EMP70 - PFAM28P - GREMLIN Contacts

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EMP70 - Endomembrane protein 70

PFAM:	PF02990	Sequences: PYDYYSLLPFCKPEGGIKKKSENLGEVLFGDRIENSPYELKMLEDETCKVLCTKTLTKEDAKFFKEAIKDDYRVNWIVDNLPAAGEKYYSTGFPLGYEDSKDGKYYLNNHLDFVILYHKDEDGERIVGFEVTPDSIKHLTTCPKNVELTEETEVTFTYSVKWEESDDIKWASRWDKYLDMVPDPHQIHWFSIINSLVIVLFLSGMVAMILLRTLRRDIARYNELDEEEESGWKLVHGDVFRPPRNPMLLSVLVGSGVQLLVMTLVTLLFALLGFLSPSNRGSLLTAMIVLYVLTGFVAGYVSARLYKTFGGKNWKKNTLLTALLFPGIVFGIFFVLNLFLWAYGSSGAVPFGTMLALLLLWFGISVPLVFLGSYFGFKKPGAIEHPVRTNQIPRQIPEPQPWYLRPIPSILLGGILPFGAIFIELYFIFSSIWLHKIYYVFGFLFLVFIILIITCAEVTIVLTYFQLCAEDYRWWWRSFLTGGSTALYVFLYSIYYFFTKLEITGF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	506 (499)
Sequences:	1542 (983)
Seq/√Len:	44.0
META:	0.28

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_E	49_K	7.483	1.00
352_G	355_L	6.001	1.00
303_A	376_G	5.739	1.00
107_L	154_V	5.374	1.00
127_V	165_S	4.638	1.00
112_D	159_S	4.450	1.00
57_T	60_D	4.427	1.00
253_V	305_L	4.291	1.00
38_Y	111_L	4.079	1.00
48_C	142_C	4.033	1.00
5_Y	13_P	3.632	1.00
306_Y	311_G	3.621	1.00
53_T	153_E	3.561	1.00
76_W	113_F	3.490	1.00
455_C	482_G	3.445	1.00
110_H	157_T	3.320	1.00
78_V	115_I	3.282	1.00
119_K	164_E	3.268	1.00
237_G	390_N	3.193	1.00
302_S	317_N	3.168	1.00
298_A	321_T	3.143	1.00
76_W	93_F	3.123	1.00
114_V	163_E	3.030	1.00
252_L	479_F	3.004	1.00
318_T	373_S	2.988	1.00
41_K	44_E	2.955	1.00
55_T	153_E	2.823	1.00
302_S	321_T	2.681	1.00
40_L	162_W	2.667	1.00
45_D	163_E	2.665	1.00
53_T	155_T	2.638	1.00
116_L	163_E	2.604	1.00
483_G	486_A	2.561	1.00
11_C	52_C	2.558	1.00
76_W	111_L	2.545	1.00
17_I	35_N	2.479	1.00
289_V	293_L	2.462	1.00
61_A	65_K	2.419	1.00
257_V	301_V	2.406	1.00
40_L	115_I	2.334	1.00
447_V	450_I	2.331	1.00
351_F	355_L	2.328	1.00
172_S	175_D	2.275	1.00
45_D	161_K	2.257	1.00
356_A	359_L	2.236	1.00
112_D	161_K	2.234	1.00
39_E	49_K	2.137	1.00
43_L	117_Y	2.116	1.00
69_K	105_Y	2.062	0.99
42_M	126_I	2.056	0.99
81_L	177_Y	2.028	0.99
439_Y	443_F	2.019	0.99
252_L	325_F	1.981	0.99
393_P	472_Y	1.979	0.99
238_D	241_R	1.957	0.99
116_L	127_V	1.952	0.99
449_I	453_I	1.920	0.99
33_I	77_I	1.895	0.99
293_L	297_V	1.883	0.99
112_D	134_D	1.879	0.99
111_L	131_V	1.874	0.99
429_F	495_Y	1.833	0.99
248_L	324_L	1.805	0.98
40_L	78_V	1.791	0.98
484_S	487_L	1.789	0.98
121_E	124_E	1.783	0.98
481_T	484_S	1.771	0.98
247_M	250_S	1.767	0.98
466_Q	475_W	1.763	0.98
330_F	334_F	1.758	0.98
41_K	46_E	1.750	0.98
411_L	487_L	1.698	0.98
82_P	173_R	1.694	0.98
333_F	349_V	1.693	0.98
338_L	342_A	1.686	0.97
10_F	95_L	1.672	0.97
58_K	62_K	1.644	0.97
13_P	17_I	1.643	0.97
65_K	105_Y	1.641	0.97
247_M	317_N	1.636	0.97
10_F	64_F	1.618	0.97
77_I	80_N	1.610	0.97
9_P	60_D	1.606	0.97
338_L	341_W	1.545	0.96
117_Y	162_W	1.542	0.96
84_A	89_Y	1.536	0.96
420_A	424_E	1.519	0.95
334_F	354_M	1.516	0.95
463_T	481_T	1.510	0.95
276_S	279_N	1.507	0.95
241_R	394_R	1.506	0.95
5_Y	8_L	1.503	0.95
114_V	161_K	1.497	0.95
81_L	173_R	1.495	0.95
74_V	95_L	1.486	0.95
32_R	350_P	1.483	0.95
180_M	347_G	1.479	0.95
221_Y	235_V	1.473	0.94
188_H	424_E	1.467	0.94
332_I	335_V	1.460	0.94
23_N	80_N	1.457	0.94
203_S	457_E	1.452	0.94
334_F	338_L	1.449	0.94
67_A	95_L	1.423	0.93
415_I	419_G	1.415	0.93
17_I	126_I	1.414	0.93
405_R	408_P	1.408	0.93
54_K	60_D	1.408	0.93
408_P	412_L	1.407	0.93
116_L	128_G	1.406	0.93
12_K	17_I	1.403	0.93
2_Y	503_I	1.397	0.93
25_G	281_G	1.395	0.93
297_V	301_V	1.393	0.93
47_T	159_S	1.382	0.92
217_D	233_K	1.380	0.92
289_V	359_L	1.379	0.92
330_F	365_S	1.377	0.92
490_F	494_I	1.374	0.92
252_L	260_L	1.373	0.92
78_V	129_F	1.372	0.92
427_F	439_Y	1.372	0.92
307_K	376_G	1.368	0.92
118_H	127_V	1.360	0.92
321_T	361_W	1.355	0.92
394_R	397_P	1.352	0.91
291_Y	297_V	1.342	0.91
64_F	156_F	1.339	0.91
285_T	289_V	1.317	0.90
355_L	359_L	1.305	0.90
95_L	105_Y	1.302	0.90
31_D	36_S	1.302	0.90
249_L	478_S	1.299	0.90
127_V	170_W	1.290	0.89
332_I	336_L	1.290	0.89
46_E	159_S	1.284	0.89
192_I	447_V	1.273	0.89
461_V	468_C	1.270	0.89
275_L	352_G	1.269	0.89
40_L	113_F	1.260	0.88
236_H	389_T	1.257	0.88
423_I	485_T	1.257	0.88
308_T	385_H	1.257	0.88
496_Y	501_L	1.240	0.87
201_F	205_M	1.239	0.87
240_F	386_P	1.237	0.87
115_I	126_I	1.213	0.86
471_D	478_S	1.212	0.86
190_F	419_G	1.211	0.86
224_L	227_E	1.208	0.86
191_S	194_N	1.204	0.86
214_L	218_I	1.200	0.86
298_A	302_S	1.197	0.86
8_L	64_F	1.193	0.85
16_G	259_L	1.188	0.85
254_G	302_S	1.184	0.85
250_S	305_L	1.175	0.84
38_Y	51_L	1.174	0.84
47_T	161_K	1.174	0.84
257_V	297_V	1.174	0.84
497_F	504_T	1.164	0.84
188_H	438_Y	1.163	0.84
255_S	324_L	1.159	0.84
56_L	61_A	1.152	0.83
426_Y	447_V	1.148	0.83
416_L	419_G	1.143	0.83
318_T	322_A	1.137	0.82
151_E	355_L	1.135	0.82
248_L	255_S	1.135	0.82
261_V	294_T	1.126	0.82
9_P	64_F	1.125	0.82
205_M	208_M	1.125	0.82
124_E	291_Y	1.124	0.82
401_P	406_P	1.124	0.82
205_M	415_I	1.123	0.82
50_V	155_T	1.121	0.82
166_D	396_I	1.120	0.81
409_S	462_L	1.110	0.81
303_A	373_S	1.100	0.80
348_A	352_G	1.100	0.80
402_W	458_V	1.096	0.80
440_V	447_V	1.090	0.80
245_N	248_L	1.090	0.80
238_D	433_W	1.089	0.80
322_A	369_V	1.081	0.79
128_G	165_S	1.081	0.79
401_P	404_L	1.080	0.79
124_E	140_T	1.077	0.79
248_L	483_G	1.077	0.79
63_F	67_A	1.074	0.79
44_E	57_T	1.073	0.79
27_V	32_R	1.072	0.79
169_K	172_S	1.069	0.78
334_F	341_W	1.067	0.78
26_E	188_H	1.067	0.78
210_L	461_V	1.066	0.78
226_E	263_T	1.064	0.78
466_Q	481_T	1.062	0.78
247_M	251_V	1.059	0.78
162_W	188_H	1.054	0.77
79_D	82_P	1.052	0.77
10_F	37_P	1.051	0.77
294_T	297_V	1.046	0.77
311_G	345_S	1.045	0.77
217_D	232_W	1.044	0.77
419_G	425_L	1.035	0.76
499_T	502_E	1.035	0.76
232_W	241_R	1.034	0.76
43_L	161_K	1.020	0.75
77_I	93_F	1.018	0.75
216_R	219_A	1.017	0.75
304_R	376_G	1.016	0.75
262_M	362_F	1.015	0.75
207_A	457_E	1.008	0.74
340_L	347_G	1.001	0.74
240_F	299_G	1.001	0.74
140_T	143_P	0.998	0.73
109_N	135_S	0.998	0.73
236_H	386_P	0.995	0.73
283_L	448_F	0.993	0.73
203_S	216_R	0.989	0.73
254_G	403_Y	0.975	0.72
126_I	305_L	0.970	0.71
205_M	215_R	0.968	0.71
288_I	484_S	0.963	0.71
313_N	316_K	0.962	0.71
420_A	477_R	0.959	0.70
262_M	283_L	0.958	0.70
2_Y	108_N	0.958	0.70
414_G	418_F	0.955	0.70
337_N	348_A	0.953	0.70
422_F	429_F	0.951	0.70
76_W	83_A	0.949	0.70
271_L	437_I	0.944	0.69
268_L	288_I	0.943	0.69
457_E	488_Y	0.943	0.69
273_G	280_R	0.940	0.69
261_V	297_V	0.938	0.69
194_N	418_F	0.937	0.69
397_P	470_E	0.932	0.68
53_T	366_V	0.930	0.68
385_H	389_T	0.929	0.68
462_L	483_G	0.929	0.68
54_K	57_T	0.929	0.68
271_L	445_F	0.926	0.68
83_A	113_F	0.924	0.67
494_I	497_F	0.924	0.67
67_A	70_D	0.923	0.67
217_D	231_G	0.921	0.67
106_Y	428_I	0.921	0.67
92_G	96_G	0.920	0.67
177_Y	188_H	0.920	0.67
228_E	425_L	0.919	0.67
140_T	144_K	0.919	0.67
261_V	268_L	0.918	0.67
56_L	64_F	0.917	0.67
373_S	454_T	0.916	0.67
307_K	315_K	0.913	0.66
26_E	31_D	0.910	0.66
81_L	188_H	0.908	0.66
218_I	303_A	0.908	0.66
292_V	298_A	0.907	0.66
15_G	18_K	0.907	0.66
466_Q	477_R	0.906	0.66
156_F	164_E	0.904	0.66
45_D	164_E	0.903	0.66
447_V	451_L	0.900	0.65
279_N	283_L	0.899	0.65
413_G	482_G	0.898	0.65
93_F	111_L	0.895	0.65
194_N	419_G	0.895	0.65
61_A	152_T	0.893	0.65
218_I	222_N	0.892	0.65
250_S	254_G	0.890	0.64
265_V	290_L	0.890	0.64
116_L	130_E	0.889	0.64
164_E	169_K	0.888	0.64
233_K	464_Y	0.887	0.64
73_R	156_F	0.885	0.64
238_D	389_T	0.884	0.64
290_L	297_V	0.882	0.64
267_L	360_L	0.882	0.64
214_L	217_D	0.878	0.63
23_N	289_V	0.875	0.63
208_M	419_G	0.873	0.63
12_K	37_P	0.871	0.63
241_R	397_P	0.871	0.63
303_A	307_K	0.869	0.63
42_M	162_W	0.866	0.62
265_V	360_L	0.861	0.62
39_E	45_D	0.860	0.62
241_R	470_E	0.858	0.62
255_S	319_L	0.855	0.61
308_T	382_A	0.854	0.61
466_Q	483_G	0.851	0.61
497_F	503_I	0.849	0.61
139_L	159_S	0.847	0.61
491_L	494_I	0.846	0.61
241_R	386_P	0.845	0.60
25_G	28_L	0.845	0.60
26_E	177_Y	0.844	0.60
238_D	394_R	0.843	0.60
197_V	212_R	0.842	0.60
60_D	63_F	0.841	0.60
330_F	362_F	0.839	0.60
416_L	450_I	0.838	0.60
211_L	218_I	0.837	0.60
130_E	485_T	0.833	0.59
74_V	130_E	0.828	0.59
79_D	92_G	0.827	0.59
280_R	350_P	0.826	0.59
285_T	328_I	0.825	0.59
109_N	174_W	0.825	0.59
229_E	236_H	0.824	0.58
124_E	144_K	0.822	0.58
372_G	376_G	0.822	0.58
318_T	370_F	0.822	0.58
66_E	70_D	0.821	0.58
138_H	141_T	0.820	0.58
213_T	429_F	0.818	0.58
262_M	294_T	0.818	0.58
309_F	483_G	0.816	0.58
207_A	267_L	0.815	0.58
84_A	177_Y	0.814	0.58
13_P	31_D	0.813	0.57
394_R	470_E	0.812	0.57
416_L	465_F	0.812	0.57
461_V	471_D	0.812	0.57
190_F	427_F	0.811	0.57
238_D	386_P	0.811	0.57
309_F	475_W	0.810	0.57
250_S	302_S	0.810	0.57
296_F	375_F	0.810	0.57
324_L	328_I	0.808	0.57
295_G	369_V	0.807	0.57
26_E	29_F	0.807	0.57
345_S	348_A	0.806	0.57
318_T	492_Y	0.805	0.57
19_K	34_E	0.804	0.57
433_W	493_S	0.804	0.57
2_Y	94_P	0.804	0.57
126_I	129_F	0.803	0.57
61_A	405_R	0.802	0.56
140_T	324_L	0.801	0.56
56_L	152_T	0.800	0.56
120_D	125_R	0.800	0.56
208_M	465_F	0.796	0.56
187_I	444_L	0.795	0.56
301_V	437_I	0.794	0.56
485_T	489_V	0.794	0.56
282_S	358_L	0.793	0.56
229_E	235_V	0.792	0.55
410_I	480_L	0.791	0.55
239_V	397_P	0.791	0.55
94_P	108_N	0.791	0.55
333_F	435_H	0.791	0.55
300_Y	321_T	0.791	0.55
424_E	433_W	0.790	0.55
81_L	438_Y	0.788	0.55
260_L	263_T	0.788	0.55
156_F	320_L	0.786	0.55
83_A	89_Y	0.786	0.55
134_D	159_S	0.784	0.55
108_N	144_K	0.784	0.55
39_E	51_L	0.781	0.54
41_K	264_L	0.778	0.54
22_E	26_E	0.776	0.54
354_M	432_I	0.776	0.54
285_T	406_P	0.776	0.54
168_I	172_S	0.773	0.54
275_L	486_A	0.773	0.54
108_N	111_L	0.773	0.54
310_G	359_L	0.773	0.54
56_L	60_D	0.772	0.54
410_I	498_F	0.768	0.53
141_T	145_N	0.764	0.53
319_L	323_L	0.762	0.53
419_G	439_Y	0.759	0.52
157_T	173_R	0.758	0.52
309_F	459_T	0.758	0.52
413_G	454_T	0.756	0.52
254_G	258_Q	0.754	0.52
333_F	373_S	0.753	0.52
1_P	203_S	0.753	0.52
201_F	419_G	0.752	0.52
310_G	363_G	0.751	0.52
266_T	362_F	0.751	0.52
45_D	87_K	0.749	0.51
197_V	473_R	0.749	0.51
119_K	166_D	0.747	0.51
349_V	354_M	0.746	0.51
391_Q	395_Q	0.744	0.51
192_I	423_I	0.744	0.51
48_C	133_P	0.744	0.51
43_L	95_L	0.742	0.51
188_H	442_G	0.742	0.51
237_G	389_T	0.740	0.50
161_K	405_R	0.738	0.50
426_Y	450_I	0.737	0.50
197_V	419_G	0.736	0.50
194_N	201_F	0.735	0.50
223_E	253_V	0.732	0.50
133_P	218_I	0.731	0.50
16_G	37_P	0.731	0.50
13_P	336_L	0.728	0.49
344_G	496_Y	0.726	0.49
108_N	133_P	0.725	0.49
21_S	339_F	0.725	0.49
191_S	458_V	0.724	0.49
288_I	339_F	0.720	0.49
157_T	357_L	0.720	0.49
404_L	466_Q	0.720	0.49
36_S	76_W	0.718	0.48
352_G	356_A	0.718	0.48
337_N	345_S	0.717	0.48
169_K	325_F	0.717	0.48
277_P	394_R	0.715	0.48
400_Q	469_A	0.715	0.48
207_A	263_T	0.710	0.48
151_E	154_V	0.708	0.47
494_I	498_F	0.707	0.47
257_V	491_L	0.706	0.47
126_I	274_F	0.705	0.47
312_K	452_I	0.704	0.47
389_T	395_Q	0.703	0.47
455_C	503_I	0.703	0.47
259_L	274_F	0.703	0.47
198_I	205_M	0.703	0.47
227_E	449_I	0.703	0.47
31_D	420_A	0.701	0.47
355_L	379_K	0.699	0.47
107_L	348_A	0.698	0.46
337_N	351_F	0.698	0.46
335_V	494_I	0.695	0.46
218_I	406_P	0.695	0.46
422_F	461_V	0.694	0.46
462_L	466_Q	0.694	0.46
50_V	56_L	0.693	0.46
166_D	331_G	0.692	0.46
210_L	421_I	0.691	0.46
107_L	356_A	0.690	0.46
205_M	454_T	0.687	0.45
238_D	397_P	0.687	0.45
255_S	259_L	0.686	0.45
368_L	396_I	0.686	0.45
188_H	440_V	0.684	0.45
484_S	492_Y	0.684	0.45
214_L	320_L	0.683	0.45
40_L	213_T	0.683	0.45
419_G	443_F	0.682	0.45
195_S	416_L	0.681	0.45
456_A	460_I	0.681	0.45
201_F	206_V	0.678	0.45
9_P	57_T	0.677	0.44
421_I	433_W	0.677	0.44
273_G	283_L	0.675	0.44
383_I	429_F	0.675	0.44
421_I	488_Y	0.672	0.44
151_E	489_V	0.670	0.44
400_Q	413_G	0.670	0.44
62_K	65_K	0.669	0.44
431_S	436_K	0.669	0.44
56_L	154_V	0.669	0.44
293_L	359_L	0.669	0.44
65_K	220_R	0.667	0.44
9_P	20_K	0.666	0.43
340_L	503_I	0.665	0.43
190_F	201_F	0.665	0.43
408_P	432_I	0.665	0.43
307_K	384_E	0.665	0.43
61_A	225_D	0.664	0.43
327_G	455_C	0.663	0.43
254_G	306_Y	0.663	0.43
40_L	160_V	0.661	0.43
451_L	488_Y	0.660	0.43
249_L	479_F	0.659	0.43
18_K	69_K	0.659	0.43
97_Y	157_T	0.658	0.43
9_P	29_F	0.658	0.43
311_G	376_G	0.658	0.43
127_V	319_L	0.658	0.43
28_L	206_V	0.658	0.43
215_R	308_T	0.657	0.43
414_G	488_Y	0.657	0.43
244_R	473_R	0.657	0.43
201_F	500_K	0.656	0.42
302_S	345_S	0.655	0.42
116_L	165_S	0.654	0.42
232_W	239_V	0.654	0.42
315_K	370_F	0.653	0.42
415_I	460_I	0.652	0.42
190_F	194_N	0.650	0.42
233_K	367_P	0.649	0.42
259_L	389_T	0.649	0.42
250_S	344_G	0.647	0.42
307_K	453_I	0.646	0.42
232_W	238_D	0.646	0.42
311_G	317_N	0.646	0.42
232_W	240_F	0.644	0.41
2_Y	41_K	0.643	0.41
447_V	457_E	0.642	0.41
185_H	443_F	0.640	0.41
107_L	156_F	0.639	0.41
144_K	147_E	0.638	0.41
112_D	132_T	0.638	0.41
421_I	485_T	0.637	0.41
188_H	325_F	0.637	0.41
451_L	493_S	0.637	0.41
239_V	394_R	0.636	0.41
46_E	249_L	0.636	0.41
450_I	459_T	0.634	0.40
421_I	451_L	0.633	0.40
246_P	249_L	0.631	0.40
97_Y	101_K	0.631	0.40
126_I	351_F	0.631	0.40
56_L	70_D	0.628	0.40
49_K	159_S	0.628	0.40
305_L	317_N	0.626	0.40
349_V	369_V	0.625	0.40
418_F	488_Y	0.624	0.39
36_S	93_F	0.624	0.39
325_F	345_S	0.623	0.39
335_V	355_L	0.623	0.39
207_A	211_L	0.622	0.39
22_E	33_I	0.620	0.39
328_I	344_G	0.620	0.39
393_P	431_S	0.618	0.39
29_F	32_R	0.616	0.39
244_R	393_P	0.616	0.39
291_Y	460_I	0.616	0.39
202_L	418_F	0.616	0.39
16_G	310_G	0.616	0.39
239_V	368_L	0.615	0.39
40_L	335_V	0.614	0.39
124_E	245_N	0.614	0.39
275_L	286_A	0.613	0.38
353_T	357_L	0.612	0.38
260_L	265_V	0.611	0.38
359_L	473_R	0.611	0.38
269_F	274_F	0.610	0.38
205_M	422_F	0.610	0.38
57_T	318_T	0.609	0.38
166_D	487_L	0.609	0.38
89_Y	287_M	0.609	0.38
318_T	369_V	0.609	0.38
438_Y	442_G	0.607	0.38
308_T	383_I	0.606	0.38
37_P	51_L	0.606	0.38
40_L	51_L	0.605	0.38
260_L	452_I	0.604	0.38
412_L	423_I	0.604	0.38
224_L	364_I	0.604	0.38
231_G	238_D	0.604	0.38
246_P	305_L	0.602	0.37
231_G	234_L	0.602	0.37
482_G	486_A	0.601	0.37
71_D	356_A	0.600	0.37
5_Y	9_P	0.600	0.37
307_K	382_A	0.599	0.37
71_D	489_V	0.599	0.37
125_R	170_W	0.598	0.37
473_R	503_I	0.597	0.37
293_L	364_I	0.596	0.37
240_F	361_W	0.596	0.37
126_I	185_H	0.594	0.37
115_I	257_V	0.594	0.37
285_T	390_N	0.594	0.37
262_M	360_L	0.593	0.37
125_R	236_H	0.593	0.37
272_L	412_L	0.593	0.37
252_L	282_S	0.592	0.37
197_V	205_M	0.591	0.37
89_Y	116_L	0.591	0.37
430_S	448_F	0.591	0.37
46_E	137_K	0.590	0.36
138_H	159_S	0.589	0.36
175_D	178_L	0.588	0.36
302_S	306_Y	0.588	0.36
75_N	190_F	0.587	0.36
5_Y	42_M	0.586	0.36
269_F	275_L	0.584	0.36
55_T	449_I	0.584	0.36
310_G	396_I	0.584	0.36
41_K	113_F	0.584	0.36
324_L	500_K	0.582	0.36
198_I	450_I	0.582	0.36
89_Y	92_G	0.581	0.36
127_V	262_M	0.580	0.36
138_H	155_T	0.580	0.36
118_H	128_G	0.580	0.36
50_V	53_T	0.578	0.35
124_E	319_L	0.578	0.35
339_F	486_A	0.576	0.35
224_L	303_A	0.575	0.35
467_L	470_E	0.574	0.35
330_F	351_F	0.573	0.35
371_L	493_S	0.573	0.35
153_E	159_S	0.573	0.35
168_I	354_M	0.572	0.35
2_Y	30_G	0.572	0.35
214_L	229_E	0.571	0.35
288_I	359_L	0.571	0.35
232_W	243_P	0.571	0.35
332_I	396_I	0.569	0.35
10_F	56_L	0.569	0.35
267_L	329_V	0.567	0.34
319_L	389_T	0.567	0.34
305_L	308_T	0.567	0.34
45_D	53_T	0.567	0.34
32_R	197_V	0.566	0.34
341_W	348_A	0.565	0.34
195_S	425_L	0.565	0.34
1_P	129_F	0.565	0.34
144_K	166_D	0.565	0.34
241_R	393_P	0.564	0.34
233_K	470_E	0.564	0.34
90_S	113_F	0.563	0.34
24_L	330_F	0.563	0.34
293_L	296_F	0.562	0.34
269_F	428_I	0.561	0.34
426_Y	430_S	0.561	0.34
135_S	174_W	0.561	0.34
116_L	168_I	0.560	0.34
194_N	439_Y	0.560	0.34
302_S	361_W	0.560	0.34
106_Y	120_D	0.560	0.34
395_Q	472_Y	0.559	0.34
244_R	260_L	0.558	0.34
238_D	470_E	0.557	0.34
248_L	298_A	0.556	0.33
12_K	54_K	0.556	0.33
73_R	91_T	0.555	0.33
341_W	351_F	0.554	0.33
286_A	325_F	0.554	0.33
308_T	328_I	0.553	0.33
40_L	102_D	0.553	0.33
179_D	182_P	0.553	0.33
213_T	216_R	0.553	0.33
464_Y	470_E	0.552	0.33
71_D	421_I	0.552	0.33
307_K	449_I	0.551	0.33
38_Y	59_E	0.551	0.33
24_L	349_V	0.551	0.33
249_L	253_V	0.551	0.33
272_L	293_L	0.551	0.33
47_T	114_V	0.550	0.33
201_F	420_A	0.548	0.33
157_T	216_R	0.548	0.33
302_S	373_S	0.548	0.33
48_C	109_N	0.547	0.33
193_I	197_V	0.547	0.33
186_Q	450_I	0.546	0.33
101_K	335_V	0.545	0.33
272_L	362_F	0.544	0.32
13_P	37_P	0.544	0.32
169_K	268_L	0.544	0.32
202_L	450_I	0.543	0.32
208_M	400_Q	0.543	0.32
432_I	456_A	0.543	0.32
269_F	392_I	0.542	0.32
108_N	204_G	0.542	0.32
258_Q	345_S	0.541	0.32
148_L	371_L	0.540	0.32
229_E	458_V	0.539	0.32
126_I	179_D	0.539	0.32
91_T	159_S	0.538	0.32
89_Y	128_G	0.538	0.32
206_V	413_G	0.538	0.32
401_P	458_V	0.537	0.32
249_L	252_L	0.536	0.32
195_S	438_Y	0.535	0.32
242_P	428_I	0.535	0.32
57_T	151_E	0.534	0.32
217_D	464_Y	0.534	0.32
144_K	331_G	0.534	0.32
440_V	461_V	0.534	0.32
252_L	497_F	0.533	0.32
218_I	221_Y	0.532	0.31
436_K	482_G	0.532	0.31
44_E	264_L	0.532	0.31
157_T	480_L	0.531	0.31
456_A	462_L	0.531	0.31
301_V	431_S	0.531	0.31
198_I	454_T	0.530	0.31
200_L	255_S	0.530	0.31
190_F	208_M	0.529	0.31
330_F	361_W	0.527	0.31
432_I	498_F	0.527	0.31
487_L	491_L	0.526	0.31
258_Q	321_T	0.524	0.31
148_L	460_I	0.522	0.31
249_L	278_S	0.522	0.31
141_T	144_K	0.522	0.31
206_V	457_E	0.522	0.31
65_K	69_K	0.521	0.31
162_W	384_E	0.521	0.31
287_M	456_A	0.521	0.31
198_I	419_G	0.521	0.31
132_T	355_L	0.520	0.30
18_K	22_E	0.520	0.30
153_E	268_L	0.520	0.30
12_K	200_L	0.520	0.30
248_L	320_L	0.519	0.30
97_Y	156_F	0.519	0.30
162_W	320_L	0.519	0.30
128_G	135_S	0.518	0.30
439_Y	442_G	0.518	0.30
450_I	465_F	0.518	0.30
221_Y	388_R	0.517	0.30
142_C	174_W	0.517	0.30
272_L	383_I	0.517	0.30
262_M	273_G	0.516	0.30
55_T	253_V	0.516	0.30
115_I	162_W	0.516	0.30
434_L	484_S	0.515	0.30
203_S	409_S	0.515	0.30
445_F	488_Y	0.514	0.30
176_K	267_L	0.514	0.30
364_I	368_L	0.514	0.30
170_W	441_F	0.513	0.30
322_A	363_G	0.512	0.30
213_T	275_L	0.512	0.30
428_I	433_W	0.510	0.30
473_R	481_T	0.510	0.30
114_V	166_D	0.510	0.30
124_E	328_I	0.510	0.30
188_H	195_S	0.509	0.30
285_T	412_L	0.509	0.30
252_L	456_A	0.509	0.30
280_R	326_P	0.508	0.29
230_S	401_P	0.508	0.29
134_D	143_P	0.508	0.29
267_L	293_L	0.507	0.29
6_S	20_K	0.507	0.29
45_D	210_L	0.506	0.29
119_K	124_E	0.506	0.29
321_T	369_V	0.506	0.29
124_E	151_E	0.505	0.29
20_K	35_N	0.505	0.29
162_W	297_V	0.505	0.29
27_V	350_P	0.504	0.29
87_K	297_V	0.504	0.29
424_E	427_F	0.504	0.29
114_V	132_T	0.503	0.29
353_T	432_I	0.503	0.29
126_I	171_A	0.501	0.29
182_P	475_W	0.500	0.29
253_V	342_A	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2kncB	1	0.1462	35.7	0.977	Contact Map
2kncA	1	0.1028	19	0.98	Contact Map
2z73A	2	0.5277	8	0.983	Contact Map
3rlfF	1	0.168	6.8	0.984	Contact Map
2c35A	1	0.1364	4.4	0.985	Contact Map
1pw4A	1	0.4368	4.4	0.985	Contact Map
4dveA	3	0.3024	4.2	0.985	Contact Map
3axsA	2	0.1265	3.5	0.986	Contact Map
2m3eA	1	0.0949	3.3	0.986	Contact Map
1x0gA	4	0.1798	3.2	0.986	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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