GREMLIN Database
DUF202 - Domain of unknown function (DUF202)
PFAM: PF02656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (66)
Sequences: 26947 (16899)
Seq/√Len: 2080.1
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A63_R2.5821.00
60_V64_R2.3841.00
61_R65_V2.2651.00
56_V60_V1.9141.00
19_A23_F1.7981.00
17_A55_L1.7441.00
6_N10_F1.7391.00
12_A15_R1.7221.00
45_L49_L1.7031.00
35_G38_G1.6631.00
7_E13_W1.6051.00
29_R32_L1.6021.00
26_A29_R1.4831.00
62_Y66_E1.4541.00
17_A58_A1.4271.00
11_L15_R1.4261.00
3_R6_N1.3771.00
13_W54_V1.3301.00
12_A16_T1.3001.00
5_A12_A1.2791.00
34_G38_G1.2631.00
24_G48_I1.2431.00
21_I51_G1.2291.00
33_P37_S1.2241.00
63_R66_E1.2231.00
19_A26_A1.2121.00
49_L53_L1.1811.00
22_A26_A1.1361.00
53_L57_L1.1251.00
36_P39_L1.1221.00
33_P36_P1.1201.00
61_R64_R1.1141.00
60_V63_R1.1071.00
3_R66_E1.1051.00
35_G39_L1.0741.00
33_P38_G1.0711.00
2_T6_N1.0701.00
42_V46_A1.0651.00
28_A44_G1.0651.00
37_S40_S1.0191.00
55_L59_A1.0161.00
59_A62_Y1.0121.00
23_F26_A0.9841.00
57_L61_R0.9831.00
41_R45_L0.9701.00
17_A51_G0.9341.00
10_F14_I0.9261.00
28_A41_R0.9171.00
14_I23_F0.9161.00
6_N62_Y0.9031.00
16_T19_A0.9031.00
17_A20_L0.8781.00
34_G37_S0.8771.00
34_G39_L0.8561.00
28_A31_F0.8221.00
26_A30_F0.8191.00
14_I55_L0.8181.00
10_F21_I0.8141.00
38_G42_V0.8111.00
7_E61_R0.8041.00
17_A24_G0.7951.00
3_R7_E0.7951.00
13_W58_A0.7941.00
39_L42_V0.7551.00
19_A22_A0.7441.00
24_G51_G0.7271.00
56_V59_A0.7041.00
27_I47_L0.7031.00
4_L7_E0.6911.00
20_L23_F0.6891.00
42_V45_L0.6881.00
25_F30_F0.6871.00
37_S41_R0.6851.00
20_L26_A0.6551.00
14_I19_A0.6521.00
31_F40_S0.6511.00
1_R15_R0.6471.00
48_I52_V0.6451.00
40_S44_G0.6281.00
50_L54_V0.6271.00
15_R19_A0.6171.00
55_L61_R0.5981.00
5_A23_F0.5961.00
32_L35_G0.5921.00
33_P39_L0.5921.00
13_W28_A0.5881.00
6_N65_V0.5701.00
23_F30_F0.5691.00
5_A8_R0.5611.00
14_I20_L0.5531.00
24_G28_A0.5431.00
5_A26_A0.5341.00
11_L20_L0.5281.00
36_P40_S0.5241.00
44_G48_I0.5241.00
19_A30_F0.5081.00
13_W61_R0.5071.00
26_A32_L0.5051.00
12_A19_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.9559 13.9 0.828 Contact Map
4i0uA 4 0.9412 10.2 0.837 Contact Map
1zzaA 1 0.6324 9.4 0.84 Contact Map
4av3A 2 0.3971 5.5 0.856 Contact Map
4lxjA 1 0.7059 4.5 0.862 Contact Map
2l2tA 2 0.5588 4.1 0.865 Contact Map
2kluA 1 0.5147 3.8 0.866 Contact Map
2m20A 2 0.4706 3.1 0.873 Contact Map
2l9uA 2 0.5147 2.7 0.876 Contact Map
2kncA 1 0.6176 2.7 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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