GREMLIN Database
Transposase_21 - Transposase family tnp2
PFAM: PF02992 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 224 (221)
Sequences: 882 (629)
Seq/√Len: 42.3
META: 0.501

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_R7_E5.6371.00
142_F160_P4.9941.00
2_M41_V4.3091.00
140_N144_A3.8381.00
195_D198_A3.7901.00
33_D132_R3.7551.00
44_G70_Y3.5971.00
110_L135_L3.3701.00
43_L133_A3.3361.00
213_S216_E3.3081.00
9_R19_A3.2301.00
94_Q147_N3.1941.00
66_I83_I2.9941.00
120_T131_L2.7161.00
156_K177_T2.7061.00
112_E116_E2.2691.00
109_E112_E2.2391.00
170_W177_T2.2361.00
219_E222_K2.2011.00
142_F145_Y2.1480.99
216_E219_E2.1360.99
170_W175_R1.9730.99
201_G204_E1.9590.99
45_L67_L1.9200.99
27_F136_L1.9150.99
218_L221_L1.8880.99
145_Y160_P1.8850.99
28_D42_R1.8830.99
15_L21_G1.8590.98
41_V109_E1.8540.98
27_F31_Y1.8490.98
41_V151_W1.8050.98
27_F134_A1.7430.98
119_E130_T1.7340.98
22_E29_R1.7340.98
151_W163_M1.7300.98
107_I148_L1.6660.97
119_E128_N1.6490.97
203_V206_R1.6300.97
3_R124_S1.6160.96
140_N148_L1.5910.96
212_L220_Q1.5660.96
200_D204_E1.5510.95
2_M151_W1.5340.95
6_A38_P1.5200.95
146_G153_T1.5020.94
45_L138_T1.4570.93
21_G27_F1.4570.93
76_L94_Q1.4530.93
186_L190_H1.4440.93
164_K220_Q1.4270.93
210_R216_E1.4090.92
91_G95_P1.3760.91
208_A211_P1.3760.91
187_P190_H1.3660.91
51_N56_M1.3500.91
51_N54_G1.3430.90
103_L148_L1.3350.90
188_P207_P1.3140.89
103_L135_L1.3130.89
88_L192_Y1.2810.88
75_W79_K1.2720.88
135_L138_T1.2600.87
55_N58_S1.2350.86
68_V82_N1.2020.85
187_P191_P1.2010.85
88_L92_P1.1960.84
2_M69_P1.1880.84
202_K205_H1.1820.84
41_V69_P1.1770.83
25_K174_G1.1710.83
41_V131_L1.1660.83
208_A216_E1.1450.82
212_L216_E1.1420.81
26_H58_S1.1380.81
46_A50_F1.1330.81
7_E198_A1.1320.81
60_Y90_P1.1250.80
147_N154_K1.1170.80
52_P114_W1.1130.80
181_G184_R1.1070.79
8_G14_K1.0940.79
181_G206_R1.0930.78
207_P210_R1.0880.78
21_G137_W1.0790.78
174_G178_C1.0760.77
28_D59_S1.0730.77
218_L222_K1.0540.76
2_M27_F1.0490.76
51_N57_S1.0440.75
215_E218_L1.0300.74
90_P105_P1.0170.73
207_P211_P1.0160.73
65_V70_Y1.0150.73
121_Y171_L1.0060.72
12_D16_R1.0060.72
64_P159_C1.0050.72
189_N194_R1.0040.72
50_F134_A1.0000.72
109_E161_V0.9950.72
43_L142_F0.9940.71
56_M59_S0.9930.71
13_G21_G0.9860.71
191_P222_K0.9850.71
212_L215_E0.9770.70
81_E94_Q0.9770.70
49_G63_W0.9700.70
186_L193_R0.9630.69
10_K19_A0.9620.69
37_E131_L0.9460.68
169_F200_D0.9370.67
34_F40_N0.9220.66
98_D154_K0.9210.66
186_L199_F0.9190.65
181_G200_D0.9140.65
201_G205_H0.9130.65
8_G11_K0.9060.64
163_M211_P0.9030.64
176_K186_L0.9020.64
8_G19_A0.8990.64
47_T140_N0.8990.64
91_G133_A0.8910.63
73_P183_R0.8900.63
15_L58_S0.8880.63
178_C181_G0.8810.62
50_F60_Y0.8790.62
198_A220_Q0.8780.62
112_E118_V0.8760.62
211_P216_E0.8760.62
50_F90_P0.8730.61
167_D206_R0.8700.61
40_N114_W0.8680.61
50_F69_P0.8660.61
206_R214_G0.8640.61
82_N88_L0.8620.60
81_E84_M0.8500.59
11_K14_K0.8480.59
62_T98_D0.8480.59
203_V208_A0.8450.59
121_Y124_S0.8430.59
215_E221_L0.8400.58
167_D217_I0.8400.58
6_A11_K0.8360.58
82_N89_I0.8350.58
104_Q111_K0.8350.58
7_E124_S0.8340.58
15_L112_E0.8320.58
131_L151_W0.8320.58
28_D89_I0.8190.56
38_P113_L0.8100.56
154_K179_Y0.8050.55
14_K187_P0.8000.55
50_F120_T0.8000.55
52_P105_P0.7870.53
197_K201_G0.7860.53
3_R6_A0.7860.53
43_L137_W0.7800.53
215_E220_Q0.7760.52
163_M220_Q0.7740.52
142_F147_N0.7730.52
122_D129_F0.7620.51
174_G195_D0.7620.51
15_L181_G0.7520.50
215_E219_E0.7480.50
188_P203_V0.7450.50
174_G182_H0.7420.49
56_M157_L0.7410.49
123_A179_Y0.7370.49
116_E188_P0.7320.48
140_N152_S0.7320.48
3_R125_T0.7310.48
69_P84_M0.7300.48
12_D30_K0.7260.48
92_P95_P0.7260.48
21_G147_N0.7250.48
169_F177_T0.7220.47
102_Y105_P0.7200.47
190_H199_F0.7150.47
184_R206_R0.7150.47
99_I103_L0.7120.46
20_D162_C0.7110.46
217_I220_Q0.7090.46
212_L221_L0.7080.46
54_G178_C0.7060.46
184_R189_N0.7060.46
104_Q158_A0.7060.46
189_N195_D0.7040.46
60_Y92_P0.7020.45
156_K170_W0.7000.45
203_V222_K0.7000.45
75_W98_D0.6990.45
205_H210_R0.6970.45
196_K206_R0.6970.45
207_P219_E0.6940.45
60_Y71_N0.6930.45
216_E222_K0.6850.44
47_T54_G0.6840.44
141_D159_C0.6830.44
128_N156_K0.6820.44
10_K115_E0.6790.43
165_D210_R0.6770.43
135_L175_R0.6740.43
10_K208_A0.6710.43
48_D91_G0.6650.42
201_G206_R0.6620.42
44_G68_V0.6610.42
10_K14_K0.6520.41
183_R193_R0.6500.41
191_P196_K0.6490.41
113_L133_A0.6460.40
36_A131_L0.6450.40
44_G78_M0.6430.40
109_E151_W0.6410.40
19_A84_M0.6410.40
114_W145_Y0.6400.40
184_R209_P0.6400.40
117_G141_D0.6390.40
189_N215_E0.6380.40
205_H217_I0.6360.39
100_D139_I0.6340.39
58_S136_L0.6340.39
125_T132_R0.6320.39
143_P148_L0.6320.39
44_G104_Q0.6280.39
145_Y161_V0.6270.39
168_S180_M0.6260.38
30_K107_I0.6250.38
22_E26_H0.6230.38
183_R186_L0.6220.38
9_R16_R0.6210.38
205_H219_E0.6180.38
34_F113_L0.6180.38
41_V45_L0.6170.38
50_F157_L0.6160.38
157_L164_K0.6150.38
83_I189_N0.6150.38
53_F191_P0.6150.38
83_I168_S0.6140.37
32_P172_K0.6120.37
197_K211_P0.6110.37
33_D36_A0.6100.37
98_D102_Y0.6050.37
62_T170_W0.6030.36
191_P197_K0.6020.36
171_L176_K0.6020.36
106_L133_A0.5990.36
3_R8_G0.5960.36
21_G136_L0.5950.36
207_P214_G0.5940.36
82_N90_P0.5930.36
210_R221_L0.5880.35
196_K219_E0.5860.35
50_F178_C0.5840.35
129_F133_A0.5830.35
9_R15_L0.5810.35
214_G218_L0.5810.35
23_A151_W0.5800.34
63_W66_I0.5790.34
215_E222_K0.5780.34
85_L161_V0.5780.34
141_D173_H0.5760.34
144_A152_S0.5750.34
5_H18_P0.5700.34
101_V183_R0.5680.33
46_A68_V0.5650.33
140_N147_N0.5640.33
85_L175_R0.5630.33
99_I135_L0.5590.33
53_F88_L0.5590.33
81_E153_T0.5580.33
57_S221_L0.5560.32
26_H30_K0.5560.32
85_L88_L0.5520.32
66_I140_N0.5510.32
132_R136_L0.5490.32
23_A26_H0.5480.32
152_S184_R0.5440.31
95_P144_A0.5440.31
87_L145_Y0.5440.31
45_L110_L0.5430.31
54_G59_S0.5380.31
45_L103_L0.5380.31
170_W173_H0.5370.31
142_F161_V0.5370.31
66_I173_H0.5360.31
27_F149_S0.5360.31
194_R205_H0.5350.31
62_T163_M0.5350.31
75_W81_E0.5350.31
68_V84_M0.5340.31
96_G179_Y0.5330.31
3_R15_L0.5330.31
48_D141_D0.5320.31
141_D162_C0.5310.30
210_R220_Q0.5310.30
93_K115_E0.5300.30
188_P210_R0.5290.30
100_D148_L0.5280.30
144_A147_N0.5280.30
170_W220_Q0.5280.30
127_E217_I0.5280.30
84_M154_K0.5270.30
177_T195_D0.5260.30
147_N152_S0.5260.30
22_E221_L0.5250.30
46_A133_A0.5250.30
100_D122_D0.5250.30
43_L67_L0.5250.30
6_A90_P0.5240.30
194_R208_A0.5220.30
138_T148_L0.5220.30
179_Y204_E0.5210.30
217_I221_L0.5160.29
188_P202_K0.5160.29
139_I185_F0.5150.29
49_G122_D0.5150.29
26_H221_L0.5130.29
43_L110_L0.5130.29
98_D177_T0.5120.29
81_E90_P0.5100.29
26_H29_R0.5080.29
90_P121_Y0.5080.29
153_T174_G0.5080.29
54_G205_H0.5080.29
24_W40_N0.5070.29
194_R197_K0.5060.28
36_A98_D0.5040.28
104_Q108_D0.5010.28
207_P216_E0.5010.28
78_M217_I0.5000.28
44_G110_L0.5000.28
92_P143_P0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nlvA 2 0.2634 14.2 0.964 Contact Map
3d7qA 2 0.2634 14 0.964 Contact Map
2nwvA 2 0.2634 14 0.964 Contact Map
2nvmA 2 0.2634 10.5 0.966 Contact Map
4opxA 1 0.3393 5.1 0.97 Contact Map
1uw0A 1 0.3527 5 0.97 Contact Map
2l08A 1 0.1473 4.3 0.971 Contact Map
2czvC 2 0.4464 4.3 0.971 Contact Map
3c8fA 1 0.4196 3.8 0.972 Contact Map
4yj0A 2 0.2857 3.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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