GREMLIN Database
Colicin_V - Colicin V production protein
PFAM: PF02674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 144 (140)
Sequences: 46325 (33719)
Seq/√Len: 2849.8
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A100_A4.0711.00
12_S107_G3.0441.00
24_E106_R2.9831.00
30_G75_G2.6861.00
44_P47_P2.5111.00
37_L71_V2.5111.00
14_L18_R2.4581.00
13_A104_L2.4071.00
36_L40_R2.0481.00
135_L138_Y2.0131.00
83_R95_D1.9301.00
21_F98_L1.9301.00
11_L15_L1.9221.00
3_I7_A1.9021.00
19_R24_E1.8931.00
17_F100_A1.8901.00
41_F44_P1.8761.00
42_Y60_A1.8571.00
130_I136_A1.7311.00
136_A140_E1.6241.00
15_L18_R1.5501.00
46_A60_A1.5301.00
56_P60_A1.4791.00
80_R84_K1.4761.00
6_L10_L1.4341.00
90_G93_G1.4141.00
5_I111_V1.4041.00
133_S136_A1.3921.00
41_F67_I1.3831.00
131_Q134_R1.3761.00
34_G38_A1.3761.00
37_L41_F1.3541.00
45_L48_L1.3481.00
9_L107_G1.3321.00
77_L81_L1.3221.00
5_I135_L1.3201.00
26_L79_G1.3191.00
44_P48_L1.3111.00
67_I71_V1.3071.00
45_L67_I1.2891.00
12_S16_G1.2881.00
47_P50_S1.2731.00
7_A11_L1.2431.00
12_S106_R1.2371.00
16_G99_G1.2351.00
57_A60_A1.2331.00
76_S80_R1.2301.00
72_L76_S1.2131.00
103_G107_G1.2121.00
40_R44_P1.2121.00
134_R137_P1.2061.00
11_L14_L1.2011.00
134_R138_Y1.1981.00
68_F72_L1.1861.00
49_L66_L1.1771.00
15_L19_R1.1691.00
114_L118_L1.1521.00
59_A63_A1.1451.00
66_L69_L1.1431.00
22_V95_D1.1351.00
128_E132_E1.0981.00
17_F96_R1.0911.00
115_L119_A1.0871.00
73_I77_L1.0811.00
9_L104_L1.0811.00
123_L126_L1.0741.00
50_S56_P1.0741.00
1_L129_W1.0711.00
116_L119_A1.0701.00
50_S59_A1.0571.00
35_L39_L1.0511.00
8_I107_G1.0451.00
23_R27_S1.0411.00
34_G71_V1.0401.00
19_R27_S1.0251.00
119_A122_P1.0241.00
114_L117_L1.0211.00
42_Y64_F1.0031.00
38_A64_F0.9991.00
70_V73_I0.9931.00
48_L51_G0.9861.00
24_E103_G0.9811.00
89_S93_G0.9771.00
107_G111_V0.9761.00
45_L63_A0.9641.00
37_L40_R0.9531.00
89_S92_G0.9521.00
23_R83_R0.9511.00
56_P59_A0.9481.00
13_A17_F0.9361.00
129_W132_E0.9321.00
10_L14_L0.9181.00
12_S103_G0.9171.00
46_A50_S0.9151.00
121_F124_P0.9081.00
21_F95_D0.9031.00
15_L24_E0.8961.00
94_L97_L0.8891.00
55_S58_L0.8871.00
76_S79_G0.8851.00
46_A63_A0.8851.00
43_P47_P0.8831.00
16_G24_E0.8811.00
93_G97_L0.8761.00
19_R23_R0.8741.00
101_V105_L0.8731.00
118_L122_P0.8721.00
127_P131_Q0.8701.00
24_E102_F0.8671.00
106_R109_L0.8561.00
53_I59_A0.8351.00
83_R87_K0.8301.00
3_I6_L0.8261.00
40_R43_P0.8261.00
39_L64_F0.8201.00
120_L124_P0.8201.00
8_I111_V0.8081.00
22_V86_V0.8081.00
23_R79_G0.7951.00
122_P125_S0.7861.00
103_G106_R0.7851.00
106_R110_I0.7791.00
42_Y46_A0.7671.00
30_G34_G0.7651.00
97_L101_V0.7601.00
81_L84_K0.7521.00
8_I12_S0.7461.00
108_L112_S0.7371.00
75_G79_G0.7371.00
9_L13_A0.7351.00
71_V75_G0.7331.00
85_L88_A0.7311.00
43_P60_A0.7271.00
47_P51_G0.7271.00
81_L85_L0.7211.00
14_L17_F0.7181.00
39_L43_P0.7171.00
114_L119_A0.7161.00
42_Y63_A0.7091.00
121_F125_S0.7061.00
58_L62_L0.7021.00
4_I8_I0.7011.00
60_A64_F0.7001.00
17_F93_G0.6971.00
112_S139_L0.6941.00
122_P126_L0.6841.00
74_L78_L0.6781.00
85_L89_S0.6741.00
58_L61_I0.6721.00
101_V104_L0.6711.00
38_A68_F0.6701.00
34_G68_F0.6691.00
80_R83_R0.6681.00
20_G99_G0.6681.00
30_G79_G0.6631.00
37_L67_I0.6521.00
93_G96_R0.6451.00
63_A67_I0.6441.00
9_L12_S0.6421.00
1_L5_I0.6401.00
34_G72_L0.6361.00
120_L123_L0.6331.00
115_L118_L0.6231.00
92_G96_R0.6211.00
98_L102_F0.6211.00
119_A124_P0.6161.00
104_L107_G0.6141.00
49_L63_A0.6081.00
9_L111_V0.6001.00
124_P127_P0.5991.00
79_G82_L0.5981.00
64_F67_I0.5951.00
117_L121_F0.5931.00
102_F106_R0.5871.00
33_L37_L0.5861.00
91_L95_D0.5831.00
55_S59_A0.5831.00
115_L136_A0.5731.00
51_G54_L0.5721.00
61_I64_F0.5711.00
33_L75_G0.5701.00
29_A33_L0.5641.00
131_Q137_P0.5631.00
25_L102_F0.5621.00
35_L64_F0.5591.00
21_F102_F0.5581.00
6_L135_L0.5571.00
95_D99_G0.5541.00
119_A140_E0.5531.00
43_P46_A0.5491.00
31_W72_L0.5451.00
137_P140_E0.5441.00
46_A49_L0.5431.00
104_L108_L0.5401.00
13_A16_G0.5391.00
72_L75_G0.5391.00
98_L101_V0.5371.00
57_A61_I0.5351.00
8_I11_L0.5331.00
24_E27_S0.5311.00
60_A63_A0.5261.00
113_L116_L0.5241.00
29_A32_V0.5211.00
74_L77_L0.5181.00
9_L108_L0.5161.00
54_L59_A0.5091.00
78_L81_L0.5071.00
136_A139_L0.5031.00
38_A42_Y0.5021.00
13_A103_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.3889 18.1 0.87 Contact Map
3udcA 3 0.6319 7.6 0.891 Contact Map
4tkrA 2 0.8889 3.1 0.909 Contact Map
4hfiA 3 0.7778 2.1 0.917 Contact Map
2nwlA 3 0.7569 1.9 0.919 Contact Map
3wajA 1 0.7778 1.9 0.919 Contact Map
3rlbA 1 0.8472 1.7 0.921 Contact Map
2zy9A 2 0.7361 1.5 0.924 Contact Map
3j9pD 4 0.9792 1.5 0.924 Contact Map
4rp9A 2 0.9236 1.4 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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