GREMLIN Database
BacA - Bacitracin resistance protein BacA
PFAM: PF02673 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (204)
Sequences: 38511 (22759)
Seq/√Len: 1593.5
META: 0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_D145_R3.7761.00
114_A132_G3.1541.00
51_I152_I2.6461.00
107_D136_L2.6421.00
64_A154_T2.5931.00
123_V128_A2.4301.00
89_I203_G2.3951.00
139_S142_A2.3241.00
37_L159_G2.2661.00
60_A150_L2.2351.00
185_R189_R2.1431.00
60_A146_F2.1401.00
87_A120_I2.1351.00
92_G200_I2.0841.00
104_T107_D2.0621.00
185_R188_K2.0581.00
72_K162_E2.0331.00
61_T154_T2.0141.00
85_A203_G2.0121.00
6_I175_V1.9651.00
160_L164_L1.9611.00
46_Y181_K1.9241.00
67_V116_A1.9191.00
2_I171_V1.8791.00
141_E188_K1.8531.00
39_T176_G1.8471.00
59_V105_W1.8441.00
193_K197_I1.8081.00
76_E162_E1.7631.00
8_Q39_T1.7541.00
7_V25_A1.7471.00
181_K185_R1.7191.00
61_T65_A1.6651.00
56_L105_W1.6591.00
56_L108_A1.6351.00
171_V175_V1.6331.00
74_F78_L1.6061.00
5_G171_V1.6011.00
64_A116_A1.5891.00
83_V87_A1.5861.00
41_L173_F1.5801.00
65_A69_L1.5791.00
173_F177_Y1.5581.00
109_L113_L1.5221.00
186_Y190_H1.5101.00
45_V48_R1.4981.00
45_V173_F1.4851.00
133_G143_A1.4821.00
98_A131_T1.4751.00
157_G161_L1.4481.00
144_A184_L1.4451.00
65_A157_G1.4301.00
96_L196_A1.4251.00
74_F77_A1.4241.00
106_K110_L1.4021.00
197_I201_A1.3881.00
111_I133_G1.3711.00
93_I97_L1.3681.00
38_G169_F1.3651.00
86_I90_V1.3551.00
71_F74_F1.3451.00
4_L22_L1.2831.00
110_L136_L1.2811.00
161_L164_L1.2761.00
65_A68_G1.2571.00
133_G138_L1.2291.00
91_G123_V1.2241.00
48_R52_L1.2231.00
196_A200_I1.2141.00
72_K76_E1.2031.00
103_L138_L1.2001.00
96_L193_K1.1961.00
96_L200_I1.1961.00
83_V120_I1.1821.00
110_L132_G1.1701.00
194_P197_I1.1641.00
99_E193_K1.1601.00
151_A155_I1.1561.00
91_G199_R1.1551.00
40_L152_I1.1441.00
49_K53_R1.1281.00
89_I200_I1.1271.00
107_D138_L1.1181.00
94_L131_T1.1121.00
22_L32_D1.1091.00
34_V169_F1.1081.00
144_A187_V1.1071.00
175_V179_A1.1021.00
35_I168_G1.1011.00
177_Y181_K1.1001.00
26_P32_D1.0971.00
129_T147_S1.0861.00
200_I204_L1.0801.00
92_G196_A1.0701.00
49_K52_L1.0681.00
95_L131_T1.0641.00
20_G84_V1.0541.00
71_F75_I1.0541.00
156_L160_L1.0511.00
46_Y177_Y1.0431.00
107_D110_L1.0411.00
100_L142_A1.0381.00
111_I150_L1.0331.00
182_W185_R1.0301.00
56_L103_L1.0291.00
116_A119_L1.0281.00
4_L25_A1.0281.00
2_I167_V1.0261.00
113_L117_L1.0231.00
6_I171_V1.0061.00
36_H155_I1.0021.00
141_E145_R0.9911.00
3_I7_V0.9861.00
114_A128_A0.9831.00
46_Y184_L0.9831.00
11_T16_V0.9811.00
24_L202_L0.9801.00
47_F184_L0.9761.00
93_I200_I0.9691.00
30_A34_V0.9671.00
54_A58_I0.9531.00
95_L127_G0.9521.00
31_F35_I0.9521.00
99_E140_R0.9511.00
44_L51_I0.9511.00
23_I84_V0.9381.00
92_G199_R0.9381.00
178_L181_K0.9361.00
40_L156_L0.9291.00
110_L114_A0.9281.00
174_V178_L0.9251.00
98_A135_L0.9241.00
113_L116_A0.9221.00
73_D77_A0.9131.00
186_Y194_P0.9021.00
94_L128_A0.9001.00
84_V88_L0.9001.00
191_S194_P0.9001.00
72_K161_L0.8971.00
33_V162_E0.8911.00
146_F150_L0.8891.00
24_L88_L0.8861.00
34_V165_L0.8851.00
167_V171_V0.8661.00
64_A119_L0.8651.00
67_V71_F0.8651.00
23_I27_A0.8601.00
75_I119_L0.8581.00
67_V119_L0.8531.00
89_I93_I0.8451.00
47_F145_R0.8441.00
67_V70_L0.8371.00
66_I70_L0.8371.00
97_L135_L0.8351.00
58_I62_I0.8351.00
103_L142_A0.8351.00
55_W59_V0.8281.00
193_K196_A0.8251.00
87_A90_V0.8211.00
45_V177_Y0.8201.00
31_F168_G0.7991.00
196_A199_R0.7951.00
150_L154_T0.7921.00
130_I192_F0.7911.00
57_L150_L0.7901.00
27_A82_P0.7891.00
83_V86_I0.7871.00
29_L32_D0.7781.00
88_L199_R0.7761.00
157_G160_L0.7751.00
88_L202_L0.7721.00
73_D76_E0.7711.00
56_L104_T0.7691.00
61_T150_L0.7661.00
166_L170_V0.7651.00
55_W105_W0.7621.00
166_L169_F0.7601.00
69_L161_L0.7571.00
106_K136_L0.7511.00
179_A182_W0.7511.00
67_V113_L0.7501.00
128_A132_G0.7461.00
46_Y180_I0.7431.00
44_L152_I0.7391.00
197_I200_I0.7331.00
181_K188_K0.7331.00
63_P109_L0.7321.00
117_L123_V0.7291.00
165_L169_F0.7241.00
169_F172_A0.7221.00
130_I144_A0.7201.00
87_A123_V0.7191.00
84_V87_A0.7171.00
105_W109_L0.7111.00
142_A145_R0.7111.00
96_L99_E0.7091.00
69_L72_K0.7081.00
100_L103_L0.7061.00
57_L149_L0.7051.00
131_T135_L0.7041.00
29_L36_H0.7031.00
47_F50_D0.7021.00
179_A183_L0.7011.00
111_I138_L0.6941.00
87_A91_G0.6881.00
190_H194_P0.6831.00
111_I146_F0.6811.00
169_F173_F0.6791.00
21_H198_Y0.6781.00
90_V123_V0.6751.00
103_L146_F0.6731.00
44_L48_R0.6721.00
91_G94_L0.6721.00
30_A33_V0.6671.00
175_V178_L0.6661.00
110_L113_L0.6661.00
23_I26_P0.6631.00
155_I159_G0.6631.00
37_L169_F0.6621.00
168_G172_A0.6621.00
88_L122_G0.6601.00
23_I32_D0.6591.00
199_R202_L0.6571.00
95_L192_F0.6521.00
117_L128_A0.6451.00
85_A89_I0.6451.00
153_P156_L0.6421.00
62_I66_I0.6421.00
103_L108_A0.6401.00
3_I25_A0.6391.00
38_G172_A0.6381.00
103_L107_D0.6371.00
64_A67_V0.6301.00
184_L188_K0.6281.00
64_A68_G0.6281.00
20_G24_L0.6281.00
69_L157_G0.6231.00
91_G95_L0.6211.00
172_A175_V0.6191.00
107_D133_G0.6181.00
91_G131_T0.6171.00
77_A80_R0.6171.00
37_L41_L0.6121.00
118_A121_P0.6081.00
201_A204_L0.6061.00
36_H39_T0.6021.00
170_V173_F0.6011.00
59_V109_L0.5991.00
91_G117_L0.5941.00
88_L91_G0.5931.00
61_T157_G0.5921.00
134_L140_R0.5911.00
33_V159_G0.5901.00
45_V49_K0.5901.00
174_V177_Y0.5891.00
25_A28_L0.5881.00
78_L120_I0.5881.00
33_V158_A0.5861.00
36_H40_L0.5851.00
186_Y191_S0.5851.00
99_E134_L0.5851.00
63_P66_I0.5811.00
23_I82_P0.5811.00
38_G42_A0.5801.00
30_A162_E0.5801.00
20_G88_L0.5801.00
188_K191_S0.5701.00
187_V192_F0.5681.00
29_L80_R0.5681.00
180_I184_L0.5671.00
199_R203_G0.5651.00
51_I149_L0.5631.00
1_A5_G0.5631.00
8_Q36_H0.5621.00
13_F176_G0.5621.00
108_A112_G0.5611.00
51_I54_A0.5601.00
92_G96_L0.5591.00
6_I10_L0.5571.00
42_A173_F0.5541.00
182_W186_Y0.5521.00
70_L73_D0.5461.00
90_V94_L0.5431.00
41_L169_F0.5391.00
82_P85_A0.5381.00
5_G9_G0.5371.00
101_E107_D0.5361.00
133_G136_L0.5331.00
13_F42_A0.5311.00
66_I69_L0.5311.00
37_L156_L0.5281.00
8_Q19_S0.5271.00
43_V180_I0.5261.00
139_S143_A0.5231.00
95_L99_E0.5231.00
10_L16_V0.5181.00
76_E80_R0.5151.00
24_L82_P0.5151.00
34_V159_G0.5141.00
70_L74_F0.5111.00
63_P68_G0.5091.00
9_G179_A0.5071.00
111_I136_L0.5031.00
13_F22_L0.5031.00
24_L84_V0.5011.00
43_V151_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jb0M 1 0.1512 6 0.952 Contact Map
4c48C 1 0.1268 5.7 0.953 Contact Map
3wajA 1 0.9415 2.7 0.96 Contact Map
3if8A 1 0.1707 2.5 0.96 Contact Map
3rceA 1 0.8732 2.3 0.961 Contact Map
1sz7A 2 0.2098 1.8 0.963 Contact Map
3ux4A 3 0.439 1.7 0.964 Contact Map
1fdmA 1 0.2439 1.7 0.964 Contact Map
4x5mA 2 0.2195 1.5 0.965 Contact Map
4p6vD 1 0.7659 1.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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