GREMLIN Database
Bac_transf - Bacterial sugar transferase
PFAM: PF02397 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 153 (152)
Sequences: 100333 (62772)
Seq/√Len: 5091.5
META: 0.881

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_R6_I3.5591.00
40_E48_P3.3711.00
40_E50_T3.2491.00
130_Y134_N3.2381.00
38_R50_T3.0461.00
26_A64_V2.5651.00
95_E99_E2.3761.00
28_K33_G2.3451.00
67_F71_T2.1811.00
30_D63_R2.1801.00
43_G113_P2.1331.00
23_I73_L2.1241.00
38_R52_Y2.1091.00
118_W122_N1.9161.00
23_I54_F1.8851.00
142_K146_K1.8541.00
118_W130_Y1.8291.00
48_P97_P1.7431.00
52_Y81_N1.6921.00
102_Y105_E1.6121.00
119_A124_R1.6021.00
117_G120_Q1.5961.00
9_S14_I1.5951.00
107_R133_E1.5821.00
24_A35_V1.5371.00
96_L99_E1.5361.00
28_K35_V1.5161.00
5_D88_S1.5081.00
80_W84_K1.4971.00
4_F8_L1.4831.00
130_Y139_L1.4541.00
14_I17_S1.4241.00
18_P21_L1.4041.00
107_R110_S1.4021.00
117_G124_R1.3921.00
20_L54_F1.3781.00
10_L83_L1.3761.00
23_I68_L1.3531.00
122_N146_K1.3501.00
81_N86_D1.3501.00
27_I31_S1.2931.00
36_F52_Y1.2901.00
9_S13_L1.2891.00
90_V144_L1.2741.00
13_L80_W1.2741.00
111_V132_I1.2651.00
42_V48_P1.2611.00
16_L20_L1.2581.00
138_W142_K1.2571.00
9_S83_L1.2341.00
42_V97_P1.2331.00
12_G16_L1.2311.00
118_W139_L1.2311.00
116_T147_T1.1981.00
8_L89_L1.1891.00
1_K140_D1.1821.00
118_W143_I1.1811.00
82_V115_I1.1631.00
52_Y80_W1.1551.00
45_N110_S1.1461.00
6_I10_L1.1381.00
30_D64_V1.1341.00
22_L26_A1.1341.00
118_W127_L1.1311.00
95_E124_R1.1301.00
44_L112_K1.1271.00
28_K31_S1.1121.00
39_Q51_I1.1031.00
95_E102_Y1.0941.00
26_A30_D1.0921.00
131_Y140_D1.0621.00
68_L71_T1.0611.00
103_E106_R1.0601.00
117_G128_D1.0531.00
8_L12_G1.0461.00
17_S20_L1.0351.00
34_P55_R1.0221.00
122_N127_L1.0221.00
146_K150_V1.0201.00
17_S21_L1.0191.00
6_I9_S1.0171.00
25_L29_L1.0151.00
134_N139_L1.0101.00
100_E106_R1.0011.00
10_L14_I0.9921.00
30_D62_T0.9911.00
46_G109_L0.9911.00
52_Y84_K0.9871.00
56_T68_L0.9661.00
1_K88_S0.9601.00
90_V116_T0.9521.00
137_L141_L0.9491.00
146_K149_P0.9301.00
13_L17_S0.9251.00
120_Q128_D0.9201.00
12_G79_L0.9031.00
79_L89_L0.9021.00
105_E126_E0.8951.00
15_L18_P0.8941.00
145_L149_P0.8941.00
1_K5_D0.8921.00
61_I69_R0.8921.00
61_I66_R0.8891.00
24_A27_I0.8781.00
136_S139_L0.8771.00
24_A28_K0.8701.00
14_I18_P0.8671.00
139_L142_K0.8601.00
82_V89_L0.8601.00
12_G89_L0.8571.00
72_S150_V0.8571.00
1_K135_W0.8431.00
39_Q96_L0.8411.00
40_E97_P0.8381.00
4_F137_L0.8261.00
20_L80_W0.8221.00
21_L25_L0.8121.00
20_L76_L0.8111.00
49_F87_M0.8071.00
27_I54_F0.8051.00
19_L23_I0.8021.00
42_V109_L0.7991.00
57_M60_R0.7891.00
92_P111_V0.7861.00
72_S123_G0.7811.00
31_S64_V0.7791.00
95_E98_E0.7781.00
129_L132_I0.7771.00
38_R51_I0.7761.00
8_L11_L0.7711.00
18_P22_L0.7691.00
129_L133_E0.7691.00
46_G106_R0.7621.00
122_N130_Y0.7601.00
95_E109_L0.7591.00
108_R124_R0.7551.00
55_R74_D0.7501.00
121_V146_K0.7471.00
35_V54_F0.7461.00
95_E119_A0.7461.00
28_K32_P0.7451.00
64_V68_L0.7421.00
132_I135_W0.7401.00
99_E119_A0.7371.00
135_W139_L0.7311.00
13_L20_L0.7311.00
89_L144_L0.7301.00
28_K34_P0.7281.00
9_S16_L0.7181.00
95_E125_V0.7131.00
27_I30_D0.7121.00
101_L105_E0.7051.00
119_A123_G0.7011.00
62_T65_G0.7011.00
42_V96_L0.7011.00
23_I26_A0.6931.00
26_A29_L0.6921.00
66_R70_K0.6901.00
100_E105_E0.6891.00
6_I11_L0.6881.00
40_E98_E0.6841.00
37_F96_L0.6791.00
7_V10_L0.6761.00
97_P100_E0.6761.00
72_S151_V0.6731.00
56_T69_R0.6681.00
27_I55_R0.6581.00
108_R129_L0.6571.00
63_R66_R0.6481.00
23_I64_V0.6471.00
21_L24_A0.6441.00
27_I35_V0.6401.00
118_W134_N0.6401.00
16_L23_I0.6381.00
80_W86_D0.6361.00
107_R129_L0.6291.00
110_S133_E0.6271.00
99_E124_R0.6261.00
95_E108_R0.6231.00
125_V129_L0.6231.00
126_E130_Y0.6191.00
100_E103_E0.6151.00
149_P152_L0.6101.00
53_K75_E0.6091.00
13_L83_L0.6051.00
121_V150_V0.6051.00
148_V151_V0.6051.00
11_L14_I0.6031.00
4_F141_L0.6021.00
120_Q123_G0.6021.00
41_R51_I0.5901.00
117_G125_V0.5881.00
7_V11_L0.5871.00
111_V135_W0.5841.00
135_W138_W0.5841.00
3_L7_V0.5811.00
16_L19_L0.5781.00
25_L28_K0.5661.00
24_A54_F0.5631.00
42_V95_E0.5581.00
81_N84_K0.5561.00
145_L148_V0.5551.00
12_G15_L0.5521.00
9_S89_L0.5511.00
141_L145_L0.5481.00
3_L6_I0.5461.00
105_E129_L0.5441.00
144_L148_V0.5441.00
27_I64_V0.5411.00
42_V99_E0.5401.00
6_I83_L0.5381.00
20_L23_I0.5371.00
41_R94_P0.5361.00
13_L16_L0.5311.00
95_E100_E0.5301.00
124_R129_L0.5271.00
44_L111_V0.5241.00
31_S34_P0.5241.00
100_E104_E0.5231.00
142_K149_P0.5221.00
9_S12_G0.5141.00
44_L47_R0.5131.00
138_W141_L0.5131.00
67_F73_L0.5091.00
31_S55_R0.5051.00
57_M61_I0.5031.00
118_W128_D0.5031.00
42_V49_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c48C 1 0.3007 3 0.95 Contact Map
4ioyX 1 0.3268 1.9 0.955 Contact Map
1jb0F 1 0.7386 1.8 0.956 Contact Map
4g7vS 1 0.2353 1.7 0.957 Contact Map
4kt0F 1 0.719 1.4 0.959 Contact Map
1xkmA 2 0.1438 1.3 0.959 Contact Map
2k44A 1 0.1765 1.3 0.96 Contact Map
4w8pB 1 0.1373 1.2 0.96 Contact Map
1uptB 2 0.1961 1.2 0.961 Contact Map
1zzaA 1 0.5033 1.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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