GREMLIN Database
Bro-N - BRO family, N-terminal domain
PFAM: PF02498 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (81)
Sequences: 26443 (16752)
Seq/√Len: 1861.3
META: 0.87

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S56_V3.1121.00
27_N30_R2.4771.00
17_V21_E2.4001.00
31_A34_K2.2341.00
64_R78_K2.0211.00
60_E83_K1.9761.00
67_Q82_A1.9591.00
30_R34_K1.9481.00
57_I62_L1.8301.00
19_V62_L1.8071.00
79_R83_K1.8071.00
4_T12_W1.7751.00
6_W10_G1.6781.00
57_I61_G1.6721.00
3_R18_D1.6671.00
25_Y28_P1.6591.00
59_E63_Y1.6531.00
73_K76_P1.6211.00
57_I65_L1.5431.00
67_Q78_K1.5301.00
6_W12_W1.5131.00
11_E58_N1.4561.00
8_E13_W1.4511.00
58_N61_G1.4151.00
43_L46_N1.3781.00
16_A57_I1.3441.00
15_S18_D1.2761.00
35_R68_S1.2551.00
13_W58_N1.2541.00
31_A35_R1.2061.00
6_W9_N1.2021.00
48_D52_R1.1901.00
15_S54_T1.1871.00
5_V8_E1.1401.00
41_K55_D1.1321.00
37_D40_G1.1141.00
20_A28_P1.0901.00
78_K82_A1.0891.00
41_K45_T1.0631.00
3_R15_S1.0601.00
43_L53_E1.0521.00
42_E46_N1.0191.00
30_R33_K0.9991.00
39_E43_L0.9951.00
30_R44_V0.9701.00
4_T8_E0.9631.00
42_E48_D0.9481.00
27_N31_A0.9411.00
40_G64_R0.9411.00
42_E45_T0.9221.00
4_T14_F0.9181.00
29_R33_K0.9161.00
14_F62_L0.8941.00
43_L47_Q0.8801.00
64_R82_A0.8791.00
24_G71_S0.8711.00
39_E79_R0.8611.00
60_E82_A0.8561.00
49_G52_R0.8271.00
64_R75_E0.8221.00
37_D75_E0.8181.00
60_E79_R0.8071.00
50_K54_T0.8031.00
62_L81_L0.7831.00
48_D51_K0.7831.00
16_A65_L0.7831.00
36_L40_G0.7801.00
2_I22_V0.7731.00
64_R68_S0.7691.00
23_L66_I0.7621.00
47_Q50_K0.7551.00
69_S74_A0.7551.00
43_L55_D0.7491.00
42_E56_V0.7491.00
63_Y81_L0.7431.00
8_E11_E0.7371.00
6_W11_E0.7361.00
64_R67_Q0.7361.00
75_E78_K0.7351.00
38_K41_K0.7301.00
46_N54_T0.7111.00
40_G44_V0.7081.00
26_S29_R0.7021.00
32_L35_R0.6961.00
68_S78_K0.6931.00
28_P31_A0.6861.00
42_E50_K0.6811.00
33_K36_L0.6721.00
63_Y77_F0.6641.00
48_D54_T0.6621.00
9_N12_W0.6601.00
67_Q81_L0.6581.00
22_V77_F0.6561.00
20_A69_S0.6541.00
24_G29_R0.6491.00
34_K37_D0.6321.00
31_A45_T0.6141.00
13_W56_V0.6121.00
37_D41_K0.6061.00
64_R79_R0.5931.00
66_I78_K0.5821.00
26_S30_R0.5771.00
40_G43_L0.5741.00
72_P75_E0.5711.00
44_V47_Q0.5661.00
62_L66_I0.5541.00
20_A25_Y0.5531.00
27_N34_K0.5491.00
32_L36_L0.5471.00
24_G73_K0.5451.00
8_E12_W0.5451.00
45_T51_K0.5401.00
29_R32_L0.5391.00
41_K44_V0.5341.00
4_T18_D0.5231.00
35_R38_K0.5231.00
36_L64_R0.5151.00
34_K38_K0.5031.00
33_K55_D0.5031.00
25_Y71_S0.5021.00
72_P76_P0.5011.00
36_L39_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m70A 1 0.5287 65.6 0.81 Contact Map
3eyiA 1 0.6207 52.6 0.824 Contact Map
1xmkA 1 0.7471 49.7 0.828 Contact Map
1oyiA 1 0.6207 23.5 0.856 Contact Map
1qgpA 1 0.6782 23.4 0.856 Contact Map
2zkzA 2 0.7931 19.5 0.861 Contact Map
3cuoA 2 0.8276 18.6 0.862 Contact Map
1q1hA 1 0.7011 17.4 0.864 Contact Map
1sfuA 1 0.6782 15.7 0.867 Contact Map
1qbjA 1 0.6437 15.2 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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