GREMLIN Database
Mntp - Putative manganese efflux pump
PFAM: PF02659 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (149)
Sequences: 14166 (10982)
Seq/√Len: 899.6
META: 0.863

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_F82_A3.9531.00
57_Y61_K3.9401.00
19_A111_G3.1151.00
59_S138_I2.7141.00
54_K57_Y2.6641.00
45_F152_L2.5721.00
13_F75_G2.4731.00
53_G57_Y2.3001.00
23_L107_A2.2561.00
19_A107_A2.2471.00
142_L146_L2.1241.00
54_K58_E2.0441.00
135_K138_I2.0191.00
9_R75_G1.9331.00
123_L127_R1.9281.00
22_P110_I1.9261.00
46_G50_F1.8411.00
102_N105_L1.7751.00
77_T80_L1.7671.00
33_A37_G1.7451.00
6_Q9_R1.7221.00
13_F78_L1.6881.00
50_F54_K1.6681.00
11_A119_L1.6251.00
3_R6_Q1.6201.00
52_G141_G1.5981.00
56_I138_I1.5541.00
16_L20_L1.5541.00
52_G145_I1.5531.00
7_A119_L1.5291.00
13_F79_L1.5091.00
17_F82_A1.5041.00
5_R9_R1.4921.00
124_L128_L1.4751.00
49_A53_G1.4541.00
131_R135_K1.4301.00
45_F49_A1.3671.00
30_S33_A1.3341.00
114_T118_S1.3111.00
109_I113_V1.3091.00
56_I141_G1.2901.00
123_L126_R1.2791.00
10_I122_V1.2791.00
28_L31_T1.2621.00
11_A115_F1.2441.00
127_R130_A1.2411.00
13_F16_L1.2151.00
105_L109_I1.2111.00
24_I90_L1.2001.00
42_W46_G1.1861.00
49_A145_I1.1631.00
18_Q114_T1.1561.00
59_S137_E1.1501.00
35_Y38_A1.1491.00
15_G115_F1.1491.00
7_A123_L1.1451.00
7_A122_V1.1451.00
128_L132_L1.1391.00
15_G19_A1.1261.00
60_F138_I1.1161.00
27_L31_T1.1121.00
44_A151_I1.1011.00
76_K80_L1.0911.00
130_A133_G1.0831.00
58_E137_E1.0811.00
106_A110_I1.0751.00
45_F148_G1.0751.00
103_I107_A1.0741.00
119_L123_L1.0731.00
34_S37_G1.0691.00
7_A11_A1.0611.00
104_L108_L1.0561.00
17_F21_M1.0531.00
50_F53_G1.0511.00
102_N106_A1.0261.00
18_Q89_A1.0181.00
95_S99_L1.0111.00
19_A22_P1.0081.00
10_I78_L1.0061.00
12_L16_L1.0021.00
149_L152_L0.9991.00
16_L19_A0.9921.00
40_D44_A0.9901.00
92_V95_S0.9881.00
138_I142_L0.9861.00
132_L135_K0.9851.00
108_L112_V0.9761.00
17_F20_L0.9611.00
114_T117_L0.9521.00
8_L13_F0.9511.00
146_L150_K0.9471.00
85_T89_A0.9411.00
74_S77_T0.9401.00
57_Y60_F0.9381.00
95_S98_F0.9281.00
30_S34_S0.9251.00
60_F63_E0.9141.00
55_M140_G0.9111.00
75_G79_L0.8881.00
4_L7_A0.8861.00
121_G125_G0.8821.00
28_L32_F0.8771.00
61_K64_E0.8631.00
33_A97_A0.8521.00
9_R13_F0.8521.00
32_F35_Y0.8511.00
125_G129_G0.8511.00
113_V117_L0.8491.00
13_F17_F0.8461.00
6_Q73_L0.8441.00
21_M83_I0.8431.00
104_L107_A0.8221.00
127_R131_R0.8221.00
66_E69_E0.8161.00
8_L115_F0.8151.00
133_G136_A0.8141.00
18_Q21_M0.8101.00
33_A98_F0.8091.00
56_I145_I0.8091.00
52_G148_G0.8071.00
14_F18_Q0.8061.00
14_F118_S0.8061.00
37_G40_D0.8041.00
23_L27_L0.8011.00
23_L104_L0.8011.00
65_E68_E0.7951.00
10_I13_F0.7901.00
79_L82_A0.7881.00
29_G94_V0.7831.00
49_A149_L0.7821.00
26_W103_I0.7781.00
132_L136_A0.7721.00
49_A148_G0.7621.00
120_L123_L0.7501.00
4_L119_L0.7491.00
71_D74_S0.7481.00
10_I73_L0.7301.00
6_Q10_I0.7281.00
36_I40_D0.7261.00
38_A41_H0.7251.00
131_R134_K0.7251.00
134_K138_I0.7221.00
11_A15_G0.7191.00
3_R7_A0.7181.00
51_I80_L0.7141.00
18_Q110_I0.7081.00
105_L108_L0.7041.00
78_L82_A0.7021.00
51_I92_V0.6941.00
135_K139_L0.6921.00
22_P89_A0.6901.00
8_L12_L0.6851.00
44_A47_L0.6811.00
22_P107_A0.6761.00
15_G111_G0.6741.00
46_G49_A0.6731.00
9_R78_L0.6711.00
122_V128_L0.6701.00
75_G78_L0.6581.00
22_P114_T0.6541.00
36_I43_I0.6481.00
96_L101_V0.6461.00
118_S122_V0.6411.00
83_I87_I0.6401.00
18_Q85_T0.6381.00
44_A48_L0.6351.00
101_V106_A0.6341.00
19_A23_L0.6311.00
64_E67_E0.6301.00
21_M85_T0.6191.00
42_W45_F0.6131.00
9_R73_L0.6121.00
51_I54_K0.6101.00
27_L30_S0.6091.00
61_K65_E0.6091.00
20_L24_I0.6041.00
79_L83_I0.6011.00
91_A94_V0.6001.00
56_I59_S0.5971.00
5_R13_F0.5921.00
50_F57_Y0.5921.00
4_L8_L0.5871.00
92_V97_A0.5831.00
126_R132_L0.5831.00
112_V116_L0.5801.00
17_F79_L0.5801.00
11_A122_V0.5791.00
62_K67_E0.5761.00
96_L110_I0.5751.00
56_I60_F0.5741.00
73_L76_K0.5711.00
29_G98_F0.5691.00
145_I149_L0.5691.00
90_L94_V0.5671.00
113_V116_L0.5671.00
89_A114_T0.5631.00
51_I81_L0.5581.00
23_L103_I0.5541.00
31_T34_S0.5511.00
95_S106_A0.5481.00
141_G145_I0.5461.00
97_A100_G0.5461.00
60_F64_E0.5441.00
12_L115_F0.5391.00
134_K137_E0.5381.00
11_A22_P0.5371.00
73_L77_T0.5371.00
94_V98_F0.5371.00
51_I58_E0.5301.00
26_W106_A0.5271.00
64_E68_E0.5261.00
47_L51_I0.5251.00
65_E69_E0.5241.00
126_R131_R0.5231.00
140_G144_L0.5191.00
63_E66_E0.5171.00
136_A139_L0.5161.00
94_V99_L0.5151.00
93_G125_G0.5121.00
9_R12_L0.5091.00
117_L121_G0.5061.00
53_G60_F0.5051.00
72_P77_T0.5011.00
139_L143_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.9408 32.2 0.875 Contact Map
3wdoA 1 0.9934 31.9 0.876 Contact Map
2gfpA 2 0.9803 29 0.878 Contact Map
2cfqA 1 0.9868 26.7 0.88 Contact Map
3o7qA 1 0.9934 26.4 0.881 Contact Map
4u4vA 1 0.9342 21.7 0.885 Contact Map
3j1zP 8 0.6053 17.3 0.89 Contact Map
4j05A 3 0.8816 15.5 0.893 Contact Map
4m64A 1 0.9934 12.9 0.897 Contact Map
3pjzA 2 0.9276 12.7 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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