GREMLIN Database
UPF0061 - Uncharacterized ACR, YdiU/UPF0061 family
PFAM: PF02696 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 470 (449)
Sequences: 10771 (7441)
Seq/√Len: 351.1
META: 0.695

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_R335_G4.5601.00
359_D412_R4.0551.00
204_A222_Y3.4491.00
20_S118_Y3.1341.00
183_I207_V3.0781.00
21_R69_E3.0441.00
99_I105_R2.9881.00
237_I297_A2.9431.00
214_E228_E2.9121.00
196_D199_L2.8661.00
353_D416_R2.8651.00
146_I243_V2.8531.00
360_L374_F2.8361.00
303_R306_E2.8191.00
369_A374_F2.7471.00
131_S154_L2.5571.00
447_E451_E2.4921.00
235_R331_A2.4601.00
57_A63_R2.3721.00
364_M374_F2.3701.00
227_E320_A2.3521.00
39_L42_E2.3491.00
439_Y468_V2.3381.00
65_P68_A2.3351.00
452_A461_P2.3011.00
162_Y169_P2.2841.00
115_R121_G2.2761.00
231_E327_L2.2711.00
39_L178_V2.2471.00
33_V459_F2.2041.00
227_E323_G2.1911.00
297_A324_F2.1831.00
28_P159_E2.1781.00
350_E419_R2.1301.00
209_A216_A2.1041.00
255_M297_A2.0821.00
445_L448_E2.0661.00
53_P57_A2.0651.00
379_S433_R2.0261.00
298_Q325_P1.9961.00
100_D106_W1.9951.00
160_P169_P1.9651.00
73_Q187_T1.9321.00
60_S155_V1.9311.00
100_D104_R1.9081.00
424_S427_E1.8841.00
31_R156_T1.8741.00
314_V317_L1.8661.00
239_Q335_G1.8511.00
314_V318_E1.8501.00
27_V62_N1.8431.00
406_F410_L1.8351.00
204_A311_L1.8271.00
141_M264_Y1.8061.00
233_Q297_A1.7871.00
275_P365_Q1.7571.00
431_A435_V1.7541.00
55_F59_F1.7491.00
52_S55_F1.7471.00
188_F257_I1.7391.00
153_A176_T1.7251.00
205_D222_Y1.7141.00
230_V320_A1.7101.00
452_A458_D1.7061.00
17_A199_L1.7051.00
231_E331_A1.6861.00
32_L56_A1.6681.00
318_E322_E1.6211.00
366_E405_A1.6201.00
315_E318_E1.6171.00
8_D13_R1.6151.00
201_R205_D1.6091.00
74_A190_Y1.6011.00
449_A465_L1.6001.00
454_A457_G1.5941.00
212_Y232_R1.5941.00
313_A317_L1.5861.00
185_F255_M1.5811.00
429_A433_R1.5751.00
340_L360_L1.5741.00
331_A334_A1.5731.00
373_L377_R1.5711.00
136_L462_F1.5671.00
313_A316_A1.5581.00
451_E455_E1.5541.00
223_L316_A1.5451.00
42_E106_W1.5441.00
191_F199_L1.5351.00
237_I250_M1.5331.00
250_M297_A1.5271.00
136_L441_P1.5151.00
274_D365_Q1.5091.00
235_R239_Q1.5081.00
224_A227_E1.5061.00
362_A366_E1.5021.00
289_A292_N1.4931.00
44_G101_P1.4871.00
37_E51_D1.4751.00
168_T455_E1.4691.00
331_A335_G1.4631.00
380_D433_R1.4601.00
207_V257_I1.4561.00
24_P93_I1.4541.00
36_N39_L1.4391.00
323_G327_L1.4321.00
312_I317_L1.4131.00
336_M357_I1.4121.00
228_E231_E1.4051.00
18_F191_F1.4041.00
389_D393_F1.4021.00
226_L230_V1.3971.00
231_E323_G1.3961.00
20_S117_P1.3931.00
228_E232_R1.3891.00
180_P260_E1.3801.00
199_L202_Q1.3801.00
22_V117_P1.3731.00
183_I188_F1.3631.00
139_E150_R1.3621.00
449_A461_P1.3601.00
332_W336_M1.3591.00
71_L94_L1.3591.00
292_N295_A1.3551.00
448_E461_P1.3481.00
226_L305_A1.3471.00
201_R222_Y1.3471.00
36_N135_Y1.3471.00
298_Q302_A1.3451.00
390_A393_F1.3431.00
212_Y228_E1.3381.00
50_L55_F1.3311.00
333_L354_A1.3281.00
234_A238_A1.3141.00
246_V270_M1.3071.00
354_A358_E1.3051.00
333_L337_R1.3031.00
316_A320_A1.2911.00
337_R349_E1.2901.00
205_D221_P1.2901.00
276_G291_G1.2851.00
360_L364_M1.2851.00
136_L466_L1.2841.00
155_V176_T1.2781.00
215_L221_P1.2721.00
108_L178_V1.2561.00
108_L176_T1.2471.00
207_V225_L1.2431.00
319_A322_E1.2401.00
208_I225_L1.2341.00
34_A463_E1.2321.00
35_L50_L1.2301.00
10_S206_Y1.2301.00
295_A298_Q1.2211.00
189_E193_A1.2201.00
33_V156_T1.2171.00
18_F199_L1.2131.00
235_R327_L1.2081.00
390_A394_L1.2071.00
34_A135_Y1.2031.00
391_S394_L1.2021.00
238_A331_A1.1971.00
49_A52_S1.1951.00
197_T201_R1.1901.00
204_A225_L1.1891.00
127_V170_E1.1891.00
225_L229_V1.1851.00
73_Q109_Q1.1831.00
290_Y371_Y1.1801.00
147_P239_Q1.1771.00
320_A323_G1.1691.00
26_P125_R1.1671.00
221_P224_A1.1601.00
461_P464_R1.1491.00
239_Q242_R1.1441.00
33_V128_L1.1431.00
246_V277_T1.1411.00
404_A408_A1.1411.00
126_A131_S1.1351.00
452_A456_Q1.1341.00
304_L307_A1.1331.00
189_E303_R1.1251.00
238_A335_G1.1201.00
104_R180_P1.1121.00
83_F193_A1.1101.00
220_N224_A1.1101.00
218_A224_A1.1071.00
329_E354_A1.1041.00
270_M277_T1.1021.00
135_Y151_A1.1011.00
352_G355_A1.0991.00
34_A462_F1.0981.00
151_A175_L1.0961.00
185_F233_Q1.0951.00
355_A359_D1.0941.00
223_L320_A1.0841.00
416_R420_E1.0811.00
106_W178_V1.0741.00
19_Y71_L1.0731.00
225_L308_L1.0731.00
410_L414_R1.0731.00
86_Q194_R1.0701.00
241_M328_Y1.0671.00
125_R159_E1.0671.00
231_E235_R1.0601.00
430_A434_A1.0551.00
315_E319_A1.0541.00
255_M301_L1.0491.00
148_T264_Y1.0481.00
127_V130_S1.0461.00
25_T125_R1.0461.00
46_D49_A1.0421.00
198_E201_R1.0411.00
76_A83_F1.0411.00
427_E430_A1.0341.00
276_G289_A1.0341.00
41_A47_P1.0281.00
82_H85_P1.0231.00
302_A306_E1.0171.00
241_M294_P1.0171.00
425_D428_R1.0161.00
22_V93_I1.0161.00
411_A415_A1.0061.00
272_A368_E1.0061.00
463_E467_E1.0031.00
399_D403_L0.9971.00
56_A155_V0.9961.00
371_Y375_F0.9951.00
274_D277_T0.9921.00
223_L312_I0.9911.00
227_E231_E0.9901.00
76_A84_A0.9871.00
54_E63_R0.9871.00
126_A173_A0.9851.00
131_S175_L0.9851.00
17_A196_D0.9841.00
28_P125_R0.9841.00
326_E330_A0.9791.00
34_A466_L0.9771.00
35_L40_A0.9771.00
350_E353_D0.9721.00
8_D105_R0.9721.00
93_I113_S0.9711.00
336_M371_Y0.9691.00
44_G100_D0.9661.00
37_E41_A0.9651.00
138_S151_A0.9631.00
214_E232_R0.9571.00
359_D405_A0.9561.00
97_E210_R0.9551.00
236_L250_M0.9551.00
15_P19_Y0.9541.00
40_A50_L0.9521.00
59_F153_A0.9511.00
32_L35_L0.9511.00
216_A221_P0.9491.00
441_P446_V0.9481.00
337_R342_L0.9451.00
137_C267_C0.9421.00
197_T310_P0.9391.00
188_F204_A0.9351.00
105_R206_Y0.9341.00
140_A144_L0.9341.00
98_V108_L0.9341.00
229_V304_L0.9331.00
298_Q321_L0.9301.00
460_S464_R0.9301.00
408_A412_R0.9291.00
132_L450_I0.9281.00
376_R379_S0.9261.00
59_F176_T0.9261.00
15_P202_Q0.9251.00
234_A324_F0.9231.00
313_A318_E0.9221.00
227_E327_L0.9191.00
54_E57_A0.9181.00
316_A319_A0.9171.00
76_A190_Y0.9161.00
161_V172_G0.9131.00
452_A460_S0.9131.00
333_L357_I0.9131.00
225_L257_I0.9101.00
56_A59_F0.9101.00
246_V279_F0.9101.00
377_R380_D0.9101.00
204_A208_I0.9071.00
24_P64_L0.9051.00
243_V339_K0.9051.00
192_A310_P0.9051.00
137_C446_V0.9041.00
49_A55_F0.9021.00
208_I221_P0.9021.00
42_E102_D0.8991.00
449_A462_F0.8921.00
128_L132_L0.8911.00
358_E362_A0.8901.00
226_L312_I0.8901.00
212_Y215_L0.8891.00
215_L228_E0.8871.00
336_M361_L0.8801.00
218_A221_P0.8781.00
415_A418_A0.8781.00
156_T459_F0.8741.00
191_F194_R0.8741.00
208_I215_L0.8721.00
146_I239_Q0.8711.00
338_A435_V0.8701.00
220_N316_A0.8701.00
206_Y210_R0.8671.00
27_V174_V0.8661.00
51_D54_E0.8651.00
230_V234_A0.8621.00
376_R433_R0.8611.00
229_V257_I0.8581.00
339_K372_T0.8561.00
454_A459_F0.8551.00
445_L465_L0.8541.00
417_L428_R0.8521.00
8_D99_I0.8521.00
142_H150_R0.8501.00
428_R431_A0.8501.00
398_L403_L0.8501.00
422_L431_A0.8491.00
230_V327_L0.8471.00
267_C446_V0.8451.00
325_P329_E0.8451.00
408_A411_A0.8411.00
334_A338_A0.8391.00
363_L367_N0.8381.00
400_D403_L0.8371.00
261_T264_Y0.8361.00
15_P18_F0.8361.00
235_R335_G0.8341.00
74_A86_Q0.8341.00
208_I222_Y0.8331.00
382_A425_D0.8311.00
27_V60_S0.8301.00
270_M290_Y0.8301.00
431_A434_A0.8291.00
188_F203_L0.8291.00
412_R415_A0.8281.00
136_L449_A0.8281.00
327_L331_A0.8251.00
109_Q176_T0.8241.00
200_L307_A0.8231.00
64_L70_P0.8221.00
92_A109_Q0.8211.00
25_T93_I0.8191.00
9_N69_E0.8181.00
97_E105_R0.8181.00
392_L395_D0.8151.00
16_E21_R0.8151.00
217_D221_P0.8141.00
58_V65_P0.8141.00
56_A60_S0.8121.00
101_P106_W0.8111.00
380_D429_A0.8111.00
414_R417_L0.8101.00
355_A358_E0.8081.00
306_E309_L0.8071.00
162_Y168_T0.8071.00
382_A385_D0.8051.00
27_V159_E0.8051.00
323_G326_E0.8021.00
47_P55_F0.8011.00
35_L55_F0.8011.00
57_A62_N0.8001.00
43_L178_V0.7991.00
9_N13_R0.7991.00
29_A158_G0.7991.00
42_E100_D0.7981.00
389_D394_L0.7981.00
164_E170_E0.7981.00
447_E455_E0.7981.00
94_L107_D0.7961.00
233_Q237_I0.7951.00
224_A228_E0.7941.00
272_A277_T0.7911.00
47_P51_D0.7911.00
381_A414_R0.7891.00
330_A334_A0.7891.00
215_L224_A0.7851.00
132_L462_F0.7831.00
74_A194_R0.7831.00
85_P190_Y0.7831.00
222_Y225_L0.7821.00
438_K441_P0.7801.00
234_A327_L0.7791.00
164_E168_T0.7721.00
198_E202_Q0.7711.00
83_F194_R0.7711.00
305_A317_L0.7701.00
376_R438_K0.7691.00
451_E456_Q0.7661.00
86_Q190_Y0.7621.00
157_T172_G0.7611.00
413_W416_R0.7611.00
379_S429_A0.7581.00
459_F462_F0.7571.00
141_M261_T0.7551.00
428_R432_M0.7551.00
189_E306_E0.7541.00
389_D392_L0.7531.00
223_L227_E0.7521.00
420_E428_R0.7511.00
74_A191_F0.7501.00
31_R457_G0.7501.00
242_R371_Y0.7481.00
38_E41_A0.7461.00
426_A430_A0.7461.00
135_Y462_F0.7461.00
25_T28_P0.7451.00
180_P211_H0.7441.00
13_R69_E0.7411.00
51_D55_F0.7401.00
226_L317_L0.7401.00
388_D393_F0.7391.00
14_L18_F0.7381.00
22_V25_T0.7381.00
37_E47_P0.7361.00
155_V174_V0.7361.00
12_A19_Y0.7351.00
410_L413_W0.7331.00
356_L412_R0.7331.00
196_D200_L0.7290.99
390_A407_D0.7240.99
309_L314_V0.7230.99
388_D391_S0.7210.99
107_D211_H0.7210.99
201_R221_P0.7180.99
298_Q324_F0.7180.99
273_Y371_Y0.7160.99
391_S395_D0.7160.99
322_E325_P0.7160.99
37_E48_A0.7120.99
72_A93_I0.7110.99
226_L301_L0.7100.99
273_Y290_Y0.7100.99
367_N405_A0.7100.99
413_W417_L0.7100.99
46_D50_L0.7090.99
200_L310_P0.7090.99
84_A190_Y0.7050.99
376_R380_D0.7050.99
183_I211_H0.7030.99
27_V125_R0.7020.99
381_A410_L0.6990.99
356_L360_L0.6980.99
158_G457_G0.6980.99
356_L416_R0.6980.99
39_L150_R0.6960.99
327_L330_A0.6950.99
451_E454_A0.6920.99
238_A242_R0.6920.99
42_E104_R0.6910.99
230_V323_G0.6910.99
205_D208_I0.6900.99
52_S56_A0.6890.99
255_M300_N0.6860.99
25_T115_R0.6850.99
405_A408_A0.6840.99
242_R336_M0.6820.99
64_L68_A0.6820.99
409_W413_W0.6810.99
407_D411_A0.6810.99
464_R468_V0.6800.99
234_A331_A0.6800.99
326_E329_E0.6800.99
226_L321_L0.6790.99
33_V462_F0.6790.99
302_A321_L0.6790.99
137_C141_M0.6780.99
38_E42_E0.6780.99
180_P258_S0.6770.99
414_R418_A0.6760.99
208_I216_A0.6750.99
221_P225_L0.6710.99
237_I255_M0.6690.99
156_T171_P0.6690.99
383_A433_R0.6690.99
222_Y311_L0.6650.99
197_T200_L0.6650.99
239_Q331_A0.6640.99
74_A118_Y0.6600.99
361_L371_Y0.6580.99
206_Y211_H0.6580.99
298_Q322_E0.6560.99
64_L95_L0.6550.99
363_L405_A0.6540.99
171_P455_E0.6520.99
109_Q174_V0.6500.99
337_R340_L0.6490.99
73_Q107_D0.6480.99
359_D363_L0.6450.99
161_V164_E0.6440.99
388_D392_L0.6400.99
348_T420_E0.6390.99
337_R350_E0.6370.99
373_L438_K0.6360.99
27_V30_P0.6360.99
295_A325_P0.6360.99
295_A329_E0.6350.99
200_L204_A0.6340.99
83_F86_Q0.6330.99
80_F84_A0.6300.99
335_G338_A0.6300.99
10_S210_R0.6280.98
205_D209_A0.6280.98
191_F202_Q0.6250.98
252_T299_W0.6220.98
352_G416_R0.6220.98
246_V278_V0.6220.98
399_D407_D0.6200.98
462_F466_L0.6200.98
106_W260_E0.6190.98
183_I206_Y0.6190.98
448_E464_R0.6180.98
201_R204_A0.6170.98
79_Q83_F0.6170.98
360_L375_F0.6150.98
448_E452_A0.6140.98
250_M255_M0.6140.98
10_S105_R0.6130.98
11_Y73_Q0.6130.98
132_L441_P0.6120.98
230_V301_L0.6110.98
35_L59_F0.6100.98
164_E281_S0.6090.98
275_P291_G0.6080.98
225_L304_L0.6080.98
58_V68_A0.6060.98
333_L358_E0.6060.98
39_L43_L0.6060.98
379_S435_V0.6050.98
107_D182_H0.6040.98
241_M332_W0.6010.98
215_L218_A0.6000.98
340_L357_I0.6000.98
318_E321_L0.6000.98
235_R238_A0.5990.98
207_V212_Y0.5990.98
183_I257_I0.5980.98
337_R353_D0.5970.98
445_L449_A0.5970.98
121_G284_H0.5970.98
446_V450_I0.5970.98
115_R125_R0.5940.98
226_L320_A0.5940.98
308_L312_I0.5940.98
415_A419_R0.5930.98
381_A384_G0.5930.98
427_E431_A0.5930.98
48_A51_D0.5910.98
227_E319_A0.5900.98
232_R259_G0.5890.98
433_R438_K0.5880.98
128_L156_T0.5870.98
23_A69_E0.5860.98
241_M290_Y0.5850.98
419_R422_L0.5850.98
86_Q191_F0.5850.98
202_Q206_Y0.5850.98
222_Y312_I0.5840.98
338_A431_A0.5830.98
179_A262_I0.5830.98
18_F74_A0.5820.98
414_R425_D0.5810.97
9_N12_A0.5810.97
363_L366_E0.5790.97
274_D291_G0.5790.97
309_L317_L0.5770.97
23_A26_P0.5770.97
307_A310_P0.5760.97
67_G96_G0.5750.97
33_V154_L0.5750.97
407_D410_L0.5740.97
187_T190_Y0.5740.97
192_A306_E0.5740.97
142_H148_T0.5740.97
82_H285_Q0.5730.97
212_Y225_L0.5720.97
463_E466_L0.5720.97
239_Q338_A0.5700.97
393_F398_L0.5700.97
161_V170_E0.5700.97
41_A46_D0.5690.97
58_V64_L0.5680.97
22_V113_S0.5680.97
383_A425_D0.5660.97
68_A96_G0.5660.97
132_L459_F0.5660.97
215_L220_N0.5660.97
235_R334_A0.5660.97
278_V281_S0.5640.97
334_A349_E0.5640.97
23_A64_L0.5630.97
199_L203_L0.5610.97
359_D362_A0.5600.97
51_D56_A0.5600.97
139_E142_H0.5590.97
413_W428_R0.5580.97
147_P236_L0.5570.97
107_D206_Y0.5570.97
349_E352_G0.5550.97
58_V63_R0.5540.97
460_S463_E0.5520.97
157_T174_V0.5520.97
110_L113_S0.5510.97
227_E230_V0.5510.97
170_E447_E0.5510.97
236_L239_Q0.5490.96
44_G102_D0.5490.96
185_F304_L0.5480.96
360_L369_A0.5470.96
132_L154_L0.5470.96
17_A202_Q0.5470.96
30_P60_S0.5470.96
17_A198_E0.5460.96
328_Y332_W0.5460.96
336_M375_F0.5450.96
87_L118_Y0.5430.96
11_Y187_T0.5420.96
36_N139_E0.5420.96
39_L106_W0.5420.96
160_P171_P0.5410.96
432_M437_P0.5410.96
363_L406_F0.5410.96
382_A429_A0.5410.96
270_M273_Y0.5400.96
400_D404_A0.5400.96
437_P440_I0.5390.96
102_D106_W0.5380.96
97_E107_D0.5360.96
187_T191_F0.5350.96
137_C269_F0.5340.96
14_L17_A0.5320.96
74_A84_A0.5320.96
309_L312_I0.5320.96
35_L52_S0.5300.96
347_E352_G0.5290.96
62_N174_V0.5280.96
445_L468_V0.5250.95
34_A154_L0.5240.95
154_L462_F0.5230.95
372_T440_I0.5220.95
425_D429_A0.5220.95
62_N125_R0.5210.95
209_A221_P0.5200.95
433_R437_P0.5200.95
242_R357_I0.5190.95
22_V71_L0.5170.95
127_V173_A0.5170.95
49_A58_V0.5170.95
273_Y277_T0.5170.95
448_E451_E0.5170.95
207_V229_V0.5160.95
246_V290_Y0.5150.95
32_L55_F0.5150.95
315_E322_E0.5150.95
342_L348_T0.5130.95
137_C268_A0.5130.95
35_L47_P0.5100.95
98_V106_W0.5100.95
11_Y15_P0.5080.95
296_I300_N0.5080.95
222_Y226_L0.5070.95
73_Q94_L0.5070.95
76_A82_H0.5060.94
329_E333_L0.5050.94
12_A71_L0.5050.94
80_F85_P0.5040.94
353_D356_L0.5020.94
382_A428_R0.5000.94
312_I316_A0.5000.94
38_E143_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nd4A 2 0.4787 55.2 0.979 Contact Map
3dxpA 2 0.5979 52.5 0.979 Contact Map
2ppqA 2 0.5617 50.1 0.979 Contact Map
3atsA 1 0.5 35 0.981 Contact Map
4oh4A 1 0.517 32.1 0.981 Contact Map
4h05A 1 0.4766 30.7 0.982 Contact Map
2olcA 3 0.5319 25 0.982 Contact Map
1zylA 1 0.6128 24.9 0.982 Contact Map
2pywA 2 0.7553 19.4 0.983 Contact Map
4orkA 1 0.5468 19 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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