GREMLIN Database
CRCB - CrcB-like protein, Camphor Resistance (CrcB)
PFAM: PF02537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (90)
Sequences: 54934 (36733)
Seq/√Len: 3872.0
META: 0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_G52_T3.6681.00
36_I44_G2.7451.00
7_G11_A2.6671.00
31_L51_F2.5351.00
4_A8_A2.2211.00
6_G42_F2.0861.00
30_V87_A2.0221.00
4_A12_L2.0191.00
61_T76_Y1.9511.00
61_T77_V1.9501.00
69_E72_L1.8381.00
76_Y80_S1.7791.00
63_R66_E1.7541.00
18_G21_V1.7291.00
35_L48_L1.6841.00
61_T73_A1.6371.00
30_V83_L1.5811.00
58_S62_L1.4511.00
39_L43_L1.4221.00
27_A31_L1.4021.00
13_A47_F1.3981.00
8_A12_L1.3711.00
12_L16_L1.3571.00
19_L23_R1.3531.00
63_R67_D1.3521.00
8_A50_G1.3341.00
40_A44_G1.3281.00
39_L44_G1.3231.00
65_L70_W1.3221.00
70_W74_L1.2751.00
26_L79_L1.2691.00
34_F87_A1.2621.00
62_L88_V1.2501.00
65_L73_A1.2491.00
40_A59_L1.2431.00
59_L63_R1.2161.00
78_L82_V1.1981.00
18_G22_A1.1961.00
17_L31_L1.1481.00
71_G75_L1.1071.00
19_L22_A1.0801.00
25_T60_E1.0781.00
20_L23_R1.0771.00
71_G74_L1.0751.00
62_L66_E1.0611.00
17_L27_A1.0151.00
79_L83_L0.9951.00
8_A11_A0.9851.00
62_L89_W0.9701.00
9_L47_F0.9611.00
13_A51_F0.9601.00
6_G47_F0.9521.00
24_G28_V0.9511.00
36_I59_L0.9461.00
36_I88_V0.9451.00
64_L76_Y0.9421.00
57_F81_V0.9251.00
3_V11_A0.9201.00
58_S88_V0.9011.00
33_S84_G0.9001.00
57_F84_G0.8961.00
26_L30_V0.8891.00
28_V51_F0.8871.00
21_V24_G0.8831.00
26_L80_S0.8701.00
11_A50_G0.8531.00
37_G88_V0.8441.00
60_E63_R0.8311.00
74_L78_L0.8311.00
26_L83_L0.8231.00
37_G41_G0.8201.00
38_L41_G0.8061.00
77_V81_V0.8041.00
42_F47_F0.7951.00
5_L8_A0.7901.00
17_L28_V0.7831.00
75_L79_L0.7801.00
58_S85_L0.7741.00
64_L72_L0.7721.00
58_S61_T0.7481.00
15_Y18_G0.7461.00
9_L12_L0.7341.00
39_L48_L0.7281.00
80_S84_G0.7001.00
47_F50_G0.6941.00
16_L20_L0.6911.00
2_L42_F0.6861.00
33_S58_S0.6841.00
9_L42_F0.6831.00
58_S81_V0.6701.00
44_G48_L0.6701.00
3_V6_G0.6701.00
7_G12_L0.6611.00
3_V50_G0.6571.00
24_G27_A0.6561.00
67_D72_L0.6511.00
56_T60_E0.6441.00
78_L81_V0.6361.00
79_L82_V0.6331.00
17_L51_F0.6321.00
18_G23_R0.6301.00
85_L88_V0.6241.00
34_F38_L0.6201.00
25_T53_T0.6121.00
13_A17_L0.6091.00
2_L5_L0.6081.00
58_S65_L0.6041.00
70_W73_A0.6011.00
72_L75_L0.5951.00
15_Y19_L0.5931.00
17_L24_G0.5911.00
46_G50_G0.5811.00
83_L87_A0.5761.00
12_L50_G0.5731.00
75_L78_L0.5731.00
3_V7_G0.5721.00
34_F91_G0.5661.00
45_T56_T0.5651.00
73_A77_V0.5631.00
25_T56_T0.5621.00
17_L21_V0.5521.00
86_A89_W0.5461.00
6_G11_A0.5401.00
57_F77_V0.5361.00
87_A91_G0.5351.00
73_A81_V0.5311.00
72_L76_Y0.5241.00
5_L9_L0.5241.00
66_E69_E0.5201.00
34_F90_L0.5171.00
86_A90_L0.5101.00
43_L47_F0.5051.00
9_L13_A0.5021.00
4_A11_A0.5011.00
33_S37_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.8913 7 0.879 Contact Map
4pgrA 1 0.3261 3.5 0.896 Contact Map
3iyzA 3 0.9022 2.2 0.905 Contact Map
2a65A 2 0.9457 2 0.908 Contact Map
3cn5A 3 0.9239 1.8 0.91 Contact Map
2zz9A 3 0.9022 1.8 0.91 Contact Map
4xp4A 1 0.9457 1.6 0.912 Contact Map
4czbA 2 1 1.3 0.917 Contact Map
3e20C 1 0.2826 1.1 0.921 Contact Map
3zojA 3 0.9565 1 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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