Hydantoinase_B - PFAM28P - GREMLIN Contacts

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Hydantoinase_B - Hydantoinase B/oxoprolinase

PFAM:	PF02538	Sequences: DPITLEVFRNRLMSIAEEMGATLQRTAFSPNIKERLDFSCALFDADGRLVAQAPHIPVHLGSMPEAVRAVLERFDDLRPGDVFILNDPYAGGTHLPDITVVTPVFHDGELVGFVASRAHHADIGGIVPGSMPPDATEIYQEGLRIPPVKLVRAGELNEDLLRLLLANVRTPDENLGDLRAQIAANRVGERRLLELVERYGLDTVRAAMDELLDYAERAMRAAIAALPDGTYEAEDYLDDGIPIRVTVTVDGDEATVDFTGTSPQVPGNINAPLAVTRAAVLYALRCLLDPDIPLNAGCLRPIEVIAPEGSILNPRPPAAVVAGNVETSQRIVDAVLGALAPDRVPAASQGTMNNLTFGGRDPRTGRPFVYYETIGGGSGARPGGDGLSAVHTHMTNTRNTPVEVLEARYPVRVERYELRPDSGGAGRHRGGLGVVREIRFLEPATVSLLSDRRRFPPWGLAGGGPGAPGRVVNLLPGKATVELKPGDVLRIETPGGGGYGDP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	502 (502)
Sequences:	20305 (11758)
Seq/√Len:	524.8
META:	0.854

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
414_E	439_R	4.426	1.00
255_T	305_I	3.894	1.00
78_R	153_A	3.821	1.00
233_A	337_G	3.593	1.00
255_T	303_E	3.592	1.00
253_E	303_E	3.520	1.00
259_T	305_I	3.277	1.00
216_E	300_R	3.235	1.00
234_E	244_R	3.085	1.00
230_T	248_T	3.068	1.00
232_E	246_T	3.041	1.00
308_E	315_R	3.002	1.00
230_T	246_T	2.951	1.00
44_D	48_R	2.906	1.00
77_L	83_F	2.856	1.00
470_R	492_E	2.843	1.00
234_E	242_P	2.728	1.00
228_D	251_G	2.722	1.00
383_G	428_H	2.611	1.00
242_P	262_S	2.571	1.00
437_E	490_R	2.507	1.00
415_R	437_E	2.507	1.00
232_E	244_R	2.445	1.00
152_R	157_N	2.442	1.00
216_E	220_R	2.430	1.00
102_T	185_N	2.410	1.00
149_K	152_R	2.384	1.00
264_Q	318_A	2.268	1.00
158_E	162_R	2.268	1.00
381_R	384_G	2.218	1.00
484_K	487_D	2.209	1.00
415_R	435_V	2.199	1.00
273_L	306_A	2.194	1.00
73_R	162_R	2.191	1.00
213_D	300_R	2.156	1.00
106_H	197_E	2.133	1.00
456_P	468_P	2.129	1.00
78_R	152_R	2.128	1.00
412_R	441_L	2.063	1.00
435_V	492_E	2.041	1.00
104_V	114_V	2.037	1.00
191_R	194_E	2.032	1.00
107_D	197_E	2.000	1.00
245_V	256_V	1.993	1.00
102_T	189_E	1.959	1.00
414_E	488_V	1.944	1.00
189_E	193_L	1.937	1.00
443_P	485_P	1.935	1.00
439_R	488_V	1.933	1.00
388_S	432_L	1.928	1.00
263_P	307_P	1.909	1.00
389_A	418_L	1.902	1.00
437_E	488_V	1.893	1.00
222_A	225_A	1.882	1.00
236_Y	242_P	1.879	1.00
201_L	205_R	1.873	1.00
126_I	134_D	1.873	1.00
385_D	429_R	1.859	1.00
109_E	201_L	1.851	1.00
248_T	255_T	1.844	1.00
243_I	334_A	1.842	1.00
126_I	140_Q	1.828	1.00
256_V	280_V	1.824	1.00
69_A	72_E	1.818	1.00
249_V	254_A	1.818	1.00
116_S	185_N	1.811	1.00
137_E	140_Q	1.800	1.00
196_V	204_V	1.784	1.00
425_A	464_G	1.783	1.00
306_A	313_N	1.764	1.00
260_G	307_P	1.757	1.00
48_R	296_A	1.755	1.00
440_F	444_A	1.750	1.00
412_R	439_R	1.743	1.00
417_E	435_V	1.741	1.00
8_F	207_A	1.733	1.00
224_A	252_D	1.724	1.00
145_I	163_L	1.716	1.00
109_E	205_R	1.715	1.00
106_H	196_V	1.694	1.00
45_A	205_R	1.684	1.00
378_S	392_T	1.683	1.00
84_I	98_I	1.677	1.00
273_L	277_R	1.666	1.00
165_L	175_L	1.660	1.00
156_L	161_L	1.659	1.00
136_T	140_Q	1.650	1.00
261_T	311_I	1.632	1.00
82_V	102_T	1.632	1.00
111_V	196_V	1.628	1.00
77_L	113_F	1.625	1.00
443_P	484_K	1.622	1.00
362_P	442_E	1.614	1.00
151_V	182_I	1.613	1.00
50_V	208_M	1.609	1.00
79_P	108_G	1.608	1.00
48_R	209_D	1.604	1.00
254_A	284_L	1.601	1.00
216_E	301_P	1.599	1.00
83_F	149_K	1.599	1.00
48_R	68_R	1.597	1.00
144_R	316_P	1.595	1.00
193_L	197_E	1.592	1.00
46_D	209_D	1.590	1.00
306_A	312_L	1.583	1.00
48_R	300_R	1.574	1.00
139_Y	316_P	1.569	1.00
120_H	181_Q	1.565	1.00
152_R	159_D	1.562	1.00
283_A	335_V	1.560	1.00
414_E	437_E	1.553	1.00
258_F	280_V	1.552	1.00
476_P	479_A	1.549	1.00
458_W	465_P	1.549	1.00
148_V	160_L	1.540	1.00
228_D	250_D	1.533	1.00
347_A	458_W	1.514	1.00
82_V	182_I	1.513	1.00
196_V	201_L	1.503	1.00
286_C	336_L	1.495	1.00
419_R	492_E	1.492	1.00
418_L	432_L	1.487	1.00
212_L	300_R	1.478	1.00
186_R	189_E	1.477	1.00
18_E	191_R	1.475	1.00
445_T	482_E	1.474	1.00
79_P	193_L	1.469	1.00
152_R	155_E	1.455	1.00
228_D	249_V	1.450	1.00
102_T	186_R	1.449	1.00
157_N	160_L	1.443	1.00
82_V	185_N	1.440	1.00
106_H	193_L	1.435	1.00
419_R	467_A	1.432	1.00
308_E	313_N	1.429	1.00
210_E	213_D	1.427	1.00
221_A	224_A	1.424	1.00
307_P	313_N	1.412	1.00
187_V	190_R	1.408	1.00
361_D	364_T	1.397	1.00
440_F	483_L	1.393	1.00
68_R	72_E	1.393	1.00
89_Y	317_P	1.388	1.00
241_I	265_V	1.388	1.00
273_L	313_N	1.387	1.00
175_L	179_R	1.380	1.00
11_R	198_R	1.378	1.00
309_G	315_R	1.376	1.00
423_G	432_L	1.369	1.00
136_T	266_P	1.366	1.00
106_H	111_V	1.361	1.00
151_V	156_L	1.358	1.00
217_R	221_A	1.346	1.00
451_D	478_K	1.345	1.00
6_E	9_R	1.340	1.00
106_H	109_E	1.339	1.00
20_G	55_H	1.338	1.00
220_R	301_P	1.333	1.00
65_E	277_R	1.332	1.00
220_R	252_D	1.328	1.00
263_P	310_S	1.324	1.00
264_Q	309_G	1.322	1.00
284_L	302_I	1.314	1.00
241_I	311_I	1.313	1.00
277_R	304_V	1.311	1.00
104_V	189_E	1.303	1.00
375_G	434_V	1.301	1.00
4_T	203_T	1.301	1.00
204_V	208_M	1.295	1.00
32_I	118_A	1.294	1.00
378_S	387_L	1.285	1.00
250_D	253_E	1.283	1.00
98_I	123_I	1.280	1.00
258_F	331_I	1.278	1.00
337_G	458_W	1.269	1.00
256_V	335_V	1.267	1.00
246_T	260_G	1.264	1.00
264_Q	315_R	1.264	1.00
228_D	252_D	1.263	1.00
48_R	212_L	1.261	1.00
435_V	490_R	1.259	1.00
19_M	188_G	1.252	1.00
247_V	256_V	1.249	1.00
82_V	151_V	1.248	1.00
241_I	262_S	1.246	1.00
186_R	190_R	1.245	1.00
250_D	255_T	1.240	1.00
79_P	189_E	1.239	1.00
419_R	435_V	1.230	1.00
70_V	83_F	1.222	1.00
224_A	251_G	1.220	1.00
226_L	249_V	1.219	1.00
73_R	90_A	1.214	1.00
210_E	214_Y	1.213	1.00
71_L	113_F	1.199	1.00
461_A	499_Y	1.193	1.00
259_T	307_P	1.188	1.00
213_D	217_R	1.187	1.00
138_I	144_R	1.180	1.00
346_A	460_L	1.173	1.00
104_V	192_L	1.173	1.00
190_R	194_E	1.170	1.00
156_L	159_D	1.168	1.00
425_A	429_R	1.164	1.00
221_A	225_A	1.161	1.00
111_V	201_L	1.153	1.00
160_L	163_L	1.146	1.00
402_V	413_V	1.141	1.00
310_S	313_N	1.137	1.00
194_E	197_E	1.132	1.00
307_P	310_S	1.132	1.00
228_D	231_Y	1.130	1.00
420_P	432_L	1.127	1.00
98_I	120_H	1.125	1.00
220_R	253_E	1.120	1.00
456_P	465_P	1.117	1.00
68_R	296_A	1.103	1.00
69_A	73_R	1.102	1.00
359_G	368_F	1.098	1.00
296_A	300_R	1.096	1.00
104_V	193_L	1.095	1.00
349_Q	376_G	1.093	1.00
230_T	250_D	1.091	1.00
209_D	213_D	1.090	1.00
24_Q	38_F	1.083	1.00
235_D	330_R	1.081	1.00
22_T	187_V	1.078	1.00
161_L	172_D	1.072	1.00
360_R	364_T	1.070	1.00
156_L	179_R	1.069	1.00
235_D	452_R	1.068	1.00
231_Y	249_V	1.067	1.00
421_D	432_L	1.064	1.00
42_L	114_V	1.062	1.00
162_R	165_L	1.059	1.00
74_F	147_P	1.053	1.00
21_A	24_Q	1.052	1.00
268_N	319_A	1.045	1.00
70_V	101_V	1.043	1.00
84_I	100_V	1.043	1.00
421_D	425_A	1.042	1.00
8_F	12_L	1.042	1.00
106_H	110_L	1.038	1.00
342_D	382_P	1.036	1.00
389_A	434_V	1.036	1.00
1_D	4_T	1.034	1.00
399_N	416_Y	1.029	1.00
159_D	162_R	1.028	1.00
233_A	334_A	1.025	1.00
87_D	146_P	1.025	1.00
112_G	204_V	1.022	1.00
413_V	438_I	1.021	1.00
475_L	479_A	1.020	1.00
314_P	318_A	1.019	1.00
143_L	164_L	1.017	1.00
24_Q	36_L	1.017	1.00
87_D	144_R	1.015	1.00
81_D	149_K	1.015	1.00
257_D	305_I	1.014	1.00
150_L	182_I	1.013	1.00
233_A	458_W	1.012	1.00
74_F	83_F	1.009	1.00
419_R	422_S	1.009	1.00
470_R	474_L	1.009	1.00
265_V	269_I	1.005	1.00
111_V	205_R	1.004	1.00
39_S	59_H	1.002	1.00
226_L	231_Y	0.998	1.00
235_D	334_A	0.996	1.00
244_R	260_G	0.996	1.00
236_Y	455_F	0.994	1.00
15_I	195_L	0.993	1.00
471_V	474_L	0.992	1.00
114_V	188_G	0.990	1.00
116_S	181_Q	0.987	1.00
247_V	338_A	0.987	1.00
148_V	163_L	0.985	1.00
165_L	172_D	0.981	1.00
11_R	195_L	0.980	1.00
469_G	494_P	0.978	1.00
429_R	432_L	0.976	1.00
282_Y	393_H	0.974	1.00
355_L	489_L	0.974	1.00
105_F	110_L	0.974	1.00
340_A	460_L	0.969	1.00
64_P	296_A	0.968	1.00
380_A	429_R	0.968	1.00
106_H	201_L	0.963	1.00
206_A	210_E	0.960	1.00
43_F	67_V	0.954	1.00
187_V	191_R	0.953	1.00
210_E	217_R	0.952	1.00
312_L	331_I	0.950	1.00
4_T	7_V	0.950	1.00
439_R	486_G	0.946	1.00
218_A	289_D	0.945	1.00
161_L	165_L	0.940	1.00
223_I	249_V	0.939	1.00
212_L	296_A	0.935	1.00
161_L	175_L	0.932	1.00
84_I	145_I	0.931	1.00
82_V	100_V	0.927	1.00
67_V	101_V	0.927	1.00
144_R	166_A	0.927	1.00
100_V	185_N	0.923	1.00
66_A	85_L	0.920	1.00
419_R	433_G	0.919	1.00
261_T	312_L	0.919	1.00
45_A	110_L	0.919	1.00
245_V	334_A	0.916	1.00
281_L	299_L	0.907	1.00
215_A	219_M	0.906	1.00
78_R	149_K	0.902	1.00
381_R	387_L	0.902	1.00
225_A	343_R	0.896	1.00
385_D	428_H	0.896	1.00
72_E	90_A	0.893	1.00
472_V	490_R	0.889	1.00
382_P	428_H	0.888	1.00
28_F	176_G	0.887	1.00
84_I	150_L	0.886	1.00
261_T	310_S	0.879	1.00
472_V	492_E	0.877	1.00
228_D	253_E	0.877	1.00
207_A	210_E	0.877	1.00
256_V	284_L	0.875	1.00
445_T	480_T	0.874	1.00
98_I	145_I	0.871	1.00
104_V	112_G	0.871	1.00
65_E	274_A	0.871	1.00
101_V	113_F	0.870	1.00
214_Y	218_A	0.869	1.00
44_D	212_L	0.869	1.00
405_L	413_V	0.869	1.00
172_D	366_R	0.866	1.00
107_D	193_L	0.865	1.00
383_G	427_R	0.861	1.00
240_G	267_G	0.859	1.00
79_P	105_F	0.858	1.00
110_L	113_F	0.855	1.00
273_L	276_T	0.852	1.00
444_A	483_L	0.847	1.00
148_V	159_D	0.845	1.00
448_L	471_V	0.835	1.00
202_D	206_A	0.829	1.00
382_P	499_Y	0.829	1.00
87_D	90_A	0.826	1.00
4_T	8_F	0.823	1.00
165_L	168_V	0.823	1.00
333_D	452_R	0.822	1.00
365_G	368_F	0.822	1.00
193_L	196_V	0.819	1.00
272_P	314_P	0.818	1.00
9_R	13_M	0.817	1.00
65_E	68_R	0.815	1.00
12_L	204_V	0.815	1.00
276_T	306_A	0.814	1.00
203_T	207_A	0.813	1.00
372_E	436_R	0.812	1.00
237_L	269_I	0.810	1.00
355_L	446_V	0.809	1.00
47_G	71_L	0.809	1.00
158_E	175_L	0.809	1.00
146_P	166_A	0.808	1.00
79_P	153_A	0.808	1.00
446_V	483_L	0.806	1.00
134_D	480_T	0.803	1.00
253_E	301_P	0.800	1.00
126_I	132_P	0.800	1.00
427_R	501_D	0.797	1.00
354_N	371_Y	0.796	1.00
442_E	485_P	0.795	1.00
163_L	167_N	0.794	1.00
374_I	491_I	0.794	1.00
76_D	158_E	0.793	1.00
315_R	318_A	0.792	1.00
112_G	208_M	0.791	1.00
450_S	471_V	0.788	1.00
157_N	161_L	0.788	1.00
116_S	184_A	0.785	1.00
157_N	162_R	0.783	1.00
245_V	258_F	0.782	1.00
84_I	164_L	0.781	1.00
158_E	161_L	0.779	1.00
381_R	428_H	0.778	1.00
149_K	153_A	0.776	1.00
265_V	311_I	0.774	1.00
446_V	489_L	0.774	1.00
127_V	132_P	0.773	1.00
214_Y	217_R	0.772	1.00
74_F	149_K	0.772	1.00
219_M	298_C	0.771	1.00
464_G	502_P	0.769	1.00
355_L	438_I	0.767	1.00
143_L	163_L	0.765	1.00
46_D	205_R	0.765	1.00
215_A	295_N	0.764	1.00
242_P	245_V	0.764	1.00
84_I	148_V	0.764	1.00
6_E	10_N	0.760	1.00
206_A	209_D	0.758	1.00
223_I	301_P	0.757	1.00
213_D	216_E	0.757	1.00
150_L	161_L	0.755	1.00
170_T	173_E	0.753	1.00
223_I	254_A	0.752	1.00
340_A	461_A	0.751	1.00
195_L	199_Y	0.749	1.00
440_F	489_L	0.746	1.00
145_I	148_V	0.745	1.00
245_V	338_A	0.743	1.00
20_G	38_F	0.741	1.00
49_L	52_Q	0.740	1.00
306_A	309_G	0.739	1.00
225_A	228_D	0.737	1.00
422_S	495_G	0.735	1.00
360_R	365_G	0.735	1.00
337_G	347_A	0.734	1.00
22_T	26_T	0.733	1.00
101_V	115_A	0.731	1.00
139_Y	167_N	0.728	1.00
182_I	186_R	0.728	1.00
203_T	206_A	0.725	1.00
192_L	196_V	0.724	1.00
258_F	312_L	0.721	1.00
114_V	185_N	0.721	1.00
287_L	344_V	0.720	1.00
330_R	451_D	0.719	1.00
404_V	408_R	0.718	1.00
43_F	63_M	0.718	1.00
247_V	254_A	0.717	1.00
256_V	302_I	0.715	1.00
77_L	110_L	0.712	1.00
107_D	201_L	0.712	1.00
272_P	320_V	0.711	1.00
162_R	166_A	0.709	1.00
374_I	434_V	0.709	1.00
19_M	40_C	0.706	1.00
236_Y	454_R	0.706	1.00
241_I	245_V	0.706	1.00
131_M	325_V	0.705	1.00
326_E	351_T	0.704	1.00
279_A	332_V	0.703	1.00
132_P	135_A	0.702	1.00
277_R	281_L	0.699	1.00
443_P	482_E	0.699	1.00
73_R	147_P	0.699	1.00
31_N	35_R	0.698	1.00
271_A	275_V	0.697	1.00
168_V	174_N	0.697	1.00
376_G	379_G	0.697	1.00
273_L	308_E	0.695	1.00
5_L	210_E	0.694	1.00
474_L	490_R	0.694	1.00
427_R	499_Y	0.693	1.00
43_F	115_A	0.690	1.00
357_F	440_F	0.686	1.00
349_Q	353_N	0.685	1.00
483_L	487_D	0.685	1.00
95_L	123_I	0.684	1.00
416_Y	436_R	0.684	1.00
112_G	192_L	0.681	1.00
345_P	348_S	0.680	1.00
100_V	182_I	0.680	1.00
239_D	265_V	0.680	1.00
123_I	130_S	0.679	1.00
151_V	161_L	0.677	1.00
73_R	158_E	0.676	1.00
8_F	11_R	0.675	1.00
239_D	454_R	0.675	1.00
150_L	156_L	0.673	1.00
84_I	160_L	0.671	1.00
200_G	203_T	0.671	1.00
382_P	427_R	0.670	1.00
239_D	267_G	0.670	1.00
114_V	189_E	0.670	1.00
336_L	344_V	0.669	1.00
262_S	265_V	0.669	1.00
423_G	466_G	0.669	1.00
104_V	188_G	0.668	1.00
282_Y	286_C	0.667	1.00
12_L	208_M	0.666	1.00
422_S	467_A	0.664	1.00
219_M	301_P	0.663	1.00
361_D	366_R	0.661	1.00
283_A	286_C	0.660	1.00
380_A	385_D	0.659	1.00
81_D	153_A	0.659	1.00
357_F	444_A	0.659	1.00
245_V	335_V	0.658	1.00
361_D	365_G	0.656	1.00
375_G	391_H	0.654	1.00
322_A	449_L	0.654	1.00
185_N	189_E	0.653	1.00
446_V	481_V	0.652	1.00
218_A	221_A	0.650	1.00
244_R	259_T	0.650	1.00
23_L	116_S	0.649	1.00
23_L	184_A	0.648	1.00
368_F	442_E	0.648	1.00
139_Y	168_V	0.647	1.00
152_R	156_L	0.647	1.00
237_L	451_D	0.647	1.00
455_F	468_P	0.646	1.00
215_A	298_C	0.645	1.00
190_R	193_L	0.645	1.00
50_V	212_L	0.644	1.00
415_R	490_R	0.644	1.00
243_I	261_T	0.643	1.00
292_I	298_C	0.641	1.00
121_A	174_N	0.640	1.00
311_I	327_T	0.640	1.00
100_V	178_L	0.639	1.00
275_V	328_S	0.638	1.00
41_A	63_M	0.637	1.00
264_Q	310_S	0.636	1.00
151_V	154_G	0.636	1.00
11_R	15_I	0.636	1.00
138_I	317_P	0.635	1.00
323_G	326_E	0.634	1.00
133_P	447_S	0.632	1.00
284_L	339_L	0.631	1.00
109_E	202_D	0.631	1.00
143_L	167_N	0.631	1.00
7_V	11_R	0.631	1.00
98_I	178_L	0.630	1.00
17_E	54_P	0.629	1.00
362_P	367_P	0.628	1.00
99_T	117_R	0.627	1.00
123_I	168_V	0.626	1.00
126_I	135_A	0.624	1.00
161_L	171_P	0.624	1.00
422_S	432_L	0.624	1.00
89_Y	320_V	0.623	1.00
138_I	316_P	0.623	1.00
11_R	14_S	0.623	1.00
194_E	198_R	0.621	1.00
45_A	109_E	0.620	1.00
76_D	149_K	0.620	1.00
362_P	443_P	0.620	1.00
195_L	204_V	0.620	1.00
100_V	150_L	0.620	1.00
404_V	407_A	0.619	1.00
430_G	495_G	0.617	1.00
66_A	99_T	0.617	1.00
212_L	215_A	0.616	1.00
137_E	167_N	0.616	1.00
467_A	492_E	0.616	1.00
172_D	175_L	0.615	1.00
196_V	205_R	0.614	1.00
483_L	489_L	0.614	1.00
218_A	292_I	0.613	1.00
8_F	203_T	0.607	1.00
250_D	303_E	0.607	1.00
222_A	288_L	0.607	1.00
59_H	62_S	0.606	1.00
150_L	178_L	0.605	1.00
65_E	72_E	0.604	1.00
459_G	465_P	0.604	1.00
437_E	492_E	0.604	1.00
165_L	171_P	0.603	1.00
447_S	480_T	0.602	1.00
222_A	343_R	0.602	1.00
202_D	205_R	0.601	1.00
135_A	319_A	0.601	1.00
368_F	444_A	0.601	1.00
70_V	85_L	0.600	1.00
74_F	159_D	0.600	1.00
280_V	304_V	0.598	1.00
337_G	340_A	0.597	1.00
248_T	305_I	0.597	1.00
285_R	290_P	0.597	1.00
402_V	416_Y	0.597	1.00
244_R	261_T	0.596	1.00
387_L	390_V	0.596	1.00
76_D	155_E	0.596	1.00
8_F	199_Y	0.595	0.99
380_A	428_H	0.595	0.99
258_F	261_T	0.595	0.99
306_A	310_S	0.592	0.99
440_F	443_P	0.592	0.99
279_A	331_I	0.591	0.99
155_E	158_E	0.590	0.99
139_Y	171_P	0.590	0.99
428_H	499_Y	0.588	0.99
243_I	331_I	0.588	0.99
69_A	90_A	0.587	0.99
368_F	443_P	0.587	0.99
88_P	320_V	0.587	0.99
236_Y	244_R	0.586	0.99
448_L	479_A	0.586	0.99
464_G	501_D	0.586	0.99
239_D	478_K	0.586	0.99
271_A	276_T	0.586	0.99
233_A	338_A	0.584	0.99
391_H	395_T	0.584	0.99
70_V	74_F	0.583	0.99
279_A	328_S	0.581	0.99
380_A	383_G	0.580	0.99
102_T	116_S	0.579	0.99
232_E	260_G	0.578	0.99
334_A	338_A	0.578	0.99
405_L	411_V	0.578	0.99
305_I	308_E	0.578	0.99
272_P	275_V	0.576	0.99
384_G	428_H	0.576	0.99
224_A	227_P	0.576	0.99
90_A	166_A	0.573	0.99
370_Y	409_Y	0.573	0.99
281_L	302_I	0.567	0.99
217_R	224_A	0.567	0.99
228_D	248_T	0.566	0.99
246_T	255_T	0.566	0.99
123_I	143_L	0.566	0.99
246_T	259_T	0.566	0.99
283_A	336_L	0.566	0.99
149_K	157_N	0.566	0.99
3_I	7_V	0.565	0.99
227_P	231_Y	0.565	0.99
45_A	112_G	0.565	0.99
87_D	138_I	0.565	0.99
34_E	404_V	0.564	0.99
2_P	6_E	0.564	0.99
333_D	350_G	0.560	0.99
259_T	310_S	0.560	0.99
199_Y	204_V	0.560	0.99
89_Y	319_A	0.560	0.99
21_A	25_R	0.559	0.99
156_L	175_L	0.558	0.99
342_D	461_A	0.556	0.99
13_M	51_A	0.553	0.99
154_G	186_R	0.553	0.99
95_L	142_G	0.553	0.99
192_L	204_V	0.553	0.99
383_G	499_Y	0.552	0.99
120_H	178_L	0.552	0.99
353_N	469_G	0.552	0.99
199_Y	203_T	0.552	0.99
139_Y	317_P	0.550	0.99
7_V	199_Y	0.550	0.99
43_F	49_L	0.550	0.99
27_A	32_I	0.549	0.99
131_M	321_V	0.549	0.99
260_G	306_A	0.548	0.99
298_C	301_P	0.548	0.99
209_D	212_L	0.547	0.99
345_P	381_R	0.547	0.99
160_L	164_L	0.547	0.99
85_L	147_P	0.545	0.99
76_D	152_R	0.545	0.99
83_F	152_R	0.543	0.99
80_G	189_E	0.543	0.99
152_R	158_E	0.542	0.99
361_D	442_E	0.542	0.99
254_A	302_I	0.542	0.99
345_P	382_P	0.541	0.99
205_R	209_D	0.541	0.99
89_Y	314_P	0.540	0.99
23_L	118_A	0.540	0.99
370_Y	373_T	0.539	0.99
349_Q	392_T	0.539	0.99
227_P	251_G	0.539	0.99
218_A	222_A	0.538	0.99
271_A	331_I	0.538	0.99
243_I	312_L	0.538	0.99
81_D	152_R	0.538	0.99
220_R	228_D	0.538	0.99
460_L	499_Y	0.538	0.99
223_I	226_L	0.537	0.99
164_L	168_V	0.537	0.99
15_I	191_R	0.536	0.99
456_P	467_A	0.536	0.99
79_P	106_H	0.536	0.99
238_D	455_F	0.536	0.99
465_P	468_P	0.536	0.99
261_T	307_P	0.535	0.99
369_V	400_T	0.534	0.99
235_D	337_G	0.534	0.99
384_G	387_L	0.534	0.99
364_T	368_F	0.533	0.99
335_V	338_A	0.533	0.99
439_R	485_P	0.532	0.99
74_F	77_L	0.532	0.99
209_D	300_R	0.532	0.99
146_P	163_L	0.531	0.99
33_K	408_R	0.530	0.99
359_G	367_P	0.530	0.99
267_G	319_A	0.529	0.99
362_P	366_R	0.529	0.99
63_M	115_A	0.529	0.99
12_L	207_A	0.528	0.99
309_G	313_N	0.528	0.99
244_R	262_S	0.528	0.99
214_Y	293_P	0.528	0.99
138_I	320_V	0.525	0.99
243_I	258_F	0.524	0.99
223_I	252_D	0.524	0.99
276_T	331_I	0.524	0.99
70_V	147_P	0.523	0.99
464_G	498_G	0.523	0.99
100_V	181_Q	0.522	0.99
135_A	268_N	0.522	0.99
222_A	291_D	0.521	0.99
70_V	77_L	0.521	0.99
285_R	294_L	0.521	0.99
347_A	350_G	0.521	0.99
20_G	40_C	0.521	0.99
9_R	211_L	0.519	0.99
208_M	212_L	0.519	0.99
102_T	154_G	0.519	0.99
15_I	192_L	0.519	0.99
269_I	327_T	0.518	0.99
145_I	164_L	0.518	0.99
67_V	115_A	0.517	0.99
375_G	389_A	0.515	0.99
49_L	54_P	0.515	0.99
170_T	174_N	0.515	0.99
434_V	493_T	0.515	0.99
50_V	204_V	0.514	0.99
94_H	97_D	0.513	0.99
87_D	316_P	0.513	0.99
64_P	68_R	0.513	0.99
77_L	149_K	0.513	0.99
388_S	418_L	0.513	0.99
161_L	179_R	0.513	0.99
249_V	252_D	0.512	0.98
212_L	297_G	0.512	0.98
277_R	296_A	0.512	0.98
89_Y	138_I	0.512	0.98
342_D	345_P	0.511	0.98
466_G	496_G	0.511	0.98
189_E	192_L	0.510	0.98
362_P	365_G	0.510	0.98
264_Q	317_P	0.510	0.98
417_E	437_E	0.510	0.98
369_V	373_T	0.509	0.98
182_I	185_N	0.509	0.98
81_D	154_G	0.508	0.98
151_V	157_N	0.508	0.98
111_V	192_L	0.507	0.98
299_L	304_V	0.507	0.98
5_L	8_F	0.506	0.98
2_P	5_L	0.505	0.98
190_R	197_E	0.504	0.98
151_V	186_R	0.503	0.98
348_S	378_S	0.503	0.98
20_G	53_A	0.502	0.98
146_P	316_P	0.502	0.98
5_L	207_A	0.502	0.98
269_I	322_A	0.502	0.98
280_V	335_V	0.502	0.98
39_S	60_L	0.501	0.98
498_G	502_P	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1j5kA	1	0.1315	49.1	0.975	Contact Map
2kzxA	1	0.2331	46.8	0.976	Contact Map
3aoeE	3	0.4223	28.4	0.978	Contact Map
1p0zA	4	0.2171	23.8	0.979	Contact Map
2yfqA	5	0.3984	21.4	0.98	Contact Map
3k92A	5	0.4183	18	0.98	Contact Map
2opvA	1	0.1454	16.7	0.981	Contact Map
3by8A	2	0.2231	15.9	0.981	Contact Map
3eeiA	2	0.3725	15.3	0.981	Contact Map
1zzkA	1	0.1394	14.8	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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