GREMLIN Database
Auxin_inducible - Auxin responsive protein
PFAM: PF02519 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (76)
Sequences: 2535 (1317)
Seq/√Len: 151.0
META: 0.06

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V84_F4.1561.00
86_Y90_L2.7331.00
38_G84_F2.5511.00
30_K48_L2.5241.00
61_R64_E2.1931.00
30_K47_P2.1521.00
86_Y89_S2.1301.00
71_P74_G2.1061.00
82_D85_E2.0431.00
63_A78_P2.0101.00
80_D83_V2.0021.00
36_Y74_G1.9431.00
23_S26_D1.8751.00
25_S28_P1.6731.00
34_A45_V1.6141.00
42_K85_E1.6001.00
16_S19_S1.4471.00
52_N71_P1.3781.00
47_P50_Y1.3591.00
56_F75_L1.3341.00
32_H45_V1.3181.00
42_K81_E1.3171.00
41_R76_T1.2991.00
14_R18_S1.2921.00
27_V32_H1.2841.00
38_G54_P1.2781.00
31_G43_R1.2541.00
52_N55_L1.1811.00
64_E68_G1.1591.00
45_V87_L1.1301.00
14_R17_S1.1291.00
67_F78_P1.1160.99
71_P77_I1.0890.99
53_H75_L1.0830.99
15_I18_S1.0710.99
32_H53_H1.0680.99
21_S24_S1.0330.99
62_Q83_V0.9530.98
66_E69_F0.9140.98
38_G81_E0.9000.98
64_E67_F0.8890.97
48_L58_E0.8870.97
39_E80_D0.8870.97
59_L88_L0.8730.97
40_E44_F0.8730.97
18_S22_S0.8700.97
56_F69_F0.8650.97
60_L78_P0.8610.97
32_H87_L0.8530.97
54_P87_L0.8450.96
49_S75_L0.8440.96
47_P65_E0.8420.96
47_P74_G0.8370.96
30_K76_T0.8330.96
72_M76_T0.8100.95
57_Q61_R0.8030.95
54_P84_F0.8010.95
66_E70_D0.7910.95
45_V53_H0.7870.95
80_D90_L0.7830.95
68_G78_P0.7780.94
50_Y76_T0.7770.94
40_E55_L0.7670.94
31_G78_P0.7670.94
44_F85_E0.7660.94
33_F48_L0.7630.94
33_F36_Y0.7400.93
31_G74_G0.7350.93
83_V86_Y0.7260.92
20_S23_S0.7250.92
40_E80_D0.7210.92
16_S23_S0.7100.91
55_L88_L0.7100.91
48_L83_V0.7060.91
60_L68_G0.6930.90
48_L84_F0.6870.90
58_E82_D0.6850.90
55_L58_E0.6820.89
36_Y50_Y0.6520.87
54_P57_Q0.6510.87
31_G75_L0.6460.87
49_S57_Q0.6270.85
57_Q74_G0.6230.85
51_L65_E0.6210.85
32_H81_E0.6110.84
48_L52_N0.6000.83
51_L62_Q0.5980.82
46_V89_S0.5910.82
15_I22_S0.5870.81
46_V83_V0.5840.81
30_K67_F0.5840.81
61_R65_E0.5830.81
80_D85_E0.5800.80
36_Y55_L0.5750.80
62_Q87_L0.5660.79
38_G46_V0.5600.78
31_G64_E0.5580.78
58_E61_R0.5580.78
37_V53_H0.5570.78
40_E86_Y0.5570.78
19_S35_V0.5500.77
41_R77_I0.5380.75
55_L80_D0.5360.75
46_V70_D0.5340.75
60_L64_E0.5310.74
16_S20_S0.5220.73
63_A75_L0.5180.72
18_S24_S0.5110.71
45_V79_C0.5100.71
49_S53_H0.5090.71
57_Q81_E0.5030.70
33_F45_V0.5010.70
46_V63_A0.5010.70
79_C87_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3drxA 3 0.7582 45.6 0.893 Contact Map
1nn7A 3 0.6044 43.9 0.894 Contact Map
4crhA 1 0.6154 40.3 0.896 Contact Map
3drzA 3 0.6593 38.4 0.897 Contact Map
1s1gA 3 0.6374 37.2 0.898 Contact Map
3kvtA 4 0.6374 34.6 0.9 Contact Map
1wj6A 1 0.8022 29.6 0.903 Contact Map
1pzqA 2 0.2857 29.1 0.904 Contact Map
4bgcA 1 0.6374 29 0.904 Contact Map
4yy8A 2 0.6374 27.4 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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