GREMLIN Database
Na_Pi_cotrans - Na+/Pi-cotransporter
PFAM: PF02690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 26292 (15686)
Seq/√Len: 1335.3
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V73_V3.1321.00
31_N34_L3.0031.00
30_S34_L2.9891.00
94_K97_A2.7801.00
66_T69_Q2.7231.00
99_A103_I2.5411.00
44_A83_I2.4191.00
4_F8_L2.3571.00
115_K118_L2.3031.00
52_T77_A2.2661.00
36_V79_I2.1491.00
133_L137_L2.1361.00
7_K11_D2.1301.00
23_R27_K2.1021.00
20_R23_R2.0891.00
110_F123_R1.9601.00
53_T57_V1.8271.00
19_D23_R1.7071.00
97_A101_P1.6531.00
53_T74_I1.6301.00
97_A100_L1.6281.00
120_N123_R1.6021.00
113_S118_L1.5491.00
22_R26_A1.5081.00
129_G132_F1.4961.00
109_L122_G1.4831.00
14_K17_A1.4361.00
125_L129_G1.4171.00
32_P72_G1.3991.00
96_A99_A1.3941.00
86_Q89_S1.3811.00
104_G108_L1.3691.00
19_D22_R1.3571.00
95_I98_L1.3081.00
119_K123_R1.3041.00
92_A97_A1.2841.00
1_L130_L1.2781.00
10_S14_K1.2591.00
118_L121_I1.2531.00
81_T84_T1.2521.00
101_P104_G1.2381.00
53_T77_A1.2271.00
56_V70_A1.2171.00
107_V111_L1.2071.00
99_A102_L1.1961.00
23_R26_A1.1761.00
18_G22_R1.1631.00
52_T73_V1.1571.00
46_I52_T1.1511.00
35_G72_G1.1501.00
121_I125_L1.1481.00
98_L101_P1.1471.00
103_I106_G1.1431.00
109_L113_S1.1371.00
102_L106_G1.1301.00
126_L129_G1.1251.00
42_V52_T1.1021.00
93_F97_A1.0881.00
129_G133_L1.0781.00
11_D14_K1.0761.00
5_G134_G1.0691.00
95_I102_L1.0631.00
93_F100_L1.0591.00
68_A72_G1.0501.00
117_R120_N1.0401.00
58_G62_A1.0381.00
16_L121_I1.0371.00
46_I51_A1.0281.00
100_L103_I1.0241.00
107_V110_F1.0111.00
108_L112_F1.0091.00
96_A136_D1.0041.00
95_I99_A0.9971.00
11_D15_K0.9951.00
40_A83_I0.9881.00
74_I78_N0.9861.00
92_A96_A0.9811.00
110_F113_S0.9741.00
94_K99_A0.9741.00
116_K119_K0.9741.00
104_G107_V0.9731.00
100_L104_G0.9691.00
83_I86_Q0.9631.00
112_F118_L0.9601.00
27_K30_S0.9561.00
32_P68_A0.9451.00
113_S119_K0.9441.00
103_I129_G0.9401.00
92_A95_I0.9391.00
29_T69_Q0.9181.00
97_A103_I0.9181.00
110_F119_K0.9171.00
60_V70_A0.8891.00
121_I124_I0.8871.00
58_G61_N0.8861.00
15_K123_R0.8831.00
7_K10_S0.8811.00
33_L37_L0.8801.00
84_T88_V0.8681.00
101_P105_I0.8591.00
102_L105_I0.8561.00
75_L78_N0.8481.00
27_K34_L0.8441.00
47_Q50_S0.8421.00
66_T70_A0.8381.00
35_G73_V0.8341.00
20_R24_I0.8311.00
12_G15_K0.8301.00
100_L133_L0.8281.00
93_F96_A0.8261.00
82_T86_Q0.8241.00
92_A103_I0.8211.00
122_G125_L0.8191.00
117_R121_I0.8191.00
96_A103_I0.8171.00
37_L41_L0.8161.00
48_S51_A0.8101.00
97_A102_L0.8101.00
93_F99_A0.8021.00
95_I100_L0.7981.00
94_K101_P0.7961.00
113_S116_K0.7871.00
37_L40_A0.7821.00
71_I75_L0.7821.00
56_V77_A0.7821.00
92_A99_A0.7761.00
8_L11_D0.7751.00
36_V76_G0.7721.00
44_A47_Q0.7641.00
109_L112_F0.7621.00
103_I107_V0.7561.00
123_R127_G0.7531.00
10_S13_L0.7351.00
94_K103_I0.7311.00
12_G123_R0.7311.00
107_V126_L0.7311.00
57_V61_N0.7301.00
67_L70_A0.7261.00
126_L130_L0.7231.00
92_A101_P0.7221.00
93_F106_G0.7041.00
41_L45_L0.7031.00
116_K120_N0.6981.00
43_T52_T0.6981.00
7_K14_K0.6971.00
47_Q84_T0.6921.00
34_L38_V0.6761.00
54_V58_G0.6741.00
119_K125_L0.6691.00
97_A104_G0.6671.00
42_V46_I0.6671.00
96_A102_L0.6611.00
95_I103_I0.6551.00
39_G73_V0.6511.00
49_S81_T0.6501.00
18_G21_L0.6471.00
96_A100_L0.6361.00
133_L136_D0.6341.00
46_I55_M0.6301.00
59_F64_L0.6261.00
109_L118_L0.6251.00
42_V55_M0.6201.00
103_I133_L0.6171.00
88_V91_G0.6141.00
36_V75_L0.6081.00
36_V72_G0.6081.00
36_V40_A0.6041.00
40_A79_I0.5991.00
56_V65_L0.5981.00
101_P106_G0.5971.00
12_G16_L0.5971.00
47_Q87_L0.5961.00
78_N85_A0.5921.00
40_A44_A0.5871.00
106_G122_G0.5831.00
125_L128_F0.5801.00
98_L103_I0.5731.00
17_A20_R0.5721.00
9_M12_G0.5711.00
126_L133_L0.5701.00
68_A71_I0.5701.00
94_K100_L0.5671.00
124_I127_G0.5651.00
130_L133_L0.5631.00
96_A106_G0.5611.00
57_V60_V0.5571.00
99_A129_G0.5571.00
35_G69_Q0.5561.00
122_G129_G0.5521.00
93_F98_L0.5511.00
120_N124_I0.5511.00
97_A106_G0.5481.00
15_K120_N0.5461.00
107_V112_F0.5421.00
32_P35_G0.5371.00
94_K98_L0.5371.00
39_G56_V0.5361.00
12_G127_G0.5341.00
34_L37_L0.5311.00
6_M10_S0.5211.00
72_G75_L0.5201.00
29_T73_V0.5161.00
74_I77_A0.5091.00
100_L106_G0.5091.00
99_A106_G0.5081.00
69_Q72_G0.5061.00
9_M13_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.9281 2.1 0.926 Contact Map
1pw4A 1 0.9353 1.7 0.93 Contact Map
3wu2I 1 0.2734 1.4 0.933 Contact Map
2wscK 1 0.4676 1.1 0.936 Contact Map
1fdmA 1 0.1223 1.1 0.938 Contact Map
3i33A 1 0.3453 1 0.938 Contact Map
4xk8K 1 0.223 1 0.94 Contact Map
3o7qA 1 0.7914 0.9 0.941 Contact Map
3ip0A 2 0.4748 0.9 0.941 Contact Map
3wu2J 1 0.1007 0.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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