GREMLIN Database
Sterile - Male sterility protein
PFAM: PF03015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (90)
Sequences: 2673 (1870)
Seq/√Len: 197.2
META: 0.451

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_N72_S2.7131.00
39_F42_N2.7011.00
60_P63_R2.6371.00
70_P73_I2.6291.00
38_P42_N2.1881.00
77_D81_N2.1451.00
69_D72_S2.0951.00
48_N52_R2.0291.00
7_Y23_V1.9461.00
84_P88_K1.9321.00
55_R68_F1.9281.00
50_N53_A1.9211.00
26_Y29_I1.8731.00
55_R63_R1.8401.00
6_A10_D1.7641.00
28_K32_A1.7221.00
26_Y30_H1.7021.00
11_L14_R1.6441.00
59_S62_D1.5401.00
39_F44_W1.4651.00
37_E40_T1.4221.00
61_E64_K1.4151.00
36_F40_T1.3941.00
77_D80_L1.3331.00
30_H33_L1.3321.00
23_V27_R1.3191.00
14_R20_P1.3141.00
3_L7_Y1.3041.00
10_D13_L1.2971.00
75_W82_Y1.2751.00
32_A35_L1.2531.00
52_R71_E1.2481.00
8_L14_R1.2121.00
10_D20_P1.2061.00
10_D18_K1.2011.00
16_T19_K1.1721.00
25_L32_A1.1521.00
80_L84_P1.1311.00
86_L90_V1.1281.00
28_K33_L1.1151.00
60_P64_K1.1091.00
36_F39_F1.1041.00
25_L28_K1.0971.00
58_L63_R1.0841.00
52_R56_A1.0681.00
74_D77_D1.0671.00
69_D73_I1.0521.00
8_L11_L1.0511.00
7_Y10_D1.0451.00
34_E37_E1.0231.00
66_F79_F1.0031.00
3_L30_H1.0021.00
69_D75_W1.0021.00
35_L38_P0.9810.99
36_F84_P0.9550.99
70_P75_W0.9550.99
44_W82_Y0.9260.99
48_N68_F0.9220.99
49_D56_A0.9140.99
24_K31_K0.9120.99
27_R31_K0.9110.99
12_L15_L0.9060.99
12_L16_T0.8910.99
37_E41_T0.8900.99
89_Y92_K0.8780.99
76_E81_N0.8750.99
4_L7_Y0.8590.99
87_R90_V0.8570.99
38_P44_W0.7920.98
24_K29_I0.7920.98
39_F89_Y0.7880.98
35_L39_F0.7870.98
29_I32_A0.7780.97
32_A36_F0.7690.97
56_A63_R0.7670.97
81_N84_P0.7650.97
10_D17_G0.7630.97
76_E80_L0.7410.97
75_W78_Y0.7390.96
38_P82_Y0.7350.96
59_S63_R0.7210.96
87_R91_L0.7190.96
53_A56_A0.7040.95
28_K31_K0.6950.95
11_L16_T0.6950.95
53_A64_K0.6940.95
21_R33_L0.6860.95
24_K28_K0.6850.95
55_R67_N0.6810.94
75_W86_L0.6770.94
7_Y14_R0.6770.94
43_E46_F0.6650.94
66_F69_D0.6630.94
44_W85_G0.6600.94
13_L16_T0.6510.93
48_N51_T0.6490.93
62_D65_L0.6370.92
49_D57_R0.6240.92
26_Y32_A0.6220.91
8_L15_L0.6210.91
18_K62_D0.6170.91
51_T75_W0.6070.90
29_I33_L0.6060.90
55_R69_D0.6050.90
50_N68_F0.6030.90
15_L19_K0.6000.90
7_Y11_L0.5970.90
8_L12_L0.5960.90
11_L18_K0.5860.89
59_S64_K0.5800.88
39_F85_G0.5800.88
23_V36_F0.5790.88
6_A9_L0.5600.87
12_L18_K0.5590.86
4_L45_V0.5580.86
9_L22_L0.5570.86
51_T68_F0.5540.86
9_L13_L0.5470.85
13_L18_K0.5450.85
32_A86_L0.5390.84
53_A57_R0.5390.84
57_R62_D0.5380.84
8_L13_L0.5350.84
48_N87_R0.5280.83
10_D15_L0.5260.83
15_L20_P0.5230.83
39_F46_F0.5220.82
48_N71_E0.5210.82
22_L32_A0.5210.82
80_L83_I0.5160.82
3_L12_L0.5150.82
41_T87_R0.5150.82
58_L64_K0.5020.80
12_L21_R0.5020.80
11_L15_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3st7A 2 0.9785 72.3 0.84 Contact Map
2gn4A 5 0.5914 60.1 0.852 Contact Map
2cm2A 1 0.4731 8.7 0.904 Contact Map
4adnA 2 0.9462 7.8 0.906 Contact Map
2eo2A 1 0.6344 7.2 0.907 Contact Map
1jv1A 2 0.6022 5 0.914 Contact Map
1ni3A 1 0.9892 4.1 0.918 Contact Map
3zxuA 1 0.8495 3.8 0.919 Contact Map
4a4aA 1 0.9677 3.5 0.921 Contact Map
3balA 4 0.4194 3.4 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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