GREMLIN Database
FlpD - Methyl-viologen-reducing hydrogenase, delta subunit
PFAM: PF02662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (123)
Sequences: 17218 (8788)
Seq/√Len: 792.4
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_E92_P3.5561.00
96_R118_K3.1961.00
5_L30_I2.4461.00
93_E118_K2.2291.00
46_K50_K2.0961.00
27_N116_T2.0941.00
82_K92_P2.0931.00
98_E111_V2.0831.00
62_P75_R2.0291.00
54_G119_I1.9631.00
106_E110_E1.8781.00
25_P113_N1.8511.00
46_K49_E1.8411.00
10_S58_A1.7941.00
107_K111_V1.7561.00
33_V39_V1.7461.00
3_A28_V1.7371.00
56_L98_E1.7021.00
110_E114_E1.6511.00
114_E118_K1.6441.00
78_V95_L1.6401.00
48_F95_L1.6251.00
54_G115_F1.6191.00
116_T120_R1.6051.00
75_R79_E1.5771.00
2_V52_A1.5751.00
36_S57_V1.5591.00
62_P99_W1.5531.00
36_S59_G1.5371.00
7_N32_R1.5371.00
75_R99_W1.4871.00
69_E73_R1.4751.00
104_E107_K1.4741.00
56_L112_V1.4661.00
59_G99_W1.4521.00
58_A98_E1.4481.00
62_P72_Y1.4241.00
118_K121_E1.4191.00
22_L109_A1.4171.00
117_E120_R1.3681.00
69_E72_Y1.3651.00
117_E121_E1.3491.00
61_H104_E1.3181.00
1_I116_T1.2901.00
111_V114_E1.2891.00
109_A113_N1.2881.00
41_P81_L1.2351.00
38_R43_F1.2231.00
28_V112_V1.2131.00
61_H64_D1.2101.00
96_R114_E1.2011.00
84_L87_E1.2011.00
40_D43_F1.1681.00
2_V47_A1.1661.00
5_L108_F1.1411.00
96_R115_F1.1311.00
108_F112_V1.1251.00
91_E94_R1.1141.00
63_G71_N1.1081.00
39_V44_I1.1011.00
79_E82_K1.1001.00
113_N117_E1.0911.00
114_E117_E1.0881.00
100_V111_V1.0501.00
5_L10_S1.0461.00
41_P80_L1.0251.00
82_K95_L1.0241.00
60_C65_C1.0201.00
96_R111_V1.0191.00
44_I55_V0.9981.00
110_E113_N0.9871.00
56_L96_R0.9841.00
113_N116_T0.9791.00
73_R77_R0.9581.00
101_S104_E0.9561.00
98_E107_K0.9421.00
16_L20_S0.9391.00
8_W67_Y0.9291.00
59_G97_L0.9231.00
34_P38_R0.9071.00
11_Y15_D0.9051.00
105_G109_A0.8911.00
74_A97_L0.8881.00
45_L81_L0.8881.00
5_L58_A0.8731.00
83_K86_E0.8661.00
84_L88_L0.8651.00
3_A56_L0.8631.00
58_A100_V0.8581.00
35_C65_C0.8571.00
18_G24_Y0.8461.00
115_F119_I0.8431.00
86_E91_E0.8361.00
78_V82_K0.8331.00
73_R87_E0.8321.00
4_F47_A0.8031.00
76_R79_E0.8021.00
7_N12_A0.8001.00
57_V78_V0.7921.00
107_K110_E0.7881.00
42_L46_K0.7821.00
61_H101_S0.7661.00
83_K87_E0.7531.00
44_I95_L0.7461.00
73_R76_R0.7331.00
16_L19_T0.7241.00
56_L111_V0.7201.00
100_V107_K0.7201.00
6_C35_C0.7101.00
7_N34_P0.7101.00
18_G21_R0.7091.00
49_E88_L0.7061.00
76_R80_L0.7001.00
5_L11_Y0.6941.00
35_C70_G0.6931.00
72_Y75_R0.6921.00
44_I81_L0.6901.00
22_L106_E0.6751.00
4_F33_V0.6731.00
39_V57_V0.6711.00
71_N99_W0.6631.00
70_G74_A0.6541.00
78_V97_L0.6521.00
65_C70_G0.6521.00
15_D18_G0.6501.00
37_G70_G0.6471.00
48_F90_I0.6471.00
82_K93_E0.6411.00
6_C65_C0.6391.00
49_E87_E0.6371.00
42_L87_E0.6351.00
72_Y76_R0.6321.00
14_A30_I0.6321.00
106_E109_A0.6291.00
58_A108_F0.6251.00
90_I94_R0.6221.00
4_F31_I0.6211.00
44_I47_A0.6211.00
11_Y32_R0.6191.00
24_Y28_V0.6191.00
3_A112_V0.6121.00
13_A17_A0.6081.00
111_V115_F0.6061.00
80_L84_L0.6041.00
68_I73_R0.6041.00
45_L84_L0.6031.00
43_F47_A0.6011.00
119_I122_L0.5931.00
9_C60_C0.5921.00
43_F46_K0.5921.00
80_L83_K0.5911.00
77_R81_L0.5881.00
27_N120_R0.5841.00
36_S39_V0.5841.00
10_S13_A0.5821.00
98_E114_E0.5711.00
81_L84_L0.5671.00
116_T119_I0.5611.00
6_C60_C0.5511.00
106_E113_N0.5421.00
33_V38_R0.5401.00
77_R87_E0.5391.00
44_I57_V0.5381.00
20_S106_E0.5361.00
40_D87_E0.5351.00
115_F118_K0.5301.00
36_S71_N0.5261.00
34_P67_Y0.5241.00
59_G71_N0.5231.00
82_K91_E0.5221.00
79_E83_K0.5201.00
12_A19_T0.5201.00
85_L90_I0.5191.00
93_E121_E0.5181.00
7_N11_Y0.5151.00
4_F39_V0.5141.00
47_A55_V0.5141.00
45_L88_L0.5101.00
41_P45_L0.5101.00
23_Q113_N0.5081.00
56_L115_F0.5081.00
63_G72_Y0.5071.00
54_G94_R0.5011.00
7_N29_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cndA 1 0.7073 53.5 0.878 Contact Map
4eacA 1 0.748 40.8 0.887 Contact Map
2eixA 2 0.6911 40.3 0.887 Contact Map
3w5hA 1 0.6992 39 0.888 Contact Map
2ozlB 2 0.9106 30.6 0.894 Contact Map
1gvhA 3 0.7398 29.4 0.895 Contact Map
1cqxA 2 0.748 29.2 0.895 Contact Map
4g1vA 3 0.7561 25.9 0.898 Contact Map
1tz9A 2 0.7317 25.1 0.898 Contact Map
3qe2A 1 0.9268 24.7 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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