GREMLIN Database
Zip - ZIP Zinc transporter
PFAM: PF02535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 333 (324)
Sequences: 5171 (4105)
Seq/√Len: 228.1
META: 0.228

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_G21_L3.8901.00
19_G22_P3.7071.00
60_A284_A3.6391.00
18_G22_P2.8331.00
39_L321_A2.8111.00
86_F295_L2.8001.00
53_F291_L2.7611.00
61_F79_G2.6061.00
153_E157_A2.4111.00
11_I15_S2.3561.00
164_G167_H2.3281.00
6_G10_A2.2841.00
145_H149_A2.2041.00
274_T278_V2.1741.00
109_K112_G2.1711.00
110_S113_H2.1591.00
15_S19_G2.1501.00
155_L158_G2.1151.00
22_P26_P2.1111.00
224_E228_G2.0971.00
113_H116_H2.0881.00
118_H121_S2.0631.00
151_S155_L2.0331.00
112_G115_S2.0091.00
141_H145_H1.9891.00
115_S118_H1.9891.00
156_A159_H1.9411.00
127_V130_D1.9371.00
114_H118_H1.9161.00
150_D153_E1.9071.00
128_S131_E1.9011.00
155_L159_H1.8901.00
120_H123_A1.8611.00
122_H126_S1.8191.00
158_G162_S1.8071.00
64_L280_G1.8041.00
143_H146_G1.7971.00
121_S124_G1.7941.00
11_I18_G1.7861.00
116_H120_H1.7851.00
15_S18_G1.7671.00
159_H163_H1.7591.00
165_H168_E1.7561.00
152_V156_A1.7481.00
81_I281_I1.7211.00
15_S22_P1.7191.00
124_G127_V1.7111.00
10_A14_A1.6871.00
14_A18_G1.6801.00
166_G169_H1.6601.00
160_G164_G1.6561.00
127_V131_E1.6501.00
165_H169_H1.6461.00
6_G217_F1.6381.00
123_A126_S1.6371.00
317_L321_A1.6331.00
141_H144_G1.6101.00
88_L285_F1.6091.00
48_L290_F1.6081.00
120_H124_G1.5981.00
163_H167_H1.5941.00
14_A17_L1.5931.00
147_H151_S1.5871.00
224_E227_E1.5871.00
197_S252_F1.5861.00
81_I85_G1.5651.00
81_I84_A1.5521.00
152_V155_L1.5521.00
148_D151_S1.5461.00
121_S125_S1.5421.00
111_E115_S1.5341.00
125_S128_S1.5341.00
147_H150_D1.5201.00
134_G137_E1.5181.00
214_L218_I1.5171.00
144_G148_D1.4991.00
162_S165_H1.4761.00
156_A162_S1.4701.00
228_G290_F1.4671.00
157_A160_G1.4601.00
194_S255_T1.4471.00
5_I9_F1.4371.00
80_L84_A1.4361.00
110_S114_H1.4361.00
132_L136_E1.4171.00
150_D155_L1.4161.00
124_G128_S1.4121.00
151_S154_S1.4121.00
158_G163_H1.4011.00
148_D153_E1.3751.00
11_I14_A1.3671.00
277_I281_I1.3521.00
116_H119_S1.3471.00
159_H162_S1.3341.00
113_H118_H1.3251.00
193_I224_E1.3251.00
139_E143_H1.3181.00
55_H329_M1.3151.00
154_S158_G1.3051.00
144_G147_H1.3011.00
135_S139_E1.3001.00
16_L20_L1.2981.00
113_H117_S1.2941.00
91_L95_L1.2891.00
143_H147_H1.2861.00
130_D133_S1.2861.00
145_H148_D1.2671.00
60_A78_A1.2651.00
140_D146_G1.2651.00
51_T55_H1.2601.00
111_E114_H1.2531.00
167_H171_S1.2491.00
114_H117_S1.2411.00
19_G23_L1.2391.00
157_A161_H1.2251.00
119_S122_H1.2241.00
316_L320_L1.2171.00
193_I200_D1.2111.00
231_L252_F1.2031.00
126_S131_E1.2011.00
121_S127_V1.1991.00
21_L26_P1.1981.00
224_E290_F1.1801.00
127_V132_L1.1801.00
15_S21_L1.1791.00
140_D144_G1.1771.00
43_F328_L1.1661.00
118_H122_H1.1651.00
11_I22_P1.1641.00
38_S42_A1.1601.00
227_E252_F1.1501.00
154_S161_H1.1451.00
126_S130_D1.1431.00
146_G151_S1.1421.00
173_E176_E1.1421.00
154_S159_H1.1371.00
122_H125_S1.1351.00
224_E252_F1.1351.00
117_S120_H1.1351.00
126_S134_G1.1331.00
72_H75_W1.1301.00
136_E140_D1.1261.00
196_H223_H1.1201.00
151_S157_A1.1181.00
302_E306_E1.1171.00
164_G168_E1.1161.00
155_L160_G1.1131.00
57_L82_A1.1071.00
123_A128_S1.1071.00
160_G166_G1.1051.00
142_G146_G1.0981.00
109_K113_H1.0971.00
125_S129_E1.0951.00
204_L220_I1.0921.00
109_K115_S1.0871.00
115_S119_S1.0821.00
140_D143_H1.0781.00
150_D154_S1.0781.00
141_H147_H1.0771.00
119_S127_V1.0761.00
144_G149_A1.0731.00
227_E290_F1.0691.00
62_E65_T1.0641.00
247_L251_L1.0551.00
78_A284_A1.0511.00
149_A152_V1.0441.00
59_E62_E1.0441.00
162_S169_H1.0431.00
49_L294_A1.0431.00
228_G252_F1.0401.00
217_F221_L1.0391.00
52_A204_L1.0371.00
149_A153_E1.0311.00
90_F94_K1.0291.00
200_D224_E1.0241.00
131_E136_E1.0201.00
117_S121_S1.0191.00
146_G149_A1.0171.00
119_S124_G1.0131.00
164_G169_H1.0131.00
224_E231_L1.0121.00
131_E135_S1.0061.00
142_G148_D1.0041.00
129_E132_L1.0011.00
60_A280_G0.9951.00
120_H128_S0.9891.00
213_G260_I0.9861.00
152_V159_H0.9851.00
119_S123_A0.9831.00
134_G138_G0.9821.00
143_H150_D0.9801.00
11_I19_G0.9751.00
327_G331_L0.9741.00
141_H146_G0.9691.00
12_L257_P0.9681.00
14_A225_I0.9651.00
156_A160_G0.9621.00
190_E248_L0.9541.00
130_D134_G0.9461.00
151_S160_G0.9461.00
142_G147_H0.9451.00
143_H149_A0.9421.00
132_L137_E0.9401.00
153_E156_A0.9381.00
182_Q185_R0.9331.00
82_A86_F0.9331.00
155_L161_H0.9291.00
153_E158_G0.9291.00
315_R319_F0.9271.00
241_S244_K0.9261.00
112_G116_H0.9191.00
122_H128_S0.9161.00
154_S157_A0.9151.00
147_H153_E0.9080.99
82_A291_L0.9040.99
118_H134_G0.9040.99
323_L327_G0.9030.99
133_S138_G0.9020.99
58_P79_G0.9010.99
21_L27_R0.8920.99
202_L263_G0.8900.99
158_G161_H0.8880.99
145_H152_V0.8870.99
128_S132_L0.8820.99
120_H126_S0.8820.99
149_A154_S0.8810.99
91_L319_F0.8770.99
128_S136_E0.8730.99
279_L283_L0.8720.99
250_L253_A0.8720.99
161_H166_G0.8710.99
116_H121_S0.8710.99
174_E178_S0.8700.99
135_S140_D0.8690.99
158_G165_H0.8680.99
198_F262_I0.8650.99
228_G232_G0.8650.99
152_V160_G0.8630.99
81_I284_A0.8620.99
66_S69_L0.8540.99
272_S275_A0.8530.99
122_H132_L0.8530.99
7_A260_I0.8480.99
9_F13_V0.8450.99
118_H128_S0.8410.99
160_G165_H0.8390.99
112_G122_H0.8380.99
117_S126_S0.8370.99
228_G234_R0.8370.99
40_L85_G0.8340.99
12_L18_G0.8330.99
131_E138_G0.8300.99
150_D159_H0.8280.99
55_H223_H0.8280.99
78_A82_A0.8270.99
14_A21_L0.8270.99
16_L22_P0.8270.99
224_E289_I0.8250.99
228_G249_N0.8210.99
57_L287_A0.8190.99
111_E116_H0.8180.99
197_S228_G0.8180.99
202_L282_L0.8170.99
118_H129_E0.8140.99
123_A127_V0.8120.99
141_H148_D0.8110.99
128_S135_S0.8090.99
128_S137_E0.8080.99
124_G129_E0.8080.99
148_D152_V0.8060.99
157_A163_H0.8040.99
50_A54_L0.8030.99
47_V329_M0.8000.99
200_D256_T0.7930.99
168_E171_S0.7900.99
83_L326_A0.7850.99
14_A19_G0.7800.98
227_E231_L0.7770.98
215_T230_G0.7770.98
116_H123_A0.7770.98
190_E194_S0.7670.98
162_S167_H0.7660.98
299_L322_L0.7600.98
110_S118_H0.7570.98
126_S157_A0.7420.98
162_S166_G0.7420.98
197_S224_E0.7410.98
52_A291_L0.7390.98
162_S168_E0.7380.98
143_H148_D0.7370.98
140_D145_H0.7370.98
52_A55_H0.7360.98
117_S122_H0.7360.98
119_S136_E0.7330.98
311_S314_L0.7330.98
55_H224_E0.7320.98
44_A51_T0.7280.98
118_H124_G0.7280.98
159_H164_G0.7240.97
123_A131_E0.7230.97
115_S122_H0.7210.97
156_A166_G0.7200.97
301_H305_S0.7190.97
123_A130_D0.7160.97
110_S115_S0.7160.97
85_G285_F0.7150.97
123_A132_L0.7140.97
58_P61_F0.7120.97
200_D227_E0.7110.97
126_S129_E0.7080.97
138_G141_H0.7080.97
310_S315_R0.7060.97
163_H169_H0.7050.97
176_E180_S0.7040.97
146_G150_D0.7020.97
3_L6_G0.7000.97
109_K114_H0.6990.97
228_G231_L0.6980.97
35_R317_L0.6970.97
149_A155_L0.6960.97
8_L18_G0.6910.97
193_I231_L0.6880.97
90_F192_G0.6860.97
155_L162_S0.6830.96
124_G133_S0.6820.96
276_L280_G0.6750.96
313_K317_L0.6750.96
56_L283_L0.6710.96
289_I293_V0.6710.96
179_L182_Q0.6690.96
21_L24_L0.6680.96
87_L322_L0.6670.96
126_S138_G0.6670.96
138_G145_H0.6660.96
156_A164_G0.6640.96
320_L323_L0.6630.96
122_H127_V0.6620.96
52_A290_F0.6600.96
124_G132_L0.6560.95
254_L257_P0.6560.95
195_F282_L0.6540.95
209_S212_L0.6490.95
45_A48_L0.6490.95
241_S246_L0.6480.95
122_H136_E0.6470.95
161_H165_H0.6470.95
77_L80_L0.6410.95
226_P252_F0.6410.95
130_D139_E0.6400.95
110_S116_H0.6390.95
123_A129_E0.6380.95
117_S123_A0.6380.95
48_L189_L0.6370.95
147_H155_L0.6360.95
128_S134_G0.6350.95
114_H121_S0.6330.95
286_S294_A0.6280.94
59_E63_S0.6260.94
156_A163_H0.6250.94
5_I8_L0.6240.94
131_E134_G0.6210.94
151_S156_A0.6210.94
12_L15_S0.6200.94
148_D156_A0.6190.94
142_G145_H0.6190.94
279_L282_L0.6180.94
134_G152_V0.6170.94
157_A162_S0.6160.94
272_S280_G0.6150.94
16_L250_L0.6150.94
12_L22_P0.6120.94
114_H124_G0.6100.93
224_E232_G0.6060.93
17_L21_L0.6050.93
160_G163_H0.6050.93
193_I228_G0.6030.93
142_G150_D0.6030.93
12_L16_L0.6010.93
119_S134_G0.6010.93
141_H149_A0.6000.93
147_H157_A0.5990.93
113_H132_L0.5970.93
114_H119_S0.5970.93
121_S129_E0.5970.93
276_L279_L0.5960.93
112_G118_H0.5940.92
158_G167_H0.5930.92
120_H125_S0.5930.92
99_L102_G0.5920.92
119_S129_E0.5910.92
144_G150_D0.5910.92
294_A297_E0.5900.92
132_L139_E0.5890.92
147_H152_V0.5890.92
117_S133_S0.5860.92
118_H125_S0.5860.92
152_V168_E0.5850.92
231_L235_L0.5850.92
220_I233_A0.5840.92
167_H170_A0.5830.92
201_G223_H0.5760.91
123_A138_G0.5760.91
24_L27_R0.5740.91
149_A156_A0.5740.91
143_H152_V0.5730.91
129_E138_G0.5720.91
285_F289_I0.5690.91
8_L15_S0.5680.91
148_D157_A0.5680.91
44_A48_L0.5680.91
18_G26_P0.5670.91
252_F256_T0.5660.91
16_L21_L0.5660.91
148_D155_L0.5640.90
196_H200_D0.5640.90
3_L9_F0.5630.90
136_E144_G0.5620.90
139_E147_H0.5620.90
163_H168_E0.5610.90
115_S133_S0.5600.90
128_S139_E0.5590.90
151_S162_S0.5560.90
39_L317_L0.5550.90
126_S136_E0.5540.90
190_E199_F0.5520.90
161_H170_A0.5510.89
83_L87_L0.5500.89
120_H129_E0.5490.89
13_V17_L0.5480.89
177_E180_S0.5450.89
124_G138_G0.5450.89
111_E119_S0.5440.89
136_E139_E0.5430.89
129_E162_S0.5420.89
157_A164_G0.5410.89
281_I285_F0.5410.89
48_L199_F0.5400.88
97_H101_H0.5400.88
197_S226_P0.5400.88
227_E230_G0.5400.88
152_V166_G0.5370.88
120_H137_E0.5370.88
157_A170_A0.5370.88
79_G82_A0.5360.88
9_F19_G0.5350.88
159_H166_G0.5340.88
127_V135_S0.5340.88
155_L165_H0.5330.88
161_H167_H0.5330.88
312_L316_L0.5310.88
152_V161_H0.5290.87
82_A85_G0.5290.87
89_F192_G0.5290.87
166_G170_A0.5270.87
122_H129_E0.5250.87
146_G157_A0.5240.87
159_H165_H0.5240.87
137_E141_H0.5240.87
197_S231_L0.5240.87
304_L307_K0.5240.87
125_S132_L0.5230.87
52_A60_A0.5220.87
121_S130_D0.5220.87
197_S230_G0.5220.87
51_T216_L0.5180.86
193_I227_E0.5180.86
150_D166_G0.5170.86
4_K22_P0.5170.86
146_G152_V0.5160.86
14_A25_L0.5160.86
125_S161_H0.5160.86
162_S171_S0.5160.86
130_D135_S0.5160.86
139_E144_G0.5160.86
234_R293_V0.5150.86
93_E296_V0.5120.86
38_S318_Q0.5110.86
190_E231_L0.5090.85
93_E232_G0.5080.85
243_R247_L0.5060.85
22_P27_R0.5040.85
190_E228_G0.5020.85
302_E322_L0.5020.85
227_E249_N0.5010.85
111_E118_H0.5010.85
95_L99_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zw9A 1 0.4264 60 0.935 Contact Map
4pypA 1 0.2613 33.9 0.945 Contact Map
3wdoA 1 0.4505 23 0.949 Contact Map
4j05A 3 0.4114 22.2 0.95 Contact Map
4djkA 2 0.3123 16.6 0.952 Contact Map
5a63B 1 0.2222 15.8 0.953 Contact Map
4m64A 1 0.3393 14.7 0.953 Contact Map
4gx0A 3 0.2492 14.6 0.954 Contact Map
4tnwA 3 0.2823 14.6 0.954 Contact Map
3b9wA 3 0.3363 13.3 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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