GREMLIN Database
NPH3 - NPH3 family
PFAM: PF03000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (228)
Sequences: 1137 (592)
Seq/√Len: 39.2
META: 0.052

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_F35_A4.9731.00
124_D175_K4.7141.00
97_E128_R4.6181.00
125_L129_I4.0861.00
184_P187_A3.2401.00
119_T170_N3.2061.00
209_S212_E3.1011.00
155_A226_S3.0601.00
205_H217_C2.9701.00
159_D194_L2.5681.00
67_E70_S2.5281.00
40_A75_F2.4021.00
159_D188_R2.3181.00
87_G93_R2.2891.00
105_D133_F2.2641.00
22_M78_G2.1840.99
89_S175_K2.1790.99
77_L158_V2.1760.99
26_G99_R2.1160.99
159_D184_P1.9620.99
123_V194_L1.9150.98
44_L216_L1.8010.98
57_L86_L1.7710.97
184_P188_R1.7520.97
113_L121_Y1.7080.97
198_I220_M1.7070.97
97_E129_I1.7000.97
216_L220_M1.6660.96
127_Q170_N1.6540.96
5_E19_I1.6530.96
156_K194_L1.6500.96
205_H225_L1.6290.96
204_A214_K1.6010.95
139_Q142_E1.6000.95
15_F19_I1.5850.95
32_I61_V1.5820.95
4_F34_E1.5670.95
134_L158_V1.5590.94
3_W188_R1.5550.94
107_A115_P1.5420.94
224_K228_E1.5300.94
33_G71_V1.5150.93
204_A209_S1.5130.93
87_G94_E1.5070.93
106_Q213_R1.4770.93
6_D155_A1.4630.92
185_D200_I1.4530.92
103_Q226_S1.4440.92
186_S198_I1.4400.92
108_T156_K1.4280.91
157_L168_D1.4100.91
134_L179_L1.3850.90
18_V41_K1.3610.89
18_V30_E1.3600.89
187_A224_K1.3560.89
22_M110_D1.3470.89
23_K194_L1.3410.88
65_P75_F1.3400.88
78_G81_R1.3340.88
203_K206_P1.3290.88
109_L208_L1.3160.87
155_A211_S1.3100.87
93_R114_I1.3020.87
87_G159_D1.3020.87
130_L179_L1.2700.86
17_R169_P1.2610.85
94_E134_L1.2570.85
150_S198_I1.2560.85
58_E128_R1.2490.85
15_F36_L1.2480.85
65_P99_R1.2460.84
81_R92_C1.2400.84
72_S125_L1.2400.84
163_A193_G1.2290.84
56_L79_L1.2160.83
16_K19_I1.2160.83
71_V130_L1.2120.83
55_V108_T1.2080.83
167_P172_K1.2020.82
6_D147_S1.1970.82
198_I219_L1.1840.81
40_A45_P1.1760.81
109_L157_L1.1660.80
190_S226_S1.1460.79
218_R222_C1.1400.79
15_F200_I1.1320.78
129_I190_S1.1310.78
10_L18_V1.1250.78
72_S230_C1.1190.77
133_F171_L1.1120.77
5_E221_D1.1110.77
210_E214_K1.1030.76
220_M229_A1.0930.76
93_R122_D1.0860.75
126_V129_I1.0830.75
40_A60_I1.0780.75
61_V92_C1.0550.73
49_D150_S1.0500.73
59_T112_L1.0470.72
164_E199_D1.0450.72
43_W101_G1.0420.72
26_G109_L1.0380.72
15_F206_P1.0370.72
40_A44_L1.0340.71
53_Q191_H1.0330.71
62_S95_E1.0310.71
101_G132_H1.0310.71
7_L165_I1.0300.71
60_I174_S1.0210.71
31_V114_I1.0190.70
81_R143_S1.0180.70
128_R171_L1.0120.70
24_S67_E1.0040.69
58_E99_R1.0040.69
46_S49_D0.9990.69
92_C115_P0.9970.69
36_L212_E0.9930.68
163_A200_I0.9910.68
7_L176_F0.9850.68
12_I228_E0.9830.68
119_T220_M0.9810.67
177_I181_E0.9750.67
149_S155_A0.9680.66
18_V229_A0.9670.66
210_E223_Q0.9650.66
122_D126_V0.9560.65
122_D165_I0.9480.65
53_Q58_E0.9470.65
1_D16_K0.9460.65
120_L208_L0.9450.64
115_P194_L0.9440.64
125_L165_I0.9380.64
99_R129_I0.9360.64
41_K158_V0.9330.63
128_R164_E0.9170.62
35_A38_H0.9130.62
83_A201_Y0.9060.61
165_I224_K0.9050.61
158_V228_E0.9040.61
60_I93_R0.9020.61
103_Q121_Y0.8930.60
100_I110_D0.8920.60
113_L165_I0.8890.60
114_I193_G0.8880.60
112_L130_L0.8810.59
58_E62_S0.8810.59
164_E193_G0.8800.59
28_K103_Q0.8800.59
193_G196_R0.8780.59
78_G230_C0.8740.58
7_L191_H0.8730.58
211_S222_C0.8720.58
36_L63_L0.8660.58
211_S227_L0.8510.56
111_D160_G0.8500.56
8_S38_H0.8470.56
33_G214_K0.8440.56
153_K216_L0.8430.56
31_V122_D0.8400.55
71_V182_A0.8390.55
123_V157_L0.8390.55
110_D161_Y0.8390.55
33_G63_L0.8350.55
138_E141_E0.8320.55
107_A157_L0.8290.54
15_F65_P0.8290.54
73_C125_L0.8260.54
151_L155_A0.8250.54
140_E143_S0.8220.54
23_K79_L0.8190.53
168_D201_Y0.8160.53
159_D191_H0.8150.53
4_F82_A0.8140.53
22_M172_K0.8100.53
99_R203_K0.8090.53
188_R194_L0.8090.53
161_Y188_R0.8070.52
149_S182_A0.8060.52
105_D206_P0.8050.52
15_F203_K0.8050.52
101_G164_E0.7960.51
112_L116_S0.7960.51
153_K186_S0.7940.51
64_L120_L0.7940.51
101_G121_Y0.7920.51
69_G182_A0.7920.51
27_V94_E0.7890.51
129_I152_L0.7860.50
95_E214_K0.7810.50
88_A152_L0.7800.50
64_L79_L0.7760.50
69_G103_Q0.7700.49
1_D107_A0.7620.48
32_I153_K0.7590.48
193_G199_D0.7570.48
196_R199_D0.7500.47
81_R199_D0.7500.47
11_S97_E0.7470.47
54_R103_Q0.7460.47
38_H183_L0.7440.47
7_L14_L0.7420.46
34_E213_R0.7410.46
192_D197_A0.7350.46
32_I56_L0.7350.46
171_L199_D0.7340.46
204_A213_R0.7330.46
3_W184_P0.7260.45
2_W35_A0.7250.45
15_F40_A0.7220.45
209_S230_C0.7210.45
78_G183_L0.7190.44
56_L114_I0.7170.44
84_I182_A0.7170.44
26_G32_I0.7170.44
154_V171_L0.7170.44
107_A114_I0.7140.44
133_F174_S0.7130.44
133_F197_A0.7130.44
109_L184_P0.7100.44
71_V222_C0.7090.43
43_W88_A0.7030.43
111_D162_L0.6960.42
163_A229_A0.6960.42
98_R175_K0.6930.42
204_A225_L0.6920.42
54_R88_A0.6900.42
144_S179_L0.6890.42
79_L210_E0.6830.41
3_W175_K0.6830.41
27_V209_S0.6820.41
66_S158_V0.6810.41
58_E187_A0.6800.41
199_D220_M0.6710.40
43_W220_M0.6690.40
19_I130_L0.6690.40
18_V109_L0.6640.40
81_R164_E0.6610.39
81_R86_L0.6580.39
30_E130_L0.6550.39
139_Q143_S0.6540.39
39_Y107_A0.6500.38
53_Q128_R0.6480.38
124_D164_E0.6470.38
164_E171_L0.6460.38
56_L93_R0.6430.38
59_T175_K0.6430.38
60_I211_S0.6430.38
82_A155_A0.6420.38
7_L128_R0.6420.38
32_I147_S0.6420.38
194_L209_S0.6420.38
152_L189_P0.6420.38
188_R191_H0.6390.37
88_A170_N0.6370.37
128_R163_A0.6350.37
36_L39_Y0.6340.37
71_V227_L0.6310.37
25_K220_M0.6290.37
61_V93_R0.6240.36
39_Y56_L0.6200.36
57_L218_R0.6170.36
69_G78_G0.6100.35
61_V94_E0.6090.35
15_F34_E0.6080.35
4_F38_H0.6080.35
61_V95_E0.6050.35
171_L208_L0.6040.34
77_L167_P0.6040.34
36_L121_Y0.6040.34
211_S226_S0.6030.34
156_K230_C0.5990.34
67_E116_S0.5970.34
2_W72_S0.5950.34
115_P179_L0.5910.33
37_M97_E0.5890.33
127_Q134_L0.5870.33
160_G216_L0.5840.33
112_L208_L0.5790.32
180_A219_L0.5760.32
6_D77_L0.5740.32
93_R110_D0.5740.32
45_P170_N0.5740.32
28_K36_L0.5730.32
62_S89_S0.5730.32
138_E142_E0.5720.32
180_A192_D0.5720.32
14_L211_S0.5710.32
8_S25_K0.5690.32
7_L18_V0.5690.32
156_K170_N0.5680.32
62_S153_K0.5670.31
4_F31_V0.5650.31
24_S158_V0.5640.31
211_S219_L0.5640.31
53_Q97_E0.5600.31
162_L198_I0.5570.31
25_K123_V0.5570.31
37_M210_E0.5560.31
73_C77_L0.5540.30
67_E121_Y0.5530.30
3_W159_D0.5510.30
46_S185_D0.5510.30
180_A213_R0.5490.30
67_E150_S0.5460.30
16_K213_R0.5460.30
40_A65_P0.5440.30
35_A186_S0.5430.30
34_E38_H0.5380.29
155_A218_R0.5370.29
100_I126_V0.5360.29
2_W126_V0.5350.29
205_H224_K0.5340.29
123_V165_I0.5340.29
217_C225_L0.5300.29
202_L229_A0.5300.29
89_S103_Q0.5290.29
207_G214_K0.5290.29
3_W10_L0.5250.28
50_E83_A0.5240.28
34_E42_K0.5240.28
165_I175_K0.5240.28
30_E56_L0.5230.28
41_K74_S0.5200.28
205_H226_S0.5180.28
98_R131_E0.5180.28
64_L166_A0.5160.28
83_A88_A0.5150.28
31_V37_M0.5150.28
197_A202_L0.5140.27
11_S210_E0.5130.27
24_S125_L0.5100.27
85_I216_L0.5100.27
192_D195_Y0.5090.27
87_G125_L0.5080.27
7_L190_S0.5070.27
208_L216_L0.5050.27
73_C101_G0.5050.27
210_E221_D0.5040.27
40_A222_C0.5040.27
30_E134_L0.5030.27
125_L214_K0.5000.26
127_Q131_E0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i3nA 2 0.4391 51.1 0.956 Contact Map
3hveA 1 0.3174 39.4 0.959 Contact Map
1j5sA 3 0.8565 32.7 0.961 Contact Map
2q01A 3 0.8826 29 0.962 Contact Map
3iacA 3 0.9043 18.8 0.965 Contact Map
4hxiA 1 0.1826 17.4 0.966 Contact Map
3v9rB 1 0.2913 14.1 0.967 Contact Map
4h4dA 1 0.2957 13.6 0.967 Contact Map
3dnfA 2 0.1957 10.9 0.969 Contact Map
3h0lB 1 0.1957 10.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.