GREMLIN Database
FtsX - FtsX-like permease family
PFAM: PF02687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (118)
Sequences: 111278 (76346)
Seq/√Len: 7028.2
META: 0.781

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_I47_F3.0991.00
39_S42_Q2.9661.00
110_L114_R2.6141.00
51_S109_G2.5401.00
90_D93_V2.1271.00
26_R50_E2.1091.00
49_T53_L2.0851.00
44_L114_R2.0831.00
118_R121_P2.0051.00
114_R118_R1.9621.00
45_R49_T1.8961.00
91_P95_L1.8591.00
71_R75_S1.8511.00
59_G98_L1.8501.00
33_R46_Q1.8461.00
71_R74_S1.8241.00
33_R38_A1.7351.00
59_G63_L1.7301.00
83_L86_P1.7281.00
68_L71_R1.6671.00
55_A105_G1.5901.00
34_K40_R1.5841.00
92_W96_L1.5451.00
62_G66_G1.5421.00
92_W95_L1.5251.00
84_A87_I1.4871.00
7_A14_G1.4841.00
88_S92_W1.4411.00
41_R45_R1.4351.00
113_A117_A1.4251.00
12_C104_V1.4121.00
40_R117_A1.4051.00
26_R29_E1.3891.00
19_M51_S1.3821.00
59_G101_S1.3561.00
64_L68_L1.3451.00
52_L106_L1.3061.00
24_T27_T1.2831.00
64_L67_L1.2781.00
68_L72_L1.2561.00
67_L71_R1.2341.00
60_L64_L1.2241.00
42_Q45_R1.2091.00
44_L110_L1.2031.00
38_A42_Q1.2021.00
88_S91_P1.2021.00
72_L76_L1.2001.00
40_R118_R1.1901.00
72_L75_S1.1611.00
29_E33_R1.1561.00
95_L99_L1.1541.00
61_L64_L1.1281.00
114_R117_A1.1241.00
108_A112_P1.1191.00
44_L117_A1.0731.00
98_L102_L1.0721.00
16_M20_L1.0471.00
84_A88_S1.0461.00
44_L113_A1.0381.00
17_N21_A1.0081.00
67_L89_I1.0051.00
58_G62_G1.0001.00
103_L107_L0.9941.00
16_M108_A0.9931.00
75_S78_P0.9761.00
55_A101_S0.9701.00
34_K43_I0.9691.00
38_A43_I0.9641.00
50_E53_L0.9621.00
95_L98_L0.9561.00
57_I60_L0.9541.00
40_R44_L0.9531.00
70_A74_S0.9471.00
55_A59_G0.9371.00
21_A25_E0.9361.00
74_S78_P0.9341.00
93_V97_A0.9311.00
94_L98_L0.9171.00
115_R119_L0.8981.00
109_G113_A0.8981.00
48_L110_L0.8971.00
27_T31_G0.8961.00
49_T52_L0.8921.00
5_G9_L0.8921.00
113_A116_A0.8861.00
28_R32_I0.8771.00
46_Q49_T0.8761.00
100_L104_V0.8751.00
51_S55_A0.8741.00
65_L69_L0.8651.00
19_M22_S0.8591.00
69_L72_L0.8531.00
99_L103_L0.8491.00
27_T119_L0.8271.00
104_V108_A0.8201.00
93_V96_L0.8151.00
31_G35_A0.8131.00
12_C108_A0.7981.00
48_L52_L0.7921.00
73_L76_L0.7861.00
96_L100_L0.7741.00
52_L105_G0.7731.00
22_S50_E0.7601.00
115_R118_R0.7591.00
26_R47_F0.7561.00
74_S87_I0.7501.00
66_G70_A0.7371.00
89_I94_L0.7321.00
91_P94_L0.7311.00
63_L94_L0.7311.00
100_L103_L0.7201.00
111_Y115_R0.7151.00
52_L55_A0.7091.00
89_I93_V0.7091.00
71_R87_I0.7081.00
65_L68_L0.7071.00
56_L60_L0.6991.00
30_I43_I0.6981.00
80_G83_L0.6961.00
27_T115_R0.6941.00
41_R44_L0.6941.00
53_L56_L0.6881.00
18_L22_S0.6861.00
56_L59_G0.6761.00
83_L87_I0.6751.00
10_V14_G0.6741.00
20_L111_Y0.6701.00
81_L84_A0.6671.00
97_A101_S0.6661.00
55_A102_L0.6651.00
99_L102_L0.6631.00
96_L99_L0.6561.00
107_L110_L0.6531.00
63_L98_L0.6511.00
19_M54_L0.6461.00
56_L102_L0.6381.00
78_P84_A0.6361.00
29_E32_I0.6311.00
24_T115_R0.6181.00
44_L48_L0.6121.00
14_G33_R0.6021.00
32_I35_A0.5971.00
40_R114_R0.5971.00
78_P81_L0.5921.00
73_L77_L0.5911.00
77_L83_L0.5861.00
53_L57_I0.5841.00
48_L106_L0.5801.00
111_Y114_R0.5771.00
63_L67_L0.5741.00
55_A109_G0.5721.00
19_M23_V0.5681.00
57_I61_L0.5651.00
70_A73_L0.5641.00
85_L88_S0.5631.00
3_F21_A0.5631.00
52_L56_L0.5491.00
82_P85_L0.5491.00
98_L101_S0.5461.00
18_L33_R0.5431.00
61_L65_L0.5411.00
23_V47_F0.5361.00
60_L63_L0.5351.00
20_L24_T0.5331.00
23_V30_I0.5311.00
83_L88_S0.5301.00
33_R42_Q0.5261.00
50_E54_L0.5261.00
107_L111_Y0.5221.00
51_S113_A0.5211.00
67_L70_A0.5111.00
106_L110_L0.5111.00
4_A7_A0.5111.00
85_L89_I0.5091.00
15_I58_G0.5011.00
67_L94_L0.5001.00
101_S105_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.9752 30.4 0.84 Contact Map
3rlfF 1 0.9091 18.5 0.856 Contact Map
4av3A 2 0.7851 16.8 0.859 Contact Map
4tquM 1 0.9835 15.6 0.861 Contact Map
4ymuD 2 0.9669 12.7 0.866 Contact Map
4il3A 1 0.843 7.5 0.879 Contact Map
2onkC 2 0.9504 6.7 0.882 Contact Map
3d31C 2 0.9008 5.1 0.888 Contact Map
4eneA 2 0.7107 4.2 0.893 Contact Map
4aw6A 2 0.9008 4.1 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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