GREMLIN Database
Tim17 - Tim17/Tim22/Tim23/Pmp24 family
PFAM: PF02466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (109)
Sequences: 2913 (1887)
Seq/√Len: 180.7
META: 0.246

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_A102_G4.5691.00
67_R70_D3.6081.00
67_R73_N3.1321.00
63_L76_I2.9351.00
59_I80_L2.9181.00
63_L77_A2.4241.00
70_D73_N2.2971.00
59_I84_L2.1511.00
53_G57_S1.9961.00
95_A98_A1.8181.00
42_G46_G1.7831.00
15_A19_V1.7211.00
21_G25_G1.6081.00
64_E69_E1.6041.00
41_R45_L1.5601.00
7_G10_F1.5591.00
32_N36_N1.5541.00
77_A81_T1.5171.00
97_A101_G1.5151.00
39_G43_P1.4941.00
27_L31_L1.4861.00
41_R44_S1.4651.00
83_A98_A1.4371.00
105_F109_S1.4011.00
12_M16_L1.3921.00
21_G24_K1.3671.00
16_L20_Y1.3511.00
12_M15_A1.3361.00
28_K32_N1.3111.00
84_L87_A1.2831.00
96_Q99_V1.2641.00
100_L104_L1.2501.00
75_I102_G1.2291.00
8_L12_M1.2191.00
56_Y74_S1.2141.00
51_V54_G1.1941.00
100_L103_A1.1931.00
29_L32_N1.1801.00
55_L59_I1.1701.00
62_L66_L1.1651.00
101_G105_F1.1641.00
99_V102_G1.1631.00
22_L25_G1.1611.00
72_W76_I1.1611.00
58_G62_L1.1201.00
59_I77_A1.0981.00
95_A102_G1.0981.00
80_L83_A1.0851.00
62_L65_K1.0721.00
14_A43_P1.0681.00
92_R95_A1.0671.00
94_A98_A1.0541.00
27_L30_R1.0371.00
39_G44_S1.0291.00
95_A99_V1.0200.99
34_V38_V1.0120.99
92_R96_Q1.0070.99
75_I79_A1.0010.99
11_L15_A0.9940.99
107_A110_G0.9870.99
9_A12_M0.9650.99
59_I62_L0.9610.99
73_N77_A0.9550.99
14_A46_G0.9420.99
11_L14_A0.9410.99
64_E73_N0.9380.99
60_E77_A0.9380.99
91_P95_A0.9330.99
63_L73_N0.9140.99
78_G82_G0.9120.99
55_L84_L0.9110.99
56_Y60_E0.8970.99
60_E74_S0.8820.98
23_F26_F0.8760.98
5_K8_L0.8740.98
4_Y50_A0.8730.98
81_T85_L0.8720.98
36_N39_G0.8670.98
43_P47_G0.8670.98
33_G37_A0.8630.98
22_L38_V0.8620.98
31_L35_L0.8580.98
74_S77_A0.8490.98
40_R44_S0.8480.98
91_P94_A0.8450.98
31_L38_V0.8360.98
53_G60_E0.8350.98
98_A101_G0.8310.98
75_I110_G0.8300.98
30_R33_G0.8160.97
31_L34_V0.8140.97
36_N40_R0.8020.97
28_K36_N0.7710.96
8_L11_L0.7690.96
42_G45_L0.7560.96
6_T54_G0.7540.96
83_A87_A0.7500.96
96_Q100_L0.7480.96
97_A109_S0.7390.95
15_A18_G0.7290.95
96_Q101_G0.7240.95
103_A108_F0.7100.94
102_G105_F0.7080.94
37_A41_R0.7040.94
17_G21_G0.7000.94
37_A44_S0.6870.93
101_G108_F0.6860.93
22_L34_V0.6770.93
9_A53_G0.6730.93
55_L81_T0.6720.93
30_R34_V0.6720.93
18_G21_G0.6700.93
71_P110_G0.6690.92
79_A98_A0.6650.92
20_Y24_K0.6580.92
39_G42_G0.6570.92
42_G47_G0.6530.92
14_A18_G0.6510.91
3_L6_T0.6500.91
5_K9_A0.6470.91
18_G22_L0.6460.91
17_G20_Y0.6450.91
96_Q102_G0.6450.91
29_L35_L0.6360.90
58_G61_C0.6320.90
101_G109_S0.6270.90
50_A88_R0.6240.90
11_L16_L0.6180.89
19_V62_L0.6180.89
35_L39_G0.6170.89
33_G43_P0.6150.89
68_K72_W0.6090.88
19_V23_F0.5950.87
107_A111_A0.5940.87
48_N58_G0.5940.87
92_R100_L0.5880.87
26_F30_R0.5880.87
48_N52_F0.5860.87
24_K41_R0.5760.86
32_N39_G0.5760.86
29_L62_L0.5740.85
103_A110_G0.5700.85
10_F21_G0.5700.85
71_P107_A0.5700.85
51_V58_G0.5690.85
21_G26_F0.5680.85
5_K10_F0.5640.84
34_V37_A0.5570.84
6_T61_C0.5550.83
61_C65_K0.5510.83
89_A93_A0.5490.83
57_S60_E0.5410.82
97_A102_G0.5280.80
104_L108_F0.5280.80
69_E73_N0.5260.80
29_L34_V0.5240.80
4_Y10_F0.5220.80
63_L66_L0.5160.79
29_L36_N0.5160.79
103_A107_A0.5150.79
105_F108_F0.5150.79
52_F86_A0.5130.78
90_G98_A0.5110.78
38_V44_S0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1okcA 1 0.8319 3.2 0.904 Contact Map
2lckA 1 0.8319 2.7 0.908 Contact Map
4c9gA 1 0.8319 2.6 0.908 Contact Map
1jb0L 1 0.354 1.7 0.917 Contact Map
4cz8A 2 0.885 1.6 0.918 Contact Map
4p6vB 1 0.9469 1.4 0.92 Contact Map
2lbgA 1 0.2389 1.4 0.921 Contact Map
2m0wA 1 0.2035 0.9 0.931 Contact Map
2nwlA 3 0.3451 0.9 0.931 Contact Map
1q90R 1 0.3451 0.8 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.