BacA - PFAM28P - GREMLIN Contacts

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BacA - Bacitracin resistance protein BacA

PFAM:	PF02673	Sequences: AIILGIVQGLTEFLPVSSSGHLILAPALLAFDVVIHLGTLLAVLVYFRKDILRAWLLIVATIPAAIVGLLFKDFIEALLRSPVVAIALIVGGILLLLAELEDLTWKDALLIGLAQALALIPGVSRSGATITGGLLLGLSREAAARFSFLLAIPTILGAGLLELLLLVGFVVAFVVGYLAIKWLLRYVKRHSFKPFAIYRIALGLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	205 (204)
Sequences:	38511 (22759)
Seq/√Len:	1593.5
META:	0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_D	145_R	3.776	1.00
114_A	132_G	3.154	1.00
51_I	152_I	2.646	1.00
107_D	136_L	2.642	1.00
64_A	154_T	2.593	1.00
123_V	128_A	2.430	1.00
89_I	203_G	2.395	1.00
139_S	142_A	2.324	1.00
37_L	159_G	2.266	1.00
60_A	150_L	2.235	1.00
185_R	189_R	2.143	1.00
60_A	146_F	2.140	1.00
87_A	120_I	2.135	1.00
92_G	200_I	2.084	1.00
104_T	107_D	2.062	1.00
185_R	188_K	2.058	1.00
72_K	162_E	2.033	1.00
61_T	154_T	2.014	1.00
85_A	203_G	2.012	1.00
6_I	175_V	1.965	1.00
160_L	164_L	1.961	1.00
46_Y	181_K	1.924	1.00
67_V	116_A	1.919	1.00
2_I	171_V	1.879	1.00
141_E	188_K	1.853	1.00
39_T	176_G	1.847	1.00
59_V	105_W	1.844	1.00
193_K	197_I	1.808	1.00
76_E	162_E	1.763	1.00
8_Q	39_T	1.754	1.00
7_V	25_A	1.747	1.00
181_K	185_R	1.719	1.00
61_T	65_A	1.665	1.00
56_L	105_W	1.659	1.00
56_L	108_A	1.635	1.00
171_V	175_V	1.633	1.00
74_F	78_L	1.606	1.00
5_G	171_V	1.601	1.00
64_A	116_A	1.589	1.00
83_V	87_A	1.586	1.00
41_L	173_F	1.580	1.00
65_A	69_L	1.579	1.00
173_F	177_Y	1.558	1.00
109_L	113_L	1.522	1.00
186_Y	190_H	1.510	1.00
45_V	48_R	1.498	1.00
45_V	173_F	1.485	1.00
133_G	143_A	1.482	1.00
98_A	131_T	1.475	1.00
157_G	161_L	1.448	1.00
144_A	184_L	1.445	1.00
65_A	157_G	1.430	1.00
96_L	196_A	1.425	1.00
74_F	77_A	1.424	1.00
106_K	110_L	1.402	1.00
197_I	201_A	1.388	1.00
111_I	133_G	1.371	1.00
93_I	97_L	1.368	1.00
38_G	169_F	1.365	1.00
86_I	90_V	1.355	1.00
71_F	74_F	1.345	1.00
4_L	22_L	1.283	1.00
110_L	136_L	1.281	1.00
161_L	164_L	1.276	1.00
65_A	68_G	1.257	1.00
133_G	138_L	1.229	1.00
91_G	123_V	1.224	1.00
48_R	52_L	1.223	1.00
196_A	200_I	1.214	1.00
72_K	76_E	1.203	1.00
103_L	138_L	1.200	1.00
96_L	193_K	1.196	1.00
96_L	200_I	1.196	1.00
83_V	120_I	1.182	1.00
110_L	132_G	1.170	1.00
194_P	197_I	1.164	1.00
99_E	193_K	1.160	1.00
151_A	155_I	1.156	1.00
91_G	199_R	1.155	1.00
40_L	152_I	1.144	1.00
49_K	53_R	1.128	1.00
89_I	200_I	1.127	1.00
107_D	138_L	1.118	1.00
94_L	131_T	1.112	1.00
22_L	32_D	1.109	1.00
34_V	169_F	1.108	1.00
144_A	187_V	1.107	1.00
175_V	179_A	1.102	1.00
35_I	168_G	1.101	1.00
177_Y	181_K	1.100	1.00
26_P	32_D	1.097	1.00
129_T	147_S	1.086	1.00
200_I	204_L	1.080	1.00
92_G	196_A	1.070	1.00
49_K	52_L	1.068	1.00
95_L	131_T	1.064	1.00
20_G	84_V	1.054	1.00
71_F	75_I	1.054	1.00
156_L	160_L	1.051	1.00
46_Y	177_Y	1.043	1.00
107_D	110_L	1.041	1.00
100_L	142_A	1.038	1.00
111_I	150_L	1.033	1.00
182_W	185_R	1.030	1.00
56_L	103_L	1.029	1.00
116_A	119_L	1.028	1.00
4_L	25_A	1.028	1.00
2_I	167_V	1.026	1.00
113_L	117_L	1.023	1.00
6_I	171_V	1.006	1.00
36_H	155_I	1.002	1.00
141_E	145_R	0.991	1.00
3_I	7_V	0.986	1.00
114_A	128_A	0.983	1.00
46_Y	184_L	0.983	1.00
11_T	16_V	0.981	1.00
24_L	202_L	0.980	1.00
47_F	184_L	0.976	1.00
93_I	200_I	0.969	1.00
30_A	34_V	0.967	1.00
54_A	58_I	0.953	1.00
95_L	127_G	0.952	1.00
31_F	35_I	0.952	1.00
99_E	140_R	0.951	1.00
44_L	51_I	0.951	1.00
23_I	84_V	0.938	1.00
92_G	199_R	0.938	1.00
178_L	181_K	0.936	1.00
40_L	156_L	0.929	1.00
110_L	114_A	0.928	1.00
174_V	178_L	0.925	1.00
98_A	135_L	0.924	1.00
113_L	116_A	0.922	1.00
73_D	77_A	0.913	1.00
186_Y	194_P	0.902	1.00
94_L	128_A	0.900	1.00
84_V	88_L	0.900	1.00
191_S	194_P	0.900	1.00
72_K	161_L	0.897	1.00
33_V	162_E	0.891	1.00
146_F	150_L	0.889	1.00
24_L	88_L	0.886	1.00
34_V	165_L	0.885	1.00
167_V	171_V	0.866	1.00
64_A	119_L	0.865	1.00
67_V	71_F	0.865	1.00
23_I	27_A	0.860	1.00
75_I	119_L	0.858	1.00
67_V	119_L	0.853	1.00
89_I	93_I	0.845	1.00
47_F	145_R	0.844	1.00
67_V	70_L	0.837	1.00
66_I	70_L	0.837	1.00
97_L	135_L	0.835	1.00
58_I	62_I	0.835	1.00
103_L	142_A	0.835	1.00
55_W	59_V	0.828	1.00
193_K	196_A	0.825	1.00
87_A	90_V	0.821	1.00
45_V	177_Y	0.820	1.00
31_F	168_G	0.799	1.00
196_A	199_R	0.795	1.00
150_L	154_T	0.792	1.00
130_I	192_F	0.791	1.00
57_L	150_L	0.790	1.00
27_A	82_P	0.789	1.00
83_V	86_I	0.787	1.00
29_L	32_D	0.778	1.00
88_L	199_R	0.776	1.00
157_G	160_L	0.775	1.00
88_L	202_L	0.772	1.00
73_D	76_E	0.771	1.00
56_L	104_T	0.769	1.00
61_T	150_L	0.766	1.00
166_L	170_V	0.765	1.00
55_W	105_W	0.762	1.00
166_L	169_F	0.760	1.00
69_L	161_L	0.757	1.00
106_K	136_L	0.751	1.00
179_A	182_W	0.751	1.00
67_V	113_L	0.750	1.00
128_A	132_G	0.746	1.00
46_Y	180_I	0.743	1.00
44_L	152_I	0.739	1.00
197_I	200_I	0.733	1.00
181_K	188_K	0.733	1.00
63_P	109_L	0.732	1.00
117_L	123_V	0.729	1.00
165_L	169_F	0.724	1.00
169_F	172_A	0.722	1.00
130_I	144_A	0.720	1.00
87_A	123_V	0.719	1.00
84_V	87_A	0.717	1.00
105_W	109_L	0.711	1.00
142_A	145_R	0.711	1.00
96_L	99_E	0.709	1.00
69_L	72_K	0.708	1.00
100_L	103_L	0.706	1.00
57_L	149_L	0.705	1.00
131_T	135_L	0.704	1.00
29_L	36_H	0.703	1.00
47_F	50_D	0.702	1.00
179_A	183_L	0.701	1.00
111_I	138_L	0.694	1.00
87_A	91_G	0.688	1.00
190_H	194_P	0.683	1.00
111_I	146_F	0.681	1.00
169_F	173_F	0.679	1.00
21_H	198_Y	0.678	1.00
90_V	123_V	0.675	1.00
103_L	146_F	0.673	1.00
44_L	48_R	0.672	1.00
91_G	94_L	0.672	1.00
30_A	33_V	0.667	1.00
175_V	178_L	0.666	1.00
110_L	113_L	0.666	1.00
23_I	26_P	0.663	1.00
155_I	159_G	0.663	1.00
37_L	169_F	0.662	1.00
168_G	172_A	0.662	1.00
88_L	122_G	0.660	1.00
23_I	32_D	0.659	1.00
199_R	202_L	0.657	1.00
95_L	192_F	0.652	1.00
117_L	128_A	0.645	1.00
85_A	89_I	0.645	1.00
153_P	156_L	0.642	1.00
62_I	66_I	0.642	1.00
103_L	108_A	0.640	1.00
3_I	25_A	0.639	1.00
38_G	172_A	0.638	1.00
103_L	107_D	0.637	1.00
64_A	67_V	0.630	1.00
184_L	188_K	0.628	1.00
64_A	68_G	0.628	1.00
20_G	24_L	0.628	1.00
69_L	157_G	0.623	1.00
91_G	95_L	0.621	1.00
172_A	175_V	0.619	1.00
107_D	133_G	0.618	1.00
91_G	131_T	0.617	1.00
77_A	80_R	0.617	1.00
37_L	41_L	0.612	1.00
118_A	121_P	0.608	1.00
201_A	204_L	0.606	1.00
36_H	39_T	0.602	1.00
170_V	173_F	0.601	1.00
59_V	109_L	0.599	1.00
91_G	117_L	0.594	1.00
88_L	91_G	0.593	1.00
61_T	157_G	0.592	1.00
134_L	140_R	0.591	1.00
33_V	159_G	0.590	1.00
45_V	49_K	0.590	1.00
174_V	177_Y	0.589	1.00
25_A	28_L	0.588	1.00
78_L	120_I	0.588	1.00
33_V	158_A	0.586	1.00
36_H	40_L	0.585	1.00
186_Y	191_S	0.585	1.00
99_E	134_L	0.585	1.00
63_P	66_I	0.581	1.00
23_I	82_P	0.581	1.00
38_G	42_A	0.580	1.00
30_A	162_E	0.580	1.00
20_G	88_L	0.580	1.00
188_K	191_S	0.570	1.00
187_V	192_F	0.568	1.00
29_L	80_R	0.568	1.00
180_I	184_L	0.567	1.00
199_R	203_G	0.565	1.00
51_I	149_L	0.563	1.00
1_A	5_G	0.563	1.00
8_Q	36_H	0.562	1.00
13_F	176_G	0.562	1.00
108_A	112_G	0.561	1.00
51_I	54_A	0.560	1.00
92_G	96_L	0.559	1.00
6_I	10_L	0.557	1.00
42_A	173_F	0.554	1.00
182_W	186_Y	0.552	1.00
70_L	73_D	0.546	1.00
90_V	94_L	0.543	1.00
41_L	169_F	0.539	1.00
82_P	85_A	0.538	1.00
5_G	9_G	0.537	1.00
101_E	107_D	0.536	1.00
133_G	136_L	0.533	1.00
13_F	42_A	0.531	1.00
66_I	69_L	0.531	1.00
37_L	156_L	0.528	1.00
8_Q	19_S	0.527	1.00
43_V	180_I	0.526	1.00
139_S	143_A	0.523	1.00
95_L	99_E	0.523	1.00
10_L	16_V	0.518	1.00
76_E	80_R	0.515	1.00
24_L	82_P	0.515	1.00
34_V	159_G	0.514	1.00
70_L	74_F	0.511	1.00
63_P	68_G	0.509	1.00
9_G	179_A	0.507	1.00
111_I	136_L	0.503	1.00
13_F	22_L	0.503	1.00
24_L	84_V	0.501	1.00
43_V	151_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jb0M	1	0.1512	6	0.952	Contact Map
4c48C	1	0.1268	5.7	0.953	Contact Map
3wajA	1	0.9415	2.7	0.96	Contact Map
3if8A	1	0.1707	2.5	0.96	Contact Map
3rceA	1	0.8732	2.3	0.961	Contact Map
1sz7A	2	0.2098	1.8	0.963	Contact Map
3ux4A	3	0.439	1.7	0.964	Contact Map
1fdmA	1	0.2439	1.7	0.964	Contact Map
4x5mA	2	0.2195	1.5	0.965	Contact Map
4p6vD	1	0.7659	1.4	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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