MBOAT - PFAM28P - GREMLIN Contacts

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MBOAT - MBOAT, membrane-bound O-acyltransferase family

PFAM:	PF03062	Sequences: FLFYSYWDWGFLSLLILLLLMVLTLFLISLFLDYYDGLKKGKSLSSLVLKLLLLLLFLYFNLGFLGLSFFTFSYISYVYDVYRGKIKEPSFLDYALYVSFFPQLVAGPIVRYKDFLPQFRKRRFRSKYEVPSNFAAGLRLFLLGLFKKVVIADNLAPYVDNIFSNPAALSSSTPLELSGLEAWLGALAYTFQIYFDFSGYSDMAIGLALLFGFGFNGARWDRLLPENFNSPYEFATSITEFWRRWHISLSTWLRDYVYIPLGNRKGKLRTYRNLLITFLLSGLWHGASWTFVLWGLLHGLLLVIERLWRRLFRKSFLKAWRRLPPLINVIFWIVLFLGTNLAFSLYVQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	348 (308)
Sequences:	4866 (4054)
Seq/√Len:	231.0
META:	0.563

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
269_R	272_R	4.474	1.00
147_K	202_D	3.350	1.00
279_L	296_L	3.129	1.00
198_S	202_D	2.841	1.00
297_L	301_L	2.822	1.00
72_F	76_S	2.821	1.00
253_L	281_S	2.741	1.00
147_K	198_S	2.695	1.00
235_A	240_E	2.589	1.00
100_F	208_A	2.508	1.00
146_F	150_V	2.454	1.00
141_F	203_M	2.452	1.00
226_E	229_N	2.321	1.00
114_D	251_T	2.307	1.00
140_L	226_E	2.306	1.00
75_I	79_Y	2.292	1.00
63_G	67_L	2.263	1.00
332_W	336_F	2.249	1.00
111_R	255_D	2.214	1.00
61_N	65_L	2.183	1.00
160_D	163_F	2.169	1.00
253_L	277_T	2.090	1.00
136_A	209_L	2.061	1.00
18_L	22_V	2.030	1.00
73_S	103_Q	1.985	1.00
262_G	273_N	1.938	1.00
91_F	95_A	1.929	1.00
61_N	64_F	1.911	1.00
90_S	93_D	1.901	1.00
63_G	66_G	1.877	1.00
236_T	240_E	1.850	1.00
328_N	332_W	1.824	1.00
237_S	305_E	1.816	1.00
68_S	72_F	1.813	1.00
166_P	169_L	1.801	1.00
112_Y	116_L	1.794	1.00
22_V	25_L	1.782	1.00
332_W	335_L	1.746	1.00
275_L	296_L	1.741	1.00
58_L	61_N	1.729	1.00
72_F	77_Y	1.720	1.00
68_S	71_T	1.713	1.00
265_K	269_R	1.701	1.00
64_F	67_L	1.697	1.00
159_V	163_F	1.682	1.00
70_F	74_Y	1.676	1.00
209_L	214_G	1.659	1.00
62_L	66_G	1.643	1.00
57_F	61_N	1.631	1.00
19_L	23_L	1.615	1.00
73_S	77_Y	1.608	1.00
329_V	332_W	1.605	1.00
115_F	119_F	1.604	1.00
148_K	152_A	1.591	1.00
239_T	305_E	1.575	1.00
60_F	64_F	1.542	1.00
103_Q	110_V	1.540	1.00
76_S	80_D	1.540	1.00
74_Y	77_Y	1.531	1.00
58_L	62_L	1.531	1.00
247_I	251_T	1.518	1.00
77_Y	80_D	1.492	1.00
72_F	75_I	1.486	1.00
258_Y	262_G	1.484	1.00
259_I	262_G	1.482	1.00
278_F	281_S	1.465	1.00
75_I	78_V	1.458	1.00
187_L	190_T	1.456	1.00
265_K	270_T	1.455	1.00
61_N	66_G	1.425	1.00
56_L	60_F	1.409	1.00
73_S	76_S	1.406	1.00
29_S	32_L	1.392	1.00
54_L	58_L	1.384	1.00
156_A	160_D	1.366	1.00
46_S	50_K	1.360	1.00
189_Y	192_Q	1.358	1.00
140_L	205_I	1.345	1.00
59_Y	63_G	1.339	1.00
26_F	29_S	1.321	1.00
163_F	166_P	1.321	1.00
215_F	224_L	1.315	1.00
188_A	192_Q	1.313	1.00
266_G	270_T	1.312	1.00
329_V	333_I	1.312	1.00
239_T	306_R	1.310	1.00
157_P	161_N	1.305	1.00
190_T	193_I	1.302	1.00
18_L	23_L	1.301	1.00
230_S	234_F	1.289	1.00
70_F	77_Y	1.286	1.00
68_S	77_Y	1.285	1.00
19_L	22_V	1.275	1.00
329_V	336_F	1.274	1.00
324_P	328_N	1.272	1.00
45_S	52_L	1.271	1.00
225_P	229_N	1.271	1.00
22_V	26_F	1.260	1.00
77_Y	81_V	1.259	1.00
283_L	292_V	1.257	1.00
227_N	231_P	1.255	1.00
79_Y	82_Y	1.252	1.00
328_N	336_F	1.249	1.00
136_A	139_R	1.246	1.00
27_L	30_L	1.241	1.00
70_F	73_S	1.232	1.00
110_V	114_D	1.232	1.00
201_S	205_I	1.232	1.00
23_L	26_F	1.221	1.00
68_S	74_Y	1.217	1.00
31_F	34_Y	1.206	1.00
28_I	31_F	1.201	1.00
266_G	269_R	1.191	1.00
21_M	25_L	1.188	1.00
110_V	225_P	1.188	1.00
68_S	76_S	1.186	1.00
333_I	336_F	1.183	1.00
23_L	27_L	1.181	1.00
268_L	272_R	1.178	1.00
331_F	335_L	1.177	1.00
45_S	49_L	1.177	1.00
137_G	206_G	1.176	1.00
74_Y	79_Y	1.167	1.00
183_W	187_L	1.164	1.00
238_I	301_L	1.160	1.00
122_R	125_R	1.138	1.00
179_G	183_W	1.136	1.00
70_F	76_S	1.124	1.00
55_L	59_Y	1.117	1.00
239_T	243_R	1.113	1.00
69_F	72_F	1.090	1.00
257_V	280_L	1.090	1.00
275_L	299_G	1.090	1.00
60_F	63_G	1.084	1.00
153_D	156_A	1.083	1.00
136_A	140_L	1.076	1.00
328_N	333_I	1.074	1.00
250_S	254_R	1.069	1.00
293_L	296_L	1.068	1.00
58_L	63_G	1.059	1.00
74_Y	78_V	1.051	1.00
161_N	164_S	1.048	1.00
40_K	43_S	1.046	1.00
325_P	328_N	1.045	1.00
62_L	65_L	1.044	1.00
61_N	67_L	1.044	1.00
47_L	50_K	1.043	1.00
59_Y	67_L	1.042	1.00
290_T	293_L	1.042	1.00
148_K	151_I	1.039	1.00
164_S	167_A	1.038	1.00
76_S	79_Y	1.037	1.00
93_D	120_R	1.034	1.00
18_L	21_M	1.034	1.00
159_V	162_I	1.033	1.00
72_F	80_D	1.033	1.00
215_F	225_P	1.025	1.00
144_G	148_K	1.025	1.00
235_A	244_R	1.024	1.00
59_Y	62_L	1.021	1.00
188_A	191_F	1.020	1.00
43_S	46_S	1.010	1.00
69_F	73_S	1.010	1.00
55_L	58_L	1.006	1.00
325_P	332_W	1.004	1.00
148_K	153_D	1.004	1.00
54_L	57_F	0.996	1.00
68_S	80_D	0.994	1.00
72_F	79_Y	0.994	1.00
68_S	73_S	0.993	1.00
79_Y	83_R	0.992	1.00
263_N	270_T	0.986	1.00
29_S	33_D	0.986	1.00
240_E	244_R	0.984	1.00
186_A	189_Y	0.984	1.00
226_E	231_P	0.983	1.00
225_P	231_P	0.980	1.00
57_F	60_F	0.978	1.00
49_L	52_L	0.975	1.00
160_D	164_S	0.974	1.00
18_L	26_F	0.973	1.00
57_F	65_L	0.969	1.00
12_L	23_L	0.967	1.00
29_S	34_Y	0.961	1.00
88_E	93_D	0.957	1.00
228_F	231_P	0.957	1.00
259_I	273_N	0.952	1.00
26_F	30_L	0.951	1.00
77_Y	82_Y	0.950	1.00
277_T	281_S	0.948	1.00
135_A	139_R	0.944	1.00
331_F	336_F	0.943	1.00
238_I	305_E	0.937	1.00
27_L	31_F	0.936	1.00
183_W	192_Q	0.934	1.00
71_T	75_I	0.932	1.00
325_P	329_V	0.928	1.00
69_F	77_Y	0.926	1.00
50_K	54_L	0.920	1.00
56_L	59_Y	0.913	1.00
12_L	18_L	0.909	1.00
263_N	266_G	0.902	0.99
55_L	60_F	0.901	0.99
30_L	33_D	0.900	0.99
141_F	210_L	0.899	0.99
270_T	306_R	0.899	0.99
54_L	61_N	0.896	0.99
68_S	75_I	0.889	0.99
69_F	74_Y	0.888	0.99
71_T	77_Y	0.886	0.99
27_L	34_Y	0.886	0.99
12_L	22_V	0.885	0.99
229_N	234_F	0.885	0.99
53_L	57_F	0.885	0.99
12_L	15_L	0.882	0.99
273_N	277_T	0.882	0.99
185_G	192_Q	0.881	0.99
45_S	48_V	0.877	0.99
189_Y	193_I	0.870	0.99
34_Y	37_G	0.864	0.99
59_Y	65_L	0.863	0.99
137_G	144_G	0.859	0.99
258_Y	263_N	0.854	0.99
46_S	49_L	0.853	0.99
24_T	27_L	0.853	0.99
165_N	169_L	0.852	0.99
53_L	56_L	0.851	0.99
278_F	302_L	0.847	0.99
103_Q	106_A	0.841	0.99
125_R	128_Y	0.839	0.99
19_L	27_L	0.837	0.99
76_S	81_V	0.833	0.99
53_L	60_F	0.833	0.99
56_L	63_G	0.833	0.99
50_K	53_L	0.832	0.99
68_S	79_Y	0.832	0.99
62_L	67_L	0.827	0.99
278_F	298_H	0.826	0.99
194_Y	198_S	0.826	0.99
18_L	25_L	0.824	0.99
20_L	24_T	0.821	0.99
36_D	41_G	0.819	0.99
47_L	51_L	0.816	0.99
326_L	330_I	0.815	0.99
152_A	156_A	0.814	0.99
60_F	67_L	0.813	0.99
261_L	276_I	0.810	0.99
20_L	27_L	0.810	0.99
305_E	308_W	0.809	0.99
229_N	232_Y	0.807	0.99
139_R	142_L	0.805	0.99
54_L	59_Y	0.800	0.99
70_F	79_Y	0.800	0.99
33_D	37_G	0.799	0.99
154_N	157_P	0.797	0.99
328_N	331_F	0.796	0.99
134_F	137_G	0.794	0.99
185_G	190_T	0.794	0.99
139_R	143_L	0.793	0.99
328_N	335_L	0.792	0.99
72_F	81_V	0.790	0.99
48_V	52_L	0.789	0.99
58_L	65_L	0.784	0.99
275_L	303_V	0.784	0.99
186_A	190_T	0.779	0.98
69_F	75_I	0.778	0.98
162_I	166_P	0.776	0.98
191_F	195_F	0.776	0.98
141_F	145_L	0.776	0.98
137_G	140_L	0.776	0.98
250_S	274_L	0.775	0.98
13_S	19_L	0.774	0.98
185_G	189_Y	0.774	0.98
73_S	78_V	0.773	0.98
80_D	83_R	0.773	0.98
165_N	168_A	0.773	0.98
272_R	276_I	0.772	0.98
70_F	75_I	0.771	0.98
42_K	49_L	0.770	0.98
71_T	74_Y	0.764	0.98
259_I	263_N	0.764	0.98
70_F	80_D	0.764	0.98
93_D	96_L	0.764	0.98
321_R	325_P	0.763	0.98
224_L	231_P	0.762	0.98
95_A	99_S	0.761	0.98
71_T	76_S	0.761	0.98
19_L	24_T	0.758	0.98
281_S	302_L	0.753	0.98
15_L	19_L	0.752	0.98
226_E	230_S	0.752	0.98
27_L	32_L	0.749	0.98
325_P	333_I	0.748	0.98
324_P	332_W	0.747	0.98
123_R	126_S	0.746	0.98
13_S	23_L	0.745	0.98
80_D	85_K	0.745	0.98
248_S	251_T	0.741	0.98
82_Y	85_K	0.740	0.98
15_L	18_L	0.738	0.98
30_L	34_Y	0.738	0.98
134_F	210_L	0.736	0.98
187_L	192_Q	0.736	0.98
12_L	19_L	0.736	0.98
322_R	325_P	0.734	0.98
58_L	67_L	0.733	0.98
193_I	232_Y	0.728	0.98
36_D	40_K	0.724	0.98
58_L	66_G	0.721	0.98
92_L	96_L	0.720	0.97
15_L	22_V	0.719	0.97
225_P	248_S	0.719	0.97
94_Y	98_V	0.716	0.97
50_K	61_N	0.715	0.97
51_L	55_L	0.714	0.97
243_R	250_S	0.713	0.97
281_S	294_W	0.708	0.97
301_L	305_E	0.707	0.97
80_D	84_G	0.707	0.97
114_D	225_P	0.705	0.97
263_N	269_R	0.704	0.97
16_I	19_L	0.703	0.97
156_A	159_V	0.699	0.97
60_F	65_L	0.695	0.97
324_P	329_V	0.690	0.97
21_M	24_T	0.689	0.97
27_L	33_D	0.688	0.97
33_D	36_D	0.687	0.97
14_L	18_L	0.686	0.97
21_M	26_F	0.685	0.97
185_G	194_Y	0.685	0.97
158_Y	162_I	0.682	0.97
327_I	332_W	0.677	0.96
70_F	78_V	0.677	0.96
23_L	31_F	0.674	0.96
162_I	169_L	0.672	0.96
104_L	110_V	0.669	0.96
224_L	227_N	0.669	0.96
14_L	22_V	0.669	0.96
73_S	110_V	0.666	0.96
153_D	157_P	0.666	0.96
54_L	60_F	0.660	0.96
41_G	49_L	0.655	0.96
16_I	20_L	0.653	0.96
185_G	188_A	0.653	0.96
71_T	79_Y	0.651	0.95
17_L	20_L	0.649	0.95
19_L	25_L	0.648	0.95
43_S	50_K	0.648	0.95
14_L	23_L	0.647	0.95
226_E	232_Y	0.647	0.95
278_F	299_G	0.645	0.95
51_L	59_Y	0.642	0.95
53_L	61_N	0.641	0.95
133_N	214_G	0.640	0.95
191_F	194_Y	0.634	0.95
179_G	182_A	0.633	0.95
178_S	181_E	0.632	0.95
264_R	269_R	0.631	0.95
24_T	31_F	0.628	0.95
232_Y	241_F	0.627	0.94
51_L	54_L	0.622	0.94
323_L	327_I	0.620	0.94
124_F	127_K	0.616	0.94
110_V	215_F	0.614	0.94
15_L	23_L	0.612	0.94
58_L	64_F	0.609	0.94
261_L	273_N	0.608	0.94
56_L	61_N	0.605	0.93
94_Y	99_S	0.605	0.93
283_L	288_S	0.605	0.93
60_F	66_G	0.603	0.93
319_A	322_R	0.601	0.93
180_L	184_L	0.601	0.93
329_V	335_L	0.599	0.93
183_W	188_A	0.598	0.93
182_A	185_G	0.596	0.93
74_Y	81_V	0.593	0.93
45_S	50_K	0.592	0.93
324_P	331_F	0.591	0.93
133_N	209_L	0.591	0.93
13_S	22_V	0.591	0.93
15_L	25_L	0.589	0.92
251_T	254_R	0.589	0.92
137_G	210_L	0.589	0.92
13_S	18_L	0.587	0.92
73_S	79_Y	0.585	0.92
75_I	80_D	0.582	0.92
78_V	82_Y	0.578	0.92
162_I	185_G	0.577	0.92
55_L	63_G	0.575	0.92
298_H	301_L	0.575	0.92
265_K	268_L	0.575	0.92
73_S	80_D	0.573	0.91
50_K	65_L	0.572	0.91
71_T	80_D	0.572	0.91
157_P	163_F	0.570	0.91
59_Y	66_G	0.568	0.91
330_I	333_I	0.565	0.91
26_F	31_F	0.563	0.91
19_L	26_F	0.560	0.90
250_S	281_S	0.560	0.90
42_K	45_S	0.557	0.90
16_I	24_T	0.555	0.90
154_N	158_Y	0.552	0.90
267_K	270_T	0.551	0.90
48_V	51_L	0.549	0.90
42_K	48_V	0.549	0.90
24_T	28_I	0.549	0.90
38_L	41_G	0.548	0.89
322_R	328_N	0.547	0.89
20_L	23_L	0.546	0.89
182_A	190_T	0.545	0.89
133_N	137_G	0.544	0.89
206_G	210_L	0.542	0.89
28_I	33_D	0.541	0.89
52_L	56_L	0.540	0.89
51_L	56_L	0.540	0.89
35_Y	39_K	0.537	0.89
155_L	159_V	0.537	0.89
299_G	303_V	0.535	0.88
327_I	331_F	0.534	0.88
52_L	60_F	0.533	0.88
74_Y	80_D	0.533	0.88
12_L	16_I	0.529	0.88
16_I	23_L	0.528	0.88
49_L	53_L	0.528	0.88
81_V	84_G	0.528	0.88
262_G	266_G	0.527	0.88
44_L	48_V	0.527	0.88
57_F	63_G	0.526	0.88
20_L	25_L	0.526	0.88
23_L	28_I	0.524	0.87
330_I	334_V	0.523	0.87
153_D	160_D	0.521	0.87
321_R	328_N	0.520	0.87
13_S	16_I	0.520	0.87
321_R	324_P	0.518	0.87
295_G	299_G	0.517	0.87
324_P	336_F	0.517	0.87
50_K	57_F	0.517	0.87
121_K	124_F	0.517	0.87
74_Y	98_V	0.516	0.87
28_I	34_Y	0.515	0.86
122_R	126_S	0.515	0.86
264_R	270_T	0.513	0.86
29_S	37_G	0.513	0.86
289_W	292_V	0.511	0.86
57_F	62_L	0.510	0.86
59_Y	64_F	0.509	0.86
98_V	103_Q	0.509	0.86
44_L	51_L	0.508	0.86
22_V	29_S	0.507	0.86
14_L	19_L	0.506	0.85
78_V	81_V	0.504	0.85
190_T	194_Y	0.503	0.85
110_V	115_F	0.503	0.85
257_V	281_S	0.502	0.85
40_K	49_L	0.502	0.85
96_L	119_F	0.501	0.85
279_L	292_V	0.500	0.85
265_K	272_R	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i2jA	1	0.0603	2	0.97	Contact Map
1lbjA	1	0.0632	1.1	0.974	Contact Map
1rmkA	1	0.0891	1.1	0.974	Contact Map
2mduA	1	0.0805	1	0.975	Contact Map
3mp7B	1	0.1552	0.9	0.975	Contact Map
2mm4A	1	0.0805	0.9	0.976	Contact Map
2ls2A	1	0.0718	0.8	0.976	Contact Map
3s8fC	1	0.0891	0.8	0.977	Contact Map
3wu2M	2	0.0805	0.7	0.977	Contact Map
3m73A	3	0.2557	0.7	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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