GREMLIN Database
GASA - Gibberellin regulated protein
PFAM: PF02704 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (60)
Sequences: 605 (209)
Seq/√Len: 26.9
META: 0.01

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_P43_E5.2831.00
5_A8_V3.0281.00
41_K57_P2.4030.99
13_A16_K2.3080.98
29_R50_M2.2890.98
25_T50_M2.2210.98
20_L24_G1.9610.95
13_A18_L1.9590.95
8_V11_S1.9130.95
7_A20_L1.7120.91
1_D7_A1.5690.86
25_T29_R1.5500.86
21_R25_T1.4060.80
22_A25_T1.3970.79
42_E48_A1.3470.77
25_T53_H1.2680.72
1_D5_A1.2170.69
2_C6_C1.2010.68
24_G28_A1.1330.63
17_K21_R1.1160.62
19_C44_C1.1070.61
15_R18_L1.0960.61
14_S18_L1.0690.59
37_T40_N1.0350.56
18_L21_R1.0260.55
3_G24_G1.0030.54
52_T56_K0.9930.53
15_R21_R0.9930.53
4_G8_V0.9660.51
51_K55_G0.9620.51
18_L22_A0.9140.47
36_G39_G0.9020.46
14_S39_G0.8990.46
31_L45_P0.8970.46
38_Y41_K0.8880.45
4_G28_A0.8750.44
42_E49_N0.8690.44
6_C9_R0.8550.43
48_A57_P0.8280.41
31_L48_A0.8240.40
42_E57_P0.8100.39
6_C10_C0.8100.39
24_G31_L0.8080.39
30_C34_P0.8000.39
35_P40_N0.7910.38
9_R46_C0.7900.38
25_T52_T0.7750.37
21_R54_G0.7620.36
32_C44_C0.7610.36
20_L28_A0.7470.35
3_G7_A0.7420.35
22_A54_G0.7360.34
4_G7_A0.7230.33
11_S45_P0.7230.33
45_P48_A0.7180.33
14_S37_T0.7180.33
47_Y57_P0.7180.33
4_G16_K0.7140.33
21_R53_H0.6890.31
13_A45_P0.6890.31
11_S38_Y0.6890.31
33_V36_G0.6790.30
12_K15_R0.6780.30
5_A12_K0.6740.30
5_A43_E0.6550.29
15_R39_G0.6390.28
31_L40_N0.6370.28
3_G31_L0.6320.28
4_G11_S0.6300.27
25_T54_G0.6250.27
16_K51_K0.6030.26
37_T45_P0.5990.26
2_C10_C0.5970.26
15_R37_T0.5930.25
48_A51_K0.5860.25
2_C9_R0.5820.25
21_R52_T0.5800.25
14_S21_R0.5690.24
29_R51_K0.5660.24
13_A31_L0.5620.24
24_G38_Y0.5580.23
18_L25_T0.5530.23
1_D4_G0.5430.23
5_A45_P0.5380.22
2_C26_C0.5310.22
13_A20_L0.5290.22
4_G38_Y0.5270.22
19_C46_C0.5220.21
15_R22_A0.5190.21
24_G45_P0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h9eC 1 0.6 10.8 0.888 Contact Map
2dw0A 1 0.95 3.6 0.911 Contact Map
1m6bA 1 1 2.9 0.915 Contact Map
2e3xA 1 0.95 2.9 0.915 Contact Map
1ccvA 1 0.75 2.8 0.915 Contact Map
1hx2A 1 0.7667 2.6 0.917 Contact Map
1yy9A 1 1 2.5 0.917 Contact Map
1tejA 2 0.9167 2.3 0.918 Contact Map
1pnhA 1 0.4167 2.1 0.921 Contact Map
2meoA 1 0.4167 2.1 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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