GREMLIN Database
MBOAT - MBOAT, membrane-bound O-acyltransferase family
PFAM: PF03062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 348 (308)
Sequences: 4866 (4054)
Seq/√Len: 231.0
META: 0.563

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_R272_R4.4741.00
147_K202_D3.3501.00
279_L296_L3.1291.00
198_S202_D2.8411.00
297_L301_L2.8221.00
72_F76_S2.8211.00
253_L281_S2.7411.00
147_K198_S2.6951.00
235_A240_E2.5891.00
100_F208_A2.5081.00
146_F150_V2.4541.00
141_F203_M2.4521.00
226_E229_N2.3211.00
114_D251_T2.3071.00
140_L226_E2.3061.00
75_I79_Y2.2921.00
63_G67_L2.2631.00
332_W336_F2.2491.00
111_R255_D2.2141.00
61_N65_L2.1831.00
160_D163_F2.1691.00
253_L277_T2.0901.00
136_A209_L2.0611.00
18_L22_V2.0301.00
73_S103_Q1.9851.00
262_G273_N1.9381.00
91_F95_A1.9291.00
61_N64_F1.9111.00
90_S93_D1.9011.00
63_G66_G1.8771.00
236_T240_E1.8501.00
328_N332_W1.8241.00
237_S305_E1.8161.00
68_S72_F1.8131.00
166_P169_L1.8011.00
112_Y116_L1.7941.00
22_V25_L1.7821.00
332_W335_L1.7461.00
275_L296_L1.7411.00
58_L61_N1.7291.00
72_F77_Y1.7201.00
68_S71_T1.7131.00
265_K269_R1.7011.00
64_F67_L1.6971.00
159_V163_F1.6821.00
70_F74_Y1.6761.00
209_L214_G1.6591.00
62_L66_G1.6431.00
57_F61_N1.6311.00
19_L23_L1.6151.00
73_S77_Y1.6081.00
329_V332_W1.6051.00
115_F119_F1.6041.00
148_K152_A1.5911.00
239_T305_E1.5751.00
60_F64_F1.5421.00
103_Q110_V1.5401.00
76_S80_D1.5401.00
74_Y77_Y1.5311.00
58_L62_L1.5311.00
247_I251_T1.5181.00
77_Y80_D1.4921.00
72_F75_I1.4861.00
258_Y262_G1.4841.00
259_I262_G1.4821.00
278_F281_S1.4651.00
75_I78_V1.4581.00
187_L190_T1.4561.00
265_K270_T1.4551.00
61_N66_G1.4251.00
56_L60_F1.4091.00
73_S76_S1.4061.00
29_S32_L1.3921.00
54_L58_L1.3841.00
156_A160_D1.3661.00
46_S50_K1.3601.00
189_Y192_Q1.3581.00
140_L205_I1.3451.00
59_Y63_G1.3391.00
26_F29_S1.3211.00
163_F166_P1.3211.00
215_F224_L1.3151.00
188_A192_Q1.3131.00
266_G270_T1.3121.00
329_V333_I1.3121.00
239_T306_R1.3101.00
157_P161_N1.3051.00
190_T193_I1.3021.00
18_L23_L1.3011.00
230_S234_F1.2891.00
70_F77_Y1.2861.00
68_S77_Y1.2851.00
19_L22_V1.2751.00
329_V336_F1.2741.00
324_P328_N1.2721.00
45_S52_L1.2711.00
225_P229_N1.2711.00
22_V26_F1.2601.00
77_Y81_V1.2591.00
283_L292_V1.2571.00
227_N231_P1.2551.00
79_Y82_Y1.2521.00
328_N336_F1.2491.00
136_A139_R1.2461.00
27_L30_L1.2411.00
70_F73_S1.2321.00
110_V114_D1.2321.00
201_S205_I1.2321.00
23_L26_F1.2211.00
68_S74_Y1.2171.00
31_F34_Y1.2061.00
28_I31_F1.2011.00
266_G269_R1.1911.00
21_M25_L1.1881.00
110_V225_P1.1881.00
68_S76_S1.1861.00
333_I336_F1.1831.00
23_L27_L1.1811.00
268_L272_R1.1781.00
331_F335_L1.1771.00
45_S49_L1.1771.00
137_G206_G1.1761.00
74_Y79_Y1.1671.00
183_W187_L1.1641.00
238_I301_L1.1601.00
122_R125_R1.1381.00
179_G183_W1.1361.00
70_F76_S1.1241.00
55_L59_Y1.1171.00
239_T243_R1.1131.00
69_F72_F1.0901.00
257_V280_L1.0901.00
275_L299_G1.0901.00
60_F63_G1.0841.00
153_D156_A1.0831.00
136_A140_L1.0761.00
328_N333_I1.0741.00
250_S254_R1.0691.00
293_L296_L1.0681.00
58_L63_G1.0591.00
74_Y78_V1.0511.00
161_N164_S1.0481.00
40_K43_S1.0461.00
325_P328_N1.0451.00
62_L65_L1.0441.00
61_N67_L1.0441.00
47_L50_K1.0431.00
59_Y67_L1.0421.00
290_T293_L1.0421.00
148_K151_I1.0391.00
164_S167_A1.0381.00
76_S79_Y1.0371.00
93_D120_R1.0341.00
18_L21_M1.0341.00
159_V162_I1.0331.00
72_F80_D1.0331.00
215_F225_P1.0251.00
144_G148_K1.0251.00
235_A244_R1.0241.00
59_Y62_L1.0211.00
188_A191_F1.0201.00
43_S46_S1.0101.00
69_F73_S1.0101.00
55_L58_L1.0061.00
325_P332_W1.0041.00
148_K153_D1.0041.00
54_L57_F0.9961.00
68_S80_D0.9941.00
72_F79_Y0.9941.00
68_S73_S0.9931.00
79_Y83_R0.9921.00
263_N270_T0.9861.00
29_S33_D0.9861.00
240_E244_R0.9841.00
186_A189_Y0.9841.00
226_E231_P0.9831.00
225_P231_P0.9801.00
57_F60_F0.9781.00
49_L52_L0.9751.00
160_D164_S0.9741.00
18_L26_F0.9731.00
57_F65_L0.9691.00
12_L23_L0.9671.00
29_S34_Y0.9611.00
88_E93_D0.9571.00
228_F231_P0.9571.00
259_I273_N0.9521.00
26_F30_L0.9511.00
77_Y82_Y0.9501.00
277_T281_S0.9481.00
135_A139_R0.9441.00
331_F336_F0.9431.00
238_I305_E0.9371.00
27_L31_F0.9361.00
183_W192_Q0.9341.00
71_T75_I0.9321.00
325_P329_V0.9281.00
69_F77_Y0.9261.00
50_K54_L0.9201.00
56_L59_Y0.9131.00
12_L18_L0.9091.00
263_N266_G0.9020.99
55_L60_F0.9010.99
30_L33_D0.9000.99
141_F210_L0.8990.99
270_T306_R0.8990.99
54_L61_N0.8960.99
68_S75_I0.8890.99
69_F74_Y0.8880.99
71_T77_Y0.8860.99
27_L34_Y0.8860.99
12_L22_V0.8850.99
229_N234_F0.8850.99
53_L57_F0.8850.99
12_L15_L0.8820.99
273_N277_T0.8820.99
185_G192_Q0.8810.99
45_S48_V0.8770.99
189_Y193_I0.8700.99
34_Y37_G0.8640.99
59_Y65_L0.8630.99
137_G144_G0.8590.99
258_Y263_N0.8540.99
46_S49_L0.8530.99
24_T27_L0.8530.99
165_N169_L0.8520.99
53_L56_L0.8510.99
278_F302_L0.8470.99
103_Q106_A0.8410.99
125_R128_Y0.8390.99
19_L27_L0.8370.99
76_S81_V0.8330.99
53_L60_F0.8330.99
56_L63_G0.8330.99
50_K53_L0.8320.99
68_S79_Y0.8320.99
62_L67_L0.8270.99
278_F298_H0.8260.99
194_Y198_S0.8260.99
18_L25_L0.8240.99
20_L24_T0.8210.99
36_D41_G0.8190.99
47_L51_L0.8160.99
326_L330_I0.8150.99
152_A156_A0.8140.99
60_F67_L0.8130.99
261_L276_I0.8100.99
20_L27_L0.8100.99
305_E308_W0.8090.99
229_N232_Y0.8070.99
139_R142_L0.8050.99
54_L59_Y0.8000.99
70_F79_Y0.8000.99
33_D37_G0.7990.99
154_N157_P0.7970.99
328_N331_F0.7960.99
134_F137_G0.7940.99
185_G190_T0.7940.99
139_R143_L0.7930.99
328_N335_L0.7920.99
72_F81_V0.7900.99
48_V52_L0.7890.99
58_L65_L0.7840.99
275_L303_V0.7840.99
186_A190_T0.7790.98
69_F75_I0.7780.98
162_I166_P0.7760.98
191_F195_F0.7760.98
141_F145_L0.7760.98
137_G140_L0.7760.98
250_S274_L0.7750.98
13_S19_L0.7740.98
185_G189_Y0.7740.98
73_S78_V0.7730.98
80_D83_R0.7730.98
165_N168_A0.7730.98
272_R276_I0.7720.98
70_F75_I0.7710.98
42_K49_L0.7700.98
71_T74_Y0.7640.98
259_I263_N0.7640.98
70_F80_D0.7640.98
93_D96_L0.7640.98
321_R325_P0.7630.98
224_L231_P0.7620.98
95_A99_S0.7610.98
71_T76_S0.7610.98
19_L24_T0.7580.98
281_S302_L0.7530.98
15_L19_L0.7520.98
226_E230_S0.7520.98
27_L32_L0.7490.98
325_P333_I0.7480.98
324_P332_W0.7470.98
123_R126_S0.7460.98
13_S23_L0.7450.98
80_D85_K0.7450.98
248_S251_T0.7410.98
82_Y85_K0.7400.98
15_L18_L0.7380.98
30_L34_Y0.7380.98
134_F210_L0.7360.98
187_L192_Q0.7360.98
12_L19_L0.7360.98
322_R325_P0.7340.98
58_L67_L0.7330.98
193_I232_Y0.7280.98
36_D40_K0.7240.98
58_L66_G0.7210.98
92_L96_L0.7200.97
15_L22_V0.7190.97
225_P248_S0.7190.97
94_Y98_V0.7160.97
50_K61_N0.7150.97
51_L55_L0.7140.97
243_R250_S0.7130.97
281_S294_W0.7080.97
301_L305_E0.7070.97
80_D84_G0.7070.97
114_D225_P0.7050.97
263_N269_R0.7040.97
16_I19_L0.7030.97
156_A159_V0.6990.97
60_F65_L0.6950.97
324_P329_V0.6900.97
21_M24_T0.6890.97
27_L33_D0.6880.97
33_D36_D0.6870.97
14_L18_L0.6860.97
21_M26_F0.6850.97
185_G194_Y0.6850.97
158_Y162_I0.6820.97
327_I332_W0.6770.96
70_F78_V0.6770.96
23_L31_F0.6740.96
162_I169_L0.6720.96
104_L110_V0.6690.96
224_L227_N0.6690.96
14_L22_V0.6690.96
73_S110_V0.6660.96
153_D157_P0.6660.96
54_L60_F0.6600.96
41_G49_L0.6550.96
16_I20_L0.6530.96
185_G188_A0.6530.96
71_T79_Y0.6510.95
17_L20_L0.6490.95
19_L25_L0.6480.95
43_S50_K0.6480.95
14_L23_L0.6470.95
226_E232_Y0.6470.95
278_F299_G0.6450.95
51_L59_Y0.6420.95
53_L61_N0.6410.95
133_N214_G0.6400.95
191_F194_Y0.6340.95
179_G182_A0.6330.95
178_S181_E0.6320.95
264_R269_R0.6310.95
24_T31_F0.6280.95
232_Y241_F0.6270.94
51_L54_L0.6220.94
323_L327_I0.6200.94
124_F127_K0.6160.94
110_V215_F0.6140.94
15_L23_L0.6120.94
58_L64_F0.6090.94
261_L273_N0.6080.94
56_L61_N0.6050.93
94_Y99_S0.6050.93
283_L288_S0.6050.93
60_F66_G0.6030.93
319_A322_R0.6010.93
180_L184_L0.6010.93
329_V335_L0.5990.93
183_W188_A0.5980.93
182_A185_G0.5960.93
74_Y81_V0.5930.93
45_S50_K0.5920.93
324_P331_F0.5910.93
133_N209_L0.5910.93
13_S22_V0.5910.93
15_L25_L0.5890.92
251_T254_R0.5890.92
137_G210_L0.5890.92
13_S18_L0.5870.92
73_S79_Y0.5850.92
75_I80_D0.5820.92
78_V82_Y0.5780.92
162_I185_G0.5770.92
55_L63_G0.5750.92
298_H301_L0.5750.92
265_K268_L0.5750.92
73_S80_D0.5730.91
50_K65_L0.5720.91
71_T80_D0.5720.91
157_P163_F0.5700.91
59_Y66_G0.5680.91
330_I333_I0.5650.91
26_F31_F0.5630.91
19_L26_F0.5600.90
250_S281_S0.5600.90
42_K45_S0.5570.90
16_I24_T0.5550.90
154_N158_Y0.5520.90
267_K270_T0.5510.90
48_V51_L0.5490.90
42_K48_V0.5490.90
24_T28_I0.5490.90
38_L41_G0.5480.89
322_R328_N0.5470.89
20_L23_L0.5460.89
182_A190_T0.5450.89
133_N137_G0.5440.89
206_G210_L0.5420.89
28_I33_D0.5410.89
52_L56_L0.5400.89
51_L56_L0.5400.89
35_Y39_K0.5370.89
155_L159_V0.5370.89
299_G303_V0.5350.88
327_I331_F0.5340.88
52_L60_F0.5330.88
74_Y80_D0.5330.88
12_L16_I0.5290.88
16_I23_L0.5280.88
49_L53_L0.5280.88
81_V84_G0.5280.88
262_G266_G0.5270.88
44_L48_V0.5270.88
57_F63_G0.5260.88
20_L25_L0.5260.88
23_L28_I0.5240.87
330_I334_V0.5230.87
153_D160_D0.5210.87
321_R328_N0.5200.87
13_S16_I0.5200.87
321_R324_P0.5180.87
295_G299_G0.5170.87
324_P336_F0.5170.87
50_K57_F0.5170.87
121_K124_F0.5170.87
74_Y98_V0.5160.87
28_I34_Y0.5150.86
122_R126_S0.5150.86
264_R270_T0.5130.86
29_S37_G0.5130.86
289_W292_V0.5110.86
57_F62_L0.5100.86
59_Y64_F0.5090.86
98_V103_Q0.5090.86
44_L51_L0.5080.86
22_V29_S0.5070.86
14_L19_L0.5060.85
78_V81_V0.5040.85
190_T194_Y0.5030.85
110_V115_F0.5030.85
257_V281_S0.5020.85
40_K49_L0.5020.85
96_L119_F0.5010.85
279_L292_V0.5000.85
265_K272_R0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i2jA 1 0.0603 2 0.97 Contact Map
1lbjA 1 0.0632 1.1 0.974 Contact Map
1rmkA 1 0.0891 1.1 0.974 Contact Map
2mduA 1 0.0805 1 0.975 Contact Map
3mp7B 1 0.1552 0.9 0.975 Contact Map
2mm4A 1 0.0805 0.9 0.976 Contact Map
2ls2A 1 0.0718 0.8 0.976 Contact Map
3s8fC 1 0.0891 0.8 0.977 Contact Map
3wu2M 2 0.0805 0.7 0.977 Contact Map
3m73A 3 0.2557 0.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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