7tm_6 - PFAM28P - GREMLIN Contacts

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7tm_6 - 7tm Odorant receptor

PFAM:	PF02949	Sequences: NIDELIDNLSLLLTSILALIKLIILLLNRKKIKELLEHLEEDDWRPLDEEERRIMLKYAKAKRIRFLLVILYILAYLLFLILILLPPLLDNETNRPLPYPLWFPFDYNDSSPYYEIIYLLQFISLFIAAIINVGVDSLFALLVLHICGQFEILSYRLENLVDDNEESEEEEYKKLKECIKHHQRILRFAELIEDIFSLILLVQFLVSTLVICLLGFQIITSLSDIAELIKYILYLIAMLLQLFIYCYIGEELTDESEKIGDAAYNSNWYNLPPKIRKLLLLIIMRSQKPLKLTAGKFFPLSLETFTSILKTSY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	313 (307)
Sequences:	5075 (4343)
Seq/√Len:	247.9
META:	0.004

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_P	115_E	4.401	1.00
250_E	254_D	4.194	1.00
111_S	115_E	4.122	1.00
151_E	255_E	3.814	1.00
55_M	59_A	3.503	1.00
79_F	83_I	3.379	1.00
243_F	305_F	2.957	1.00
54_I	58_Y	2.911	1.00
62_K	65_R	2.668	1.00
54_I	57_K	2.656	1.00
273_P	277_K	2.607	1.00
158_E	265_N	2.585	1.00
72_Y	76_Y	2.574	1.00
273_P	276_R	2.561	1.00
86_P	90_D	2.521	1.00
56_L	60_K	2.509	1.00
98_P	102_W	2.467	1.00
182_H	186_L	2.455	1.00
153_L	185_I	2.399	1.00
52_R	59_A	2.272	1.00
97_L	102_W	2.215	1.00
105_F	117_I	2.204	1.00
83_I	87_P	2.143	1.00
150_F	290_L	2.112	1.00
136_D	241_Q	2.002	1.00
112_P	116_I	1.974	1.00
54_I	59_A	1.969	1.00
146_I	188_F	1.965	1.00
21_K	136_D	1.927	1.00
28_N	31_K	1.918	1.00
55_M	58_Y	1.913	1.00
110_S	115_E	1.908	1.00
56_L	59_A	1.899	1.00
110_S	113_Y	1.895	1.00
157_L	282_I	1.871	1.00
95_R	102_W	1.859	1.00
149_Q	181_H	1.851	1.00
146_I	189_A	1.848	1.00
193_E	293_T	1.847	1.00
67_L	71_L	1.777	1.00
263_A	282_I	1.772	1.00
52_R	55_M	1.756	1.00
154_S	258_K	1.755	1.00
52_R	56_L	1.727	1.00
78_L	82_L	1.713	1.00
80_L	84_L	1.678	1.00
176_K	180_K	1.666	1.00
79_F	82_L	1.651	1.00
104_P	107_Y	1.640	1.00
68_L	72_Y	1.612	1.00
193_E	296_K	1.609	1.00
156_R	181_H	1.603	1.00
31_K	191_L	1.595	1.00
51_E	57_K	1.559	1.00
75_A	79_F	1.559	1.00
154_S	262_A	1.547	1.00
105_F	108_N	1.544	1.00
271_L	275_I	1.522	1.00
51_E	54_I	1.513	1.00
98_P	104_P	1.505	1.00
103_F	106_D	1.498	1.00
86_P	92_E	1.498	1.00
88_L	92_E	1.496	1.00
97_L	101_L	1.480	1.00
53_R	57_K	1.474	1.00
180_K	183_Q	1.448	1.00
87_P	91_N	1.438	1.00
51_E	55_M	1.437	1.00
239_L	309_L	1.428	1.00
90_D	93_T	1.427	1.00
267_N	270_N	1.411	1.00
72_Y	75_A	1.409	1.00
298_F	304_T	1.396	1.00
87_P	90_D	1.391	1.00
69_V	72_Y	1.381	1.00
43_D	47_L	1.377	1.00
66_F	70_I	1.365	1.00
48_D	51_E	1.365	1.00
260_G	283_I	1.352	1.00
225_I	228_L	1.347	1.00
172_Y	278_L	1.342	1.00
42_D	46_P	1.333	1.00
75_A	83_I	1.332	1.00
193_E	197_S	1.324	1.00
69_V	73_I	1.319	1.00
306_T	310_K	1.318	1.00
76_Y	79_F	1.307	1.00
55_M	60_K	1.296	1.00
186_L	285_R	1.293	1.00
49_E	52_R	1.291	1.00
157_L	263_A	1.288	1.00
87_P	93_T	1.281	1.00
73_I	76_Y	1.270	1.00
51_E	59_A	1.257	1.00
67_L	72_Y	1.254	1.00
110_S	114_Y	1.247	1.00
201_L	295_G	1.240	1.00
308_I	312_S	1.235	1.00
51_E	58_Y	1.233	1.00
71_L	74_L	1.231	1.00
99_Y	102_W	1.195	1.00
40_E	43_D	1.195	1.00
136_D	203_Q	1.194	1.00
77_L	81_I	1.190	1.00
160_L	178_C	1.184	1.00
255_E	258_K	1.180	1.00
95_R	101_L	1.179	1.00
96_P	102_W	1.164	1.00
79_F	87_P	1.163	1.00
253_T	301_S	1.161	1.00
52_R	58_Y	1.157	1.00
98_P	101_L	1.147	1.00
86_P	91_N	1.146	1.00
186_L	290_L	1.138	1.00
87_P	92_E	1.136	1.00
95_R	100_P	1.131	1.00
95_R	98_P	1.127	1.00
80_L	83_I	1.121	1.00
71_L	75_A	1.119	1.00
256_S	290_L	1.109	1.00
49_E	54_I	1.103	1.00
53_R	56_L	1.100	1.00
291_K	299_P	1.097	1.00
77_L	83_I	1.095	1.00
258_K	261_D	1.092	1.00
101_L	104_P	1.091	1.00
224_D	227_E	1.090	1.00
260_G	286_S	1.087	1.00
74_L	78_L	1.086	1.00
243_F	247_Y	1.085	1.00
155_Y	159_N	1.069	1.00
52_R	57_K	1.056	1.00
309_L	312_S	1.055	1.00
67_L	75_A	1.054	1.00
48_D	54_I	1.052	1.00
86_P	93_T	1.050	1.00
111_S	114_Y	1.048	1.00
44_W	47_L	1.048	1.00
86_P	89_L	1.046	1.00
215_G	219_I	1.046	1.00
39_L	42_D	1.039	1.00
95_R	99_Y	1.038	1.00
172_Y	176_K	1.035	1.00
207_S	242_L	1.032	1.00
179_I	278_L	1.032	1.00
76_Y	80_L	1.027	1.00
293_T	296_K	1.018	1.00
67_L	74_L	1.012	1.00
239_L	305_F	1.010	1.00
283_I	287_Q	1.008	1.00
50_E	54_I	1.004	1.00
281_L	284_M	1.004	1.00
203_Q	207_S	1.003	1.00
69_V	76_Y	1.002	1.00
50_E	53_R	0.998	1.00
140_A	248_I	0.995	1.00
143_V	252_L	0.993	1.00
263_A	283_I	0.991	1.00
260_G	287_Q	0.989	1.00
148_G	152_I	0.986	1.00
68_L	74_L	0.986	1.00
67_L	70_I	0.983	1.00
50_E	58_Y	0.982	1.00
76_Y	82_L	0.982	1.00
70_I	76_Y	0.981	1.00
85_L	90_D	0.980	1.00
104_P	108_N	0.979	1.00
31_K	194_D	0.973	1.00
94_N	98_P	0.972	1.00
88_L	91_N	0.966	1.00
247_Y	251_E	0.964	1.00
146_I	192_I	0.963	1.00
49_E	58_Y	0.960	1.00
109_D	113_Y	0.958	1.00
69_V	83_I	0.958	1.00
72_Y	83_I	0.958	1.00
113_Y	116_I	0.954	1.00
147_C	255_E	0.953	1.00
156_R	177_E	0.947	1.00
70_I	83_I	0.943	1.00
154_S	158_E	0.940	1.00
227_E	230_K	0.939	1.00
150_F	259_I	0.937	1.00
43_D	46_P	0.934	1.00
34_E	191_L	0.930	1.00
103_F	107_Y	0.930	1.00
118_Y	122_F	0.929	1.00
85_L	92_E	0.928	1.00
224_D	231_Y	0.917	1.00
175_L	179_I	0.914	1.00
146_I	185_I	0.912	1.00
277_K	280_L	0.912	1.00
53_R	60_K	0.911	1.00
38_H	184_R	0.906	1.00
42_D	47_L	0.897	1.00
154_S	255_E	0.897	1.00
181_H	184_R	0.889	1.00
72_Y	77_L	0.877	1.00
13_L	206_V	0.877	1.00
165_E	168_E	0.874	1.00
96_P	100_P	0.872	0.99
52_R	60_K	0.869	0.99
109_D	112_P	0.869	0.99
109_D	114_Y	0.866	0.99
138_L	142_L	0.865	0.99
280_L	284_M	0.864	0.99
70_I	77_L	0.864	0.99
78_L	83_I	0.862	0.99
305_F	309_L	0.856	0.99
68_L	75_A	0.855	0.99
76_Y	83_I	0.854	0.99
164_N	167_S	0.853	0.99
284_M	287_Q	0.852	0.99
68_L	82_L	0.851	0.99
57_K	60_K	0.848	0.99
225_I	231_Y	0.847	0.99
159_N	162_D	0.846	0.99
286_S	289_P	0.843	0.99
181_H	185_I	0.835	0.99
179_I	282_I	0.833	0.99
50_E	56_L	0.832	0.99
193_E	294_A	0.830	0.99
163_D	174_K	0.829	0.99
173_K	176_K	0.828	0.99
150_F	185_I	0.827	0.99
300_L	304_T	0.825	0.99
157_L	178_C	0.825	0.99
68_L	83_I	0.823	0.99
150_F	256_S	0.822	0.99
161_V	267_N	0.821	0.99
40_E	44_W	0.817	0.99
79_F	84_L	0.816	0.99
97_L	100_P	0.814	0.99
68_L	78_L	0.813	0.99
117_I	121_Q	0.810	0.99
251_E	254_D	0.810	0.99
111_S	116_I	0.808	0.99
74_L	80_L	0.808	0.99
51_E	56_L	0.803	0.99
204_F	241_Q	0.802	0.99
49_E	59_A	0.799	0.99
48_D	52_R	0.795	0.99
275_I	278_L	0.793	0.99
149_Q	185_I	0.791	0.99
71_L	76_Y	0.788	0.99
106_D	109_D	0.785	0.99
176_K	179_I	0.785	0.99
24_I	28_N	0.784	0.99
85_L	91_N	0.781	0.99
224_D	228_L	0.776	0.99
41_E	45_R	0.776	0.99
94_N	102_W	0.775	0.99
66_F	72_Y	0.773	0.99
200_L	300_L	0.772	0.99
264_Y	268_W	0.771	0.99
70_I	79_F	0.770	0.99
79_F	89_L	0.770	0.99
68_L	71_L	0.769	0.99
11_L	14_T	0.766	0.99
75_A	82_L	0.764	0.99
259_I	262_A	0.764	0.99
100_P	103_F	0.763	0.99
39_L	43_D	0.760	0.99
294_A	298_F	0.758	0.99
250_E	302_L	0.756	0.99
139_F	196_F	0.754	0.99
53_R	59_A	0.754	0.99
49_E	56_L	0.753	0.99
43_D	55_M	0.750	0.98
66_F	71_L	0.749	0.98
204_F	304_T	0.748	0.98
231_Y	234_Y	0.746	0.98
46_P	51_E	0.745	0.98
99_Y	105_F	0.743	0.98
176_K	278_L	0.741	0.98
8_N	12_L	0.739	0.98
69_V	84_L	0.737	0.98
94_N	97_L	0.735	0.98
67_L	83_I	0.733	0.98
201_L	293_T	0.730	0.98
69_V	77_L	0.725	0.98
73_I	79_F	0.724	0.98
272_P	276_R	0.723	0.98
89_L	92_E	0.719	0.98
66_F	69_V	0.716	0.98
37_E	41_E	0.715	0.98
49_E	53_R	0.712	0.98
178_C	247_Y	0.711	0.98
72_Y	79_F	0.709	0.98
166_E	169_E	0.707	0.98
30_K	34_E	0.706	0.98
72_Y	78_L	0.705	0.98
164_N	168_E	0.704	0.98
189_A	290_L	0.703	0.98
29_R	33_K	0.700	0.98
83_I	86_P	0.698	0.98
74_L	79_F	0.698	0.98
156_R	174_K	0.696	0.98
94_N	100_P	0.695	0.97
89_L	93_T	0.693	0.97
179_I	182_H	0.691	0.97
101_L	121_Q	0.690	0.97
100_P	104_P	0.690	0.97
109_D	115_E	0.689	0.97
49_E	60_K	0.688	0.97
68_L	79_F	0.685	0.97
260_G	264_Y	0.684	0.97
74_L	77_L	0.682	0.97
81_I	86_P	0.681	0.97
82_L	86_P	0.680	0.97
82_L	90_D	0.675	0.97
48_D	53_R	0.672	0.97
164_N	169_E	0.672	0.97
154_S	259_I	0.671	0.97
50_E	57_K	0.671	0.97
219_I	223_S	0.670	0.97
70_I	75_A	0.669	0.97
68_L	76_Y	0.668	0.97
276_R	280_L	0.667	0.97
54_I	60_K	0.667	0.97
67_L	77_L	0.666	0.97
145_H	148_G	0.663	0.97
200_L	204_F	0.661	0.97
84_L	89_L	0.660	0.97
153_L	178_C	0.659	0.97
72_Y	82_L	0.658	0.97
67_L	79_F	0.657	0.96
211_I	309_L	0.657	0.96
66_F	82_L	0.656	0.96
150_F	189_A	0.652	0.96
190_E	288_K	0.652	0.96
96_P	99_Y	0.649	0.96
139_F	301_S	0.647	0.96
246_C	304_T	0.647	0.96
70_I	74_L	0.645	0.96
70_I	78_L	0.645	0.96
149_Q	246_C	0.644	0.96
94_N	99_Y	0.643	0.96
144_L	248_I	0.642	0.96
14_T	234_Y	0.635	0.96
187_R	191_L	0.634	0.96
207_S	211_I	0.633	0.96
74_L	83_I	0.633	0.96
230_K	233_L	0.631	0.96
68_L	73_I	0.631	0.96
66_F	73_I	0.628	0.95
190_E	285_R	0.628	0.95
211_I	312_S	0.625	0.95
88_L	93_T	0.624	0.95
203_Q	241_Q	0.623	0.95
72_Y	81_I	0.622	0.95
246_C	305_F	0.619	0.95
259_I	282_I	0.618	0.95
69_V	75_A	0.617	0.95
266_S	275_I	0.615	0.95
182_H	286_S	0.613	0.95
120_L	124_S	0.612	0.95
147_C	249_G	0.611	0.95
46_P	50_E	0.610	0.95
50_E	59_A	0.610	0.95
44_W	56_L	0.609	0.95
53_R	58_Y	0.608	0.95
66_F	84_L	0.607	0.95
217_Q	220_T	0.605	0.94
282_I	286_S	0.603	0.94
73_I	77_L	0.603	0.94
76_Y	81_I	0.602	0.94
208_T	212_C	0.601	0.94
277_K	281_L	0.600	0.94
201_L	205_L	0.599	0.94
242_L	308_I	0.598	0.94
52_R	62_K	0.595	0.94
48_D	57_K	0.594	0.94
126_F	130_I	0.593	0.94
118_Y	121_Q	0.591	0.94
59_A	62_K	0.590	0.94
12_L	15_S	0.590	0.94
165_E	169_E	0.589	0.94
78_L	84_L	0.589	0.94
294_A	304_T	0.589	0.94
42_D	54_I	0.586	0.94
149_Q	153_L	0.586	0.94
36_L	138_L	0.585	0.93
75_A	78_L	0.583	0.93
109_D	116_I	0.582	0.93
75_A	81_I	0.582	0.93
11_L	15_S	0.580	0.93
283_I	286_S	0.576	0.93
96_P	101_L	0.575	0.93
183_Q	186_L	0.571	0.93
29_R	39_L	0.569	0.92
274_K	283_I	0.567	0.92
155_Y	158_E	0.567	0.92
97_L	104_P	0.567	0.92
212_C	216_F	0.566	0.92
74_L	81_I	0.565	0.92
43_D	145_H	0.565	0.92
44_W	55_M	0.563	0.92
69_V	82_L	0.562	0.92
264_Y	283_I	0.561	0.92
72_Y	84_L	0.560	0.92
51_E	60_K	0.560	0.92
66_F	79_F	0.560	0.92
83_I	92_E	0.557	0.92
66_F	83_I	0.555	0.92
191_L	195_I	0.554	0.91
41_E	44_W	0.553	0.91
47_L	58_Y	0.552	0.91
76_Y	87_P	0.551	0.91
110_S	116_I	0.551	0.91
257_E	261_D	0.548	0.91
223_S	228_L	0.548	0.91
15_S	18_A	0.547	0.91
251_E	255_E	0.546	0.91
256_S	285_R	0.545	0.91
25_L	38_H	0.544	0.91
42_D	45_R	0.544	0.91
67_L	73_I	0.544	0.91
84_L	88_L	0.541	0.91
272_P	275_I	0.540	0.90
22_L	26_L	0.538	0.90
241_Q	248_I	0.537	0.90
156_R	178_C	0.536	0.90
63_R	78_L	0.536	0.90
43_D	59_A	0.533	0.90
98_P	118_Y	0.533	0.90
197_S	296_K	0.532	0.90
31_K	34_E	0.531	0.90
224_D	234_Y	0.530	0.90
49_E	57_K	0.530	0.90
64_I	75_A	0.529	0.90
274_K	278_L	0.528	0.89
81_I	93_T	0.527	0.89
13_L	16_I	0.526	0.89
203_Q	234_Y	0.524	0.89
32_I	142_L	0.522	0.89
167_S	170_E	0.521	0.89
295_G	300_L	0.518	0.89
208_T	214_L	0.518	0.89
291_K	301_S	0.515	0.88
45_R	57_K	0.514	0.88
32_I	195_I	0.513	0.88
68_L	77_L	0.513	0.88
27_L	30_K	0.512	0.88
48_D	55_M	0.512	0.88
207_S	308_I	0.511	0.88
43_D	58_Y	0.510	0.88
125_L	129_A	0.510	0.88
175_L	275_I	0.508	0.88
50_E	159_N	0.508	0.88
261_D	265_N	0.508	0.88
52_R	65_R	0.507	0.87
102_W	105_F	0.507	0.87
207_S	241_Q	0.503	0.87
121_Q	149_Q	0.503	0.87
218_I	228_L	0.503	0.87
71_L	78_L	0.502	0.87
78_L	86_P	0.500	0.87
98_P	103_F	0.500	0.87
42_D	55_M	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hkqA	2	0.1725	18.9	0.945	Contact Map
2bg9B	1	0.3099	7.9	0.953	Contact Map
3ukmA	2	0.5911	3.2	0.961	Contact Map
3vw7A	1	0.1022	3	0.962	Contact Map
2bg9A	1	0.3003	2.5	0.963	Contact Map
2bg9C	1	0.3003	2.3	0.964	Contact Map
1y66A	3	0.1597	2.3	0.964	Contact Map
2kogA	1	0.2748	2.2	0.964	Contact Map
3s8fA	1	0.3067	2.2	0.965	Contact Map
2bg9E	1	0.2971	2	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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