GREMLIN Database
Conotoxin - Conotoxin
PFAM: PF02950 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (72)
Sequences: 590 (371)
Seq/√Len: 43.7
META: 0.014

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_T55_G2.9621.00
1_M5_V2.4081.00
19_T22_L2.2971.00
1_M4_T2.1241.00
8_I12_L2.0240.99
17_L21_Q1.9960.99
17_L22_L1.9380.99
51_T63_R1.9000.99
5_V8_I1.8280.98
31_P34_R1.7680.98
10_A14_L1.7110.98
66_S72_P1.5700.96
62_R66_S1.5430.96
20_L24_G1.5280.95
30_R33_K1.4880.95
18_A21_Q1.4380.94
35_L38_R1.4370.94
66_S71_C1.4260.93
19_T23_D1.4060.93
52_P55_G1.3870.92
61_D72_P1.3340.91
5_V15_T1.2960.89
21_Q24_G1.2870.89
69_C74_C1.2690.88
50_C57_C1.2170.86
62_R67_G1.1840.85
64_C74_C1.1830.85
4_T10_A1.1680.84
63_R66_S1.1680.84
19_T24_G1.1520.83
59_D62_R1.1300.82
17_L20_L1.1010.80
18_A22_L1.0950.80
52_P70_D1.0930.80
48_R55_G1.0710.78
39_K43_R1.0660.78
55_G73_C1.0540.77
11_L15_T1.0510.77
30_R36_Q1.0390.76
51_T62_R1.0160.74
55_G62_R1.0160.74
44_S47_T0.9840.72
56_Y62_R0.9670.71
66_S70_D0.9560.70
68_W72_P0.9540.70
18_A25_D0.9470.69
20_L23_D0.9430.69
61_D66_S0.9280.67
41_D45_K0.9270.67
27_P32_A0.9040.65
17_L23_D0.8980.65
60_R63_R0.8740.63
8_I14_L0.8640.62
49_R62_R0.8590.61
56_Y71_C0.8430.60
10_A15_T0.8410.60
25_D29_D0.8400.60
61_D73_C0.8390.60
6_V24_G0.8370.59
60_R67_G0.8300.59
1_M8_I0.8160.57
39_K44_S0.8110.57
15_T27_P0.7940.55
4_T14_L0.7900.55
60_R72_P0.7840.54
12_L21_Q0.7780.54
49_R63_R0.7690.53
56_Y59_D0.7570.52
25_D30_R0.7500.51
41_D47_T0.7500.51
45_K48_R0.7490.51
8_I15_T0.7490.51
56_Y61_D0.7480.51
59_D68_W0.7200.48
38_R41_D0.7160.48
50_C64_C0.6960.46
51_T56_Y0.6960.46
67_G70_D0.6830.45
22_L25_D0.6540.42
63_R68_W0.6520.42
9_V37_D0.6500.42
31_P38_R0.6320.40
67_G71_C0.6320.40
8_I11_L0.6310.40
70_D73_C0.6270.40
22_L26_Q0.6260.39
40_S44_S0.6150.38
39_K42_E0.6140.38
54_G68_W0.6110.38
51_T67_G0.6060.38
6_V25_D0.5760.35
2_K10_A0.5690.34
52_P56_Y0.5640.34
48_R60_R0.5610.34
27_P35_L0.5580.33
20_L26_Q0.5550.33
61_D68_W0.5530.33
28_A40_S0.5520.33
34_R39_K0.5490.33
53_P56_Y0.5470.32
21_Q26_Q0.5340.31
2_K69_C0.5200.30
35_L41_D0.5150.30
31_P36_Q0.5120.30
28_A36_Q0.5090.29
60_R68_W0.5080.29
1_M6_V0.5070.29
41_D61_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yz2A 1 0.3333 88.9 0.735 Contact Map
1fu3A 1 0.36 88.1 0.739 Contact Map
1g1pA 1 0.36 87.3 0.742 Contact Map
1f3kA 1 0.3333 87.3 0.742 Contact Map
1fygA 1 0.3333 86.9 0.744 Contact Map
1hvwA 1 0.3333 85.7 0.748 Contact Map
1cnnA 1 0.3333 72.8 0.778 Contact Map
1v4qA 1 0.3333 72 0.779 Contact Map
1omcA 1 0.32 44.9 0.814 Contact Map
2m36A 1 0.3467 32 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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