GREMLIN Database
DDHD - DDHD domain
PFAM: PF02862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 208 (202)
Sequences: 1047 (750)
Seq/√Len: 52.8
META: 0.101

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A48_L2.4771.00
133_I137_E2.4661.00
78_I174_L2.3991.00
10_A15_L2.3871.00
66_I170_I2.3491.00
142_D145_T2.1841.00
137_E140_E2.1281.00
48_L62_L2.1181.00
144_Y147_S2.1131.00
126_E131_A2.1071.00
143_S146_A2.1011.00
132_S139_G2.0861.00
141_E145_T2.0851.00
114_S117_A2.0731.00
63_E169_R2.0001.00
118_L121_S1.9591.00
112_R119_A1.9521.00
120_A123_S1.9391.00
158_E161_V1.9321.00
80_H84_G1.8880.99
13_S79_P1.8100.99
126_E135_S1.8010.99
132_S136_E1.7830.99
51_I78_I1.7830.99
31_P34_D1.7710.99
50_N54_P1.7390.99
139_G142_D1.7320.99
61_R64_P1.7210.99
132_S135_S1.7150.99
135_S139_G1.6890.99
52_F175_Q1.6870.99
128_A133_I1.6650.99
6_E46_K1.6280.98
142_D146_A1.6240.98
136_E139_G1.6220.98
134_E137_E1.6210.98
130_E134_E1.6200.98
53_H61_R1.5970.98
139_G144_Y1.5840.98
134_E140_E1.5740.98
157_A161_V1.5740.98
144_Y148_S1.5650.98
146_A149_I1.5070.97
18_F60_Y1.4990.97
133_I136_E1.4950.97
190_H193_Y1.4920.97
131_A137_E1.4910.97
18_F58_V1.4900.97
115_S118_L1.4870.97
110_L113_E1.4700.97
7_N49_Y1.4630.97
122_S126_E1.4360.96
130_E135_S1.4300.96
129_S133_I1.4260.96
129_S136_E1.3680.95
117_A120_A1.3660.95
65_L169_R1.3650.95
127_R135_S1.3590.95
114_S118_L1.3330.94
61_R169_R1.3250.94
1_L4_E1.3230.94
134_E139_G1.3180.94
148_S151_S1.3150.94
179_L182_E1.3000.93
129_S135_S1.2950.93
138_S144_Y1.2950.93
125_E128_A1.2870.93
129_S132_S1.2830.93
182_E186_A1.2830.93
124_S131_A1.2810.93
115_S120_A1.2770.93
131_A136_E1.2750.93
96_K99_V1.2700.93
109_R113_E1.2650.93
133_I138_S1.2580.92
166_W203_I1.2540.92
127_R137_E1.2420.92
7_N47_Q1.2400.92
28_T31_P1.2340.92
129_S137_E1.2320.92
179_L186_A1.2190.91
100_L105_S1.2170.91
147_S150_S1.1990.90
132_S137_E1.1950.90
135_S138_S1.1890.90
124_S130_E1.1830.90
111_T118_L1.1770.90
8_F48_L1.1680.89
179_L191_L1.1630.89
131_A134_E1.1400.88
134_E138_S1.1320.88
140_E144_Y1.1320.88
113_E118_L1.1310.88
54_P173_V1.1200.87
127_R132_S1.1190.87
27_I178_P1.1140.87
129_S138_S1.1130.87
52_F61_R1.1090.87
123_S126_E1.1040.86
132_S138_S1.1030.86
133_I142_D1.0950.86
136_E142_D1.0940.86
120_A125_E1.0770.85
126_E132_S1.0690.84
125_E129_S1.0620.84
66_I165_N1.0470.83
116_A121_S1.0440.83
128_A131_A1.0340.82
140_E143_S1.0180.81
138_S142_D1.0170.81
132_S142_D1.0160.81
122_S125_E1.0150.81
27_I203_I1.0040.81
113_E120_A1.0020.80
134_E146_A1.0010.80
192_S195_E0.9910.80
19_L200_A0.9780.79
136_E140_E0.9780.79
47_Q168_G0.9760.79
130_E141_E0.9710.78
86_E89_T0.9660.78
125_E134_E0.9600.77
124_S127_R0.9600.77
84_G87_G0.9570.77
127_R133_I0.9420.76
201_L208_Y0.9400.76
144_Y149_I0.9380.76
19_L22_R0.9340.75
131_A135_S0.9330.75
79_P82_K0.9310.75
141_E144_Y0.9270.75
81_Y84_G0.9210.74
157_A160_K0.9140.74
116_A119_A0.9120.74
113_E116_A0.9110.74
118_L124_S0.9100.74
115_S119_A0.9060.73
165_N206_Q0.9040.73
135_S145_T0.9020.73
130_E136_E0.8960.72
137_E146_A0.8950.72
60_Y63_E0.8920.72
172_Y203_I0.8910.72
138_S141_E0.8810.71
2_D53_H0.8790.71
7_N17_L0.8770.71
128_A136_E0.8770.71
121_S130_E0.8720.70
5_V16_G0.8670.70
141_E147_S0.8560.69
135_S148_S0.8530.69
87_G92_G0.8490.68
163_A170_I0.8450.68
140_E147_S0.8430.68
130_E137_E0.8430.68
124_S135_S0.8330.67
111_T123_S0.8220.66
125_E131_A0.8220.66
137_E141_E0.8200.66
133_I141_E0.8180.65
126_E133_I0.8100.65
23_G175_Q0.8050.64
117_A124_S0.8030.64
136_E146_A0.8020.64
135_S141_E0.8010.64
94_D97_Q0.7990.64
121_S124_S0.7980.63
53_H175_Q0.7940.63
89_T93_A0.7930.63
126_E130_E0.7880.62
118_L126_E0.7820.62
117_A121_S0.7810.62
87_G94_D0.7800.62
45_C191_L0.7770.61
102_S106_S0.7740.61
92_G95_L0.7710.61
128_A134_E0.7670.60
113_E117_A0.7660.60
126_E136_E0.7660.60
119_A125_E0.7640.60
180_E208_Y0.7640.60
127_R131_A0.7630.60
145_T148_S0.7620.60
1_L34_D0.7620.60
26_I168_G0.7570.59
73_L177_G0.7520.59
138_S146_A0.7490.59
61_R65_L0.7480.58
140_E146_A0.7470.58
139_G147_S0.7450.58
183_Y186_A0.7400.58
136_E145_T0.7380.57
130_E133_I0.7350.57
123_S149_I0.7320.57
114_S121_S0.7310.57
115_S122_S0.7280.56
86_E93_A0.7260.56
135_S143_S0.7240.56
64_P169_R0.7220.56
139_G143_S0.7160.55
127_R144_Y0.7140.55
110_L118_L0.7140.55
90_R95_L0.7040.54
31_P37_D0.7040.54
102_S105_S0.7030.54
54_P61_R0.6980.53
81_Y85_K0.6950.53
111_T115_S0.6930.53
123_S144_Y0.6930.53
101_L104_L0.6930.53
128_A135_S0.6920.53
95_L103_S0.6850.52
134_E143_S0.6830.52
135_S149_I0.6760.51
89_T92_G0.6750.51
83_G172_Y0.6740.51
191_L196_S0.6700.50
118_L123_S0.6690.50
112_R116_A0.6690.50
111_T117_A0.6680.50
28_T39_Q0.6670.50
111_T116_A0.6670.50
8_F13_S0.6590.49
110_L114_S0.6590.49
80_H85_K0.6580.49
134_E144_Y0.6580.49
119_A122_S0.6580.49
110_L119_A0.6570.49
55_T194_W0.6560.49
167_N182_E0.6560.49
45_C179_L0.6520.48
80_H175_Q0.6470.48
41_G44_A0.6450.48
36_E59_A0.6410.47
81_Y199_V0.6400.47
134_E141_E0.6400.47
135_S140_E0.6400.47
116_A120_A0.6390.47
194_W201_L0.6380.47
134_E142_D0.6360.47
1_L5_V0.6330.46
23_G54_P0.6330.46
126_E129_S0.6320.46
145_T150_S0.6300.46
27_I46_K0.6290.46
182_E189_S0.6290.46
183_Y189_S0.6270.46
175_Q198_D0.6240.45
162_G165_N0.6190.45
3_F12_G0.6140.44
131_A140_E0.6130.44
182_E185_S0.6110.44
54_P174_L0.6050.43
121_S126_E0.6050.43
136_E144_Y0.6040.43
138_S145_T0.6030.43
119_A127_R0.6030.43
110_L116_A0.5980.43
46_K207_I0.5970.43
131_A138_S0.5940.42
137_E147_S0.5910.42
135_S142_D0.5890.42
135_S144_Y0.5890.42
146_A150_S0.5890.42
18_F54_P0.5840.41
97_Q172_Y0.5770.41
88_L93_A0.5720.40
16_G23_G0.5690.40
43_P65_L0.5620.39
116_A122_S0.5620.39
20_A47_Q0.5600.39
88_L91_L0.5520.38
5_V186_A0.5500.38
52_F75_P0.5500.38
120_A138_S0.5500.38
117_A132_S0.5470.38
140_E145_T0.5460.37
152_E161_V0.5460.37
86_E92_G0.5440.37
178_P201_L0.5430.37
138_S148_S0.5420.37
143_S147_S0.5390.37
195_E205_R0.5350.36
137_E149_I0.5330.36
90_R96_K0.5300.36
100_L109_R0.5220.35
4_E7_N0.5210.35
119_A143_S0.5210.35
142_D149_I0.5180.35
139_G148_S0.5180.35
27_I40_Y0.5160.35
73_L79_P0.5160.35
16_G207_I0.5140.34
101_L105_S0.5120.34
138_S143_S0.5100.34
115_S137_E0.5100.34
92_G96_K0.5090.34
116_A124_S0.5050.34
114_S119_A0.5050.34
165_N176_E0.5020.33
115_S121_S0.5020.33
64_P196_S0.5000.33
120_A137_E0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwxA 2 0.3317 8.5 0.957 Contact Map
1f35A 2 0.4375 6.8 0.959 Contact Map
3fbiB 1 0.3029 3.6 0.964 Contact Map
4i9xA 2 0.3269 2.8 0.966 Contact Map
4hicA 1 0.2019 2.2 0.968 Contact Map
2zvmU 1 0.0625 2.1 0.968 Contact Map
3p3gA 1 0.2837 1.9 0.969 Contact Map
3uhmA 1 0.2837 1.9 0.969 Contact Map
2npmA 2 0.2837 1.8 0.969 Contact Map
4ogqE 1 0.1298 1.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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