GREMLIN Database
7tm_6 - 7tm Odorant receptor
PFAM: PF02949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 313 (307)
Sequences: 5075 (4343)
Seq/√Len: 247.9
META: 0.004

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_P115_E4.4011.00
250_E254_D4.1941.00
111_S115_E4.1221.00
151_E255_E3.8141.00
55_M59_A3.5031.00
79_F83_I3.3791.00
243_F305_F2.9571.00
54_I58_Y2.9111.00
62_K65_R2.6681.00
54_I57_K2.6561.00
273_P277_K2.6071.00
158_E265_N2.5851.00
72_Y76_Y2.5741.00
273_P276_R2.5611.00
86_P90_D2.5211.00
56_L60_K2.5091.00
98_P102_W2.4671.00
182_H186_L2.4551.00
153_L185_I2.3991.00
52_R59_A2.2721.00
97_L102_W2.2151.00
105_F117_I2.2041.00
83_I87_P2.1431.00
150_F290_L2.1121.00
136_D241_Q2.0021.00
112_P116_I1.9741.00
54_I59_A1.9691.00
146_I188_F1.9651.00
21_K136_D1.9271.00
28_N31_K1.9181.00
55_M58_Y1.9131.00
110_S115_E1.9081.00
56_L59_A1.8991.00
110_S113_Y1.8951.00
157_L282_I1.8711.00
95_R102_W1.8591.00
149_Q181_H1.8511.00
146_I189_A1.8481.00
193_E293_T1.8471.00
67_L71_L1.7771.00
263_A282_I1.7721.00
52_R55_M1.7561.00
154_S258_K1.7551.00
52_R56_L1.7271.00
78_L82_L1.7131.00
80_L84_L1.6781.00
176_K180_K1.6661.00
79_F82_L1.6511.00
104_P107_Y1.6401.00
68_L72_Y1.6121.00
193_E296_K1.6091.00
156_R181_H1.6031.00
31_K191_L1.5951.00
51_E57_K1.5591.00
75_A79_F1.5591.00
154_S262_A1.5471.00
105_F108_N1.5441.00
271_L275_I1.5221.00
51_E54_I1.5131.00
98_P104_P1.5051.00
103_F106_D1.4981.00
86_P92_E1.4981.00
88_L92_E1.4961.00
97_L101_L1.4801.00
53_R57_K1.4741.00
180_K183_Q1.4481.00
87_P91_N1.4381.00
51_E55_M1.4371.00
239_L309_L1.4281.00
90_D93_T1.4271.00
267_N270_N1.4111.00
72_Y75_A1.4091.00
298_F304_T1.3961.00
87_P90_D1.3911.00
69_V72_Y1.3811.00
43_D47_L1.3771.00
66_F70_I1.3651.00
48_D51_E1.3651.00
260_G283_I1.3521.00
225_I228_L1.3471.00
172_Y278_L1.3421.00
42_D46_P1.3331.00
75_A83_I1.3321.00
193_E197_S1.3241.00
69_V73_I1.3191.00
306_T310_K1.3181.00
76_Y79_F1.3071.00
55_M60_K1.2961.00
186_L285_R1.2931.00
49_E52_R1.2911.00
157_L263_A1.2881.00
87_P93_T1.2811.00
73_I76_Y1.2701.00
51_E59_A1.2571.00
67_L72_Y1.2541.00
110_S114_Y1.2471.00
201_L295_G1.2401.00
308_I312_S1.2351.00
51_E58_Y1.2331.00
71_L74_L1.2311.00
99_Y102_W1.1951.00
40_E43_D1.1951.00
136_D203_Q1.1941.00
77_L81_I1.1901.00
160_L178_C1.1841.00
255_E258_K1.1801.00
95_R101_L1.1791.00
96_P102_W1.1641.00
79_F87_P1.1631.00
253_T301_S1.1611.00
52_R58_Y1.1571.00
98_P101_L1.1471.00
86_P91_N1.1461.00
186_L290_L1.1381.00
87_P92_E1.1361.00
95_R100_P1.1311.00
95_R98_P1.1271.00
80_L83_I1.1211.00
71_L75_A1.1191.00
256_S290_L1.1091.00
49_E54_I1.1031.00
53_R56_L1.1001.00
291_K299_P1.0971.00
77_L83_I1.0951.00
258_K261_D1.0921.00
101_L104_P1.0911.00
224_D227_E1.0901.00
260_G286_S1.0871.00
74_L78_L1.0861.00
243_F247_Y1.0851.00
155_Y159_N1.0691.00
52_R57_K1.0561.00
309_L312_S1.0551.00
67_L75_A1.0541.00
48_D54_I1.0521.00
86_P93_T1.0501.00
111_S114_Y1.0481.00
44_W47_L1.0481.00
86_P89_L1.0461.00
215_G219_I1.0461.00
39_L42_D1.0391.00
95_R99_Y1.0381.00
172_Y176_K1.0351.00
207_S242_L1.0321.00
179_I278_L1.0321.00
76_Y80_L1.0271.00
293_T296_K1.0181.00
67_L74_L1.0121.00
239_L305_F1.0101.00
283_I287_Q1.0081.00
50_E54_I1.0041.00
281_L284_M1.0041.00
203_Q207_S1.0031.00
69_V76_Y1.0021.00
50_E53_R0.9981.00
140_A248_I0.9951.00
143_V252_L0.9931.00
263_A283_I0.9911.00
260_G287_Q0.9891.00
148_G152_I0.9861.00
68_L74_L0.9861.00
67_L70_I0.9831.00
50_E58_Y0.9821.00
76_Y82_L0.9821.00
70_I76_Y0.9811.00
85_L90_D0.9801.00
104_P108_N0.9791.00
31_K194_D0.9731.00
94_N98_P0.9721.00
88_L91_N0.9661.00
247_Y251_E0.9641.00
146_I192_I0.9631.00
49_E58_Y0.9601.00
109_D113_Y0.9581.00
69_V83_I0.9581.00
72_Y83_I0.9581.00
113_Y116_I0.9541.00
147_C255_E0.9531.00
156_R177_E0.9471.00
70_I83_I0.9431.00
154_S158_E0.9401.00
227_E230_K0.9391.00
150_F259_I0.9371.00
43_D46_P0.9341.00
34_E191_L0.9301.00
103_F107_Y0.9301.00
118_Y122_F0.9291.00
85_L92_E0.9281.00
224_D231_Y0.9171.00
175_L179_I0.9141.00
146_I185_I0.9121.00
277_K280_L0.9121.00
53_R60_K0.9111.00
38_H184_R0.9061.00
42_D47_L0.8971.00
154_S255_E0.8971.00
181_H184_R0.8891.00
72_Y77_L0.8771.00
13_L206_V0.8771.00
165_E168_E0.8741.00
96_P100_P0.8720.99
52_R60_K0.8690.99
109_D112_P0.8690.99
109_D114_Y0.8660.99
138_L142_L0.8650.99
280_L284_M0.8640.99
70_I77_L0.8640.99
78_L83_I0.8620.99
305_F309_L0.8560.99
68_L75_A0.8550.99
76_Y83_I0.8540.99
164_N167_S0.8530.99
284_M287_Q0.8520.99
68_L82_L0.8510.99
57_K60_K0.8480.99
225_I231_Y0.8470.99
159_N162_D0.8460.99
286_S289_P0.8430.99
181_H185_I0.8350.99
179_I282_I0.8330.99
50_E56_L0.8320.99
193_E294_A0.8300.99
163_D174_K0.8290.99
173_K176_K0.8280.99
150_F185_I0.8270.99
300_L304_T0.8250.99
157_L178_C0.8250.99
68_L83_I0.8230.99
150_F256_S0.8220.99
161_V267_N0.8210.99
40_E44_W0.8170.99
79_F84_L0.8160.99
97_L100_P0.8140.99
68_L78_L0.8130.99
117_I121_Q0.8100.99
251_E254_D0.8100.99
111_S116_I0.8080.99
74_L80_L0.8080.99
51_E56_L0.8030.99
204_F241_Q0.8020.99
49_E59_A0.7990.99
48_D52_R0.7950.99
275_I278_L0.7930.99
149_Q185_I0.7910.99
71_L76_Y0.7880.99
106_D109_D0.7850.99
176_K179_I0.7850.99
24_I28_N0.7840.99
85_L91_N0.7810.99
224_D228_L0.7760.99
41_E45_R0.7760.99
94_N102_W0.7750.99
66_F72_Y0.7730.99
200_L300_L0.7720.99
264_Y268_W0.7710.99
70_I79_F0.7700.99
79_F89_L0.7700.99
68_L71_L0.7690.99
11_L14_T0.7660.99
75_A82_L0.7640.99
259_I262_A0.7640.99
100_P103_F0.7630.99
39_L43_D0.7600.99
294_A298_F0.7580.99
250_E302_L0.7560.99
139_F196_F0.7540.99
53_R59_A0.7540.99
49_E56_L0.7530.99
43_D55_M0.7500.98
66_F71_L0.7490.98
204_F304_T0.7480.98
231_Y234_Y0.7460.98
46_P51_E0.7450.98
99_Y105_F0.7430.98
176_K278_L0.7410.98
8_N12_L0.7390.98
69_V84_L0.7370.98
94_N97_L0.7350.98
67_L83_I0.7330.98
201_L293_T0.7300.98
69_V77_L0.7250.98
73_I79_F0.7240.98
272_P276_R0.7230.98
89_L92_E0.7190.98
66_F69_V0.7160.98
37_E41_E0.7150.98
49_E53_R0.7120.98
178_C247_Y0.7110.98
72_Y79_F0.7090.98
166_E169_E0.7070.98
30_K34_E0.7060.98
72_Y78_L0.7050.98
164_N168_E0.7040.98
189_A290_L0.7030.98
29_R33_K0.7000.98
83_I86_P0.6980.98
74_L79_F0.6980.98
156_R174_K0.6960.98
94_N100_P0.6950.97
89_L93_T0.6930.97
179_I182_H0.6910.97
101_L121_Q0.6900.97
100_P104_P0.6900.97
109_D115_E0.6890.97
49_E60_K0.6880.97
68_L79_F0.6850.97
260_G264_Y0.6840.97
74_L77_L0.6820.97
81_I86_P0.6810.97
82_L86_P0.6800.97
82_L90_D0.6750.97
48_D53_R0.6720.97
164_N169_E0.6720.97
154_S259_I0.6710.97
50_E57_K0.6710.97
219_I223_S0.6700.97
70_I75_A0.6690.97
68_L76_Y0.6680.97
276_R280_L0.6670.97
54_I60_K0.6670.97
67_L77_L0.6660.97
145_H148_G0.6630.97
200_L204_F0.6610.97
84_L89_L0.6600.97
153_L178_C0.6590.97
72_Y82_L0.6580.97
67_L79_F0.6570.96
211_I309_L0.6570.96
66_F82_L0.6560.96
150_F189_A0.6520.96
190_E288_K0.6520.96
96_P99_Y0.6490.96
139_F301_S0.6470.96
246_C304_T0.6470.96
70_I74_L0.6450.96
70_I78_L0.6450.96
149_Q246_C0.6440.96
94_N99_Y0.6430.96
144_L248_I0.6420.96
14_T234_Y0.6350.96
187_R191_L0.6340.96
207_S211_I0.6330.96
74_L83_I0.6330.96
230_K233_L0.6310.96
68_L73_I0.6310.96
66_F73_I0.6280.95
190_E285_R0.6280.95
211_I312_S0.6250.95
88_L93_T0.6240.95
203_Q241_Q0.6230.95
72_Y81_I0.6220.95
246_C305_F0.6190.95
259_I282_I0.6180.95
69_V75_A0.6170.95
266_S275_I0.6150.95
182_H286_S0.6130.95
120_L124_S0.6120.95
147_C249_G0.6110.95
46_P50_E0.6100.95
50_E59_A0.6100.95
44_W56_L0.6090.95
53_R58_Y0.6080.95
66_F84_L0.6070.95
217_Q220_T0.6050.94
282_I286_S0.6030.94
73_I77_L0.6030.94
76_Y81_I0.6020.94
208_T212_C0.6010.94
277_K281_L0.6000.94
201_L205_L0.5990.94
242_L308_I0.5980.94
52_R62_K0.5950.94
48_D57_K0.5940.94
126_F130_I0.5930.94
118_Y121_Q0.5910.94
59_A62_K0.5900.94
12_L15_S0.5900.94
165_E169_E0.5890.94
78_L84_L0.5890.94
294_A304_T0.5890.94
42_D54_I0.5860.94
149_Q153_L0.5860.94
36_L138_L0.5850.93
75_A78_L0.5830.93
109_D116_I0.5820.93
75_A81_I0.5820.93
11_L15_S0.5800.93
283_I286_S0.5760.93
96_P101_L0.5750.93
183_Q186_L0.5710.93
29_R39_L0.5690.92
274_K283_I0.5670.92
155_Y158_E0.5670.92
97_L104_P0.5670.92
212_C216_F0.5660.92
74_L81_I0.5650.92
43_D145_H0.5650.92
44_W55_M0.5630.92
69_V82_L0.5620.92
264_Y283_I0.5610.92
72_Y84_L0.5600.92
51_E60_K0.5600.92
66_F79_F0.5600.92
83_I92_E0.5570.92
66_F83_I0.5550.92
191_L195_I0.5540.91
41_E44_W0.5530.91
47_L58_Y0.5520.91
76_Y87_P0.5510.91
110_S116_I0.5510.91
257_E261_D0.5480.91
223_S228_L0.5480.91
15_S18_A0.5470.91
251_E255_E0.5460.91
256_S285_R0.5450.91
25_L38_H0.5440.91
42_D45_R0.5440.91
67_L73_I0.5440.91
84_L88_L0.5410.91
272_P275_I0.5400.90
22_L26_L0.5380.90
241_Q248_I0.5370.90
156_R178_C0.5360.90
63_R78_L0.5360.90
43_D59_A0.5330.90
98_P118_Y0.5330.90
197_S296_K0.5320.90
31_K34_E0.5310.90
224_D234_Y0.5300.90
49_E57_K0.5300.90
64_I75_A0.5290.90
274_K278_L0.5280.89
81_I93_T0.5270.89
13_L16_I0.5260.89
203_Q234_Y0.5240.89
32_I142_L0.5220.89
167_S170_E0.5210.89
295_G300_L0.5180.89
208_T214_L0.5180.89
291_K301_S0.5150.88
45_R57_K0.5140.88
32_I195_I0.5130.88
68_L77_L0.5130.88
27_L30_K0.5120.88
48_D55_M0.5120.88
207_S308_I0.5110.88
43_D58_Y0.5100.88
125_L129_A0.5100.88
175_L275_I0.5080.88
50_E159_N0.5080.88
261_D265_N0.5080.88
52_R65_R0.5070.87
102_W105_F0.5070.87
207_S241_Q0.5030.87
121_Q149_Q0.5030.87
218_I228_L0.5030.87
71_L78_L0.5020.87
78_L86_P0.5000.87
98_P103_F0.5000.87
42_D55_M0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hkqA 2 0.1725 18.9 0.945 Contact Map
2bg9B 1 0.3099 7.9 0.953 Contact Map
3ukmA 2 0.5911 3.2 0.961 Contact Map
3vw7A 1 0.1022 3 0.962 Contact Map
2bg9A 1 0.3003 2.5 0.963 Contact Map
2bg9C 1 0.3003 2.3 0.964 Contact Map
1y66A 3 0.1597 2.3 0.964 Contact Map
2kogA 1 0.2748 2.2 0.964 Contact Map
3s8fA 1 0.3067 2.2 0.965 Contact Map
2bg9E 1 0.2971 2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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