GREMLIN Database
MlaE - Permease MlaE
PFAM: PF02405 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 212 (210)
Sequences: 35125 (16716)
Seq/√Len: 1153.5
META: 0.903

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_I205_A4.6161.00
108_L170_A3.3801.00
5_M111_M3.2021.00
176_Q197_T3.1801.00
128_Y139_P3.1681.00
6_Y11_G2.9541.00
52_L123_G2.8161.00
176_Q193_R2.8141.00
20_G119_A2.6621.00
7_F11_G2.5671.00
17_A118_I2.4791.00
17_A122_V2.2941.00
36_R41_E2.1721.00
65_V112_L2.1341.00
55_E161_K2.1051.00
109_V167_F2.0021.00
116_T120_D1.9521.00
180_T190_A1.9321.00
49_A146_L1.9191.00
116_T162_A1.9031.00
144_S148_D1.9011.00
164_V209_L1.8981.00
81_R90_E1.8831.00
185_E189_R1.8291.00
81_R86_I1.8171.00
172_I201_L1.8151.00
46_D145_G1.8151.00
132_V139_P1.7851.00
4_Q104_R1.7741.00
175_Y179_R1.7691.00
105_V167_F1.7651.00
176_Q179_R1.7541.00
21_F126_G1.7251.00
189_R193_R1.7061.00
8_I73_I1.7011.00
48_V127_G1.6731.00
152_L156_L1.6661.00
145_G148_D1.6521.00
12_S69_V1.6311.00
13_L118_I1.6131.00
101_V174_C1.5761.00
109_V163_V1.5481.00
46_D149_A1.5231.00
94_I99_Y1.5231.00
168_I201_L1.5201.00
128_Y143_L1.5181.00
156_L160_I1.4891.00
63_L199_S1.4821.00
31_G47_L1.4531.00
128_Y132_V1.3991.00
55_E206_D1.3921.00
90_E96_P1.3621.00
8_I108_L1.3311.00
57_G120_D1.3261.00
173_G194_A1.3161.00
138_S141_A1.3161.00
77_L100_L1.3111.00
3_R7_F1.3021.00
105_V170_A1.2871.00
181_K186_G1.2801.00
180_T186_G1.2751.00
120_D158_G1.2721.00
70_G173_G1.2651.00
129_L133_L1.2401.00
173_G198_S1.2351.00
86_I100_L1.2181.00
165_F206_D1.2161.00
4_Q7_F1.2161.00
140_G144_S1.1981.00
53_V150_L1.1851.00
49_A150_L1.1811.00
143_L147_Q1.1791.00
144_S147_Q1.1761.00
207_Y211_A1.1671.00
61_T119_A1.1451.00
84_E87_D1.1421.00
82_V187_V1.1411.00
52_L57_G1.1391.00
50_L54_R1.1271.00
6_Y10_V1.1131.00
97_V101_V1.1121.00
54_R154_D1.1091.00
117_I159_L1.1031.00
14_P17_A1.1011.00
151_D154_D1.0991.00
101_V178_L1.0961.00
127_G142_Y1.0891.00
131_A135_L1.0811.00
81_R179_R1.0741.00
116_T158_G1.0721.00
34_Q37_R1.0661.00
8_I111_M1.0601.00
201_L205_A1.0591.00
40_A43_Y1.0591.00
76_E104_R1.0451.00
193_R197_T1.0421.00
97_V102_V1.0411.00
9_G111_M1.0411.00
153_S156_L1.0321.00
54_R157_V1.0191.00
32_A135_L1.0101.00
27_L51_S1.0081.00
118_I122_V1.0071.00
7_F76_E1.0071.00
142_Y146_L1.0041.00
124_I146_L1.0031.00
46_D50_L0.9851.00
10_V14_P0.9831.00
163_V167_F0.9781.00
141_A145_G0.9771.00
117_I120_D0.9761.00
81_R178_L0.9681.00
89_L99_Y0.9651.00
73_I108_L0.9631.00
161_K206_D0.9601.00
172_I176_Q0.9571.00
105_V171_L0.9441.00
111_M114_L0.9431.00
139_P143_L0.9431.00
141_A144_S0.9371.00
117_I121_L0.9351.00
183_G186_G0.9311.00
16_V119_A0.9281.00
53_V155_V0.9281.00
164_V205_A0.9271.00
78_G180_T0.9261.00
53_V120_D0.9211.00
61_T116_T0.9201.00
112_L166_G0.9181.00
167_F171_L0.9171.00
32_A36_R0.9161.00
197_T201_L0.9121.00
33_Y37_R0.9071.00
121_L125_L0.9061.00
96_P178_L0.9051.00
66_A202_I0.9041.00
81_R87_D0.9021.00
131_A137_I0.8961.00
153_S157_V0.8901.00
109_V166_G0.8871.00
95_D98_R0.8831.00
172_I197_T0.8801.00
164_V168_I0.8801.00
74_A194_A0.8791.00
112_L169_I0.8791.00
125_L129_L0.8731.00
168_I172_I0.8721.00
153_S160_I0.8681.00
81_R181_K0.8661.00
125_L128_Y0.8611.00
157_V209_L0.8601.00
108_L166_G0.8601.00
157_V160_I0.8551.00
4_Q73_I0.8511.00
8_I69_V0.8461.00
87_D90_E0.8461.00
66_A198_S0.8461.00
85_Q199_S0.8451.00
53_V158_G0.8451.00
64_I199_S0.8451.00
13_L17_A0.8371.00
53_V124_I0.8121.00
35_L47_L0.8121.00
25_M130_V0.8101.00
17_A20_G0.8061.00
169_I198_S0.8051.00
57_G119_A0.8011.00
79_T184_A0.7971.00
41_E44_V0.7941.00
81_R182_G0.7891.00
50_L154_D0.7801.00
11_G14_P0.7781.00
155_V159_L0.7751.00
160_I164_V0.7731.00
171_L175_Y0.7731.00
79_T82_V0.7711.00
114_L117_I0.7711.00
21_F129_L0.7701.00
25_M29_L0.7691.00
49_A124_I0.7661.00
176_Q190_A0.7601.00
33_Y36_R0.7481.00
198_S202_I0.7481.00
32_A44_V0.7471.00
22_F25_M0.7451.00
194_A198_S0.7411.00
5_M110_I0.7341.00
19_T64_I0.7341.00
102_V106_L0.7331.00
62_A202_I0.7281.00
107_A111_M0.7271.00
205_A209_L0.7251.00
159_L163_V0.7251.00
21_F122_V0.7241.00
45_G146_L0.7231.00
35_L40_A0.7171.00
67_G195_V0.7081.00
62_A112_L0.7021.00
28_A131_A0.7011.00
45_G137_I0.6981.00
30_Q51_S0.6921.00
186_G189_R0.6921.00
204_V208_L0.6911.00
108_L112_L0.6911.00
18_L200_V0.6901.00
148_D151_D0.6881.00
5_M9_G0.6881.00
42_S46_D0.6861.00
66_A169_I0.6821.00
127_G131_A0.6801.00
3_R185_E0.6801.00
48_V51_S0.6791.00
62_A165_F0.6791.00
79_T187_V0.6771.00
132_V136_G0.6701.00
10_V13_L0.6681.00
79_T83_T0.6671.00
17_A21_F0.6661.00
28_A48_V0.6631.00
34_Q47_L0.6621.00
181_K189_R0.6621.00
2_V6_Y0.6611.00
190_A193_R0.6611.00
23_I60_L0.6601.00
73_I174_C0.6601.00
114_L118_I0.6531.00
143_L146_L0.6521.00
58_P116_T0.6521.00
52_L120_D0.6521.00
128_Y142_Y0.6521.00
20_G57_G0.6411.00
4_Q8_I0.6411.00
77_L101_V0.6411.00
192_T196_V0.6401.00
160_I163_V0.6381.00
66_A70_G0.6351.00
3_R6_Y0.6341.00
12_S68_R0.6321.00
203_L207_Y0.6311.00
57_G116_T0.6311.00
8_I107_A0.6301.00
78_G190_A0.6281.00
105_V109_V0.6261.00
166_G170_A0.6261.00
179_R190_A0.6261.00
73_I104_R0.6231.00
43_Y46_D0.6231.00
192_T195_V0.6191.00
5_M107_A0.6161.00
74_A191_T0.6141.00
86_I178_L0.6141.00
148_D152_L0.6141.00
62_A66_A0.6121.00
82_V180_T0.6081.00
130_V134_L0.6061.00
25_M207_Y0.6061.00
2_V5_M0.6021.00
150_L155_V0.5901.00
169_I173_G0.5891.00
204_V207_Y0.5881.00
47_L51_S0.5881.00
104_R174_C0.5861.00
163_V166_G0.5861.00
16_V61_T0.5841.00
16_V115_L0.5811.00
130_V133_L0.5791.00
45_G145_G0.5751.00
151_D156_L0.5741.00
57_G61_T0.5731.00
7_F72_A0.5711.00
45_G131_A0.5691.00
42_S145_G0.5681.00
14_P18_L0.5671.00
98_R102_V0.5671.00
175_Y178_L0.5661.00
85_Q94_I0.5621.00
77_L174_C0.5621.00
149_A152_L0.5581.00
20_G61_T0.5551.00
20_G24_G0.5551.00
116_T159_L0.5541.00
97_V178_L0.5531.00
106_L109_V0.5521.00
19_T85_Q0.5521.00
28_A127_G0.5491.00
31_G35_L0.5491.00
47_L50_L0.5471.00
27_L31_G0.5471.00
65_V69_V0.5451.00
37_R46_D0.5401.00
90_E93_G0.5391.00
65_V169_I0.5381.00
86_I96_P0.5371.00
110_I113_P0.5371.00
175_Y197_T0.5371.00
37_R40_A0.5351.00
5_M8_I0.5331.00
89_L94_I0.5311.00
145_G149_A0.5301.00
136_G139_P0.5291.00
73_I173_G0.5261.00
206_D209_L0.5201.00
4_Q107_A0.5201.00
112_L116_T0.5151.00
48_V52_L0.5141.00
30_Q210_T0.5111.00
7_F189_R0.5101.00
109_V170_A0.5081.00
20_G23_I0.5071.00
176_Q194_A0.5071.00
182_G188_G0.5071.00
207_Y210_T0.5061.00
40_A44_V0.5061.00
71_S195_V0.5051.00
4_Q76_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.4811 3.3 0.954 Contact Map
3d31C 2 0.7972 2.7 0.956 Contact Map
3rlfF 1 0.7972 2.5 0.957 Contact Map
4ymuD 2 0.8302 2.4 0.958 Contact Map
2mgyA 1 0.4575 2.2 0.958 Contact Map
2a65A 2 0.8868 2 0.959 Contact Map
2onkC 2 0.4858 1.8 0.961 Contact Map
4tquM 1 0.8443 1.5 0.962 Contact Map
4lz6A 1 0.5472 1.5 0.962 Contact Map
4humA 1 0.5377 1.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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