GREMLIN Database
DDE_Tnp_IS66 - Transposase IS66 family
PFAM: PF03050 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 280 (273)
Sequences: 49130 (30570)
Seq/√Len: 1850.2
META: 0.961

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_A127_L2.7401.00
129_S144_H2.5391.00
196_L200_R2.4561.00
71_H255_A2.4261.00
126_I145_Q2.4241.00
110_S115_V2.3091.00
209_K236_W2.2871.00
209_K213_E2.2741.00
15_L29_I2.2371.00
71_H128_V2.1931.00
68_P247_R2.1761.00
63_E102_A2.1631.00
126_I248_V2.1131.00
265_G269_S2.0871.00
19_D32_R2.0731.00
108_H115_V2.0461.00
263_V266_R2.0321.00
146_G238_A2.0091.00
149_A251_D1.9921.00
151_L232_L1.9521.00
108_H118_E1.9471.00
92_L262_V1.9381.00
27_E39_R1.8981.00
128_V249_P1.8961.00
113_G137_K1.8851.00
148_W175_I1.8801.00
11_L15_L1.8741.00
241_R244_D1.8661.00
13_A49_A1.8521.00
69_V128_V1.7971.00
149_A253_N1.7891.00
71_H254_L1.7831.00
72_A95_Y1.7801.00
61_K104_L1.7721.00
96_V254_L1.7161.00
170_E174_R1.7041.00
156_V159_A1.7001.00
194_L198_Q1.6851.00
61_K106_D1.6811.00
14_Y19_D1.6801.00
128_V145_Q1.6781.00
145_Q248_V1.6761.00
60_L102_A1.6761.00
189_S192_E1.6621.00
131_G235_H1.6461.00
185_A196_L1.6361.00
184_E200_R1.6131.00
31_A36_P1.6021.00
19_D29_I1.5991.00
4_Y45_W1.5981.00
131_G231_Y1.5931.00
61_K65_L1.5921.00
24_Y39_R1.5921.00
146_G235_H1.5901.00
168_A171_A1.5871.00
18_A28_E1.5871.00
154_K157_E1.5411.00
236_W240_L1.5351.00
95_Y119_L1.5331.00
76_G89_K1.5201.00
179_Y251_D1.5161.00
59_A62_E1.5121.00
77_V272_F1.5091.00
9_L45_W1.5091.00
21_L29_I1.5051.00
254_L258_A1.5031.00
226_G230_R1.4911.00
155_F232_L1.4821.00
224_K227_K1.4581.00
156_V160_E1.4501.00
126_I245_D1.4311.00
169_A173_K1.4191.00
144_H238_A1.4131.00
23_L46_V1.4111.00
94_V258_A1.3921.00
13_A46_V1.3901.00
54_E58_E1.3831.00
203_P207_A1.3791.00
57_Y104_L1.3781.00
131_G146_G1.3731.00
16_K26_Q1.3671.00
264_L268_N1.3631.00
201_S205_L1.3611.00
113_G117_E1.3591.00
9_L48_R1.3501.00
145_Q241_R1.3351.00
211_W215_Q1.3281.00
181_I185_A1.3161.00
94_V255_A1.3121.00
193_R197_R1.3021.00
67_S97_T1.2771.00
60_L104_L1.2721.00
171_A211_W1.2691.00
12_V45_W1.2651.00
117_E137_K1.2531.00
179_Y183_R1.2521.00
111_R132_Y1.2381.00
197_R200_R1.2261.00
96_V258_A1.2221.00
202_R206_D1.2201.00
272_F278_A1.2101.00
63_E66_A1.2021.00
275_E279_E1.1951.00
159_A169_A1.1951.00
59_A63_E1.1881.00
70_L123_F1.1871.00
41_T44_N1.1841.00
151_L239_L1.1731.00
180_A183_R1.1721.00
106_D119_L1.1711.00
126_I143_T1.1581.00
230_R234_K1.1571.00
112_G115_V1.1521.00
201_S204_L1.1511.00
38_S41_T1.1481.00
54_E279_E1.1401.00
47_G276_R1.1341.00
193_R196_L1.1321.00
56_L60_L1.1301.00
71_H252_N1.1261.00
171_A208_L1.1171.00
71_H249_P1.1151.00
249_P254_L1.1121.00
235_H238_A1.1041.00
27_E42_L1.0981.00
201_S236_W1.0941.00
175_I179_Y1.0771.00
176_R179_Y1.0761.00
182_E186_R1.0751.00
257_R260_R1.0741.00
12_V30_L1.0711.00
94_V259_I1.0701.00
242_F250_I1.0641.00
201_S242_F1.0591.00
74_E111_R1.0571.00
12_V42_L1.0531.00
215_Q218_R1.0491.00
76_G91_W1.0481.00
197_R201_S1.0471.00
22_P25_R1.0451.00
198_Q202_R1.0401.00
207_A211_W1.0351.00
252_N255_A1.0331.00
148_W205_L1.0301.00
29_I33_L1.0301.00
9_L49_A1.0301.00
195_A199_E1.0281.00
171_A174_R1.0251.00
95_Y106_D1.0211.00
74_E91_W1.0201.00
79_V107_Y1.0191.00
212_L232_L1.0181.00
168_A172_L1.0141.00
213_E236_W0.9981.00
74_E135_Y0.9831.00
11_L29_I0.9831.00
196_L199_E0.9821.00
57_Y61_K0.9801.00
212_L229_I0.9791.00
208_L232_L0.9781.00
64_L70_L0.9721.00
23_L43_A0.9721.00
97_T102_A0.9691.00
4_Y9_L0.9661.00
85_G278_A0.9661.00
202_R243_L0.9651.00
133_S136_D0.9621.00
238_A241_R0.9611.00
71_H96_V0.9581.00
180_A184_E0.9551.00
103_V258_A0.9481.00
143_T241_R0.9481.00
20_H268_N0.9461.00
114_E118_E0.9461.00
124_K141_G0.9441.00
136_D238_A0.9431.00
167_E171_A0.9421.00
260_R263_V0.9411.00
192_E196_L0.9411.00
58_E61_K0.9401.00
48_R52_L0.9391.00
182_E185_A0.9351.00
139_A144_H0.9351.00
177_E204_L0.9311.00
11_L33_L0.9261.00
15_L21_L0.9261.00
20_H25_R0.9251.00
6_P10_A0.9241.00
174_R207_A0.9191.00
90_G109_P0.9151.00
131_G154_K0.9141.00
90_G107_Y0.9131.00
143_T245_D0.9121.00
241_R248_V0.9061.00
78_R87_G0.9051.00
15_L19_D0.9031.00
14_Y18_A0.8971.00
267_K270_L0.8941.00
179_Y182_E0.8941.00
114_E117_E0.8931.00
206_D240_L0.8891.00
26_Q30_L0.8871.00
91_W111_R0.8861.00
192_E195_A0.8861.00
181_I184_E0.8831.00
136_D144_H0.8821.00
251_D257_R0.8811.00
205_L209_K0.8781.00
176_R180_A0.8711.00
80_L87_G0.8701.00
64_L102_A0.8701.00
173_K176_R0.8701.00
69_V249_P0.8681.00
192_E197_R0.8661.00
174_R177_E0.8631.00
23_L42_L0.8611.00
200_R203_P0.8531.00
81_D273_R0.8531.00
113_G134_G0.8521.00
149_A153_R0.8461.00
201_S208_L0.8421.00
208_L211_W0.8391.00
154_K227_K0.8371.00
136_D146_G0.8341.00
43_A47_G0.8301.00
168_A173_K0.8291.00
158_A228_A0.8271.00
79_V90_G0.8241.00
95_Y116_P0.8191.00
204_L207_A0.8151.00
254_L257_R0.8111.00
77_V107_Y0.8091.00
216_L230_R0.8041.00
200_R207_A0.8031.00
219_V226_G0.8021.00
132_Y135_Y0.8021.00
41_T45_W0.7981.00
209_K233_L0.7981.00
95_Y115_V0.7971.00
148_W250_I0.7961.00
213_E233_L0.7961.00
167_E215_Q0.7941.00
208_L212_L0.7941.00
17_Y46_V0.7921.00
209_K240_L0.7881.00
205_L208_L0.7861.00
276_R279_E0.7861.00
81_D84_R0.7821.00
241_R245_D0.7801.00
219_V225_L0.7721.00
165_S168_A0.7661.00
190_P194_L0.7571.00
107_Y275_E0.7571.00
11_L30_L0.7571.00
177_E180_A0.7541.00
56_L59_A0.7491.00
223_S226_G0.7491.00
110_S114_E0.7471.00
264_L267_K0.7441.00
18_A32_R0.7431.00
213_E216_L0.7401.00
61_K119_L0.7401.00
223_S227_K0.7341.00
58_E62_E0.7331.00
201_S207_A0.7321.00
193_R201_S0.7261.00
166_P169_A0.7251.00
85_G90_G0.7231.00
104_L119_L0.7221.00
62_E65_L0.7211.00
178_L243_L0.7211.00
77_V92_L0.7171.00
106_D115_V0.7151.00
136_D235_H0.7051.00
237_D240_L0.7041.00
8_L12_V0.7041.00
225_L228_A0.7031.00
109_P275_E0.7021.00
24_Y27_E0.6921.00
194_L197_R0.6901.00
168_A174_R0.6881.00
204_L208_L0.6881.00
161_A224_K0.6851.00
182_E246_G0.6851.00
78_R89_K0.6841.00
50_A57_Y0.6801.00
206_D209_K0.6801.00
11_L26_Q0.6791.00
74_E132_Y0.6781.00
154_K231_Y0.6771.00
183_R186_R0.6721.00
259_I263_V0.6681.00
148_W239_L0.6681.00
4_Y8_L0.6661.00
191_E194_L0.6641.00
181_I196_L0.6601.00
205_L243_L0.6601.00
19_D25_R0.6591.00
152_R156_V0.6541.00
178_L201_S0.6541.00
126_I241_R0.6531.00
186_R249_P0.6531.00
15_L26_Q0.6521.00
274_S277_G0.6501.00
115_V118_E0.6491.00
106_D118_E0.6491.00
156_V173_K0.6471.00
118_E121_G0.6391.00
117_E138_L0.6381.00
175_I178_L0.6371.00
91_W132_Y0.6361.00
70_L120_L0.6351.00
90_G275_E0.6341.00
206_D210_A0.6321.00
190_P193_R0.6301.00
207_A210_A0.6301.00
169_A172_L0.6281.00
131_G151_L0.6281.00
167_E172_L0.6271.00
28_E32_R0.6261.00
16_K23_L0.6261.00
37_L41_T0.6251.00
209_K212_L0.6201.00
215_Q229_I0.6201.00
40_G43_A0.6191.00
8_L30_L0.6171.00
12_V26_Q0.6151.00
174_R208_L0.6141.00
53_L57_Y0.6131.00
157_E160_E0.6101.00
229_I233_L0.6061.00
170_E173_K0.6031.00
174_R204_L0.6021.00
185_A193_R0.6011.00
178_L181_I0.5991.00
200_R204_L0.5971.00
165_S169_A0.5931.00
131_G136_D0.5921.00
69_V247_R0.5881.00
191_E195_A0.5881.00
185_A188_L0.5881.00
112_G132_Y0.5881.00
129_S146_G0.5871.00
156_V172_L0.5871.00
176_R183_R0.5851.00
226_G229_I0.5811.00
107_Y278_A0.5801.00
181_I201_S0.5771.00
232_L239_L0.5761.00
116_P138_L0.5761.00
44_N48_R0.5741.00
62_E66_A0.5741.00
188_L192_E0.5741.00
131_G239_L0.5731.00
194_L201_S0.5731.00
227_K230_R0.5711.00
13_A17_Y0.5701.00
57_Y60_L0.5661.00
16_K265_G0.5651.00
127_L142_I0.5621.00
65_L122_G0.5621.00
210_A214_E0.5621.00
65_L123_F0.5611.00
162_D167_E0.5601.00
85_G88_K0.5601.00
16_K46_V0.5591.00
96_V255_A0.5591.00
167_E170_E0.5561.00
128_V248_V0.5541.00
51_E54_E0.5541.00
222_K226_G0.5541.00
69_V248_V0.5521.00
245_D248_V0.5511.00
77_V262_V0.5501.00
70_L95_Y0.5491.00
4_Y41_T0.5481.00
197_R208_L0.5481.00
193_R200_R0.5471.00
189_S193_R0.5461.00
205_L244_D0.5461.00
235_H239_L0.5441.00
230_R233_L0.5421.00
63_E67_S0.5411.00
96_V103_V0.5401.00
198_Q201_S0.5391.00
159_A163_P0.5381.00
190_P246_G0.5371.00
188_L196_L0.5311.00
216_L233_L0.5301.00
8_L35_V0.5301.00
177_E207_A0.5291.00
111_R134_G0.5271.00
84_R88_K0.5241.00
106_D279_E0.5241.00
148_W151_L0.5221.00
54_E57_Y0.5171.00
197_R204_L0.5161.00
178_L182_E0.5151.00
233_L236_W0.5131.00
24_Y28_E0.5131.00
111_R135_Y0.5121.00
202_R240_L0.5111.00
46_V50_A0.5101.00
134_G137_K0.5081.00
133_S234_K0.5071.00
225_L229_I0.5061.00
149_A250_I0.5031.00
27_E36_P0.5021.00
105_F259_I0.5011.00
116_P119_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.7714 93.6 0.907 Contact Map
1pdnC 1 0.1643 74.7 0.93 Contact Map
4fcyA 4 0.725 65.7 0.934 Contact Map
1jkoC 1 0.1571 59.2 0.937 Contact Map
2elhA 1 0.2429 56 0.938 Contact Map
2gloA 1 0.1929 55.1 0.938 Contact Map
2k27A 1 0.2607 54.3 0.939 Contact Map
2bw3A 3 0.8821 50.2 0.94 Contact Map
1k78A 1 0.175 49.4 0.94 Contact Map
2x48A 1 0.15 43.7 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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