GREMLIN Database
DDT - DDT domain
PFAM: PF02791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (58)
Sequences: 1139 (715)
Seq/√Len: 93.8
META: 0.395

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_V30_F3.3001.00
13_L22_L2.7951.00
13_L49_I2.3141.00
6_L31_V2.2911.00
25_F45_L2.2451.00
39_P42_P1.9121.00
9_V16_F1.8281.00
5_D8_M1.7291.00
30_F34_L1.6561.00
11_E27_L1.6151.00
16_F20_L1.6141.00
11_E48_E1.5991.00
10_W14_N1.5901.00
33_A46_L1.5711.00
50_H57_L1.4921.00
21_G35_L1.4621.00
38_D41_G1.3670.99
25_F43_S1.3270.99
12_F20_L1.2990.99
8_M27_L1.2970.99
52_A55_K1.2500.99
39_P47_D1.2300.98
4_G12_F1.1960.98
20_L52_A1.1530.98
13_L53_L1.1320.97
14_N23_S1.1200.97
30_F46_L1.0890.97
50_H53_L1.0870.97
12_F53_L1.0550.96
11_E58_L1.0460.96
13_L31_V0.9730.94
28_D36_H0.9710.94
4_G54_L0.9690.94
34_L54_L0.9680.94
13_L25_F0.9530.93
48_E51_V0.9080.91
29_D51_V0.9060.91
25_F52_A0.8880.90
10_W23_S0.8860.90
11_E31_V0.8750.90
18_E21_G0.8650.89
44_E48_E0.8450.88
9_V19_V0.8430.88
12_F31_V0.7980.85
31_V35_L0.7960.85
3_V55_K0.7950.85
5_D47_D0.7820.84
32_A37_S0.7640.82
6_L27_L0.7430.80
22_L52_A0.7420.80
29_D48_E0.7390.80
23_S45_L0.7310.79
51_V58_L0.7200.78
28_D48_E0.7070.77
30_F45_L0.7050.77
18_E29_D0.7020.77
4_G15_V0.6870.75
4_G32_A0.6740.74
8_M12_F0.6340.69
36_H42_P0.6240.68
3_V36_H0.6230.68
32_A38_D0.6140.67
8_M37_S0.6140.67
11_E56_A0.6010.65
24_P57_L0.5940.64
55_K58_L0.5930.64
27_L42_P0.5920.64
9_V39_P0.5920.64
5_D39_P0.5840.63
11_E16_F0.5840.63
6_L11_E0.5790.62
7_L57_L0.5770.62
12_F16_F0.5670.60
12_F17_G0.5620.60
29_D50_H0.5540.59
26_T59_R0.5440.57
9_V41_G0.5430.57
30_F49_I0.5410.57
16_F57_L0.5350.56
31_V58_L0.5350.56
3_V7_L0.5320.56
8_M18_E0.5310.55
43_S54_L0.5200.54
47_D50_H0.5180.54
5_D15_V0.5130.53
26_T35_L0.5020.51
17_G56_A0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y9yB 1 1 80 0.723 Contact Map
4cemA 1 0.9667 7.2 0.85 Contact Map
2wx4A 3 0.7167 4.6 0.863 Contact Map
2ahmA 2 0.45 3.6 0.871 Contact Map
4jpzB 1 0.9833 3.2 0.873 Contact Map
3ub0B 2 0.6167 3 0.875 Contact Map
3q3eA 1 0.65 2.7 0.879 Contact Map
4wbdA 2 0.9 2.7 0.879 Contact Map
4ycuA 3 0.9 2.6 0.879 Contact Map
4dckA 3 0.9833 2.5 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.