GREMLIN Database
DUF155 - Uncharacterised ACR, YagE family COG1723
PFAM: PF02582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 160 (159)
Sequences: 3949 (2586)
Seq/√Len: 205.1
META: 0.752

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E20_E3.1561.00
15_S18_E2.9221.00
33_E37_F2.7291.00
24_R27_K2.7011.00
33_E39_E2.5871.00
14_L18_E2.5751.00
64_D68_Q2.5321.00
12_W63_A2.5001.00
91_E95_K2.4831.00
140_E144_A2.3861.00
105_E108_K2.2521.00
21_E24_R2.1281.00
92_E100_P2.0791.00
42_P52_K2.0641.00
33_E36_E1.9481.00
35_F39_E1.9251.00
93_L111_G1.9131.00
11_F14_L1.9041.00
38_E48_V1.8961.00
94_A112_E1.8921.00
31_E73_A1.8911.00
11_F23_L1.8171.00
14_L19_E1.8021.00
104_R108_K1.7771.00
102_S105_E1.7611.00
20_E24_R1.7421.00
3_L26_L1.6361.00
3_L9_V1.6071.00
17_E20_E1.6071.00
94_A115_L1.6051.00
92_E96_T1.6041.00
93_L107_L1.5511.00
4_F67_A1.5281.00
71_A124_L1.5131.00
23_L27_K1.5111.00
18_E21_E1.4991.00
12_W59_L1.4881.00
140_E143_Y1.4821.00
53_D58_R1.4761.00
140_E151_E1.4731.00
81_K84_D1.4731.00
70_V73_A1.4271.00
79_V120_I1.4241.00
97_G111_G1.4151.00
147_R153_K1.4061.00
28_E31_E1.4001.00
97_G108_K1.3991.00
43_R50_V1.3921.00
129_K140_E1.3611.00
143_Y147_R1.3471.00
11_F19_E1.3301.00
151_E154_E1.3181.00
10_V67_A1.3181.00
65_A146_L1.2801.00
86_T114_L1.2731.00
34_E37_F1.2721.00
3_L22_F1.2591.00
73_A76_E1.2511.00
81_K85_R1.2481.00
89_L106_L1.2441.00
85_R109_F1.2311.00
133_L140_E1.2261.00
17_E21_E1.2251.00
6_Y75_Y1.1891.00
34_E38_E1.1851.00
44_I49_I1.1811.00
71_A127_L1.1571.00
70_V118_H1.1371.00
70_V136_D1.1281.00
68_Q151_E1.1201.00
17_E25_R1.1111.00
94_A108_K1.0991.00
87_E91_E1.0901.00
90_A114_L1.0871.00
137_P149_E1.0581.00
109_F112_E1.0571.00
131_D134_W1.0471.00
47_D50_V1.0421.00
54_L59_L1.0251.00
36_E40_D1.0071.00
36_E48_V1.0021.00
61_V132_L0.9961.00
66_L150_F0.9921.00
32_T37_F0.9861.00
63_A122_L0.9751.00
8_V67_A0.9691.00
76_E143_Y0.9631.00
82_L112_E0.9610.99
42_P126_L0.9540.99
5_R10_V0.9520.99
31_E39_E0.9430.99
96_T100_P0.9420.99
6_Y67_A0.9400.99
131_D135_D0.9390.99
129_K151_E0.9370.99
120_I123_R0.9280.99
135_D138_E0.9250.99
100_P106_L0.9240.99
68_Q147_R0.9210.99
39_E59_L0.9180.99
36_E39_E0.9130.99
85_R112_E0.9090.99
134_W140_E0.9030.99
148_D154_E0.9020.99
85_R105_E0.8990.99
107_L110_I0.8900.99
34_E39_E0.8870.99
45_E50_V0.8850.99
20_E25_R0.8780.99
121_N124_L0.8710.99
144_A147_R0.8560.99
33_E40_D0.8540.99
130_P134_W0.8320.99
55_S58_R0.8310.99
28_E38_E0.8240.98
82_L109_F0.8220.98
78_R119_R0.8180.98
116_V119_R0.8160.98
18_E25_R0.8140.98
6_Y126_L0.8130.98
101_L105_E0.8010.98
16_E19_E0.7960.98
46_G61_V0.7910.98
31_E35_F0.7890.98
57_E139_L0.7890.98
65_A143_Y0.7860.98
153_K157_R0.7820.98
65_A150_F0.7710.98
109_F125_E0.7680.98
76_E130_P0.7640.97
51_L62_I0.7610.97
49_I142_L0.7580.97
67_A112_E0.7510.97
49_I58_R0.7500.97
4_F60_L0.7460.97
155_R159_L0.7450.97
46_G137_P0.7420.97
51_L58_R0.7380.97
22_F26_L0.7340.97
2_F12_W0.7290.97
30_P33_E0.7220.96
32_T36_E0.7220.96
49_I146_L0.7160.96
145_R148_D0.7150.96
52_K58_R0.7120.96
8_V71_A0.7110.96
94_A97_G0.7090.96
22_F25_R0.6990.96
85_R92_E0.6950.96
128_D133_L0.6880.95
41_E47_D0.6810.95
91_E148_D0.6780.95
129_K154_E0.6750.95
60_L82_L0.6740.95
124_L152_L0.6730.95
39_E54_L0.6710.95
2_F63_A0.6610.94
58_R61_V0.6580.94
129_K133_L0.6570.94
35_F38_E0.6520.94
63_A89_L0.6520.94
4_F7_G0.6490.94
143_Y158_A0.6460.94
86_T115_L0.6450.93
60_L133_L0.6440.93
86_T117_R0.6430.93
107_L139_L0.6410.93
68_Q97_G0.6400.93
47_D149_E0.6350.93
11_F69_S0.6340.93
32_T94_A0.6330.93
31_E36_E0.6320.93
11_F22_F0.6320.93
38_E50_V0.6310.93
90_A113_A0.6310.93
34_E40_D0.6280.93
113_A117_R0.6240.92
111_G115_L0.6200.92
21_E25_R0.6170.92
44_I50_V0.6160.92
31_E37_F0.6130.92
121_N125_E0.6070.91
95_K104_R0.6070.91
86_T109_F0.6060.91
129_K147_R0.6020.91
60_L103_R0.6010.91
109_F120_I0.5990.91
84_D87_E0.5970.91
29_E32_T0.5930.90
109_F113_A0.5850.90
56_P96_T0.5850.90
9_V23_L0.5840.90
57_E136_D0.5830.90
45_E48_V0.5820.89
53_D95_K0.5750.89
92_E95_K0.5730.89
120_I143_Y0.5690.88
90_A117_R0.5680.88
29_E33_E0.5580.87
122_L125_E0.5570.87
49_I150_F0.5560.87
41_E44_I0.5560.87
147_R151_E0.5530.87
70_V78_R0.5520.87
6_Y68_Q0.5500.87
135_D145_R0.5490.87
90_A111_G0.5480.86
56_P119_R0.5460.86
18_E22_F0.5440.86
36_E95_K0.5440.86
1_V22_F0.5410.86
86_T110_I0.5390.86
133_L139_L0.5350.85
86_T113_A0.5330.85
60_L156_Y0.5310.85
59_L121_N0.5260.84
39_E51_L0.5250.84
85_R158_A0.5240.84
108_K112_E0.5240.84
31_E34_E0.5230.84
111_G114_L0.5220.84
9_V81_K0.5210.84
93_L118_H0.5200.83
102_S127_L0.5190.83
144_A148_D0.5190.83
39_E50_V0.5180.83
22_F30_P0.5170.83
68_Q75_Y0.5160.83
38_E81_K0.5150.83
32_T38_E0.5150.83
24_R53_D0.5120.83
11_F66_L0.5080.82
120_I147_R0.5080.82
86_T107_L0.5080.82
45_E51_L0.5070.82
127_L156_Y0.5050.82
78_R116_V0.5030.81
136_D140_E0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dgsA 1 0.3625 11.3 0.934 Contact Map
3oiqB 1 0.1875 11.2 0.934 Contact Map
3sgiA 1 0.3438 7.4 0.939 Contact Map
3j8bC 1 0.2938 6.6 0.941 Contact Map
4lh6A 1 0.3875 5 0.944 Contact Map
3c0uA 2 0.45 4.6 0.945 Contact Map
3qneA 2 0.9375 4.1 0.946 Contact Map
3uq8A 1 0.3375 3.6 0.948 Contact Map
1mp9A 2 0.7625 3.4 0.948 Contact Map
1m2dA 2 0.2375 3.4 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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