GREMLIN Database
Vut_1 - Putative vitamin uptake transporter
PFAM: PF02592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (148)
Sequences: 18639 (10420)
Seq/√Len: 856.5
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_L110_V3.1761.00
48_I56_E2.9821.00
45_W49_A2.7051.00
17_L29_V2.6781.00
64_R122_G2.6001.00
54_A57_A2.5501.00
31_W78_F2.2871.00
109_L133_Y2.2441.00
68_A118_I2.2311.00
25_R28_R2.2071.00
79_L106_V2.0351.00
53_E56_E1.9961.00
86_K89_K1.9631.00
124_L127_S1.9131.00
40_A44_I1.9041.00
75_V114_I1.8741.00
79_L83_V1.8451.00
117_T121_Y1.8281.00
105_L137_V1.8061.00
127_S131_T1.7131.00
113_L129_I1.6901.00
95_H98_L1.6881.00
23_K27_R1.6701.00
113_L117_T1.6481.00
125_L129_I1.6421.00
82_Y86_K1.6401.00
2_A47_A1.6221.00
86_K90_L1.6051.00
87_L98_L1.5851.00
112_T136_K1.5821.00
18_T85_A1.5811.00
53_E57_A1.5261.00
133_Y137_V1.5241.00
38_L70_L1.4601.00
34_F74_L1.4191.00
30_I81_V1.3921.00
91_T95_H1.3761.00
128_L132_Q1.3751.00
116_I129_I1.3741.00
123_S127_S1.3601.00
116_I132_Q1.3481.00
97_W148_Y1.3461.00
96_L100_N1.3301.00
109_L113_L1.3291.00
139_V143_L1.3171.00
33_G73_Y1.3161.00
45_W48_I1.2871.00
71_I118_I1.2811.00
31_W35_A1.2741.00
126_L130_L1.2701.00
23_K85_A1.2641.00
24_K27_R1.2641.00
31_W74_L1.2201.00
72_A114_I1.2201.00
76_G107_S1.2091.00
117_T129_I1.2041.00
27_R78_F1.1991.00
39_L43_M1.1981.00
24_K28_R1.1981.00
98_L102_G1.1901.00
65_I119_A1.1681.00
6_L43_M1.1661.00
87_L102_G1.1621.00
126_L129_I1.1621.00
124_L128_L1.1491.00
146_L149_L1.1371.00
143_L146_L1.1321.00
100_N144_T1.1271.00
79_L82_Y1.1211.00
19_E99_R1.1161.00
134_L138_L1.1081.00
138_L142_L1.1041.00
23_K82_Y1.1041.00
117_T125_L1.0991.00
83_V87_L1.0961.00
41_A63_P1.0881.00
115_F119_A1.0811.00
16_I20_V1.0761.00
85_A89_K1.0711.00
92_G95_H1.0591.00
4_V132_Q1.0511.00
46_L49_A1.0481.00
42_L45_W1.0461.00
91_T98_L1.0351.00
27_R31_W1.0301.00
83_V86_K1.0151.00
34_F70_L1.0101.00
48_I55_F0.9991.00
32_L36_A0.9951.00
101_I144_T0.9761.00
71_I114_I0.9641.00
102_G106_V0.9591.00
34_F73_Y0.9501.00
41_A45_W0.9501.00
116_I128_L0.9431.00
44_I59_F0.9351.00
96_L147_T0.9301.00
78_F82_Y0.9211.00
87_L90_L0.9171.00
2_A50_L0.9151.00
42_L46_L0.9021.00
101_I141_V0.8921.00
12_L147_T0.8891.00
37_N41_A0.8751.00
22_G25_R0.8641.00
32_L35_A0.8631.00
112_T132_Q0.8631.00
89_K93_G0.8611.00
15_D80_D0.8541.00
121_Y125_L0.8361.00
130_L134_L0.8341.00
101_I105_L0.8261.00
65_I115_F0.8211.00
71_I75_V0.8181.00
143_L147_T0.8141.00
15_D103_S0.8141.00
41_A66_V0.7791.00
69_S111_D0.7781.00
63_P66_V0.7771.00
17_L26_A0.7741.00
63_P67_L0.7711.00
55_F58_V0.7711.00
44_I47_A0.7661.00
37_N70_L0.7521.00
132_Q136_K0.7491.00
129_I133_Y0.7441.00
131_T135_F0.7421.00
77_Q81_V0.7261.00
140_A143_L0.7251.00
15_D104_T0.7181.00
48_I60_G0.7151.00
72_A76_G0.7121.00
4_V135_F0.7091.00
25_R29_V0.7091.00
37_N66_V0.7081.00
74_L78_F0.7071.00
7_F10_T0.7041.00
19_E88_K0.7031.00
75_V110_V0.7011.00
144_T148_Y0.7001.00
37_N40_A0.6941.00
83_V106_V0.6921.00
44_I48_I0.6901.00
54_A58_V0.6851.00
105_L133_Y0.6841.00
113_L130_L0.6821.00
61_Q66_V0.6721.00
84_F100_N0.6701.00
43_M47_A0.6671.00
64_R120_F0.6631.00
80_D107_S0.6621.00
87_L91_T0.6561.00
106_V109_L0.6531.00
84_F96_L0.6511.00
28_R32_L0.6481.00
45_W61_Q0.6461.00
114_I118_I0.6411.00
4_V116_I0.6361.00
2_A6_L0.6351.00
111_D136_K0.6341.00
23_K81_V0.6321.00
135_F139_V0.6121.00
104_T140_A0.6081.00
64_R118_I0.6071.00
11_F15_D0.6051.00
38_L42_L0.6051.00
3_G6_L0.6011.00
97_W101_I0.6011.00
41_A44_I0.6011.00
64_R121_Y0.5981.00
122_G125_L0.5951.00
80_D84_F0.5941.00
89_K92_G0.5931.00
8_P12_L0.5911.00
13_I16_I0.5911.00
67_L71_I0.5901.00
112_T133_Y0.5881.00
120_F128_L0.5811.00
82_Y85_A0.5811.00
18_T84_F0.5811.00
70_L74_L0.5801.00
100_N143_L0.5781.00
48_I59_F0.5781.00
71_I78_F0.5781.00
26_A30_I0.5771.00
61_Q65_I0.5741.00
45_W63_P0.5731.00
10_T13_I0.5721.00
64_R68_A0.5721.00
27_R82_Y0.5711.00
84_F88_K0.5681.00
72_A111_D0.5681.00
18_T81_V0.5671.00
111_D115_F0.5641.00
12_L146_L0.5641.00
57_A61_Q0.5631.00
80_D103_S0.5621.00
127_S130_L0.5591.00
123_S126_L0.5581.00
14_T80_D0.5571.00
72_A110_V0.5571.00
18_T26_A0.5551.00
90_L98_L0.5511.00
11_F14_T0.5511.00
64_R125_L0.5441.00
62_T66_V0.5441.00
67_L118_I0.5421.00
56_E60_G0.5361.00
144_T147_T0.5331.00
98_L101_I0.5321.00
41_A62_T0.5281.00
4_V8_P0.5281.00
109_L129_I0.5271.00
30_I34_F0.5221.00
49_A56_E0.5211.00
124_L131_T0.5201.00
35_A38_L0.5191.00
12_L143_L0.5191.00
72_A118_I0.5151.00
125_L128_L0.5141.00
14_T18_T0.5071.00
48_I58_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4humA 1 0.9467 11.1 0.905 Contact Map
3mktA 1 0.94 7.9 0.911 Contact Map
3w4tA 1 0.9533 6.4 0.915 Contact Map
4m64A 1 0.8333 5.9 0.916 Contact Map
3aqpA 1 0.9133 5.2 0.919 Contact Map
3w9iA 3 0.9 5.1 0.919 Contact Map
4rfsS 1 0.9133 4.8 0.92 Contact Map
4lz6A 1 0.5733 4.6 0.921 Contact Map
4k0jA 3 0.8733 4 0.923 Contact Map
4tphA 2 0.76 3.8 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.