Zip - PFAM28P - GREMLIN Contacts

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Zip - ZIP Zinc transporter

PFAM:	PF02535	Sequences: FGLKIGALFAILVASLLGGLLPLLLPRLPKLISRRVLSLLLAFAAGVLLATAFLHLLPEAFESLTSPCLGGHHGWPLAGLIALAGFLLFFLVEKLVHRLGHGHHHHGEKSEGHHSHSHSHSHAGSSVSEDELSGSEEGEDHGHGHGHDADSVESLAAGHGHSHGHGHEHASHEESEESLSRQKLRGLLLELGISFHSFFDGLALGFSASPSLGLTLFIAILFHEIPEGLGLGARLLQAGFSRRKALLLNLLFALTTPLGIAIGLGVRSNPNSGTALIVLGILLAFSAGIFLYVALVELLPHEFLSEKRQSSLKLRLLQFLALLLGAGLMALLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	333 (324)
Sequences:	5171 (4105)
Seq/√Len:	228.1
META:	0.228

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_G	21_L	3.890	1.00
19_G	22_P	3.707	1.00
60_A	284_A	3.639	1.00
18_G	22_P	2.833	1.00
39_L	321_A	2.811	1.00
86_F	295_L	2.800	1.00
53_F	291_L	2.761	1.00
61_F	79_G	2.606	1.00
153_E	157_A	2.411	1.00
11_I	15_S	2.356	1.00
164_G	167_H	2.328	1.00
6_G	10_A	2.284	1.00
145_H	149_A	2.204	1.00
274_T	278_V	2.174	1.00
109_K	112_G	2.171	1.00
110_S	113_H	2.159	1.00
15_S	19_G	2.150	1.00
155_L	158_G	2.115	1.00
22_P	26_P	2.111	1.00
224_E	228_G	2.097	1.00
113_H	116_H	2.088	1.00
118_H	121_S	2.063	1.00
151_S	155_L	2.033	1.00
112_G	115_S	2.009	1.00
141_H	145_H	1.989	1.00
115_S	118_H	1.989	1.00
156_A	159_H	1.941	1.00
127_V	130_D	1.937	1.00
114_H	118_H	1.916	1.00
150_D	153_E	1.907	1.00
128_S	131_E	1.901	1.00
155_L	159_H	1.890	1.00
120_H	123_A	1.861	1.00
122_H	126_S	1.819	1.00
158_G	162_S	1.807	1.00
64_L	280_G	1.804	1.00
143_H	146_G	1.797	1.00
121_S	124_G	1.794	1.00
11_I	18_G	1.786	1.00
116_H	120_H	1.785	1.00
15_S	18_G	1.767	1.00
159_H	163_H	1.759	1.00
165_H	168_E	1.756	1.00
152_V	156_A	1.748	1.00
81_I	281_I	1.721	1.00
15_S	22_P	1.719	1.00
124_G	127_V	1.711	1.00
10_A	14_A	1.687	1.00
14_A	18_G	1.680	1.00
166_G	169_H	1.660	1.00
160_G	164_G	1.656	1.00
127_V	131_E	1.650	1.00
165_H	169_H	1.646	1.00
6_G	217_F	1.638	1.00
123_A	126_S	1.637	1.00
317_L	321_A	1.633	1.00
141_H	144_G	1.610	1.00
88_L	285_F	1.609	1.00
48_L	290_F	1.608	1.00
120_H	124_G	1.598	1.00
163_H	167_H	1.594	1.00
14_A	17_L	1.593	1.00
147_H	151_S	1.587	1.00
224_E	227_E	1.587	1.00
197_S	252_F	1.586	1.00
81_I	85_G	1.565	1.00
81_I	84_A	1.552	1.00
152_V	155_L	1.552	1.00
148_D	151_S	1.546	1.00
121_S	125_S	1.542	1.00
111_E	115_S	1.534	1.00
125_S	128_S	1.534	1.00
147_H	150_D	1.520	1.00
134_G	137_E	1.518	1.00
214_L	218_I	1.517	1.00
144_G	148_D	1.499	1.00
162_S	165_H	1.476	1.00
156_A	162_S	1.470	1.00
228_G	290_F	1.467	1.00
157_A	160_G	1.460	1.00
194_S	255_T	1.447	1.00
5_I	9_F	1.437	1.00
80_L	84_A	1.436	1.00
110_S	114_H	1.436	1.00
132_L	136_E	1.417	1.00
150_D	155_L	1.416	1.00
124_G	128_S	1.412	1.00
151_S	154_S	1.412	1.00
158_G	163_H	1.401	1.00
148_D	153_E	1.375	1.00
11_I	14_A	1.367	1.00
277_I	281_I	1.352	1.00
116_H	119_S	1.347	1.00
159_H	162_S	1.334	1.00
113_H	118_H	1.325	1.00
193_I	224_E	1.325	1.00
139_E	143_H	1.318	1.00
55_H	329_M	1.315	1.00
154_S	158_G	1.305	1.00
144_G	147_H	1.301	1.00
135_S	139_E	1.300	1.00
16_L	20_L	1.298	1.00
113_H	117_S	1.294	1.00
91_L	95_L	1.289	1.00
143_H	147_H	1.286	1.00
130_D	133_S	1.286	1.00
145_H	148_D	1.267	1.00
60_A	78_A	1.265	1.00
140_D	146_G	1.265	1.00
51_T	55_H	1.260	1.00
111_E	114_H	1.253	1.00
167_H	171_S	1.249	1.00
114_H	117_S	1.241	1.00
19_G	23_L	1.239	1.00
157_A	161_H	1.225	1.00
119_S	122_H	1.224	1.00
316_L	320_L	1.217	1.00
193_I	200_D	1.211	1.00
231_L	252_F	1.203	1.00
126_S	131_E	1.201	1.00
121_S	127_V	1.199	1.00
21_L	26_P	1.198	1.00
224_E	290_F	1.180	1.00
127_V	132_L	1.180	1.00
15_S	21_L	1.179	1.00
140_D	144_G	1.177	1.00
43_F	328_L	1.166	1.00
118_H	122_H	1.165	1.00
11_I	22_P	1.164	1.00
38_S	42_A	1.160	1.00
227_E	252_F	1.150	1.00
154_S	161_H	1.145	1.00
126_S	130_D	1.143	1.00
146_G	151_S	1.142	1.00
173_E	176_E	1.142	1.00
154_S	159_H	1.137	1.00
122_H	125_S	1.135	1.00
224_E	252_F	1.135	1.00
117_S	120_H	1.135	1.00
126_S	134_G	1.133	1.00
72_H	75_W	1.130	1.00
136_E	140_D	1.126	1.00
196_H	223_H	1.120	1.00
151_S	157_A	1.118	1.00
302_E	306_E	1.117	1.00
164_G	168_E	1.116	1.00
155_L	160_G	1.113	1.00
57_L	82_A	1.107	1.00
123_A	128_S	1.107	1.00
160_G	166_G	1.105	1.00
142_G	146_G	1.098	1.00
109_K	113_H	1.097	1.00
125_S	129_E	1.095	1.00
204_L	220_I	1.092	1.00
109_K	115_S	1.087	1.00
115_S	119_S	1.082	1.00
140_D	143_H	1.078	1.00
150_D	154_S	1.078	1.00
141_H	147_H	1.077	1.00
119_S	127_V	1.076	1.00
144_G	149_A	1.073	1.00
227_E	290_F	1.069	1.00
62_E	65_T	1.064	1.00
247_L	251_L	1.055	1.00
78_A	284_A	1.051	1.00
149_A	152_V	1.044	1.00
59_E	62_E	1.044	1.00
162_S	169_H	1.043	1.00
49_L	294_A	1.043	1.00
228_G	252_F	1.040	1.00
217_F	221_L	1.039	1.00
52_A	204_L	1.037	1.00
149_A	153_E	1.031	1.00
90_F	94_K	1.029	1.00
200_D	224_E	1.024	1.00
131_E	136_E	1.020	1.00
117_S	121_S	1.019	1.00
146_G	149_A	1.017	1.00
119_S	124_G	1.013	1.00
164_G	169_H	1.013	1.00
224_E	231_L	1.012	1.00
131_E	135_S	1.006	1.00
142_G	148_D	1.004	1.00
129_E	132_L	1.001	1.00
60_A	280_G	0.995	1.00
120_H	128_S	0.989	1.00
213_G	260_I	0.986	1.00
152_V	159_H	0.985	1.00
119_S	123_A	0.983	1.00
134_G	138_G	0.982	1.00
143_H	150_D	0.980	1.00
11_I	19_G	0.975	1.00
327_G	331_L	0.974	1.00
141_H	146_G	0.969	1.00
12_L	257_P	0.968	1.00
14_A	225_I	0.965	1.00
156_A	160_G	0.962	1.00
190_E	248_L	0.954	1.00
130_D	134_G	0.946	1.00
151_S	160_G	0.946	1.00
142_G	147_H	0.945	1.00
143_H	149_A	0.942	1.00
132_L	137_E	0.940	1.00
153_E	156_A	0.938	1.00
182_Q	185_R	0.933	1.00
82_A	86_F	0.933	1.00
155_L	161_H	0.929	1.00
153_E	158_G	0.929	1.00
315_R	319_F	0.927	1.00
241_S	244_K	0.926	1.00
112_G	116_H	0.919	1.00
122_H	128_S	0.916	1.00
154_S	157_A	0.915	1.00
147_H	153_E	0.908	0.99
82_A	291_L	0.904	0.99
118_H	134_G	0.904	0.99
323_L	327_G	0.903	0.99
133_S	138_G	0.902	0.99
58_P	79_G	0.901	0.99
21_L	27_R	0.892	0.99
202_L	263_G	0.890	0.99
158_G	161_H	0.888	0.99
145_H	152_V	0.887	0.99
128_S	132_L	0.882	0.99
120_H	126_S	0.882	0.99
149_A	154_S	0.881	0.99
91_L	319_F	0.877	0.99
128_S	136_E	0.873	0.99
279_L	283_L	0.872	0.99
250_L	253_A	0.872	0.99
161_H	166_G	0.871	0.99
116_H	121_S	0.871	0.99
174_E	178_S	0.870	0.99
135_S	140_D	0.869	0.99
158_G	165_H	0.868	0.99
198_F	262_I	0.865	0.99
228_G	232_G	0.865	0.99
152_V	160_G	0.863	0.99
81_I	284_A	0.862	0.99
66_S	69_L	0.854	0.99
272_S	275_A	0.853	0.99
122_H	132_L	0.853	0.99
7_A	260_I	0.848	0.99
9_F	13_V	0.845	0.99
118_H	128_S	0.841	0.99
160_G	165_H	0.839	0.99
112_G	122_H	0.838	0.99
117_S	126_S	0.837	0.99
228_G	234_R	0.837	0.99
40_L	85_G	0.834	0.99
12_L	18_G	0.833	0.99
131_E	138_G	0.830	0.99
150_D	159_H	0.828	0.99
55_H	223_H	0.828	0.99
78_A	82_A	0.827	0.99
14_A	21_L	0.827	0.99
16_L	22_P	0.827	0.99
224_E	289_I	0.825	0.99
228_G	249_N	0.821	0.99
57_L	287_A	0.819	0.99
111_E	116_H	0.818	0.99
197_S	228_G	0.818	0.99
202_L	282_L	0.817	0.99
118_H	129_E	0.814	0.99
123_A	127_V	0.812	0.99
141_H	148_D	0.811	0.99
128_S	135_S	0.809	0.99
128_S	137_E	0.808	0.99
124_G	129_E	0.808	0.99
148_D	152_V	0.806	0.99
157_A	163_H	0.804	0.99
50_A	54_L	0.803	0.99
47_V	329_M	0.800	0.99
200_D	256_T	0.793	0.99
168_E	171_S	0.790	0.99
83_L	326_A	0.785	0.99
14_A	19_G	0.780	0.98
227_E	231_L	0.777	0.98
215_T	230_G	0.777	0.98
116_H	123_A	0.777	0.98
190_E	194_S	0.767	0.98
162_S	167_H	0.766	0.98
299_L	322_L	0.760	0.98
110_S	118_H	0.757	0.98
126_S	157_A	0.742	0.98
162_S	166_G	0.742	0.98
197_S	224_E	0.741	0.98
52_A	291_L	0.739	0.98
162_S	168_E	0.738	0.98
143_H	148_D	0.737	0.98
140_D	145_H	0.737	0.98
52_A	55_H	0.736	0.98
117_S	122_H	0.736	0.98
119_S	136_E	0.733	0.98
311_S	314_L	0.733	0.98
55_H	224_E	0.732	0.98
44_A	51_T	0.728	0.98
118_H	124_G	0.728	0.98
159_H	164_G	0.724	0.97
123_A	131_E	0.723	0.97
115_S	122_H	0.721	0.97
156_A	166_G	0.720	0.97
301_H	305_S	0.719	0.97
123_A	130_D	0.716	0.97
110_S	115_S	0.716	0.97
85_G	285_F	0.715	0.97
123_A	132_L	0.714	0.97
58_P	61_F	0.712	0.97
200_D	227_E	0.711	0.97
126_S	129_E	0.708	0.97
138_G	141_H	0.708	0.97
310_S	315_R	0.706	0.97
163_H	169_H	0.705	0.97
176_E	180_S	0.704	0.97
146_G	150_D	0.702	0.97
3_L	6_G	0.700	0.97
109_K	114_H	0.699	0.97
228_G	231_L	0.698	0.97
35_R	317_L	0.697	0.97
149_A	155_L	0.696	0.97
8_L	18_G	0.691	0.97
193_I	231_L	0.688	0.97
90_F	192_G	0.686	0.97
155_L	162_S	0.683	0.96
124_G	133_S	0.682	0.96
276_L	280_G	0.675	0.96
313_K	317_L	0.675	0.96
56_L	283_L	0.671	0.96
289_I	293_V	0.671	0.96
179_L	182_Q	0.669	0.96
21_L	24_L	0.668	0.96
87_L	322_L	0.667	0.96
126_S	138_G	0.667	0.96
138_G	145_H	0.666	0.96
156_A	164_G	0.664	0.96
320_L	323_L	0.663	0.96
122_H	127_V	0.662	0.96
52_A	290_F	0.660	0.96
124_G	132_L	0.656	0.95
254_L	257_P	0.656	0.95
195_F	282_L	0.654	0.95
209_S	212_L	0.649	0.95
45_A	48_L	0.649	0.95
241_S	246_L	0.648	0.95
122_H	136_E	0.647	0.95
161_H	165_H	0.647	0.95
77_L	80_L	0.641	0.95
226_P	252_F	0.641	0.95
130_D	139_E	0.640	0.95
110_S	116_H	0.639	0.95
123_A	129_E	0.638	0.95
117_S	123_A	0.638	0.95
48_L	189_L	0.637	0.95
147_H	155_L	0.636	0.95
128_S	134_G	0.635	0.95
114_H	121_S	0.633	0.95
286_S	294_A	0.628	0.94
59_E	63_S	0.626	0.94
156_A	163_H	0.625	0.94
5_I	8_L	0.624	0.94
131_E	134_G	0.621	0.94
151_S	156_A	0.621	0.94
12_L	15_S	0.620	0.94
148_D	156_A	0.619	0.94
142_G	145_H	0.619	0.94
279_L	282_L	0.618	0.94
134_G	152_V	0.617	0.94
157_A	162_S	0.616	0.94
272_S	280_G	0.615	0.94
16_L	250_L	0.615	0.94
12_L	22_P	0.612	0.94
114_H	124_G	0.610	0.93
224_E	232_G	0.606	0.93
17_L	21_L	0.605	0.93
160_G	163_H	0.605	0.93
193_I	228_G	0.603	0.93
142_G	150_D	0.603	0.93
12_L	16_L	0.601	0.93
119_S	134_G	0.601	0.93
141_H	149_A	0.600	0.93
147_H	157_A	0.599	0.93
113_H	132_L	0.597	0.93
114_H	119_S	0.597	0.93
121_S	129_E	0.597	0.93
276_L	279_L	0.596	0.93
112_G	118_H	0.594	0.92
158_G	167_H	0.593	0.92
120_H	125_S	0.593	0.92
99_L	102_G	0.592	0.92
119_S	129_E	0.591	0.92
144_G	150_D	0.591	0.92
294_A	297_E	0.590	0.92
132_L	139_E	0.589	0.92
147_H	152_V	0.589	0.92
117_S	133_S	0.586	0.92
118_H	125_S	0.586	0.92
152_V	168_E	0.585	0.92
231_L	235_L	0.585	0.92
220_I	233_A	0.584	0.92
167_H	170_A	0.583	0.92
201_G	223_H	0.576	0.91
123_A	138_G	0.576	0.91
24_L	27_R	0.574	0.91
149_A	156_A	0.574	0.91
143_H	152_V	0.573	0.91
129_E	138_G	0.572	0.91
285_F	289_I	0.569	0.91
8_L	15_S	0.568	0.91
148_D	157_A	0.568	0.91
44_A	48_L	0.568	0.91
18_G	26_P	0.567	0.91
252_F	256_T	0.566	0.91
16_L	21_L	0.566	0.91
148_D	155_L	0.564	0.90
196_H	200_D	0.564	0.90
3_L	9_F	0.563	0.90
136_E	144_G	0.562	0.90
139_E	147_H	0.562	0.90
163_H	168_E	0.561	0.90
115_S	133_S	0.560	0.90
128_S	139_E	0.559	0.90
151_S	162_S	0.556	0.90
39_L	317_L	0.555	0.90
126_S	136_E	0.554	0.90
190_E	199_F	0.552	0.90
161_H	170_A	0.551	0.89
83_L	87_L	0.550	0.89
120_H	129_E	0.549	0.89
13_V	17_L	0.548	0.89
177_E	180_S	0.545	0.89
124_G	138_G	0.545	0.89
111_E	119_S	0.544	0.89
136_E	139_E	0.543	0.89
129_E	162_S	0.542	0.89
157_A	164_G	0.541	0.89
281_I	285_F	0.541	0.89
48_L	199_F	0.540	0.88
97_H	101_H	0.540	0.88
197_S	226_P	0.540	0.88
227_E	230_G	0.540	0.88
152_V	166_G	0.537	0.88
120_H	137_E	0.537	0.88
157_A	170_A	0.537	0.88
79_G	82_A	0.536	0.88
9_F	19_G	0.535	0.88
159_H	166_G	0.534	0.88
127_V	135_S	0.534	0.88
155_L	165_H	0.533	0.88
161_H	167_H	0.533	0.88
312_L	316_L	0.531	0.88
152_V	161_H	0.529	0.87
82_A	85_G	0.529	0.87
89_F	192_G	0.529	0.87
166_G	170_A	0.527	0.87
122_H	129_E	0.525	0.87
146_G	157_A	0.524	0.87
159_H	165_H	0.524	0.87
137_E	141_H	0.524	0.87
197_S	231_L	0.524	0.87
304_L	307_K	0.524	0.87
125_S	132_L	0.523	0.87
52_A	60_A	0.522	0.87
121_S	130_D	0.522	0.87
197_S	230_G	0.522	0.87
51_T	216_L	0.518	0.86
193_I	227_E	0.518	0.86
150_D	166_G	0.517	0.86
4_K	22_P	0.517	0.86
146_G	152_V	0.516	0.86
14_A	25_L	0.516	0.86
125_S	161_H	0.516	0.86
162_S	171_S	0.516	0.86
130_D	135_S	0.516	0.86
139_E	144_G	0.516	0.86
234_R	293_V	0.515	0.86
93_E	296_V	0.512	0.86
38_S	318_Q	0.511	0.86
190_E	231_L	0.509	0.85
93_E	232_G	0.508	0.85
243_R	247_L	0.506	0.85
22_P	27_R	0.504	0.85
190_E	228_G	0.502	0.85
302_E	322_L	0.502	0.85
227_E	249_N	0.501	0.85
111_E	118_H	0.501	0.85
95_L	99_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zw9A	1	0.4264	60	0.935	Contact Map
4pypA	1	0.2613	33.9	0.945	Contact Map
3wdoA	1	0.4505	23	0.949	Contact Map
4j05A	3	0.4114	22.2	0.95	Contact Map
4djkA	2	0.3123	16.6	0.952	Contact Map
5a63B	1	0.2222	15.8	0.953	Contact Map
4m64A	1	0.3393	14.7	0.953	Contact Map
4gx0A	3	0.2492	14.6	0.954	Contact Map
4tnwA	3	0.2823	14.6	0.954	Contact Map
3b9wA	3	0.3363	13.3	0.954	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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