CemA - PFAM28P - GREMLIN Contacts

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CemA - CemA family

PFAM:	PF03040	Sequences: SRYKTLISLRFLLLLIIVPLLIQQLSKNFLLEPWVDNWWNTEQSEIFLNDEQEEEALEELQEFEELLLFEELIGEAPELSLEELEEKIHEKAIELAKEYNEESIHAIKNVFADIISFIAFSGLLILGKRELAILKSFIDEFLYGLSDTAKAFLIILFTDLFVGFHSPHGWEVLLEGVARHFGLPENRDFIFLFIATFPVILDTIFKYWIFRYLNRISPSAVATYHNMNE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	229 (228)
Sequences:	752 (405)
Seq/√Len:	26.8
META:	0.36

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_E	68_L	5.307	1.00
214_N	221_V	3.405	1.00
127_G	130_E	3.130	1.00
117_F	124_L	3.094	1.00
36_D	108_K	2.936	1.00
32_E	108_K	2.888	1.00
216_I	221_V	2.792	1.00
200_I	215_R	2.787	1.00
91_K	94_E	2.766	1.00
55_E	102_E	2.472	0.99
174_L	195_A	2.426	0.99
66_L	70_E	2.413	0.99
164_F	197_F	2.342	0.98
119_A	123_L	2.328	0.98
167_P	203_T	2.265	0.98
103_S	106_A	2.248	0.98
221_V	226_N	2.235	0.98
14_L	18_V	2.207	0.98
47_F	56_A	2.176	0.98
158_T	197_F	2.121	0.97
31_L	115_I	2.090	0.97
2_R	153_L	2.011	0.96
155_I	227_M	2.000	0.96
220_A	229_E	1.988	0.96
216_I	226_N	1.964	0.95
34_W	73_I	1.880	0.94
8_S	23_Q	1.844	0.94
200_I	204_I	1.832	0.93
161_F	194_I	1.819	0.93
56_A	103_S	1.773	0.92
32_E	36_D	1.710	0.91
214_N	226_N	1.685	0.90
51_E	185_E	1.650	0.89
187_R	191_F	1.614	0.88
39_W	52_Q	1.598	0.87
34_W	38_W	1.574	0.87
144_G	149_A	1.571	0.86
114_I	118_I	1.562	0.86
211_R	214_N	1.551	0.86
30_L	74_G	1.523	0.85
70_E	190_I	1.520	0.85
214_N	223_T	1.503	0.84
60_L	123_L	1.503	0.84
91_K	225_H	1.496	0.84
89_H	112_A	1.475	0.83
154_I	215_R	1.473	0.83
10_R	78_E	1.464	0.82
13_L	24_Q	1.442	0.81
158_T	209_I	1.422	0.80
113_D	180_H	1.397	0.79
123_L	178_A	1.385	0.78
3_Y	10_R	1.345	0.76
53_E	151_A	1.343	0.76
175_E	187_R	1.341	0.76
192_L	195_A	1.336	0.76
147_D	150_K	1.325	0.75
203_T	211_R	1.318	0.75
15_L	27_K	1.318	0.75
65_E	85_E	1.315	0.75
14_L	24_Q	1.304	0.74
167_P	211_R	1.293	0.73
152_F	169_G	1.290	0.73
179_R	224_Y	1.275	0.72
121_S	125_I	1.267	0.72
151_A	154_I	1.265	0.72
4_K	136_S	1.245	0.71
98_E	118_I	1.242	0.70
85_E	88_I	1.238	0.70
61_Q	65_E	1.235	0.70
37_N	93_I	1.224	0.69
197_F	204_I	1.220	0.69
117_F	123_L	1.219	0.69
3_Y	153_L	1.215	0.69
5_T	154_I	1.213	0.68
152_F	197_F	1.211	0.68
122_G	126_L	1.204	0.68
117_F	205_F	1.195	0.67
10_R	183_L	1.186	0.67
211_R	223_T	1.185	0.67
197_F	201_L	1.183	0.66
67_L	121_S	1.164	0.65
58_E	62_E	1.162	0.65
184_P	205_F	1.162	0.65
63_F	91_K	1.158	0.65
121_S	130_E	1.157	0.65
37_N	41_T	1.155	0.65
115_I	119_A	1.155	0.65
224_Y	228_N	1.144	0.64
179_R	185_E	1.143	0.64
3_Y	133_I	1.127	0.63
161_F	228_N	1.126	0.63
214_N	224_Y	1.124	0.62
186_N	202_D	1.117	0.62
131_L	181_F	1.110	0.61
117_F	121_S	1.106	0.61
70_E	75_E	1.105	0.61
123_L	130_E	1.102	0.61
78_E	177_V	1.101	0.61
133_I	136_S	1.100	0.61
202_D	228_N	1.097	0.61
221_V	225_H	1.096	0.60
189_F	221_V	1.086	0.60
210_F	213_L	1.086	0.60
159_D	180_H	1.085	0.60
87_K	90_E	1.084	0.60
118_I	164_F	1.081	0.59
70_E	78_E	1.066	0.58
164_F	196_T	1.065	0.58
171_E	191_F	1.049	0.57
46_I	49_N	1.047	0.57
22_I	115_I	1.045	0.57
136_S	140_E	1.044	0.57
37_N	62_E	1.038	0.56
120_F	174_L	1.034	0.56
151_A	228_N	1.032	0.56
102_E	179_R	1.032	0.56
12_L	126_L	1.027	0.55
155_I	193_F	1.024	0.55
221_V	224_Y	1.022	0.55
39_W	104_I	1.020	0.55
156_L	197_F	1.019	0.55
197_F	203_T	1.018	0.55
185_E	224_Y	1.017	0.55
42_E	48_L	1.016	0.55
48_L	115_I	1.005	0.54
69_F	184_P	0.989	0.53
142_L	212_Y	0.983	0.52
220_A	228_N	0.980	0.52
29_F	107_I	0.976	0.52
202_D	224_Y	0.968	0.51
203_T	216_I	0.964	0.51
71_E	74_G	0.962	0.51
167_P	225_H	0.949	0.50
152_F	158_T	0.947	0.49
179_R	188_D	0.944	0.49
61_Q	122_G	0.941	0.49
156_L	192_L	0.940	0.49
14_L	123_L	0.939	0.49
40_N	43_Q	0.929	0.48
212_Y	220_A	0.928	0.48
168_H	197_F	0.926	0.48
199_V	206_K	0.921	0.47
84_L	101_E	0.920	0.47
29_F	32_E	0.918	0.47
114_I	173_L	0.918	0.47
144_G	154_I	0.913	0.47
52_Q	99_Y	0.904	0.46
118_I	138_I	0.902	0.46
43_Q	65_E	0.896	0.46
99_Y	224_Y	0.891	0.45
2_R	136_S	0.888	0.45
15_L	25_L	0.887	0.45
207_Y	211_R	0.887	0.45
146_S	149_A	0.879	0.44
9_L	117_F	0.878	0.44
14_L	128_K	0.868	0.44
172_V	193_F	0.864	0.43
196_T	228_N	0.864	0.43
167_P	196_T	0.854	0.42
112_A	194_I	0.854	0.42
198_P	206_K	0.852	0.42
189_F	214_N	0.849	0.42
188_D	191_F	0.839	0.41
129_R	132_A	0.838	0.41
2_R	141_F	0.838	0.41
93_I	119_A	0.837	0.41
202_D	206_K	0.836	0.41
42_E	118_I	0.826	0.40
140_E	143_Y	0.826	0.40
81_L	99_Y	0.823	0.40
39_W	190_I	0.822	0.40
133_I	201_L	0.819	0.40
53_E	58_E	0.819	0.40
38_W	125_I	0.816	0.40
15_L	19_P	0.816	0.40
29_F	34_W	0.815	0.40
162_V	196_T	0.812	0.39
70_E	204_I	0.808	0.39
168_H	196_T	0.800	0.39
165_H	170_W	0.800	0.39
139_D	148_T	0.794	0.38
148_T	215_R	0.788	0.38
212_Y	219_S	0.787	0.38
95_L	98_E	0.782	0.37
46_I	63_F	0.779	0.37
44_S	93_I	0.779	0.37
4_K	40_N	0.779	0.37
110_V	144_G	0.772	0.37
76_A	79_L	0.769	0.36
50_D	153_L	0.769	0.36
130_E	200_I	0.766	0.36
161_F	195_A	0.765	0.36
166_S	170_W	0.762	0.36
2_R	9_L	0.757	0.36
83_E	86_E	0.753	0.35
152_F	159_D	0.751	0.35
78_E	85_E	0.750	0.35
196_T	201_L	0.747	0.35
16_I	130_E	0.745	0.35
24_Q	28_N	0.740	0.34
26_S	112_A	0.738	0.34
56_A	192_L	0.731	0.34
120_F	176_G	0.730	0.34
65_E	216_I	0.726	0.33
117_F	128_K	0.722	0.33
107_I	160_L	0.720	0.33
54_E	58_E	0.720	0.33
34_W	87_K	0.720	0.33
57_L	60_L	0.718	0.33
213_L	217_S	0.713	0.33
11_F	127_G	0.713	0.33
62_E	74_G	0.713	0.33
114_I	124_L	0.710	0.32
29_F	86_E	0.709	0.32
3_Y	140_E	0.707	0.32
30_L	59_E	0.705	0.32
7_I	10_R	0.705	0.32
11_F	51_E	0.704	0.32
139_D	161_F	0.702	0.32
32_E	38_W	0.700	0.32
207_Y	214_N	0.699	0.32
109_N	180_H	0.694	0.31
210_F	218_P	0.693	0.31
189_F	197_F	0.691	0.31
155_I	194_I	0.687	0.31
207_Y	213_L	0.687	0.31
164_F	172_V	0.686	0.31
2_R	12_L	0.686	0.31
109_N	137_F	0.684	0.31
5_T	149_A	0.681	0.31
209_I	214_N	0.680	0.30
112_A	178_A	0.680	0.30
103_S	205_F	0.679	0.30
171_E	186_N	0.677	0.30
96_A	160_L	0.677	0.30
200_I	228_N	0.675	0.30
76_A	101_E	0.674	0.30
22_I	40_N	0.673	0.30
210_F	227_M	0.671	0.30
25_L	58_E	0.670	0.30
49_N	171_E	0.669	0.30
175_E	185_E	0.669	0.30
131_L	135_K	0.668	0.30
180_H	193_F	0.668	0.30
129_R	157_F	0.665	0.30
25_L	34_W	0.664	0.29
110_V	185_E	0.662	0.29
26_S	32_E	0.659	0.29
50_D	70_E	0.654	0.29
66_L	102_E	0.653	0.29
51_E	136_S	0.650	0.29
12_L	118_I	0.649	0.29
27_K	186_N	0.647	0.28
196_T	209_I	0.645	0.28
209_I	221_V	0.644	0.28
3_Y	7_I	0.643	0.28
47_F	207_Y	0.640	0.28
64_E	88_I	0.638	0.28
6_L	214_N	0.637	0.28
5_T	151_A	0.633	0.28
42_E	153_L	0.631	0.27
64_E	85_E	0.631	0.27
30_L	42_E	0.629	0.27
125_I	186_N	0.628	0.27
67_L	138_I	0.623	0.27
98_E	102_E	0.621	0.27
39_W	164_F	0.620	0.27
60_L	64_E	0.618	0.27
38_W	82_E	0.618	0.27
54_E	183_L	0.618	0.27
57_L	69_F	0.616	0.27
148_T	154_I	0.615	0.26
199_V	209_I	0.610	0.26
21_L	37_N	0.610	0.26
39_W	70_E	0.608	0.26
65_E	136_S	0.608	0.26
189_F	226_N	0.605	0.26
149_A	155_I	0.605	0.26
31_L	35_V	0.604	0.26
185_E	190_I	0.600	0.26
14_L	32_E	0.600	0.26
176_G	215_R	0.595	0.25
34_W	86_E	0.595	0.25
11_F	39_W	0.591	0.25
4_K	225_H	0.590	0.25
9_L	75_E	0.590	0.25
121_S	124_L	0.590	0.25
56_A	69_F	0.589	0.25
81_L	102_E	0.587	0.25
121_S	146_S	0.586	0.25
78_E	101_E	0.586	0.25
17_I	43_Q	0.585	0.25
196_T	227_M	0.585	0.25
10_R	57_L	0.580	0.24
2_R	32_E	0.575	0.24
10_R	123_L	0.573	0.24
173_L	202_D	0.572	0.24
141_F	154_I	0.570	0.24
105_H	200_I	0.566	0.24
9_L	141_F	0.559	0.23
65_E	121_S	0.557	0.23
76_A	82_E	0.556	0.23
74_G	179_R	0.555	0.23
90_E	94_E	0.554	0.23
38_W	42_E	0.552	0.23
16_I	107_I	0.552	0.23
57_L	185_E	0.551	0.23
70_E	122_G	0.551	0.23
50_D	63_F	0.548	0.23
167_P	197_F	0.540	0.22
47_F	103_S	0.535	0.22
154_I	167_P	0.535	0.22
96_A	100_N	0.534	0.22
5_T	228_N	0.534	0.22
2_R	29_F	0.534	0.22
30_L	117_F	0.533	0.22
26_S	128_K	0.532	0.22
162_V	195_A	0.527	0.22
175_E	191_F	0.526	0.22
55_E	183_L	0.522	0.21
130_E	181_F	0.521	0.21
23_Q	28_N	0.521	0.21
3_Y	51_E	0.520	0.21
183_L	216_I	0.519	0.21
168_H	228_N	0.518	0.21
205_F	216_I	0.513	0.21
213_L	218_P	0.513	0.21
51_E	54_E	0.513	0.21
159_D	201_L	0.512	0.21
46_I	164_F	0.510	0.21
9_L	61_Q	0.508	0.21
9_L	127_G	0.507	0.21
22_I	104_I	0.506	0.21
115_I	122_G	0.506	0.21
23_Q	128_K	0.506	0.21
160_L	192_L	0.506	0.21
169_G	208_W	0.506	0.21
134_L	146_S	0.505	0.21
31_L	144_G	0.505	0.21
161_F	168_H	0.504	0.21
204_I	226_N	0.504	0.21
51_E	153_L	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q5nA	2	0.2969	16.8	0.969	Contact Map
1b8xA	2	0.31	16.3	0.969	Contact Map
3gx0A	2	0.3057	15.8	0.969	Contact Map
2fheA	2	0.31	12.3	0.971	Contact Map
4w66A	2	0.3231	10.5	0.971	Contact Map
4hi7A	2	0.31	9.6	0.972	Contact Map
2pvqA	2	0.3013	9.4	0.972	Contact Map
2v6kA	2	0.3057	9.3	0.972	Contact Map
3ic8A	3	0.31	8.7	0.972	Contact Map
4gf0A	2	0.3144	8.6	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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