GREMLIN Database
DUF188 - Uncharacterized BCR, YaiI/YqxD family COG1671
PFAM: PF02639 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (129)
Sequences: 13908 (8138)
Seq/√Len: 716.5
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_W48_R3.5901.00
49_A71_A2.7181.00
64_A68_E2.6141.00
12_P30_E2.5891.00
97_D101_S2.4461.00
43_D65_R2.2661.00
113_S116_D2.2441.00
44_W47_E2.1851.00
3_Y15_L2.1391.00
72_R127_L2.1291.00
14_T30_E2.0941.00
118_S122_N2.0921.00
123_A126_R2.0371.00
49_A55_V1.9791.00
55_V66_C1.9461.00
58_A76_P1.9071.00
99_L104_V1.8441.00
64_A90_L1.8331.00
51_P70_G1.7531.00
66_C71_A1.7281.00
80_L127_L1.6931.00
75_N81_F1.6481.00
61_P90_L1.6421.00
10_G28_L1.6271.00
8_R125_D1.6191.00
37_G40_A1.6081.00
7_E26_S1.6081.00
66_C73_V1.6051.00
32_V44_W1.5391.00
80_L123_A1.4821.00
114_K117_R1.4431.00
32_V48_R1.4141.00
49_A66_C1.4061.00
68_E87_G1.3861.00
79_E89_R1.3761.00
112_F117_R1.3601.00
23_V31_L1.3591.00
2_L13_V1.3521.00
115_K119_R1.3451.00
72_R80_L1.3141.00
70_G83_E1.3131.00
125_D129_T1.3031.00
98_D102_S1.2991.00
9_H125_D1.2921.00
4_R121_A1.2911.00
40_A43_D1.2851.00
75_N79_E1.2691.00
64_A87_G1.2661.00
54_L127_L1.2541.00
15_L23_V1.2491.00
43_D47_E1.2301.00
92_M96_M1.2231.00
56_I76_P1.2191.00
73_V81_F1.2151.00
122_N126_R1.1861.00
91_A95_L1.1841.00
58_A75_N1.1811.00
3_Y29_I1.1591.00
46_V65_R1.1411.00
103_G106_T1.1221.00
6_A13_V1.0881.00
22_R25_P1.0811.00
67_L86_I1.0771.00
98_D101_S1.0651.00
88_E92_M1.0611.00
94_D97_D1.0591.00
3_Y24_P1.0521.00
91_A94_D1.0501.00
7_E28_L1.0501.00
17_A31_L1.0391.00
116_D119_R1.0391.00
87_G91_A1.0171.00
123_A127_L1.0131.00
121_A125_D0.9861.00
114_K118_S0.9591.00
20_P36_A0.9561.00
82_T85_N0.9491.00
50_G53_D0.9371.00
106_T109_P0.9291.00
14_T32_V0.9231.00
92_M95_L0.9231.00
94_D98_D0.9181.00
118_S121_A0.9181.00
13_V29_I0.9111.00
39_D43_D0.9081.00
65_R68_E0.8971.00
95_L99_L0.8891.00
16_V41_A0.8881.00
16_V48_R0.8801.00
5_V128_L0.8761.00
20_P31_L0.8641.00
5_V121_A0.8551.00
11_L128_L0.8361.00
2_L120_F0.8311.00
74_L123_A0.8281.00
68_E83_E0.8271.00
67_L94_D0.8271.00
18_N40_A0.8211.00
90_L94_D0.8161.00
34_V41_A0.7911.00
35_P40_A0.7901.00
119_R122_N0.7881.00
115_K118_S0.7681.00
5_V9_H0.7681.00
15_L29_I0.7671.00
7_E10_G0.7611.00
43_D46_V0.7461.00
60_I89_R0.7441.00
38_F97_D0.7411.00
7_E27_P0.7391.00
81_F85_N0.7351.00
10_G27_P0.7271.00
89_R92_M0.7261.00
49_A69_K0.7231.00
18_N36_A0.7201.00
75_N89_R0.7191.00
20_P23_V0.7181.00
85_N89_R0.7171.00
55_V71_A0.7141.00
67_L83_E0.7081.00
119_R123_A0.7031.00
85_N88_E0.6971.00
20_P33_V0.6941.00
19_Q31_L0.6881.00
67_L71_A0.6771.00
73_V80_L0.6691.00
52_G72_R0.6641.00
26_S29_I0.6621.00
96_M106_T0.6601.00
81_F89_R0.6531.00
38_F43_D0.6471.00
14_T48_R0.6421.00
60_I81_F0.6401.00
15_L31_L0.6361.00
6_A28_L0.6351.00
113_S119_R0.6351.00
67_L85_N0.6321.00
74_L80_L0.6261.00
20_P25_P0.6211.00
126_R129_T0.6181.00
9_H129_T0.6151.00
2_L124_L0.6131.00
21_L31_L0.6101.00
4_R7_E0.6101.00
18_N21_L0.6031.00
12_P28_L0.6011.00
50_G69_K0.5951.00
88_E91_A0.5911.00
63_A81_F0.5901.00
102_S105_R0.5881.00
35_P38_F0.5861.00
46_V69_K0.5831.00
5_V8_R0.5801.00
1_I121_A0.5791.00
87_G94_D0.5791.00
46_V66_C0.5691.00
7_E25_P0.5691.00
96_M105_R0.5681.00
80_L126_R0.5611.00
77_R116_D0.5591.00
25_P31_L0.5581.00
23_V29_I0.5581.00
77_R112_F0.5581.00
56_I74_L0.5561.00
122_N125_D0.5541.00
47_E65_R0.5531.00
96_M99_L0.5521.00
92_M102_S0.5501.00
46_V49_A0.5491.00
34_V100_R0.5441.00
36_A40_A0.5441.00
20_P35_P0.5411.00
16_V34_V0.5411.00
89_R94_D0.5391.00
110_A116_D0.5381.00
9_H128_L0.5371.00
5_V125_D0.5351.00
92_M98_D0.5331.00
74_L127_L0.5331.00
120_F124_L0.5281.00
25_P29_I0.5271.00
61_P64_A0.5191.00
35_P43_D0.5191.00
102_S106_T0.5181.00
54_L128_L0.5151.00
3_Y23_V0.5141.00
88_E95_L0.5121.00
18_N23_V0.5111.00
11_L28_L0.5070.99
60_I94_D0.5060.99
25_P28_L0.5050.99
86_I89_R0.5050.99
18_N34_V0.5040.99
91_A98_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uqtA 2 0.9769 70.5 0.9 Contact Map
4mj7A 2 0.6308 65.9 0.903 Contact Map
3hblA 4 0.9615 61.8 0.905 Contact Map
3t5tA 2 0.9846 61.3 0.906 Contact Map
2dzdA 2 0.9615 58 0.908 Contact Map
1b43A 2 0.9538 56.5 0.908 Contact Map
3u9tA 3 0.9615 54.4 0.909 Contact Map
1bgxT 1 0.8231 53.4 0.91 Contact Map
2vpqA 2 0.9615 52.2 0.911 Contact Map
4qshA 4 0.8077 50.1 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.