GREMLIN Database
YitT_membrane - Uncharacterised 5xTM membrane BCR, YitT family COG1284
PFAM: PF02588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 207 (204)
Sequences: 19634 (13061)
Seq/√Len: 914.5
META: 0.722

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_T74_Y4.7031.00
198_K201_E4.6731.00
4_L119_G3.0341.00
30_V52_L2.9731.00
10_L82_F2.7791.00
46_G84_D2.6191.00
17_N86_L2.5291.00
104_F166_L2.5191.00
177_K181_F2.4511.00
196_S199_P2.3021.00
13_A82_F2.2081.00
200_E204_D2.2041.00
37_L48_L2.1861.00
157_G165_A2.1771.00
14_F18_L2.1751.00
58_I62_K2.1551.00
9_A78_L2.0691.00
161_G164_T2.0511.00
37_L41_T1.9961.00
15_G109_L1.9481.00
8_G112_G1.9461.00
61_Y66_K1.9421.00
196_S202_I1.9291.00
23_N101_A1.8791.00
150_V154_L1.8001.00
49_I83_L1.7961.00
5_I75_A1.7631.00
6_T78_L1.7541.00
77_L81_L1.7511.00
44_P84_D1.7341.00
50_L77_L1.7241.00
12_A79_L1.7161.00
140_S143_K1.7041.00
43_I48_L1.7001.00
48_L52_L1.6951.00
67_R71_K1.6301.00
30_V56_L1.6211.00
142_G180_D1.6211.00
146_L176_S1.5831.00
50_L80_S1.5731.00
21_I45_V1.5701.00
20_L171_T1.5451.00
98_P164_T1.5421.00
47_L84_D1.5371.00
44_P47_L1.4961.00
116_V123_T1.4901.00
10_L86_L1.4861.00
8_G116_V1.4831.00
147_I151_V1.4631.00
133_L137_T1.4611.00
63_F136_K1.4601.00
130_A145_I1.4481.00
2_Y71_K1.4431.00
102_A106_G1.4041.00
78_L82_F1.3871.00
111_I182_V1.3851.00
26_A156_A1.3811.00
126_T148_I1.3791.00
20_L105_G1.3701.00
68_F122_S1.3671.00
114_G182_V1.3261.00
151_V155_A1.3241.00
61_Y69_A1.3121.00
74_Y78_L1.3001.00
63_F132_I1.2891.00
15_G112_G1.2691.00
157_G162_W1.2611.00
59_L63_F1.2571.00
38_S45_V1.2551.00
81_L84_D1.2401.00
57_L76_V1.2311.00
5_I121_G1.2201.00
59_L132_I1.2201.00
12_A112_G1.2121.00
24_G39_Y1.2121.00
15_G108_L1.1941.00
51_L55_P1.1921.00
93_P96_D1.1691.00
9_A79_L1.1621.00
47_L51_L1.1511.00
64_L68_F1.1471.00
173_F177_K1.1311.00
151_V154_L1.1301.00
62_K66_K1.1151.00
40_L159_V1.1141.00
133_L144_V1.1121.00
107_V178_V1.1121.00
12_A109_L1.1111.00
75_A121_G1.0961.00
79_L83_L1.0741.00
54_I58_I1.0701.00
45_V83_L1.0661.00
60_G69_A1.0511.00
24_G164_T1.0501.00
25_L102_A1.0371.00
153_I172_L1.0331.00
35_L38_S1.0201.00
41_T48_L1.0191.00
113_I123_T1.0171.00
26_A168_S1.0171.00
154_L158_F1.0131.00
11_L111_I1.0041.00
123_T127_D1.0001.00
14_F86_L0.9981.00
177_K180_D0.9791.00
200_E203_A0.9721.00
81_L85_L0.9701.00
46_G50_L0.9581.00
201_E204_D0.9551.00
38_S42_G0.9531.00
9_A82_F0.9501.00
2_Y6_T0.9471.00
139_I144_V0.9461.00
46_G80_S0.9451.00
117_F131_L0.9421.00
63_F135_K0.9421.00
34_A49_I0.9411.00
161_G165_A0.9411.00
45_V49_I0.9391.00
34_A48_L0.9391.00
43_I47_L0.9391.00
90_P93_P0.9351.00
102_A171_T0.9351.00
107_V173_F0.9301.00
6_T82_F0.9281.00
4_L115_L0.9271.00
56_L128_I0.9211.00
148_I152_I0.8991.00
99_L167_Y0.8941.00
147_I150_V0.8941.00
4_L118_R0.8891.00
97_D167_Y0.8881.00
113_I117_F0.8871.00
96_D163_E0.8841.00
2_Y74_Y0.8841.00
57_L72_T0.8811.00
55_P59_L0.8761.00
36_L155_A0.8681.00
58_I61_Y0.8641.00
60_G128_I0.8631.00
109_L175_A0.8621.00
92_P95_T0.8561.00
110_G114_G0.8511.00
139_I143_K0.8451.00
114_G118_R0.8391.00
9_A75_A0.8331.00
143_K147_I0.8291.00
116_V121_G0.8281.00
38_S48_L0.8271.00
105_G171_T0.8161.00
144_V147_I0.8061.00
126_T149_D0.8031.00
56_L129_L0.8011.00
33_I37_L0.7981.00
142_G179_I0.7981.00
68_F131_L0.7971.00
64_L131_L0.7951.00
16_L21_I0.7921.00
145_I149_D0.7871.00
99_L170_I0.7851.00
16_L31_T0.7831.00
134_N138_G0.7831.00
66_K69_A0.7811.00
21_I35_L0.7741.00
132_I136_K0.7721.00
49_I80_S0.7711.00
126_T152_I0.7711.00
178_V181_F0.7701.00
201_E205_A0.7571.00
131_L141_I0.7551.00
70_I74_Y0.7531.00
172_L176_S0.7511.00
148_I151_V0.7491.00
11_L108_L0.7481.00
6_T9_A0.7461.00
95_T163_E0.7401.00
155_A158_F0.7371.00
3_L7_L0.7361.00
97_D163_E0.7331.00
66_K70_I0.7311.00
21_I38_S0.7301.00
33_I155_A0.7271.00
9_A13_A0.7211.00
199_P203_A0.7181.00
82_F86_L0.7131.00
82_F85_L0.7081.00
92_P96_D0.7071.00
27_D35_L0.7061.00
89_P92_P0.6991.00
55_P58_I0.6961.00
115_L119_G0.6961.00
13_A86_L0.6951.00
31_T49_I0.6941.00
103_I174_V0.6921.00
48_L51_L0.6891.00
37_L52_L0.6881.00
100_L104_F0.6841.00
122_S131_L0.6781.00
57_L73_I0.6751.00
131_L135_K0.6721.00
90_P94_L0.6691.00
7_L11_L0.6681.00
12_A15_G0.6671.00
199_P202_I0.6591.00
57_L128_I0.6551.00
30_V34_A0.6551.00
106_G171_T0.6521.00
39_Y160_F0.6501.00
117_F127_D0.6471.00
60_G68_F0.6451.00
149_D172_L0.6431.00
16_L79_L0.6421.00
89_P93_P0.6371.00
77_L80_S0.6361.00
98_P101_A0.6341.00
20_L27_D0.6341.00
17_N21_I0.6331.00
134_N141_I0.6331.00
31_T79_L0.6281.00
100_L166_L0.6271.00
13_A83_L0.6241.00
184_E188_Q0.6241.00
111_I115_L0.6231.00
15_G20_L0.6231.00
36_L159_V0.6191.00
146_L173_F0.6191.00
175_A179_I0.6181.00
98_P102_A0.6161.00
176_S179_I0.6151.00
102_A170_I0.6131.00
98_P167_Y0.6131.00
150_V169_L0.6101.00
49_I79_L0.6071.00
9_A116_V0.6061.00
102_A174_V0.6011.00
91_F94_L0.6001.00
19_F104_F0.5981.00
33_I152_I0.5981.00
202_I206_I0.5931.00
117_F145_I0.5921.00
72_T122_S0.5901.00
72_T128_I0.5881.00
79_L82_F0.5871.00
36_L152_I0.5871.00
157_G161_G0.5851.00
145_I179_I0.5841.00
30_V126_T0.5841.00
134_N144_V0.5831.00
36_L156_A0.5811.00
130_A144_V0.5791.00
98_P163_E0.5791.00
142_G176_S0.5781.00
76_V80_S0.5781.00
179_I183_L0.5741.00
154_L169_L0.5731.00
131_L134_N0.5721.00
71_K121_G0.5711.00
89_P94_L0.5711.00
35_L39_Y0.5711.00
35_L45_V0.5691.00
12_A113_I0.5681.00
33_I148_I0.5651.00
113_I149_D0.5651.00
143_K180_D0.5631.00
100_L167_Y0.5611.00
13_A79_L0.5611.00
15_G19_F0.5611.00
11_L115_L0.5611.00
80_S84_D0.5581.00
25_L171_T0.5561.00
8_G75_A0.5541.00
88_P91_F0.5541.00
202_I205_A0.5531.00
50_L54_I0.5531.00
160_F164_T0.5491.00
19_F101_A0.5491.00
29_G32_G0.5481.00
25_L98_P0.5431.00
153_I156_A0.5431.00
59_L62_K0.5401.00
145_I176_S0.5381.00
36_L40_L0.5371.00
53_N76_V0.5341.00
137_T144_V0.5311.00
37_L40_L0.5301.00
12_A123_T0.5281.00
114_G183_L0.5271.00
62_K80_S0.5271.00
4_L7_L0.5261.00
50_L53_N0.5251.00
117_F130_A0.5241.00
26_A35_L0.5221.00
113_I179_I0.5211.00
88_P94_L0.5201.00
47_L50_L0.5181.00
181_F186_F0.5161.00
155_A159_V0.5131.00
103_I170_I0.5091.00
26_A152_I0.5061.00
143_K146_L0.5061.00
75_A123_T0.5031.00
64_L135_K0.5021.00
69_A73_I0.5011.00
24_G38_S0.5011.00
44_P48_L0.5011.00
136_K144_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8889 3.5 0.951 Contact Map
1yo3A 2 0.087 2.4 0.955 Contact Map
4q46A 1 0.3816 2 0.957 Contact Map
2cfqA 1 0.8599 2 0.957 Contact Map
3j1zP 8 0.9227 1.5 0.96 Contact Map
4ikvA 1 0.8889 1.4 0.961 Contact Map
4f0zC 1 0.087 1.3 0.961 Contact Map
4oh3A 2 0.9179 1.3 0.961 Contact Map
4he8K 1 0.4348 1.3 0.961 Contact Map
3b5dA 2 0.4638 1.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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