GREMLIN Database
CbiN - Cobalt transport protein component CbiN
PFAM: PF02553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (66)
Sequences: 2446 (1553)
Seq/√Len: 191.1
META: 0.756

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_W53_P3.7341.00
54_S57_I3.1311.00
63_A66_A2.7521.00
34_A37_E2.3441.00
14_V18_L2.1511.00
32_E58_E2.1341.00
19_V22_A2.0571.00
3_L7_L1.9551.00
27_A31_A1.9291.00
33_E36_E1.8541.00
42_Y45_W1.6791.00
22_A54_S1.6661.00
15_P19_V1.6051.00
10_L14_V1.5951.00
12_A16_L1.5581.00
35_I42_Y1.5101.00
56_E59_S1.4941.00
32_E36_E1.4151.00
5_L9_V1.3681.00
25_G29_D1.3621.00
25_G30_Q1.2931.00
29_D32_E1.2901.00
4_L7_L1.2171.00
4_L8_V1.1861.00
53_P57_I1.1711.00
8_V11_L1.0971.00
2_L5_L1.0851.00
57_I60_L1.0741.00
19_V50_W1.0131.00
9_V13_V1.0071.00
15_P24_F1.0041.00
29_D33_E0.9850.99
59_S63_A0.9810.99
37_E43_E0.9730.99
2_L6_L0.9720.99
7_L11_L0.9640.99
31_A35_I0.9550.99
8_V12_A0.9430.99
24_F63_A0.9290.99
41_G44_P0.9160.99
30_Q33_E0.8990.99
44_P48_P0.8960.99
22_A57_I0.8530.98
8_V31_A0.8510.98
9_V12_A0.8290.98
32_E51_E0.8220.98
33_E47_E0.8200.98
13_V61_L0.8200.98
27_A60_L0.8190.98
29_D60_L0.8190.98
13_V17_F0.8110.98
15_P18_L0.8110.98
44_P47_E0.7940.97
34_A38_I0.7670.97
2_L7_L0.7500.96
32_E35_I0.7470.96
39_N50_W0.7280.96
21_G43_E0.7260.96
11_L15_P0.7250.96
60_L63_A0.7150.95
36_E41_G0.7090.95
43_E51_E0.7010.95
16_L19_V0.6970.95
62_F65_Q0.6910.94
8_V15_P0.6500.92
51_E55_G0.6470.92
12_A15_P0.6340.92
26_G31_A0.6240.91
31_A34_A0.6200.91
4_L15_P0.6170.90
55_G59_S0.6070.90
52_P61_L0.6010.89
38_I44_P0.6010.89
36_E40_P0.5960.89
61_L64_L0.5930.89
57_I61_L0.5870.88
55_G58_E0.5800.87
27_A32_E0.5760.87
30_Q58_E0.5740.87
27_A63_A0.5730.87
57_I66_A0.5700.87
51_E54_S0.5670.86
26_G29_D0.5580.85
5_L14_V0.5560.85
31_A40_P0.5490.85
9_V64_L0.5450.84
10_L19_V0.5410.84
51_E60_L0.5410.84
15_P45_W0.5380.83
27_A34_A0.5370.83
14_V19_V0.5350.83
33_E39_N0.5330.83
5_L17_F0.5320.83
21_G24_F0.5190.81
24_F59_S0.5160.81
15_P20_K0.5150.81
6_L36_E0.5100.80
33_E37_E0.5100.80
26_G67_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4um9B 2 0 4.4 0.904 Contact Map
2qv6A 4 0.4925 3.1 0.911 Contact Map
3pmqA 1 0.1045 2.2 0.918 Contact Map
4av3A 2 0.3433 2.1 0.918 Contact Map
2w3zA 1 0.2388 2 0.919 Contact Map
2ww8A 1 0 1.9 0.92 Contact Map
3hzqA 3 0.3433 1.9 0.92 Contact Map
3qhoA 1 0 1.8 0.922 Contact Map
4c7rA 3 0.8657 1.7 0.923 Contact Map
4lm8A 1 0.1791 1.7 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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