GREMLIN Database
CemA - CemA family
PFAM: PF03040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 229 (228)
Sequences: 752 (405)
Seq/√Len: 26.8
META: 0.36

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_E68_L5.3071.00
214_N221_V3.4051.00
127_G130_E3.1301.00
117_F124_L3.0941.00
36_D108_K2.9361.00
32_E108_K2.8881.00
216_I221_V2.7921.00
200_I215_R2.7871.00
91_K94_E2.7661.00
55_E102_E2.4720.99
174_L195_A2.4260.99
66_L70_E2.4130.99
164_F197_F2.3420.98
119_A123_L2.3280.98
167_P203_T2.2650.98
103_S106_A2.2480.98
221_V226_N2.2350.98
14_L18_V2.2070.98
47_F56_A2.1760.98
158_T197_F2.1210.97
31_L115_I2.0900.97
2_R153_L2.0110.96
155_I227_M2.0000.96
220_A229_E1.9880.96
216_I226_N1.9640.95
34_W73_I1.8800.94
8_S23_Q1.8440.94
200_I204_I1.8320.93
161_F194_I1.8190.93
56_A103_S1.7730.92
32_E36_D1.7100.91
214_N226_N1.6850.90
51_E185_E1.6500.89
187_R191_F1.6140.88
39_W52_Q1.5980.87
34_W38_W1.5740.87
144_G149_A1.5710.86
114_I118_I1.5620.86
211_R214_N1.5510.86
30_L74_G1.5230.85
70_E190_I1.5200.85
214_N223_T1.5030.84
60_L123_L1.5030.84
91_K225_H1.4960.84
89_H112_A1.4750.83
154_I215_R1.4730.83
10_R78_E1.4640.82
13_L24_Q1.4420.81
158_T209_I1.4220.80
113_D180_H1.3970.79
123_L178_A1.3850.78
3_Y10_R1.3450.76
53_E151_A1.3430.76
175_E187_R1.3410.76
192_L195_A1.3360.76
147_D150_K1.3250.75
203_T211_R1.3180.75
15_L27_K1.3180.75
65_E85_E1.3150.75
14_L24_Q1.3040.74
167_P211_R1.2930.73
152_F169_G1.2900.73
179_R224_Y1.2750.72
121_S125_I1.2670.72
151_A154_I1.2650.72
4_K136_S1.2450.71
98_E118_I1.2420.70
85_E88_I1.2380.70
61_Q65_E1.2350.70
37_N93_I1.2240.69
197_F204_I1.2200.69
117_F123_L1.2190.69
3_Y153_L1.2150.69
5_T154_I1.2130.68
152_F197_F1.2110.68
122_G126_L1.2040.68
117_F205_F1.1950.67
10_R183_L1.1860.67
211_R223_T1.1850.67
197_F201_L1.1830.66
67_L121_S1.1640.65
58_E62_E1.1620.65
184_P205_F1.1620.65
63_F91_K1.1580.65
121_S130_E1.1570.65
37_N41_T1.1550.65
115_I119_A1.1550.65
224_Y228_N1.1440.64
179_R185_E1.1430.64
3_Y133_I1.1270.63
161_F228_N1.1260.63
214_N224_Y1.1240.62
186_N202_D1.1170.62
131_L181_F1.1100.61
117_F121_S1.1060.61
70_E75_E1.1050.61
123_L130_E1.1020.61
78_E177_V1.1010.61
133_I136_S1.1000.61
202_D228_N1.0970.61
221_V225_H1.0960.60
189_F221_V1.0860.60
210_F213_L1.0860.60
159_D180_H1.0850.60
87_K90_E1.0840.60
118_I164_F1.0810.59
70_E78_E1.0660.58
164_F196_T1.0650.58
171_E191_F1.0490.57
46_I49_N1.0470.57
22_I115_I1.0450.57
136_S140_E1.0440.57
37_N62_E1.0380.56
120_F174_L1.0340.56
151_A228_N1.0320.56
102_E179_R1.0320.56
12_L126_L1.0270.55
155_I193_F1.0240.55
221_V224_Y1.0220.55
39_W104_I1.0200.55
156_L197_F1.0190.55
197_F203_T1.0180.55
185_E224_Y1.0170.55
42_E48_L1.0160.55
48_L115_I1.0050.54
69_F184_P0.9890.53
142_L212_Y0.9830.52
220_A228_N0.9800.52
29_F107_I0.9760.52
202_D224_Y0.9680.51
203_T216_I0.9640.51
71_E74_G0.9620.51
167_P225_H0.9490.50
152_F158_T0.9470.49
179_R188_D0.9440.49
61_Q122_G0.9410.49
156_L192_L0.9400.49
14_L123_L0.9390.49
40_N43_Q0.9290.48
212_Y220_A0.9280.48
168_H197_F0.9260.48
199_V206_K0.9210.47
84_L101_E0.9200.47
29_F32_E0.9180.47
114_I173_L0.9180.47
144_G154_I0.9130.47
52_Q99_Y0.9040.46
118_I138_I0.9020.46
43_Q65_E0.8960.46
99_Y224_Y0.8910.45
2_R136_S0.8880.45
15_L25_L0.8870.45
207_Y211_R0.8870.45
146_S149_A0.8790.44
9_L117_F0.8780.44
14_L128_K0.8680.44
172_V193_F0.8640.43
196_T228_N0.8640.43
167_P196_T0.8540.42
112_A194_I0.8540.42
198_P206_K0.8520.42
189_F214_N0.8490.42
188_D191_F0.8390.41
129_R132_A0.8380.41
2_R141_F0.8380.41
93_I119_A0.8370.41
202_D206_K0.8360.41
42_E118_I0.8260.40
140_E143_Y0.8260.40
81_L99_Y0.8230.40
39_W190_I0.8220.40
133_I201_L0.8190.40
53_E58_E0.8190.40
38_W125_I0.8160.40
15_L19_P0.8160.40
29_F34_W0.8150.40
162_V196_T0.8120.39
70_E204_I0.8080.39
168_H196_T0.8000.39
165_H170_W0.8000.39
139_D148_T0.7940.38
148_T215_R0.7880.38
212_Y219_S0.7870.38
95_L98_E0.7820.37
46_I63_F0.7790.37
44_S93_I0.7790.37
4_K40_N0.7790.37
110_V144_G0.7720.37
76_A79_L0.7690.36
50_D153_L0.7690.36
130_E200_I0.7660.36
161_F195_A0.7650.36
166_S170_W0.7620.36
2_R9_L0.7570.36
83_E86_E0.7530.35
152_F159_D0.7510.35
78_E85_E0.7500.35
196_T201_L0.7470.35
16_I130_E0.7450.35
24_Q28_N0.7400.34
26_S112_A0.7380.34
56_A192_L0.7310.34
120_F176_G0.7300.34
65_E216_I0.7260.33
117_F128_K0.7220.33
107_I160_L0.7200.33
54_E58_E0.7200.33
34_W87_K0.7200.33
57_L60_L0.7180.33
213_L217_S0.7130.33
11_F127_G0.7130.33
62_E74_G0.7130.33
114_I124_L0.7100.32
29_F86_E0.7090.32
3_Y140_E0.7070.32
30_L59_E0.7050.32
7_I10_R0.7050.32
11_F51_E0.7040.32
139_D161_F0.7020.32
32_E38_W0.7000.32
207_Y214_N0.6990.32
109_N180_H0.6940.31
210_F218_P0.6930.31
189_F197_F0.6910.31
155_I194_I0.6870.31
207_Y213_L0.6870.31
164_F172_V0.6860.31
2_R12_L0.6860.31
109_N137_F0.6840.31
5_T149_A0.6810.31
209_I214_N0.6800.30
112_A178_A0.6800.30
103_S205_F0.6790.30
171_E186_N0.6770.30
96_A160_L0.6770.30
200_I228_N0.6750.30
76_A101_E0.6740.30
22_I40_N0.6730.30
210_F227_M0.6710.30
25_L58_E0.6700.30
49_N171_E0.6690.30
175_E185_E0.6690.30
131_L135_K0.6680.30
180_H193_F0.6680.30
129_R157_F0.6650.30
25_L34_W0.6640.29
110_V185_E0.6620.29
26_S32_E0.6590.29
50_D70_E0.6540.29
66_L102_E0.6530.29
51_E136_S0.6500.29
12_L118_I0.6490.29
27_K186_N0.6470.28
196_T209_I0.6450.28
209_I221_V0.6440.28
3_Y7_I0.6430.28
47_F207_Y0.6400.28
64_E88_I0.6380.28
6_L214_N0.6370.28
5_T151_A0.6330.28
42_E153_L0.6310.27
64_E85_E0.6310.27
30_L42_E0.6290.27
125_I186_N0.6280.27
67_L138_I0.6230.27
98_E102_E0.6210.27
39_W164_F0.6200.27
60_L64_E0.6180.27
38_W82_E0.6180.27
54_E183_L0.6180.27
57_L69_F0.6160.27
148_T154_I0.6150.26
199_V209_I0.6100.26
21_L37_N0.6100.26
39_W70_E0.6080.26
65_E136_S0.6080.26
189_F226_N0.6050.26
149_A155_I0.6050.26
31_L35_V0.6040.26
185_E190_I0.6000.26
14_L32_E0.6000.26
176_G215_R0.5950.25
34_W86_E0.5950.25
11_F39_W0.5910.25
4_K225_H0.5900.25
9_L75_E0.5900.25
121_S124_L0.5900.25
56_A69_F0.5890.25
81_L102_E0.5870.25
121_S146_S0.5860.25
78_E101_E0.5860.25
17_I43_Q0.5850.25
196_T227_M0.5850.25
10_R57_L0.5800.24
2_R32_E0.5750.24
10_R123_L0.5730.24
173_L202_D0.5720.24
141_F154_I0.5700.24
105_H200_I0.5660.24
9_L141_F0.5590.23
65_E121_S0.5570.23
76_A82_E0.5560.23
74_G179_R0.5550.23
90_E94_E0.5540.23
38_W42_E0.5520.23
16_I107_I0.5520.23
57_L185_E0.5510.23
70_E122_G0.5510.23
50_D63_F0.5480.23
167_P197_F0.5400.22
47_F103_S0.5350.22
154_I167_P0.5350.22
96_A100_N0.5340.22
5_T228_N0.5340.22
2_R29_F0.5340.22
30_L117_F0.5330.22
26_S128_K0.5320.22
162_V195_A0.5270.22
175_E191_F0.5260.22
55_E183_L0.5220.21
130_E181_F0.5210.21
23_Q28_N0.5210.21
3_Y51_E0.5200.21
183_L216_I0.5190.21
168_H228_N0.5180.21
205_F216_I0.5130.21
213_L218_P0.5130.21
51_E54_E0.5130.21
159_D201_L0.5120.21
46_I164_F0.5100.21
9_L61_Q0.5080.21
9_L127_G0.5070.21
22_I104_I0.5060.21
115_I122_G0.5060.21
23_Q128_K0.5060.21
160_L192_L0.5060.21
169_G208_W0.5060.21
134_L146_S0.5050.21
31_L144_G0.5050.21
161_F168_H0.5040.21
204_I226_N0.5040.21
51_E153_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q5nA 2 0.2969 16.8 0.969 Contact Map
1b8xA 2 0.31 16.3 0.969 Contact Map
3gx0A 2 0.3057 15.8 0.969 Contact Map
2fheA 2 0.31 12.3 0.971 Contact Map
4w66A 2 0.3231 10.5 0.971 Contact Map
4hi7A 2 0.31 9.6 0.972 Contact Map
2pvqA 2 0.3013 9.4 0.972 Contact Map
2v6kA 2 0.3057 9.3 0.972 Contact Map
3ic8A 3 0.31 8.7 0.972 Contact Map
4gf0A 2 0.3144 8.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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