GREMLIN Database
DUF239 - Domain of unknown function (DUF239)
PFAM: PF03080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 220 (218)
Sequences: 1679 (1322)
Seq/√Len: 89.6
META: 0.379

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_C68_C4.6081.00
160_P201_D4.2321.00
45_D49_R4.0711.00
90_Y158_H4.0011.00
158_H162_E3.9411.00
32_I125_F3.6281.00
37_Q43_Y3.4221.00
42_L67_L3.3651.00
34_A101_I3.2271.00
56_D61_T3.1001.00
20_W139_G3.0811.00
5_N48_P2.9581.00
96_E171_R2.7571.00
109_N122_A2.5711.00
38_V48_P2.2541.00
140_G154_M2.2241.00
79_A82_A2.1941.00
42_L65_N2.1681.00
75_S116_E2.0761.00
171_R211_W2.0711.00
84_I97_I1.9931.00
55_T58_Y1.8501.00
48_P87_V1.8361.00
5_N47_N1.8351.00
77_S116_E1.7931.00
3_V84_I1.7851.00
90_Y166_K1.7781.00
13_E152_T1.7481.00
54_W124_L1.7271.00
18_Q33_E1.6621.00
50_L99_I1.6361.00
54_W70_G1.5751.00
16_L141_E1.5741.00
73_Q77_S1.5731.00
17_S217_Y1.5621.00
128_L131_S1.5471.00
91_G166_K1.5461.00
18_Q51_F1.5351.00
121_P124_L1.5271.00
73_Q119_Y1.5231.00
149_H152_T1.5221.00
47_N83_A1.5141.00
14_F39_Y1.4961.00
13_E144_S1.4951.00
202_I215_F1.4771.00
22_V31_T1.4640.99
161_S201_D1.4570.99
52_I80_L1.4490.99
78_I117_V1.4470.99
17_S170_F1.4420.99
90_Y162_E1.4400.99
100_L176_V1.4230.99
162_E166_K1.3930.99
2_N94_Q1.3880.99
37_Q64_Y1.3860.99
142_V154_M1.3800.99
13_E149_H1.3540.99
159_F201_D1.3510.99
56_D60_K1.3110.99
17_S36_W1.2870.99
18_Q141_E1.2800.99
168_A217_Y1.2660.98
16_L33_E1.2650.98
50_L84_I1.2590.98
142_V152_T1.2590.98
163_G216_Y1.2320.98
34_A112_L1.2100.98
33_E141_E1.2050.98
89_T92_G1.2020.98
194_A201_D1.1940.98
138_W173_I1.1900.98
53_Y61_T1.1860.98
112_L120_W1.1770.98
36_W48_P1.1720.98
51_F141_E1.1700.97
72_V121_P1.1640.97
211_W214_Y1.1520.97
78_I114_Y1.1470.97
104_D107_T1.1470.97
97_I114_Y1.1470.97
74_T119_Y1.1390.97
8_V15_S1.1310.97
88_S94_Q1.1240.97
170_F215_F1.1190.97
163_G167_A1.1090.97
1_I17_S1.1050.96
156_S167_A1.1040.96
49_R80_L1.1000.96
4_W156_S1.0970.96
94_Q164_F1.0930.96
58_Y61_T1.0930.96
52_I66_L1.0900.96
78_I82_A1.0800.96
144_S150_T1.0770.96
101_I112_L1.0630.96
3_V38_V1.0530.95
105_P122_A1.0520.95
86_P95_Y1.0510.95
144_S149_H1.0300.95
140_G217_Y1.0290.95
156_S169_Y1.0240.95
53_Y64_Y1.0220.94
144_S147_G1.0150.94
54_W62_G1.0130.94
74_T111_W1.0110.94
18_Q31_T1.0090.94
96_E169_Y1.0050.94
13_E143_V1.0030.94
99_I114_Y0.9870.93
43_Y65_N0.9810.93
56_D63_C0.9790.93
156_S216_Y0.9770.93
18_Q58_Y0.9740.93
17_S139_G0.9680.93
21_V133_A0.9670.93
194_A197_P0.9660.93
22_V137_Q0.9600.92
20_W31_T0.9550.92
7_K153_Q0.9510.92
75_S78_I0.9450.92
8_V40_P0.9390.92
16_L31_T0.9370.91
103_K108_G0.9310.91
160_P194_A0.9260.91
13_E142_V0.9250.91
54_W120_W0.9220.91
206_G213_T0.9210.91
55_T61_T0.9140.90
57_G60_K0.9110.90
4_W88_S0.9060.90
144_S152_T0.9010.90
159_F220_P0.8920.89
26_G57_G0.8840.89
66_L71_F0.8810.89
17_S168_A0.8800.89
134_T178_S0.8770.89
14_F37_Q0.8770.89
101_I120_W0.8740.88
92_G133_A0.8710.88
23_S128_L0.8700.88
208_S214_Y0.8640.88
68_C199_C0.8630.88
170_F217_Y0.8600.88
39_Y42_L0.8580.87
109_N119_Y0.8500.87
170_F173_I0.8490.87
1_I11_P0.8470.87
215_F219_G0.8400.86
34_A50_L0.8340.86
9_E12_D0.8300.86
43_Y49_R0.8300.86
111_W119_Y0.8270.85
136_V175_Y0.8180.85
55_T62_G0.8140.85
20_W33_E0.8140.85
40_P43_Y0.8110.84
194_A202_I0.8080.84
158_H166_K0.8060.84
34_A99_I0.7960.83
30_N126_T0.7940.83
177_D180_N0.7850.82
94_Q169_Y0.7850.82
150_T153_Q0.7770.82
54_W69_P0.7750.82
196_N199_C0.7700.81
14_F18_Q0.7690.81
188_A193_Y0.7680.81
71_F80_L0.7630.81
71_F199_C0.7590.80
88_S156_S0.7530.80
2_N165_G0.7490.79
75_S119_Y0.7490.79
63_C177_D0.7460.79
25_S28_G0.7430.79
73_Q76_N0.7410.79
51_F64_Y0.7410.79
11_P46_N0.7360.78
27_G59_Q0.7350.78
53_Y62_G0.7330.78
43_Y67_L0.7320.78
40_P46_N0.7250.77
21_V34_A0.7230.77
57_G61_T0.7170.76
101_I122_A0.7160.76
43_Y64_Y0.7150.76
19_I34_A0.7140.76
133_A136_V0.7120.76
1_I170_F0.7120.76
31_T37_Q0.7090.75
186_P191_T0.7060.75
6_P15_S0.7050.75
14_F141_E0.6990.74
63_C139_G0.6980.74
18_Q55_T0.6970.74
95_Y99_I0.6970.74
32_I126_T0.6960.74
43_Y47_N0.6950.74
33_E36_W0.6920.74
66_L74_T0.6900.73
128_L132_G0.6890.73
53_Y141_E0.6870.73
100_L113_Y0.6870.73
30_N125_F0.6860.73
88_S92_G0.6850.73
71_F117_V0.6830.73
33_E48_P0.6820.73
55_T139_G0.6780.72
207_Y210_D0.6760.72
16_L37_Q0.6700.71
203_I215_F0.6690.71
151_S199_C0.6670.71
22_V26_G0.6630.71
22_V135_L0.6600.70
21_V32_I0.6550.70
18_Q53_Y0.6530.69
167_A216_Y0.6510.69
23_S126_T0.6480.69
53_Y56_D0.6470.69
56_D59_Q0.6370.67
97_I101_I0.6350.67
125_F139_G0.6350.67
50_L112_L0.6320.67
96_E172_N0.6320.67
54_W61_T0.6320.67
9_E13_E0.6300.67
164_F169_Y0.6290.66
70_G121_P0.6270.66
40_P133_A0.6250.66
165_G216_Y0.6250.66
160_P167_A0.6240.66
136_V177_D0.6220.66
89_T93_T0.6220.66
209_G214_Y0.6220.66
9_E148_G0.6180.65
13_E150_T0.6160.65
159_F197_P0.6120.64
84_I87_V0.6120.64
41_S46_N0.6110.64
16_L64_Y0.6110.64
78_I100_L0.6110.64
73_Q111_W0.6100.64
21_V30_N0.6080.64
156_S164_F0.6060.64
183_V186_P0.6040.63
75_S80_L0.6010.63
20_W58_Y0.5970.62
32_I129_L0.5960.62
89_T116_E0.5940.62
31_T58_Y0.5930.62
2_N90_Y0.5920.62
22_V136_V0.5910.62
51_F138_W0.5910.62
83_A202_I0.5900.62
102_W105_P0.5890.61
19_I138_W0.5840.61
71_F74_T0.5840.61
6_P141_E0.5840.61
6_P153_Q0.5820.61
51_F111_W0.5800.60
165_G202_I0.5790.60
42_L64_Y0.5750.60
19_I101_I0.5720.59
3_V97_I0.5700.59
1_I19_I0.5680.59
40_P50_L0.5680.59
62_G70_G0.5680.59
16_L39_Y0.5660.58
24_G128_L0.5650.58
142_V195_D0.5650.58
97_I100_L0.5650.58
80_L196_N0.5640.58
84_I171_R0.5600.58
30_N170_F0.5570.57
68_C139_G0.5570.57
31_T39_Y0.5560.57
55_T156_S0.5550.57
204_D213_T0.5530.57
160_P170_F0.5530.57
32_I54_W0.5520.57
205_G209_G0.5520.57
39_Y43_Y0.5500.56
54_W63_C0.5490.56
60_K198_N0.5470.56
160_P164_F0.5470.56
127_G131_S0.5470.56
81_G216_Y0.5450.56
96_E216_Y0.5450.56
174_Q212_G0.5450.56
3_V36_W0.5420.55
33_E51_F0.5410.55
5_N46_N0.5400.55
53_Y65_N0.5400.55
156_S160_P0.5370.54
8_V38_V0.5370.54
207_Y213_T0.5370.54
160_P169_Y0.5350.54
174_Q186_P0.5350.54
32_I40_P0.5350.54
84_I114_Y0.5330.54
41_S176_V0.5310.54
70_G126_T0.5300.54
196_N212_G0.5290.53
198_N203_I0.5270.53
31_T137_Q0.5260.53
88_S165_G0.5230.53
97_I174_Q0.5230.53
173_I215_F0.5220.52
78_I129_L0.5220.52
82_A159_F0.5210.52
211_W216_Y0.5210.52
118_G121_P0.5200.52
87_V90_Y0.5180.52
104_D109_N0.5180.52
102_W113_Y0.5180.52
28_G57_G0.5170.52
89_T117_V0.5160.52
142_V151_S0.5130.51
209_G213_T0.5130.51
75_S82_A0.5130.51
23_S167_A0.5130.51
6_P33_E0.5120.51
185_P190_L0.5110.51
122_A131_S0.5100.51
11_P15_S0.5040.50
14_F22_V0.5010.50
70_G124_L0.5000.49
4_W163_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jt4A 1 0.3045 3.1 0.968 Contact Map
1nm7A 1 0.2455 2.6 0.969 Contact Map
2ct4A 1 0.3045 2.3 0.97 Contact Map
2lx7A 1 0.2591 2.3 0.97 Contact Map
1x6gA 1 0.2773 2.2 0.97 Contact Map
2v1qA 1 0.2545 2.2 0.97 Contact Map
2bt9A 3 0.4045 2.1 0.971 Contact Map
2cudA 1 0.3409 1.9 0.971 Contact Map
2iimA 2 0.2636 1.8 0.972 Contact Map
2a28A 1 0.2364 1.7 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.