DUF222 - PFAM28P - GREMLIN Contacts

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DUF222 - Domain of unknown function (DUF222)

PFAM:	PF02720	Sequences: CFAALAELEAAARRLAAAAARLLAELDARGGWAADGARSAAAWLAAALGLSPGAARRRVRVARALRERLPATAAALAAGEISYAHARAIARAAAALPDAVDAAAVDAAEAALLERARRLTPAQLRRAARRLRARLDPDGAERDERAARRRRLTLRPDDDGMVRLRGRLPPEDGAALDAALDALAAPLPADAGAGDPRTPAQRRADALVELARRALAAGALPRPGGVRPQVVVTVDLETLAGGAGAAALLGGGGPIPAETARRLACDASLRVVLDPDGEPLDVGRTTRLPPPALRRALRARD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	301 (294)
Sequences:	14802 (11404)
Seq/√Len:	665.1
META:	0.781

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_V	173_G	5.086	1.00
172_D	208_V	3.659	1.00
12_A	16_A	3.631	1.00
12_A	19_A	3.411	1.00
290_P	293_L	3.205	1.00
150_R	205_D	3.035	1.00
169_P	172_D	2.860	1.00
80_E	117_R	2.799	1.00
199_P	203_R	2.696	1.00
235_D	238_T	2.566	1.00
151_R	200_A	2.458	1.00
120_T	123_Q	2.396	1.00
168_L	204_A	2.342	1.00
157_D	163_R	2.335	1.00
163_R	167_R	2.330	1.00
198_T	201_Q	2.300	1.00
153_T	165_R	2.215	1.00
256_P	259_T	2.213	1.00
154_L	177_D	2.175	1.00
175_A	212_R	2.152	1.00
152_L	164_L	2.133	1.00
294_R	298_R	2.055	1.00
9_E	19_A	2.050	1.00
161_M	167_R	1.989	1.00
61_V	87_R	1.985	1.00
119_L	127_A	1.981	1.00
76_L	86_A	1.977	1.00
166_G	207_L	1.941	1.00
72_T	89_I	1.935	1.00
143_D	147_A	1.909	1.00
157_D	167_R	1.876	1.00
16_A	19_A	1.853	1.00
176_L	211_A	1.842	1.00
282_V	290_P	1.798	1.00
235_D	239_L	1.795	1.00
136_D	139_G	1.781	1.00
168_L	173_G	1.750	1.00
152_L	166_G	1.712	1.00
106_D	109_E	1.704	1.00
82_S	85_H	1.704	1.00
9_E	13_R	1.687	1.00
11_A	15_L	1.670	1.00
115_R	119_L	1.664	1.00
57_R	87_R	1.659	1.00
162_V	177_D	1.654	1.00
45_A	52_P	1.616	1.00
210_L	214_A	1.615	1.00
74_A	78_A	1.585	1.00
101_D	104_A	1.579	1.00
177_D	181_D	1.563	1.00
130_R	134_R	1.552	1.00
109_E	113_L	1.550	1.00
277_G	281_D	1.544	1.00
236_L	240_A	1.543	1.00
109_E	112_L	1.538	1.00
207_L	211_A	1.538	1.00
238_T	241_G	1.519	1.00
155_R	165_R	1.518	1.00
246_A	249_L	1.500	1.00
144_E	148_R	1.497	1.00
115_R	127_A	1.496	1.00
41_A	56_R	1.495	1.00
127_A	130_R	1.464	1.00
255_I	260_A	1.461	1.00
61_V	83_Y	1.432	1.00
162_V	170_P	1.424	1.00
268_S	285_T	1.413	1.00
247_A	250_G	1.401	1.00
153_T	200_A	1.400	1.00
181_D	203_R	1.397	1.00
72_T	86_A	1.397	1.00
183_L	186_P	1.394	1.00
116_A	124_L	1.373	1.00
50_L	55_A	1.373	1.00
72_T	81_I	1.356	1.00
54_A	84_A	1.336	1.00
257_A	261_R	1.330	1.00
75_A	80_E	1.325	1.00
61_V	86_A	1.321	1.00
291_P	295_R	1.319	1.00
271_V	299_A	1.316	1.00
12_A	15_L	1.315	1.00
258_E	261_R	1.311	1.00
85_H	124_L	1.296	1.00
168_L	176_L	1.291	1.00
27_D	40_A	1.291	1.00
30_G	33_A	1.283	1.00
156_P	162_V	1.282	1.00
176_L	207_L	1.275	1.00
144_E	147_A	1.267	1.00
20_A	24_A	1.265	1.00
255_I	259_T	1.245	1.00
289_P	293_L	1.239	1.00
18_A	22_L	1.235	1.00
65_L	73_A	1.216	1.00
154_L	162_V	1.211	1.00
72_T	109_E	1.210	1.00
197_R	205_D	1.204	1.00
11_A	14_R	1.198	1.00
184_A	203_R	1.197	1.00
18_A	21_R	1.192	1.00
152_L	180_L	1.189	1.00
282_V	286_T	1.178	1.00
175_A	208_V	1.170	1.00
25_E	29_R	1.166	1.00
156_P	177_D	1.166	1.00
119_L	123_Q	1.160	1.00
84_A	87_R	1.160	1.00
71_A	110_A	1.153	1.00
201_Q	205_D	1.149	1.00
32_W	40_A	1.148	1.00
89_I	124_L	1.141	1.00
122_A	126_R	1.138	1.00
151_R	167_R	1.127	1.00
19_A	23_L	1.126	1.00
73_A	77_A	1.119	1.00
112_L	116_A	1.117	1.00
289_P	297_L	1.113	1.00
88_A	125_R	1.098	1.00
234_V	239_L	1.093	1.00
143_D	146_A	1.093	1.00
102_A	105_V	1.093	1.00
274_D	278_E	1.065	1.00
71_A	74_A	1.062	1.00
108_A	112_L	1.060	1.00
52_P	56_R	1.055	1.00
142_R	146_A	1.047	1.00
20_A	23_L	1.040	1.00
15_L	19_A	1.034	1.00
72_T	113_L	1.033	1.00
54_A	58_R	1.027	1.00
37_A	46_A	1.021	1.00
209_E	213_R	1.019	1.00
9_E	12_A	1.018	1.00
183_L	210_L	1.017	1.00
66_R	73_A	1.014	1.00
174_A	178_A	1.007	1.00
171_E	262_R	1.006	1.00
286_T	290_P	1.002	1.00
275_P	281_D	1.002	1.00
41_A	52_P	1.000	1.00
211_A	215_L	0.998	1.00
178_A	182_A	0.998	1.00
14_R	18_A	0.997	1.00
50_L	58_R	0.996	1.00
166_G	173_G	0.987	1.00
105_V	109_E	0.987	1.00
69_L	90_A	0.986	1.00
164_L	176_L	0.985	1.00
154_L	173_G	0.981	1.00
22_L	26_L	0.978	1.00
51_S	54_A	0.975	1.00
111_A	115_R	0.973	1.00
27_D	32_W	0.970	1.00
282_V	293_L	0.969	1.00
151_R	165_R	0.968	1.00
124_L	128_A	0.965	1.00
49_G	85_H	0.962	1.00
115_R	118_R	0.957	1.00
271_V	282_V	0.957	1.00
169_P	208_V	0.955	1.00
228_P	233_T	0.953	1.00
64_A	90_A	0.953	1.00
110_A	114_E	0.953	1.00
76_L	83_Y	0.952	1.00
234_V	238_T	0.949	1.00
85_H	121_P	0.943	1.00
278_E	292_A	0.943	1.00
19_A	26_L	0.943	1.00
130_R	133_A	0.941	1.00
286_T	289_P	0.941	1.00
27_D	63_R	0.940	1.00
8_L	18_A	0.938	1.00
13_R	19_A	0.936	1.00
56_R	60_R	0.934	1.00
171_E	259_T	0.933	1.00
179_A	183_L	0.933	1.00
235_D	241_G	0.929	1.00
238_T	242_G	0.928	1.00
92_A	128_A	0.927	1.00
143_D	148_R	0.926	1.00
212_R	216_A	0.925	1.00
191_A	194_G	0.925	1.00
145_R	148_R	0.923	1.00
259_T	262_R	0.922	1.00
181_D	185_A	0.920	1.00
188_P	202_R	0.918	1.00
9_E	16_A	0.915	1.00
293_L	297_L	0.914	1.00
125_R	129_R	0.910	1.00
202_R	206_A	0.908	1.00
8_L	19_A	0.905	1.00
91_R	125_R	0.902	1.00
279_P	282_V	0.899	1.00
8_L	15_L	0.895	1.00
278_E	281_D	0.895	1.00
250_G	253_G	0.893	1.00
13_R	16_A	0.892	1.00
75_A	81_I	0.889	1.00
16_A	20_A	0.886	1.00
39_S	42_A	0.885	1.00
176_L	208_V	0.885	1.00
270_R	295_R	0.881	1.00
235_D	240_A	0.881	1.00
237_E	241_G	0.877	1.00
15_L	18_A	0.877	1.00
137_P	140_A	0.876	1.00
8_L	22_L	0.875	1.00
155_R	163_R	0.875	1.00
101_D	105_V	0.872	1.00
197_R	201_Q	0.869	1.00
209_E	212_R	0.866	1.00
24_A	66_R	0.864	1.00
246_A	260_A	0.862	1.00
57_R	61_V	0.859	1.00
21_R	77_A	0.852	1.00
21_R	73_A	0.849	1.00
57_R	84_A	0.848	1.00
53_G	57_R	0.847	1.00
74_A	77_A	0.845	1.00
32_W	36_G	0.845	1.00
21_R	24_A	0.844	1.00
11_A	18_A	0.843	1.00
183_L	187_L	0.842	1.00
42_A	52_P	0.840	1.00
41_A	45_A	0.838	1.00
104_A	107_A	0.835	1.00
246_A	250_G	0.835	1.00
64_A	94_A	0.832	1.00
179_A	210_L	0.832	1.00
180_L	203_R	0.830	1.00
114_E	118_R	0.829	1.00
247_A	251_G	0.828	1.00
23_L	26_L	0.827	1.00
187_L	190_D	0.826	1.00
10_A	14_R	0.825	1.00
185_A	188_P	0.822	1.00
270_R	273_L	0.820	1.00
119_L	124_L	0.818	1.00
50_L	54_A	0.818	1.00
236_L	241_G	0.812	1.00
147_A	150_R	0.806	1.00
213_R	217_A	0.802	1.00
29_R	32_W	0.799	1.00
41_A	55_A	0.797	1.00
28_A	66_R	0.796	1.00
21_R	25_E	0.794	1.00
71_A	109_E	0.793	1.00
233_T	239_L	0.792	1.00
241_G	244_G	0.790	1.00
109_E	116_A	0.790	1.00
98_D	101_D	0.790	1.00
103_A	106_D	0.788	1.00
183_L	209_E	0.787	1.00
128_A	132_R	0.786	1.00
229_Q	233_T	0.785	1.00
14_R	19_A	0.784	1.00
83_Y	87_R	0.780	1.00
105_V	108_A	0.780	1.00
108_A	111_A	0.779	1.00
8_L	23_L	0.773	1.00
103_A	107_A	0.773	1.00
246_A	251_G	0.767	1.00
54_A	57_R	0.763	1.00
114_E	117_R	0.761	1.00
185_A	189_A	0.760	1.00
157_D	161_M	0.760	1.00
23_L	44_L	0.759	1.00
181_D	184_A	0.758	1.00
113_L	116_A	0.757	1.00
106_D	110_A	0.755	1.00
19_A	22_L	0.755	1.00
19_A	58_R	0.749	1.00
237_E	240_A	0.742	1.00
71_A	113_L	0.741	1.00
102_A	106_D	0.737	1.00
164_L	168_L	0.734	1.00
13_R	26_L	0.732	1.00
95_A	132_R	0.730	1.00
123_Q	126_R	0.724	1.00
13_R	18_A	0.722	1.00
88_A	124_L	0.722	1.00
233_T	237_E	0.721	1.00
59_V	63_R	0.718	1.00
87_R	91_R	0.716	1.00
156_P	174_A	0.713	1.00
112_L	128_A	0.712	1.00
131_L	134_R	0.711	1.00
154_L	166_G	0.708	1.00
10_A	13_R	0.705	1.00
179_A	215_L	0.703	1.00
143_D	256_P	0.703	1.00
32_W	37_A	0.702	1.00
185_A	199_P	0.700	1.00
277_G	280_L	0.694	1.00
128_A	131_L	0.693	1.00
228_P	232_V	0.690	1.00
88_A	128_A	0.690	1.00
69_L	72_T	0.687	1.00
280_L	283_G	0.683	1.00
145_R	149_R	0.681	1.00
154_L	164_L	0.681	1.00
13_R	21_R	0.681	1.00
204_A	208_V	0.678	1.00
249_L	252_G	0.677	1.00
69_L	93_A	0.676	1.00
230_V	234_V	0.676	1.00
65_L	86_A	0.676	1.00
238_T	244_G	0.674	1.00
88_A	91_R	0.674	1.00
234_V	260_A	0.672	1.00
226_V	229_Q	0.672	1.00
271_V	275_P	0.670	1.00
194_G	197_R	0.668	1.00
26_L	31_G	0.667	1.00
261_R	265_C	0.666	1.00
32_W	35_D	0.664	1.00
206_A	210_L	0.663	1.00
61_V	90_A	0.660	1.00
150_R	201_Q	0.659	1.00
183_L	214_A	0.659	1.00
136_D	140_A	0.659	1.00
14_R	21_R	0.658	1.00
36_G	39_S	0.658	1.00
12_A	23_L	0.658	1.00
191_A	195_D	0.655	1.00
242_G	245_A	0.654	1.00
17_A	76_L	0.652	1.00
133_A	137_P	0.650	1.00
198_T	205_D	0.648	1.00
113_L	117_R	0.646	1.00
179_A	182_A	0.646	1.00
179_A	211_A	0.644	1.00
247_A	260_A	0.644	1.00
16_A	23_L	0.643	1.00
230_V	239_L	0.643	1.00
248_L	251_G	0.641	1.00
211_A	214_A	0.640	1.00
142_R	145_R	0.637	1.00
27_D	31_G	0.637	1.00
53_G	56_R	0.636	1.00
43_W	47_A	0.635	1.00
108_A	131_L	0.635	1.00
159_D	167_R	0.631	1.00
289_P	294_R	0.625	1.00
233_T	241_G	0.625	1.00
131_L	135_L	0.624	1.00
271_V	274_D	0.624	1.00
17_A	21_R	0.623	1.00
180_L	184_A	0.623	1.00
280_L	296_A	0.621	1.00
150_R	169_P	0.621	1.00
31_G	34_A	0.621	1.00
150_R	161_M	0.614	1.00
281_D	284_R	0.612	1.00
64_A	68_R	0.611	1.00
175_A	211_A	0.609	1.00
149_R	167_R	0.608	1.00
168_L	208_V	0.606	1.00
127_A	131_L	0.606	1.00
168_L	172_D	0.604	1.00
229_Q	270_R	0.604	1.00
287_R	297_L	0.599	1.00
272_V	275_P	0.597	1.00
187_L	202_R	0.596	1.00
238_T	245_A	0.595	1.00
282_V	295_R	0.594	1.00
208_V	211_A	0.594	1.00
262_R	265_C	0.593	1.00
239_L	242_G	0.591	1.00
67_E	70_P	0.589	1.00
42_A	46_A	0.589	1.00
279_P	296_A	0.587	1.00
93_A	96_L	0.586	1.00
107_A	111_A	0.585	1.00
12_A	20_A	0.585	1.00
163_R	166_G	0.583	1.00
230_V	264_A	0.583	1.00
257_A	260_A	0.582	1.00
112_L	115_R	0.581	1.00
142_R	147_A	0.580	1.00
11_A	19_A	0.579	1.00
97_P	100_V	0.576	1.00
97_P	101_D	0.575	1.00
38_R	42_A	0.573	1.00
220_L	224_G	0.570	1.00
8_L	11_A	0.569	1.00
17_A	20_A	0.566	1.00
229_Q	268_S	0.565	1.00
12_A	18_A	0.563	1.00
57_R	83_Y	0.563	1.00
235_D	243_A	0.562	1.00
239_L	243_A	0.562	1.00
223_P	226_V	0.559	1.00
75_A	113_L	0.559	1.00
146_A	170_P	0.558	1.00
174_A	177_D	0.557	1.00
219_A	223_P	0.556	1.00
16_A	83_Y	0.555	1.00
214_A	217_A	0.553	1.00
81_I	85_H	0.553	1.00
16_A	22_L	0.552	1.00
40_A	59_V	0.551	1.00
172_D	211_A	0.547	1.00
237_E	242_G	0.545	1.00
9_E	23_L	0.545	1.00
231_V	271_V	0.545	1.00
261_R	264_A	0.545	1.00
149_R	161_M	0.544	1.00
180_L	207_L	0.544	1.00
183_L	213_R	0.542	1.00
203_R	210_L	0.540	1.00
60_R	64_A	0.539	1.00
233_T	236_L	0.539	1.00
8_L	14_R	0.538	1.00
280_L	293_L	0.538	1.00
129_R	133_A	0.537	1.00
58_R	62_A	0.536	1.00
65_L	76_L	0.536	1.00
86_A	90_A	0.536	1.00
23_L	58_R	0.535	1.00
20_A	25_E	0.532	1.00
166_G	176_L	0.532	1.00
24_A	28_A	0.527	0.99
92_A	96_L	0.527	0.99
200_A	203_R	0.526	0.99
14_R	20_A	0.521	0.99
240_A	243_A	0.520	0.99
11_A	16_A	0.514	0.99
16_A	26_L	0.512	0.99
138_D	141_E	0.511	0.99
20_A	26_L	0.511	0.99
111_A	127_A	0.510	0.99
191_A	196_P	0.510	0.99
88_A	92_A	0.509	0.99
241_G	245_A	0.508	0.99
10_A	19_A	0.506	0.99
129_R	132_R	0.504	0.99
161_M	169_P	0.502	0.99
236_L	242_G	0.501	0.99
279_P	283_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vz0A	3	0.3621	72.4	0.919	Contact Map
3mkyB	2	0.3754	55.6	0.927	Contact Map
4umkA	2	0.3721	54.9	0.928	Contact Map
1r71A	2	0.3688	7.4	0.953	Contact Map
4nnoA	1	0.1694	2.7	0.962	Contact Map
1p4wA	1	0.2525	2.5	0.963	Contact Map
3sztA	2	0.2658	1.7	0.966	Contact Map
2rnjA	1	0.2126	1.6	0.967	Contact Map
4nqwB	1	0.2226	1.5	0.967	Contact Map
2q0oA	2	0.2625	1.4	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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