GREMLIN Database
Chromate_transp - Chromate transporter
PFAM: PF02417 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (155)
Sequences: 61645 (34764)
Seq/√Len: 2792.3
META: 0.865

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_Q38_E5.2371.00
27_R31_E3.7051.00
4_F77_G3.2671.00
37_T40_E3.2401.00
28_E32_R3.0181.00
40_E66_A2.6401.00
2_E33_R2.4001.00
61_T75_T2.3691.00
44_G62_F2.3031.00
26_Q31_E2.2551.00
5_L9_K2.2411.00
27_R32_R2.2041.00
9_K28_E2.1591.00
144_P147_L2.1401.00
136_V140_F2.0841.00
36_L63_I1.9551.00
7_F29_L1.9541.00
135_F139_L1.9291.00
6_F28_E1.8801.00
8_L12_L1.8611.00
65_Y71_A1.8591.00
4_F80_L1.8301.00
73_V77_G1.7751.00
39_E43_D1.7321.00
115_G119_A1.7201.00
4_F73_V1.7031.00
26_Q123_R1.6681.00
131_A135_F1.5801.00
28_E33_R1.5401.00
137_A141_F1.5241.00
6_F33_R1.4941.00
103_Q107_Y1.4061.00
14_S21_V1.3661.00
38_E127_S1.3621.00
61_T71_A1.3461.00
99_N102_V1.3131.00
31_E38_E1.3121.00
119_A123_R1.3051.00
13_L24_L1.2971.00
25_M29_L1.2931.00
3_L74_A1.2871.00
21_V56_A1.2721.00
6_F29_L1.2591.00
130_I134_A1.2421.00
25_M60_A1.2401.00
100_P104_A1.2261.00
9_K13_L1.2141.00
130_I141_F1.2041.00
151_A155_A1.1941.00
132_A136_V1.1901.00
92_L96_F1.1631.00
44_G59_L1.1581.00
6_F10_L1.1381.00
38_E42_L1.1111.00
150_L153_G1.1111.00
29_L63_I1.1101.00
97_R103_Q1.1071.00
5_L8_L1.0961.00
147_L151_A1.0951.00
48_A59_L1.0911.00
29_L35_W1.0731.00
104_A108_G1.0711.00
98_G103_Q1.0581.00
105_A109_I1.0561.00
10_L25_M1.0491.00
18_G21_V1.0461.00
146_I150_L1.0401.00
122_L126_R1.0271.00
6_F35_W1.0251.00
138_L148_V1.0181.00
136_V141_F1.0151.00
137_A143_V1.0141.00
64_G74_A1.0061.00
150_L154_L1.0031.00
68_V72_L0.9821.00
84_L88_A0.9801.00
94_E97_R0.9761.00
4_F8_L0.9731.00
72_L76_L0.9721.00
83_F87_L0.9721.00
131_A138_L0.9701.00
101_W105_A0.9481.00
8_L11_G0.9421.00
31_E34_G0.9391.00
96_F99_N0.9301.00
60_A78_F0.9281.00
40_E43_D0.9211.00
134_A148_V0.9201.00
80_L84_L0.9191.00
143_V147_L0.9191.00
64_G70_G0.9181.00
130_I133_A0.9141.00
102_V105_A0.9041.00
3_L7_F0.8901.00
69_L72_L0.8821.00
95_R99_N0.8761.00
121_A125_A0.8711.00
134_A152_A0.8681.00
101_W104_A0.8671.00
6_F9_K0.8651.00
91_P95_R0.8601.00
122_L125_A0.8451.00
128_A132_A0.8441.00
100_P103_Q0.8421.00
18_G58_Q0.8401.00
11_G82_S0.8391.00
143_V148_V0.8361.00
69_L73_V0.8351.00
92_L95_R0.8281.00
56_A78_F0.8281.00
119_A122_L0.8261.00
111_A115_G0.8261.00
147_L150_L0.8221.00
2_E6_F0.8131.00
96_F102_V0.8131.00
70_G77_G0.8121.00
123_R126_R0.8021.00
30_V41_F0.8001.00
148_V152_A0.7981.00
7_F60_A0.7981.00
123_R127_S0.7951.00
138_L141_F0.7931.00
120_A124_L0.7881.00
137_A140_F0.7831.00
55_L59_L0.7821.00
48_A55_L0.7801.00
22_L41_F0.7781.00
128_A131_A0.7731.00
133_A137_A0.7691.00
67_G70_G0.7671.00
45_L59_L0.7641.00
29_L33_R0.7631.00
76_L80_L0.7621.00
89_L92_L0.7561.00
2_E5_L0.7551.00
8_L80_L0.7481.00
95_R98_G0.7481.00
12_L85_L0.7421.00
129_L141_F0.7421.00
87_L91_P0.7411.00
129_L133_A0.7371.00
108_G112_A0.7331.00
130_I138_L0.7301.00
3_L73_V0.7231.00
42_L124_L0.7231.00
89_L93_Y0.7221.00
75_T79_F0.7181.00
10_L28_E0.7181.00
44_G47_L0.7121.00
29_L36_L0.7121.00
82_S85_L0.7121.00
86_V90_A0.7091.00
84_L87_L0.7071.00
131_A139_L0.7041.00
133_A140_F0.7041.00
65_Y68_V0.7001.00
48_A58_Q0.7001.00
99_N103_Q0.6981.00
88_A92_L0.6951.00
134_A138_L0.6951.00
135_F138_L0.6921.00
57_I79_F0.6901.00
136_V139_L0.6891.00
7_F74_A0.6811.00
111_A119_A0.6711.00
41_F45_L0.6691.00
74_A77_G0.6671.00
133_A141_F0.6671.00
80_L83_F0.6671.00
10_L13_L0.6661.00
103_Q110_K0.6621.00
8_L77_G0.6591.00
130_I135_F0.6591.00
105_A108_G0.6581.00
14_S20_A0.6561.00
151_A154_L0.6511.00
129_L132_A0.6421.00
68_V71_A0.6421.00
117_I121_A0.6331.00
113_V116_L0.6311.00
94_E98_G0.6271.00
104_A107_Y0.6251.00
130_I140_F0.6231.00
18_G54_P0.6221.00
22_L45_L0.6211.00
91_P94_E0.6141.00
57_I61_T0.6141.00
131_A134_A0.6121.00
47_L51_T0.6091.00
152_A156_G0.6051.00
11_G78_F0.6021.00
107_Y111_A0.5991.00
26_Q42_L0.5981.00
120_A123_R0.5981.00
21_V78_F0.5921.00
11_G24_L0.5911.00
41_F59_L0.5851.00
143_V151_A0.5841.00
107_Y110_K0.5781.00
132_A140_F0.5761.00
93_Y102_V0.5741.00
7_F11_G0.5741.00
85_L88_A0.5711.00
45_L54_P0.5701.00
132_A135_F0.5701.00
90_A94_E0.5691.00
48_A51_T0.5671.00
55_L62_F0.5631.00
135_F141_F0.5611.00
66_A69_L0.5601.00
70_G74_A0.5561.00
142_K145_P0.5551.00
19_Y55_L0.5511.00
10_L24_L0.5511.00
146_I149_I0.5491.00
55_L58_Q0.5471.00
22_L59_L0.5461.00
3_L70_G0.5331.00
145_P149_I0.5291.00
134_A141_F0.5261.00
58_Q75_T0.5261.00
49_Q55_L0.5221.00
85_L89_L0.5201.00
55_L145_P0.5141.00
21_V57_I0.5141.00
137_A148_V0.5121.00
54_P57_I0.5121.00
59_L63_I0.5061.00
36_L40_E0.5061.00
44_G48_A0.5051.00
131_A141_F0.5041.00
135_F140_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h3oA 1 0.2803 8.8 0.931 Contact Map
2mnsA 1 0.1274 6.8 0.935 Contact Map
2l8sA 1 0.1274 3.2 0.944 Contact Map
2kncA 1 0.1465 1.7 0.952 Contact Map
2xf7A 3 0.3121 1.5 0.953 Contact Map
2m3eA 1 0.1465 1.5 0.953 Contact Map
2i68A 2 0.0955 1.4 0.954 Contact Map
4d2jA 4 0.2994 1.4 0.954 Contact Map
2diiA 1 0.2229 1.3 0.955 Contact Map
2nwlA 3 0.3503 1.3 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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