GREMLIN Database
DUF177 - Uncharacterized ACR, COG1399
PFAM: PF02620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (114)
Sequences: 48384 (34407)
Seq/√Len: 3222.5
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_T23_P2.7821.00
6_S25_D2.7671.00
14_D79_P2.6351.00
116_A119_K2.5241.00
8_T21_E2.4951.00
3_G28_F2.3891.00
10_E21_E2.3871.00
16_C85_C2.3721.00
2_T29_D2.2141.00
15_R80_L2.0961.00
4_R27_D2.0221.00
10_E19_P2.0121.00
115_A118_K1.9891.00
26_V74_A1.9781.00
96_A101_E1.9611.00
4_R25_D1.8611.00
85_C91_C1.8481.00
16_C81_C1.8271.00
65_E69_E1.8231.00
52_E56_Y1.8181.00
14_D78_K1.7721.00
20_F79_P1.7421.00
32_F66_L1.7421.00
5_L26_V1.7001.00
30_L70_E1.6741.00
11_L22_L1.6321.00
52_E55_P1.6191.00
18_E81_C1.5661.00
7_A24_V1.5381.00
51_E55_P1.4891.00
6_S23_P1.4761.00
86_K99_N1.4341.00
68_R72_L1.4201.00
18_E97_N1.3741.00
11_L79_P1.3361.00
53_V56_Y1.3281.00
11_L20_F1.3041.00
92_P95_G1.2921.00
12_E19_P1.2881.00
91_C94_C1.2631.00
12_E20_F1.2251.00
28_F70_E1.2031.00
62_D65_E1.1901.00
110_I115_A1.1701.00
16_C91_C1.1691.00
111_D116_A1.1651.00
84_D87_G1.1601.00
90_L94_C1.1351.00
51_E54_L1.1331.00
18_E100_E1.1271.00
13_C16_C1.1231.00
32_F61_I1.1151.00
65_E68_R1.1101.00
11_L75_L1.0951.00
26_V70_E1.0421.00
97_N100_E1.0331.00
7_A71_L1.0221.00
22_L76_P1.0121.00
81_C85_C1.0111.00
26_V30_L0.9961.00
99_N102_P0.9901.00
20_F81_C0.9901.00
91_C95_G0.9721.00
94_C97_N0.9611.00
94_C98_L0.9561.00
98_L101_E0.9521.00
110_I118_K0.9451.00
64_A68_R0.9451.00
85_C90_L0.9401.00
93_V98_L0.9371.00
96_A102_P0.9351.00
35_G38_E0.9191.00
110_I113_R0.9011.00
87_G91_C0.8961.00
70_E74_A0.8861.00
9_V22_L0.8791.00
66_L69_E0.8661.00
96_A99_N0.8651.00
112_P115_A0.8651.00
66_L70_E0.8631.00
104_D107_E0.8471.00
50_D54_L0.8401.00
115_A119_K0.8281.00
30_L66_L0.8061.00
106_E109_E0.7891.00
91_C98_L0.7831.00
114_W117_L0.7791.00
91_C96_A0.7761.00
93_V96_A0.7731.00
11_L76_P0.7681.00
70_E73_L0.7631.00
23_P26_V0.7581.00
93_V105_C0.7521.00
2_T27_D0.7471.00
9_V24_V0.7351.00
95_G98_L0.7271.00
92_P96_A0.7211.00
22_L79_P0.7161.00
114_W118_K0.7101.00
56_Y59_D0.7011.00
81_C84_D0.6991.00
15_R78_K0.6981.00
30_L69_E0.6941.00
12_E17_L0.6911.00
49_E52_E0.6801.00
51_E56_Y0.6781.00
3_G66_L0.6661.00
97_N103_C0.6631.00
87_G90_L0.6611.00
9_V75_L0.6541.00
41_E44_E0.6461.00
24_V74_A0.6441.00
92_P98_L0.6381.00
93_V107_E0.6361.00
96_A100_E0.6361.00
90_L95_G0.6321.00
14_D17_L0.6261.00
95_G99_N0.6221.00
93_V97_N0.6151.00
94_C99_N0.6141.00
91_C97_N0.6051.00
18_E82_R0.6041.00
93_V104_D0.6041.00
98_L102_P0.6001.00
101_E104_D0.5971.00
35_G39_A0.5951.00
34_P56_Y0.5951.00
91_C99_N0.5921.00
99_N103_C0.5921.00
111_D114_W0.5911.00
90_L93_V0.5881.00
98_L103_C0.5871.00
13_C81_C0.5851.00
13_C85_C0.5851.00
107_E110_I0.5821.00
42_E45_E0.5821.00
94_C103_C0.5761.00
34_P38_E0.5751.00
92_P97_N0.5721.00
5_L70_E0.5651.00
82_R86_K0.5601.00
100_E103_C0.5581.00
33_V53_V0.5571.00
97_N101_E0.5481.00
50_D56_Y0.5461.00
103_C107_E0.5451.00
38_E55_P0.5421.00
113_R116_A0.5411.00
93_V106_E0.5401.00
38_E42_E0.5371.00
20_F78_K0.5321.00
69_E73_L0.5311.00
114_W120_L0.5301.00
101_E105_C0.5271.00
50_D55_P0.5271.00
28_F74_A0.5261.00
37_E41_E0.5241.00
41_E45_E0.5241.00
81_C87_G0.5231.00
5_L67_V0.5221.00
72_L75_L0.5171.00
94_C105_C0.5171.00
54_L66_L0.5141.00
96_A104_D0.5141.00
65_E72_L0.5081.00
97_N102_P0.5071.00
95_G103_C0.5051.00
22_L25_D0.5051.00
75_L79_P0.5031.00
83_E86_K0.5011.00
90_L103_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ee8A 2 0.3388 4.8 0.906 Contact Map
1ornA 1 0.8099 2.7 0.917 Contact Map
3zmsC 1 0 2.4 0.919 Contact Map
3wupA 3 0.2562 2.4 0.919 Contact Map
1i7fA 2 0 2.2 0.921 Contact Map
2i5oA 1 0.2727 2 0.923 Contact Map
2gviA 3 0.3223 1.5 0.927 Contact Map
1wiiA 1 0.3967 1.5 0.928 Contact Map
4odjA 2 0.8017 1.4 0.93 Contact Map
1fv5A 1 0.2975 1.2 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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