GREMLIN Database
KdpC - K+-transporting ATPase, c chain
PFAM: PF02669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 182 (179)
Sequences: 18565 (11426)
Seq/√Len: 854.0
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_R95_R3.0861.00
115_L131_A2.9631.00
133_L151_R2.8291.00
2_R6_R2.7251.00
28_Q36_N2.5191.00
137_P147_E2.4761.00
149_Q152_A2.3141.00
39_L46_V2.3031.00
61_Y181_D2.2921.00
133_L155_A2.2331.00
41_E46_V2.1931.00
33_D50_E2.1831.00
97_A101_A2.1241.00
152_A156_A2.0411.00
50_E175_E1.9921.00
157_H179_A1.9741.00
62_F176_L1.9711.00
126_H159_E1.9641.00
63_H102_E1.9501.00
133_L158_T1.9241.00
86_P90_D1.9161.00
136_V147_E1.8701.00
136_V154_V1.8671.00
146_S149_Q1.8541.00
126_H170_R1.7751.00
26_I30_L1.7441.00
8_T12_T1.7291.00
53_G64_G1.7241.00
96_V116_V1.7201.00
147_E151_R1.6991.00
93_K97_A1.6971.00
162_Q166_L1.6931.00
90_D94_A1.6551.00
159_E170_R1.6411.00
151_R155_A1.6311.00
129_P158_T1.6271.00
89_I93_K1.6171.00
87_A90_D1.6161.00
48_G174_L1.5631.00
90_D93_K1.5151.00
91_R118_A1.4751.00
106_A109_A1.4581.00
127_I132_A1.4441.00
145_L150_V1.4381.00
136_V151_R1.4311.00
145_L149_Q1.4141.00
76_S123_L1.4121.00
159_E175_E1.3921.00
103_N106_A1.3561.00
42_R45_K1.3461.00
162_Q170_R1.3191.00
115_L134_Y1.3151.00
94_A98_A1.3051.00
95_R98_A1.3021.00
157_H175_E1.2961.00
137_P141_K1.2931.00
55_P70_G1.2641.00
98_A102_E1.2591.00
156_A179_A1.2441.00
62_F139_V1.2391.00
7_L11_L1.2371.00
58_D61_Y1.2311.00
160_G169_P1.2301.00
129_P133_L1.2251.00
133_L136_V1.2221.00
18_A22_A1.2131.00
96_V100_R1.1901.00
38_S51_L1.1841.00
96_V111_V1.1741.00
99_L131_A1.1641.00
11_L15_T1.1621.00
41_E44_G1.1531.00
87_A91_R1.1431.00
32_P36_N1.1381.00
148_A152_A1.1361.00
81_L85_N1.1341.00
42_R178_L1.1271.00
136_V150_V1.1261.00
161_R169_P1.1251.00
69_A72_D1.1241.00
113_V117_T1.0931.00
55_P64_G1.0891.00
61_Y143_R1.0861.00
99_L134_Y1.0851.00
141_K144_G1.0851.00
143_R181_D1.0721.00
59_P102_E1.0591.00
153_L176_L1.0521.00
100_R105_G1.0441.00
25_G29_V1.0401.00
161_R168_E1.0351.00
42_R47_V1.0311.00
105_G108_T1.0291.00
3_P6_R1.0171.00
131_A134_Y1.0171.00
152_A155_A1.0171.00
95_R118_A1.0121.00
148_A151_R1.0091.00
69_A75_A1.0061.00
12_T16_G0.9961.00
21_L25_G0.9941.00
68_A118_A0.9901.00
103_N138_R0.9881.00
133_L137_P0.9861.00
106_A134_Y0.9831.00
130_A133_L0.9541.00
68_A79_S0.9521.00
66_P92_V0.9351.00
59_P142_A0.9321.00
79_S118_A0.9291.00
6_R10_V0.9251.00
114_D128_S0.9221.00
15_T18_A0.9211.00
13_V18_A0.8941.00
149_Q156_A0.8921.00
31_F34_Q0.8911.00
91_R94_A0.8811.00
81_L88_L0.8731.00
56_F64_G0.8721.00
88_L91_R0.8711.00
72_D75_A0.8711.00
38_S49_S0.8671.00
99_L115_L0.8651.00
94_A97_A0.8631.00
112_P134_Y0.8621.00
114_D127_I0.8601.00
105_G141_K0.8581.00
69_A77_G0.8571.00
16_G20_P0.8541.00
6_R9_L0.8541.00
77_G80_N0.8531.00
22_A25_G0.8531.00
63_H138_R0.8491.00
105_G109_A0.8471.00
155_A158_T0.8441.00
99_L103_N0.8371.00
27_A35_A0.8351.00
79_S91_R0.8231.00
53_G71_Y0.8211.00
58_D63_H0.8151.00
8_T15_T0.8121.00
97_A100_R0.8091.00
154_V158_T0.8001.00
115_L127_I0.7871.00
62_F153_L0.7861.00
38_S50_E0.7851.00
8_T11_L0.7841.00
4_A8_T0.7841.00
26_I29_V0.7821.00
62_F154_V0.7761.00
64_G71_Y0.7731.00
111_V134_Y0.7701.00
73_A123_L0.7681.00
17_L20_P0.7651.00
139_V142_A0.7641.00
114_D131_A0.7621.00
24_T27_A0.7591.00
100_R108_T0.7541.00
163_L166_L0.7511.00
17_L21_L0.7491.00
76_S121_S0.7471.00
24_T28_Q0.7441.00
92_V117_T0.7391.00
70_G77_G0.7391.00
3_P7_L0.7351.00
16_G24_T0.7281.00
85_N89_I0.7261.00
172_N175_E0.7251.00
89_I92_V0.7191.00
174_L178_L0.7161.00
95_R99_L0.7141.00
81_L87_A0.7051.00
41_E45_K0.7001.00
139_V176_L0.6941.00
105_G134_Y0.6931.00
52_I123_L0.6891.00
86_P89_I0.6851.00
111_V116_V0.6831.00
40_I174_L0.6811.00
92_V116_V0.6801.00
63_H103_N0.6801.00
11_L14_L0.6771.00
153_L179_A0.6771.00
56_F61_Y0.6771.00
151_R154_V0.6761.00
60_K142_A0.6751.00
104_P134_Y0.6721.00
153_L157_H0.6721.00
162_Q165_F0.6701.00
14_L18_A0.6661.00
127_I131_A0.6641.00
19_Y23_V0.6621.00
140_A143_R0.6521.00
127_I173_V0.6451.00
143_R150_V0.6431.00
103_N134_Y0.6401.00
78_G118_A0.6361.00
63_H99_L0.6351.00
110_P134_Y0.6311.00
161_R167_G0.6311.00
175_E179_A0.6271.00
73_A76_S0.6251.00
66_P81_L0.6251.00
175_E178_L0.6191.00
93_K96_V0.6151.00
56_F174_L0.6141.00
104_P108_T0.6141.00
33_D41_E0.6121.00
22_A26_I0.6051.00
57_T61_Y0.6041.00
21_L24_T0.6041.00
99_L102_E0.6011.00
92_V95_R0.5991.00
53_G69_A0.5961.00
79_S95_R0.5961.00
13_V17_L0.5931.00
10_V14_L0.5921.00
17_L24_T0.5911.00
99_L111_V0.5881.00
103_N109_A0.5871.00
63_H134_Y0.5791.00
164_G167_G0.5781.00
74_A77_G0.5751.00
113_V116_V0.5741.00
100_R110_P0.5691.00
98_A101_A0.5671.00
64_G115_L0.5661.00
88_L92_V0.5631.00
81_L91_R0.5631.00
63_H98_A0.5601.00
9_L12_T0.5591.00
143_R180_L0.5591.00
103_N137_P0.5591.00
9_L13_V0.5571.00
71_Y123_L0.5561.00
10_V13_V0.5561.00
136_V139_V0.5551.00
70_G75_A0.5551.00
100_R104_P0.5531.00
5_L9_L0.5511.00
102_E106_A0.5471.00
99_L106_A0.5431.00
155_A160_G0.5421.00
34_Q50_E0.5411.00
82_G88_L0.5391.00
81_L118_A0.5351.00
4_A7_L0.5321.00
159_E172_N0.5301.00
40_I50_E0.5291.00
100_R111_V0.5281.00
23_V26_I0.5261.00
18_A21_L0.5251.00
126_H175_E0.5251.00
33_D38_S0.5231.00
114_D130_A0.5211.00
163_L167_G0.5191.00
113_V130_A0.5171.00
34_Q38_S0.5171.00
103_N108_T0.5131.00
40_I175_E0.5091.00
92_V96_V0.5091.00
100_R106_A0.5081.00
47_V178_L0.5081.00
11_L20_P0.5051.00
27_A30_L0.5051.00
58_D142_A0.5051.00
84_T89_I0.5021.00
132_A139_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhfA 1 0.2857 33.3 0.951 Contact Map
3ne5A 3 0.9176 26.1 0.953 Contact Map
4mt1A 3 0.9341 11.7 0.96 Contact Map
4dx5A 3 0.967 11.5 0.96 Contact Map
4xrvA 1 0.7473 8.5 0.962 Contact Map
1toaA 1 0.8352 8.5 0.962 Contact Map
3w6vA 1 0.3407 6.5 0.964 Contact Map
4utoA 1 0.8297 6.4 0.965 Contact Map
4c2mD 1 0.3022 6.3 0.965 Contact Map
4h63V 1 0.5385 6.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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