GREMLIN Database
CobS - Cobalamin-5-phosphate synthase
PFAM: PF02654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (197)
Sequences: 17130 (12859)
Seq/√Len: 916.2
META: 0.785

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_R84_E4.3681.00
70_A98_A3.7291.00
126_M196_Q3.3981.00
31_L54_L3.3121.00
82_R183_R3.1661.00
67_A99_L2.8471.00
122_S196_Q2.7121.00
34_V53_A2.5651.00
118_A203_V2.4751.00
52_A101_L2.4241.00
66_L102_V2.3131.00
129_L195_T2.2561.00
51_V107_F2.2341.00
102_V201_L2.2341.00
91_I96_V2.2191.00
48_A105_L2.2131.00
180_A191_V2.1231.00
77_R81_R2.0951.00
5_L20_F2.0761.00
48_A104_L2.0291.00
78_D81_R2.0161.00
60_A97_L1.9591.00
75_G85_I1.9271.00
69_T191_V1.8981.00
44_L107_F1.8551.00
177_R181_R1.8351.00
48_A107_F1.8311.00
55_V101_L1.8091.00
2_L26_L1.7711.00
106_K200_E1.7251.00
176_L180_A1.6241.00
67_A95_G1.5971.00
106_K197_E1.5961.00
100_V104_L1.5721.00
80_E84_E1.5661.00
175_L179_L1.5411.00
133_L177_R1.5321.00
142_A146_G1.5291.00
130_M192_L1.5281.00
105_L201_L1.4951.00
100_V103_L1.4741.00
72_G86_M1.4281.00
79_R82_R1.4241.00
35_A50_A1.4171.00
27_I57_L1.4171.00
35_A114_P1.4131.00
31_L50_A1.4121.00
104_L107_F1.3981.00
178_R181_R1.3881.00
3_Q10_V1.3821.00
187_V192_L1.3471.00
34_V38_L1.3341.00
79_R83_L1.3291.00
17_A130_M1.3211.00
30_L53_A1.3011.00
63_L99_L1.2851.00
69_T73_L1.2841.00
125_A199_A1.2801.00
102_V106_K1.2721.00
172_A202_A1.2661.00
36_W40_L1.2651.00
55_V63_L1.2441.00
174_L178_R1.2351.00
74_G94_F1.2341.00
73_L82_R1.2321.00
27_I58_T1.2281.00
67_A91_I1.2281.00
44_L111_A1.2151.00
55_V60_A1.2141.00
46_A50_A1.2061.00
138_D142_A1.2011.00
63_L197_E1.1781.00
173_A177_R1.1741.00
54_L119_P1.1661.00
179_L183_R1.1611.00
121_L203_V1.1571.00
107_F111_A1.1451.00
187_V191_V1.1371.00
73_L184_L1.1241.00
178_R182_R1.1241.00
48_A108_A1.1201.00
119_P200_E1.1061.00
184_L191_V1.1011.00
25_L120_V1.0911.00
67_A93_A1.0871.00
116_L120_V1.0851.00
47_A51_V1.0771.00
32_A116_L1.0761.00
44_L108_A1.0751.00
109_A201_L1.0741.00
12_D15_R1.0731.00
35_A39_S1.0701.00
82_R184_L1.0551.00
96_V100_V1.0521.00
97_L103_L1.0471.00
55_V97_L1.0421.00
130_M145_A1.0351.00
2_L23_V1.0341.00
66_L70_A1.0311.00
134_P181_R1.0251.00
96_V99_L1.0201.00
66_L198_L1.0091.00
6_T27_I1.0071.00
75_G82_R1.0061.00
68_D189_G1.0031.00
91_I95_G1.0001.00
64_D68_D0.9981.00
79_R185_G0.9921.00
195_T199_A0.9911.00
4_F140_L0.9881.00
3_Q11_P0.9861.00
27_I119_P0.9821.00
176_L195_T0.9811.00
38_L46_A0.9811.00
128_L132_L0.9771.00
55_V103_L0.9711.00
32_A36_W0.9461.00
102_V197_E0.9421.00
135_Y142_A0.9321.00
77_R85_I0.9271.00
37_L40_L0.9241.00
47_A111_A0.9191.00
108_A112_A0.9161.00
136_A188_T0.9101.00
133_L181_R0.9001.00
90_R93_A0.8991.00
116_L119_P0.8921.00
199_A203_V0.8861.00
106_K201_L0.8801.00
133_L187_V0.8771.00
2_L10_V0.8761.00
176_L183_R0.8721.00
25_L116_L0.8711.00
38_L42_L0.8701.00
77_R82_R0.8531.00
31_L35_A0.8491.00
63_L97_L0.8481.00
123_R196_Q0.8461.00
78_D84_E0.8261.00
27_I31_L0.8251.00
30_L57_L0.8231.00
129_L133_L0.8231.00
118_A204_L0.8211.00
7_R56_L0.8171.00
136_A186_G0.8161.00
54_L118_A0.8141.00
47_A107_F0.8081.00
129_L177_R0.8071.00
109_A112_A0.8001.00
63_L106_K0.7961.00
23_V26_L0.7951.00
7_R59_G0.7941.00
45_L109_A0.7931.00
135_Y140_L0.7901.00
37_L41_L0.7871.00
67_A96_V0.7841.00
66_L98_A0.7821.00
169_A173_A0.7761.00
119_P122_S0.7751.00
8_L57_L0.7751.00
83_L188_T0.7731.00
118_A122_S0.7731.00
93_A97_L0.7691.00
196_Q199_A0.7691.00
75_G78_D0.7661.00
17_A127_V0.7631.00
179_L191_V0.7621.00
47_A110_L0.7601.00
110_L115_L0.7501.00
35_A46_A0.7491.00
105_L109_A0.7481.00
36_W39_S0.7421.00
122_S200_E0.7401.00
39_S46_A0.7361.00
68_D190_D0.7241.00
17_A148_V0.7221.00
140_L143_A0.7191.00
49_L105_L0.7161.00
63_L103_L0.7101.00
180_A183_R0.7081.00
109_A204_L0.7071.00
8_L30_L0.7071.00
72_G76_G0.7071.00
43_P112_A0.7061.00
51_V103_L0.7011.00
38_L41_L0.7011.00
135_Y141_G0.7001.00
54_L200_E0.7001.00
197_E200_E0.6951.00
84_E90_R0.6881.00
151_A156_L0.6881.00
19_F22_L0.6801.00
5_L23_V0.6751.00
119_P197_E0.6741.00
132_L177_R0.6721.00
50_A54_L0.6711.00
28_G32_A0.6711.00
105_L108_A0.6681.00
20_F144_F0.6641.00
137_P142_A0.6591.00
117_A203_V0.6581.00
31_L119_P0.6511.00
124_A128_L0.6491.00
89_S94_F0.6471.00
198_L202_A0.6461.00
52_A56_L0.6441.00
35_A47_A0.6421.00
60_A94_F0.6381.00
78_D82_R0.6351.00
42_L46_A0.6351.00
115_L119_P0.6351.00
160_A164_A0.6331.00
74_G82_R0.6311.00
83_L86_M0.6301.00
5_L126_M0.6291.00
31_L53_A0.6281.00
16_A20_F0.6271.00
34_V37_L0.6191.00
4_F13_L0.6181.00
82_R94_F0.6181.00
32_A119_P0.6171.00
44_L47_A0.6131.00
172_A176_L0.6131.00
125_A173_A0.6121.00
168_A172_A0.6091.00
122_S203_V0.6061.00
85_I94_F0.6031.00
70_A94_F0.6031.00
176_L179_L0.6031.00
108_A111_A0.6031.00
51_V101_L0.6021.00
59_G76_G0.5981.00
135_Y145_A0.5971.00
28_G119_P0.5941.00
73_L191_V0.5891.00
87_K138_D0.5871.00
187_V195_T0.5851.00
64_D190_D0.5841.00
126_M192_L0.5831.00
29_L33_L0.5831.00
28_G120_V0.5771.00
170_L174_L0.5731.00
133_L192_L0.5731.00
32_A35_A0.5731.00
131_A148_V0.5731.00
3_Q7_R0.5721.00
33_L37_L0.5711.00
88_D93_A0.5691.00
175_L178_R0.5681.00
70_A194_A0.5651.00
145_A192_L0.5641.00
71_D88_D0.5631.00
192_L195_T0.5631.00
51_V110_L0.5581.00
43_P46_A0.5571.00
38_L49_L0.5561.00
27_I54_L0.5521.00
66_L194_A0.5521.00
53_A57_L0.5511.00
60_A74_G0.5491.00
25_L29_L0.5491.00
69_T74_G0.5491.00
172_A198_L0.5491.00
69_T184_L0.5451.00
69_T194_A0.5441.00
33_L36_W0.5401.00
157_A160_A0.5391.00
125_A195_T0.5381.00
72_G82_R0.5331.00
44_L48_A0.5321.00
117_A120_V0.5311.00
59_G94_F0.5301.00
76_G81_R0.5271.00
129_L187_V0.5271.00
124_A127_V0.5271.00
7_R76_G0.5251.00
131_A150_R0.5251.00
126_M195_T0.5231.00
128_L173_A0.5221.00
17_A144_F0.5221.00
98_A102_V0.5221.00
38_L43_P0.5201.00
18_R21_P0.5201.00
74_G77_R0.5201.00
62_H68_D0.5181.00
130_M133_L0.5121.00
24_G28_G0.5091.00
145_A187_V0.5081.00
181_R185_G0.5071.00
52_A105_L0.5061.00
179_L182_R0.5051.00
72_G85_I0.5051.00
4_F61_L0.5041.00
68_D71_D0.5031.00
93_A96_V0.5011.00
91_I99_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j45G 1 0.2927 2.2 0.961 Contact Map
4o6mA 2 0.8341 1.8 0.963 Contact Map
4bpmA 3 0.278 1.8 0.963 Contact Map
2jttC 1 0.1512 1.7 0.963 Contact Map
2wjnL 1 0.5707 1.6 0.964 Contact Map
2zydA 2 0.2878 1.6 0.964 Contact Map
3ic9A 2 0.2537 1.4 0.965 Contact Map
1afoA 2 0.1951 1.3 0.966 Contact Map
3d9sA 3 0.2829 1.2 0.966 Contact Map
2kogA 1 0.1854 1.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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