11_C196_V0.5480.33
1_G215_E0.5450.33
125_R211_E0.5410.32
183_A187_L0.5410.32
216_G229_V0.5410.32
46_D222_R0.5400.32
111_S114_L0.5400.32
3_S31_R0.5380.32
190_S195_K0.5380.32
23_Q135_V0.5360.32
84_Y199_A0.5350.32
26_S139_E0.5340.32
11_C16_L0.5330.32
187_L199_A0.5310.32
186_S192_K0.5300.31
114_L227_T0.5290.31
76_E230_S0.5290.31
34_V91_A0.5250.31
177_F205_A0.5230.31
67_S73_D0.5220.31
158_W214_E0.5220.31
17_Q77_L0.5180.30
88_R99_L0.5160.30
25_L190_S0.5150.30
85_L210_I0.5140.30
140_S203_L0.5130.30
183_A218_E0.5090.30
140_S227_T0.5080.30
80_E132_E0.5080.30
74_G211_E0.5070.30
19_P135_V0.5060.29
10_D220_L0.5050.29
59_K163_K0.5030.29
36_E132_E0.5030.29
163_K168_K0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xa3A 2 0.547 11.4 0.957 Contact Map
1lwuB 1 0.265 11 0.957 Contact Map
3ljmA 3 0.1239 8.4 0.959 Contact Map
2eroA 2 0.2735 7.9 0.96 Contact Map
2vmlA 3 0.2308 7.8 0.96 Contact Map
4po5B 3 0.2308 7.4 0.96 Contact Map
1kn1A 3 0.2308 7.2 0.961 Contact Map
1z0kB 1 0.2564 6.9 0.961 Contact Map
4zn6A 2 0.3632 5.8 0.962 Contact Map
1y4mA 6 0.141 5.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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