CRCB - PFAM28P - GREMLIN Contacts

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CRCB - CrcB-like protein, Camphor Resistance (CrcB)

PFAM:	PF02537	Sequences: LLVALGGALGALARYLLGLLVARGTLAVNVLGSFLIGLLAGFLGTGFLGGFTTFSTFSLETLRLLEDGEWGLALLYVLLSVVLGLAAVWLGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	92 (90)
Sequences:	54934 (36733)
Seq/√Len:	3872.0
META:	0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_G	52_T	3.668	1.00
36_I	44_G	2.745	1.00
7_G	11_A	2.667	1.00
31_L	51_F	2.535	1.00
4_A	8_A	2.221	1.00
6_G	42_F	2.086	1.00
30_V	87_A	2.022	1.00
4_A	12_L	2.019	1.00
61_T	76_Y	1.951	1.00
61_T	77_V	1.950	1.00
69_E	72_L	1.838	1.00
76_Y	80_S	1.779	1.00
63_R	66_E	1.754	1.00
18_G	21_V	1.729	1.00
35_L	48_L	1.684	1.00
61_T	73_A	1.637	1.00
30_V	83_L	1.581	1.00
58_S	62_L	1.451	1.00
39_L	43_L	1.422	1.00
27_A	31_L	1.402	1.00
13_A	47_F	1.398	1.00
8_A	12_L	1.371	1.00
12_L	16_L	1.357	1.00
19_L	23_R	1.353	1.00
63_R	67_D	1.352	1.00
8_A	50_G	1.334	1.00
40_A	44_G	1.328	1.00
39_L	44_G	1.323	1.00
65_L	70_W	1.322	1.00
70_W	74_L	1.275	1.00
26_L	79_L	1.269	1.00
34_F	87_A	1.262	1.00
62_L	88_V	1.250	1.00
65_L	73_A	1.249	1.00
40_A	59_L	1.243	1.00
59_L	63_R	1.216	1.00
78_L	82_V	1.198	1.00
18_G	22_A	1.196	1.00
17_L	31_L	1.148	1.00
71_G	75_L	1.107	1.00
19_L	22_A	1.080	1.00
25_T	60_E	1.078	1.00
20_L	23_R	1.077	1.00
71_G	74_L	1.075	1.00
62_L	66_E	1.061	1.00
17_L	27_A	1.015	1.00
79_L	83_L	0.995	1.00
8_A	11_A	0.985	1.00
62_L	89_W	0.970	1.00
9_L	47_F	0.961	1.00
13_A	51_F	0.960	1.00
6_G	47_F	0.952	1.00
24_G	28_V	0.951	1.00
36_I	59_L	0.946	1.00
36_I	88_V	0.945	1.00
64_L	76_Y	0.942	1.00
57_F	81_V	0.925	1.00
3_V	11_A	0.920	1.00
58_S	88_V	0.901	1.00
33_S	84_G	0.900	1.00
57_F	84_G	0.896	1.00
26_L	30_V	0.889	1.00
28_V	51_F	0.887	1.00
21_V	24_G	0.883	1.00
26_L	80_S	0.870	1.00
11_A	50_G	0.853	1.00
37_G	88_V	0.844	1.00
60_E	63_R	0.831	1.00
74_L	78_L	0.831	1.00
26_L	83_L	0.823	1.00
37_G	41_G	0.820	1.00
38_L	41_G	0.806	1.00
77_V	81_V	0.804	1.00
42_F	47_F	0.795	1.00
5_L	8_A	0.790	1.00
17_L	28_V	0.783	1.00
75_L	79_L	0.780	1.00
58_S	85_L	0.774	1.00
64_L	72_L	0.772	1.00
58_S	61_T	0.748	1.00
15_Y	18_G	0.746	1.00
9_L	12_L	0.734	1.00
39_L	48_L	0.728	1.00
80_S	84_G	0.700	1.00
47_F	50_G	0.694	1.00
16_L	20_L	0.691	1.00
2_L	42_F	0.686	1.00
33_S	58_S	0.684	1.00
9_L	42_F	0.683	1.00
58_S	81_V	0.670	1.00
44_G	48_L	0.670	1.00
3_V	6_G	0.670	1.00
7_G	12_L	0.661	1.00
3_V	50_G	0.657	1.00
24_G	27_A	0.656	1.00
67_D	72_L	0.651	1.00
56_T	60_E	0.644	1.00
78_L	81_V	0.636	1.00
79_L	82_V	0.633	1.00
17_L	51_F	0.632	1.00
18_G	23_R	0.630	1.00
85_L	88_V	0.624	1.00
34_F	38_L	0.620	1.00
25_T	53_T	0.612	1.00
13_A	17_L	0.609	1.00
2_L	5_L	0.608	1.00
58_S	65_L	0.604	1.00
70_W	73_A	0.601	1.00
72_L	75_L	0.595	1.00
15_Y	19_L	0.593	1.00
17_L	24_G	0.591	1.00
46_G	50_G	0.581	1.00
83_L	87_A	0.576	1.00
12_L	50_G	0.573	1.00
75_L	78_L	0.573	1.00
3_V	7_G	0.572	1.00
34_F	91_G	0.566	1.00
45_T	56_T	0.565	1.00
73_A	77_V	0.563	1.00
25_T	56_T	0.562	1.00
17_L	21_V	0.552	1.00
86_A	89_W	0.546	1.00
6_G	11_A	0.540	1.00
57_F	77_V	0.536	1.00
87_A	91_G	0.535	1.00
73_A	81_V	0.531	1.00
72_L	76_Y	0.524	1.00
5_L	9_L	0.524	1.00
66_E	69_E	0.520	1.00
34_F	90_L	0.517	1.00
86_A	90_L	0.510	1.00
43_L	47_F	0.505	1.00
9_L	13_A	0.502	1.00
4_A	11_A	0.501	1.00
33_S	37_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nwlA	3	0.8913	7	0.879	Contact Map
4pgrA	1	0.3261	3.5	0.896	Contact Map
3iyzA	3	0.9022	2.2	0.905	Contact Map
2a65A	2	0.9457	2	0.908	Contact Map
3cn5A	3	0.9239	1.8	0.91	Contact Map
2zz9A	3	0.9022	1.8	0.91	Contact Map
4xp4A	1	0.9457	1.6	0.912	Contact Map
4czbA	2	1	1.3	0.917	Contact Map
3e20C	1	0.2826	1.1	0.921	Contact Map
3zojA	3	0.9565	1	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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