GREMLIN Database
Keratin - Keratin
PFAM: PF02422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (91)
Sequences: 617 (237)
Seq/√Len: 24.9
META: 0.016

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_L7_P2.7010.99
76_V80_G2.5680.99
28_Q53_F2.5260.99
80_G87_G2.3750.98
29_C32_S2.3700.98
85_Y89_G2.0640.96
57_S64_S2.0500.95
22_N43_V1.9980.95
79_S85_Y1.9320.94
69_S72_G1.8840.93
82_S86_G1.8660.93
55_Q59_V1.8250.92
3_S9_C1.6000.85
20_S45_F1.5710.84
71_L77_P1.5610.84
8_P11_V1.5480.83
82_S88_L1.5340.83
15_Q19_N1.4730.80
14_P55_Q1.4710.80
44_T52_S1.4000.76
13_C40_P1.3930.76
75_G79_S1.3400.73
6_L43_V1.3100.71
51_S63_G1.2820.70
34_V64_S1.2750.69
20_S27_R1.2720.69
22_N27_R1.2510.68
27_R50_L1.2500.68
44_T51_S1.2490.68
27_R51_S1.2440.67
84_G92_G1.2420.67
49_I52_S1.2350.67
30_P53_F1.2340.67
66_A71_L1.2300.66
33_T44_T1.2280.66
82_S89_G1.2190.66
70_S73_S1.2070.65
70_S74_G1.1870.64
18_A60_G1.1820.63
71_L75_G1.1700.62
61_S66_A1.1290.60
35_V57_S1.1220.59
45_F49_I1.1190.59
73_S80_G1.1150.59
2_Y5_C1.1040.58
49_I54_P1.1020.58
73_S82_S1.1000.58
76_V88_L1.0980.57
34_V52_S1.0940.57
19_N62_S1.0850.57
86_G91_Y1.0710.56
47_G55_Q1.0600.55
78_G87_G1.0600.55
33_T37_Q1.0390.53
63_G86_G1.0310.53
45_F57_S0.9780.49
73_S79_S0.9760.49
84_G90_G0.9750.49
14_P68_G0.9740.49
86_G90_G0.9370.46
30_P63_G0.9210.45
2_Y6_L0.9190.45
74_G78_G0.8970.43
37_Q45_F0.8940.43
28_Q36_I0.8900.42
78_G81_G0.8860.42
11_V44_T0.8810.42
69_S79_S0.8760.42
38_P65_A0.8640.41
83_F89_G0.8610.40
22_N62_S0.8520.40
3_S11_V0.8430.39
72_G77_P0.8420.39
88_L91_Y0.8260.38
12_C15_Q0.8200.38
85_Y88_L0.8140.37
4_L54_P0.8020.36
77_P89_G0.7800.35
85_Y90_G0.7710.34
24_P30_P0.7710.34
71_L80_G0.7560.33
76_V82_S0.7430.33
4_L8_P0.7320.32
28_Q45_F0.7270.32
79_S84_G0.7260.32
82_S91_Y0.7180.31
38_P63_G0.7140.31
13_C56_E0.7120.31
78_G92_G0.7110.31
20_S38_P0.7070.30
5_C52_S0.6970.30
39_P61_S0.6960.30
10_G30_P0.6870.29
31_D47_G0.6720.28
13_C17_L0.6650.28
24_P43_V0.6640.28
86_G92_G0.6590.27
53_F64_S0.6580.27
79_S82_S0.6570.27
21_C45_F0.6550.27
13_C58_V0.6550.27
13_C34_V0.6500.27
23_E69_S0.6430.27
82_S85_Y0.6370.26
72_G78_G0.6310.26
17_L52_S0.6260.26
26_V50_L0.6220.25
82_S87_G0.6170.25
74_G83_F0.6080.25
84_G88_L0.6020.24
82_S90_G0.5990.24
15_Q39_P0.5970.24
27_R30_P0.5900.24
40_P56_E0.5900.24
9_C26_V0.5900.24
36_I65_A0.5820.23
71_L76_V0.5680.23
50_L73_S0.5660.22
39_P50_L0.5630.22
27_R35_V0.5610.22
36_I43_V0.5470.22
9_C24_P0.5450.21
70_S77_P0.5440.21
61_S80_G0.5440.21
75_G88_L0.5430.21
27_R38_P0.5400.21
2_Y7_P0.5390.21
53_F57_S0.5330.21
2_Y13_C0.5310.21
61_S65_A0.5260.21
70_S78_G0.5180.20
65_A72_G0.5170.20
77_P83_F0.5110.20
56_E73_S0.5060.20
15_Q34_V0.5050.20
36_I63_G0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zpxA 1 0.1684 4.4 0.945 Contact Map
1l6jA 1 0.4 3.9 0.946 Contact Map
2nx7A 1 0.1789 3.6 0.947 Contact Map
4ladB 1 0.3263 2.7 0.95 Contact Map
2hm3A 1 0.2105 2.1 0.953 Contact Map
2nx6A 1 0.1684 1.9 0.954 Contact Map
4dpvZ 8 0.2737 1.9 0.954 Contact Map
1eaiC 1 0.5053 1.7 0.955 Contact Map
1wqcA 1 0.1895 1.7 0.955 Contact Map
1jfnA 1 0.4526 1.6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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