GREMLIN Database
DUF169 - Uncharacterised ArCR, COG2043
PFAM: PF02596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 206 (202)
Sequences: 9872 (6745)
Seq/√Len: 474.6
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_A131_L4.0361.00
169_G198_S3.2861.00
14_A115_A3.2701.00
11_P113_D3.1611.00
199_K202_E3.1341.00
127_N189_D2.9761.00
18_L108_V2.7441.00
85_S88_A2.5961.00
54_T57_D2.5221.00
16_K120_D2.4861.00
44_A109_Y2.4831.00
43_L49_K2.3951.00
50_T110_A2.3941.00
91_R94_E2.3341.00
90_R94_E2.3201.00
129_A188_D2.3201.00
127_N130_Q2.2331.00
3_E11_P2.1941.00
75_E78_S2.1801.00
155_R159_A2.1751.00
40_F53_T2.1111.00
76_L79_G2.0951.00
19_D103_K2.0821.00
74_E77_L2.0341.00
187_P190_E1.9971.00
110_A115_A1.9761.00
32_P35_D1.9721.00
165_P194_A1.9511.00
21_E105_K1.8881.00
75_E79_G1.8501.00
74_E78_S1.8421.00
84_K141_A1.8081.00
24_I28_A1.7261.00
16_K117_F1.7181.00
100_P103_K1.7181.00
126_A130_Q1.7001.00
50_T114_K1.6841.00
20_E23_E1.5871.00
121_V194_A1.5831.00
104_Y166_Y1.5821.00
148_E170_E1.5781.00
141_A202_E1.5671.00
142_T202_E1.5561.00
88_A91_R1.5321.00
124_F134_L1.4941.00
91_R95_A1.4811.00
138_A171_P1.4761.00
195_I203_M1.4631.00
144_G170_E1.4551.00
54_T106_A1.4481.00
74_E79_G1.4331.00
124_F195_I1.4221.00
24_I27_G1.4161.00
31_P34_K1.3951.00
80_E83_F1.3851.00
36_A39_Q1.3661.00
19_D105_K1.3401.00
50_T116_P1.3211.00
201_E205_E1.3131.00
10_T45_R1.2821.00
52_Y108_V1.2781.00
15_V123_L1.2671.00
83_F92_F1.2661.00
134_L193_F1.2601.00
121_V166_Y1.2311.00
97_P159_A1.2301.00
110_A117_F1.2281.00
146_R150_S1.2081.00
202_E205_E1.2071.00
83_F89_A1.1981.00
83_F88_A1.1811.00
58_H64_A1.1691.00
196_P199_K1.1551.00
149_V152_P1.1481.00
164_Y168_T1.1421.00
37_G67_L1.1371.00
87_E90_R1.1151.00
42_A45_R1.1141.00
128_P191_L1.1051.00
37_G162_V1.1021.00
53_T58_H1.0991.00
132_M181_R1.0981.00
24_I52_Y1.0971.00
138_A193_F1.0871.00
27_G30_R1.0851.00
86_P90_R1.0741.00
197_G200_L1.0671.00
201_E204_V1.0631.00
50_T108_V1.0541.00
175_L191_L1.0501.00
82_Y87_E1.0331.00
151_F173_L1.0281.00
80_E84_K1.0131.00
9_K189_D1.0131.00
25_P28_A1.0111.00
9_K127_N1.0111.00
171_P193_F1.0091.00
14_A110_A0.9991.00
18_L106_A0.9981.00
64_A70_K0.9951.00
141_A205_E0.9931.00
167_L171_P0.9761.00
121_V165_P0.9711.00
139_Q144_G0.9681.00
30_R57_D0.9601.00
161_I192_L0.9581.00
197_G201_E0.9571.00
163_A167_L0.9541.00
20_E105_K0.9521.00
21_E106_A0.9481.00
108_V117_F0.9421.00
17_F104_Y0.9421.00
3_E7_R0.9401.00
122_V200_L0.9361.00
195_I200_L0.9341.00
86_P89_A0.9321.00
40_F109_Y0.9291.00
71_E101_A0.9141.00
72_L75_E0.9111.00
17_F166_Y0.9061.00
133_L136_Q0.9031.00
37_G41_W0.8961.00
13_V41_W0.8881.00
195_I199_K0.8871.00
40_F51_F0.8871.00
52_Y106_A0.8851.00
125_Y192_L0.8831.00
127_N188_D0.8821.00
126_A134_L0.8801.00
66_T159_A0.8781.00
173_L176_G0.8641.00
84_K88_A0.8561.00
58_H63_G0.8521.00
62_G66_T0.8471.00
125_Y186_L0.8461.00
171_P199_K0.8441.00
99_L163_A0.8431.00
125_Y190_E0.8391.00
88_A92_F0.8291.00
155_R160_D0.8291.00
168_T172_N0.8261.00
65_Y98_R0.8251.00
88_A143_G0.8241.00
100_P167_L0.8221.00
2_L6_L0.8211.00
85_S91_R0.8181.00
91_R143_G0.8161.00
70_K79_G0.8101.00
93_V96_I0.8091.00
180_A183_Y0.8071.00
68_G102_G0.8061.00
122_V197_G0.8021.00
134_L203_M0.8021.00
45_R125_Y0.7951.00
170_E199_K0.7911.00
110_A116_P0.7871.00
70_K73_P0.7871.00
54_T105_K0.7821.00
125_Y180_A0.7771.00
135_I193_F0.7741.00
147_L150_S0.7741.00
21_E25_P0.7681.00
55_A105_K0.7641.00
131_L191_L0.7631.00
165_P172_N0.7611.00
157_G177_C0.7601.00
128_P189_D0.7581.00
72_L77_L0.7521.00
119_P197_G0.7501.00
174_S177_C0.7501.00
123_L194_A0.7481.00
2_L124_F0.7311.00
157_G192_L0.7311.00
137_A203_M0.7301.00
87_E91_R0.7261.00
3_E113_D0.7261.00
29_G49_K0.7231.00
31_P35_D0.7131.00
85_S89_A0.7121.00
176_G186_L0.7121.00
146_R152_P0.7111.00
157_G180_A0.7101.00
71_E77_L0.7101.00
41_W183_Y0.7081.00
81_G84_K0.7061.00
85_S90_R0.7021.00
147_L151_F0.6991.00
82_Y86_P0.6971.00
165_P168_T0.6941.00
171_P195_I0.6891.00
17_F99_L0.6891.00
19_D104_Y0.6881.00
25_P29_G0.6861.00
72_L76_L0.6851.00
164_Y172_N0.6841.00
186_L190_E0.6791.00
178_I182_V0.6781.00
99_L167_L0.6701.00
2_L8_L0.6631.00
78_S86_P0.6611.00
129_A133_L0.6571.00
150_S164_Y0.6541.00
37_G109_Y0.6531.00
42_A46_R0.6521.00
70_K77_L0.6511.00
54_T59_G0.6491.00
16_K23_E0.6481.00
148_E151_F0.6451.00
54_T58_H0.6441.00
146_R160_D0.6431.00
67_L107_V0.6401.00
16_K115_A0.6401.00
64_A69_F0.6391.00
55_A58_H0.6371.00
178_I183_Y0.6351.00
36_A183_Y0.6301.00
198_S202_E0.6250.99
156_A160_D0.6230.99
16_K19_D0.6230.99
67_L162_V0.6190.99
58_H69_F0.6160.99
36_A42_A0.6150.99
10_T190_E0.6140.99
142_T199_K0.6120.99
92_F95_A0.6120.99
88_A141_A0.6060.99
175_L180_A0.6020.99
2_L204_V0.5980.99
73_P76_L0.5970.99
96_I159_A0.5930.99
100_P104_Y0.5900.99
120_D166_Y0.5880.99
136_Q153_G0.5880.99
62_G156_A0.5870.99
48_G113_D0.5830.99
82_Y89_A0.5820.99
19_D101_A0.5810.99
15_V109_Y0.5810.99
164_Y170_E0.5790.99
26_E29_G0.5760.99
63_G67_L0.5750.99
97_P167_L0.5750.99
166_Y169_G0.5740.99
29_G33_K0.5730.99
112_L122_V0.5720.99
200_L203_M0.5710.99
67_L163_A0.5700.99
30_R35_D0.5690.99
9_K187_P0.5670.99
36_A61_P0.5660.99
28_A50_T0.5650.99
30_R34_K0.5620.99
55_A64_A0.5600.99
73_P77_L0.5570.99
21_E52_Y0.5570.99
58_H107_V0.5570.99
147_L153_G0.5560.99
89_A93_V0.5510.99
179_G182_V0.5490.99
18_L22_P0.5490.99
99_L102_G0.5490.99
82_Y85_S0.5480.99
28_A56_E0.5480.99
48_G111_P0.5470.99
140_Y143_G0.5460.99
50_T53_T0.5460.99
144_G147_L0.5450.99
70_K75_E0.5450.99
13_V109_Y0.5440.99
180_A184_T0.5440.99
176_G180_A0.5430.99
126_A193_F0.5420.99
5_L8_L0.5410.99
55_A69_F0.5370.98
99_L103_K0.5350.98
29_G32_P0.5330.98
161_I194_A0.5290.98
80_E86_P0.5280.98
13_V44_A0.5280.98
112_L115_A0.5240.98
156_A159_A0.5230.98
131_L173_L0.5230.98
30_R33_K0.5220.98
7_R11_P0.5190.98
138_A203_M0.5170.98
22_P26_E0.5170.98
33_K43_L0.5160.98
37_G107_V0.5160.98
69_F107_V0.5140.98
28_A108_V0.5130.98
97_P168_T0.5130.98
199_K203_M0.5130.98
159_A163_A0.5090.98
14_A122_V0.5090.98
62_G177_C0.5040.98
135_I173_L0.5040.98
173_L191_L0.5030.98
3_E9_K0.5030.98
131_L193_F0.5020.98
49_K114_K0.5010.98
89_A92_F0.5010.98
133_L137_A0.5000.98
41_W123_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vejA 2 0.0825 15.9 0.941 Contact Map
4c23A 1 0.4272 11.2 0.945 Contact Map
3u7qB 2 0.6262 6.1 0.951 Contact Map
2ktrA 2 0.2524 5.3 0.952 Contact Map
1wj6A 1 0.2816 5.1 0.953 Contact Map
1wmhB 1 0.2476 3.4 0.957 Contact Map
4mjsB 1 0.2524 3.2 0.957 Contact Map
1qguB 2 0.6214 2.8 0.958 Contact Map
2rafA 2 0.3641 2.7 0.959 Contact Map
2bkfA 1 0.2524 2.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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