GREMLIN Database
Cornifin - Cornifin (SPRR) family
PFAM: PF02389 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (110)
Sequences: 639 (564)
Seq/√Len: 53.8
META: 0.471

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_K68_K2.0431.00
63_E79_E2.0261.00
58_T74_L2.0211.00
36_K52_K1.9481.00
60_K76_K1.9461.00
50_L82_T1.8160.99
42_T74_L1.7760.99
66_T82_T1.7470.99
45_V61_V1.7390.99
53_V69_V1.7300.99
42_T58_T1.6680.99
44_K60_K1.6640.99
44_K76_K1.6340.98
43_T59_T1.6320.98
50_L66_T1.6160.98
68_K84_K1.5650.98
59_T75_T1.5530.98
82_T98_L1.5360.98
60_K92_K1.4920.97
36_K84_K1.4750.97
34_T66_T1.4720.97
67_P99_T1.4670.97
98_L114_T1.4420.97
34_T50_L1.4060.96
47_E79_E1.4000.96
94_P110_P1.3910.96
68_K100_K1.3690.95
90_T106_T1.3460.95
51_T67_P1.3300.95
30_P62_P1.3190.94
37_V53_V1.3110.94
67_P83_P1.3020.94
52_K84_K1.3020.94
62_P78_P1.2900.94
47_E63_E1.2680.93
61_V77_V1.2470.92
34_T82_T1.2260.92
54_P102_P1.2230.92
44_K68_K1.2140.91
58_T106_T1.2110.91
38_P54_P1.2110.91
77_V93_V1.1880.90
28_K60_K1.1580.89
40_P56_P1.1410.89
43_T67_P1.1400.88
34_T98_L1.1380.88
50_L98_L1.1260.88
35_T51_T1.1190.88
58_T90_T1.1180.87
28_K44_K1.1180.87
52_K100_K1.1070.87
57_C73_C1.1020.87
44_K92_K1.0990.87
71_E87_E1.0990.87
43_T75_T1.0900.86
40_P88_P1.0760.85
74_L90_T1.0710.85
42_T66_T1.0700.85
28_K76_K1.0690.85
77_V109_V1.0670.85
76_K108_K1.0570.84
55_E79_E1.0530.84
35_T83_P1.0520.84
26_T42_T1.0500.84
78_P94_P1.0410.83
33_C49_C1.0360.83
56_P72_P1.0350.83
56_P88_P1.0330.83
93_V109_V1.0190.82
95_E111_E1.0160.82
84_K100_K1.0150.82
51_T83_P1.0030.81
39_E55_E0.9930.80
76_K92_K0.9900.80
40_P72_P0.9850.80
66_T114_T0.9850.80
55_E71_E0.9800.80
63_E95_E0.9720.79
39_E71_E0.9710.79
85_V101_V0.9670.79
57_C105_C0.9640.78
62_P94_P0.9560.78
53_V85_V0.9550.78
26_T74_L0.9500.77
49_C65_C0.9490.77
92_K108_K0.9320.76
46_P62_P0.9300.76
54_P70_P0.9240.75
47_E95_E0.9170.75
48_P80_P0.9150.75
75_T107_T0.8890.73
30_P46_P0.8840.72
83_P99_T0.8820.72
38_P70_P0.8770.72
43_T91_T0.8730.71
41_C57_C0.8680.71
78_P110_P0.8650.70
64_P96_P0.8600.70
35_T67_P0.8550.70
71_E103_E0.8490.69
79_E95_E0.8460.69
42_T90_T0.8430.68
36_K68_K0.8390.68
41_C73_C0.8260.67
66_T98_L0.8210.66
61_V93_V0.8190.66
29_V61_V0.8130.66
67_P115_P0.8010.65
51_T75_T0.7990.64
82_T114_T0.7810.63
75_T91_T0.7790.62
26_T58_T0.7760.62
49_C73_C0.7710.62
52_K76_K0.7700.61
59_T91_T0.7680.61
65_C81_C0.7670.61
67_P91_T0.7600.60
49_C97_C0.7510.59
41_C89_C0.7510.59
64_P80_P0.7480.59
42_T82_T0.7430.59
97_C113_C0.7330.58
69_V85_V0.7320.58
74_L106_T0.7310.57
70_P86_P0.7290.57
69_V101_V0.7120.55
29_V45_V0.7080.55
55_E87_E0.6910.53
57_C89_C0.6890.53
50_L74_L0.6870.53
59_T107_T0.6770.52
66_T90_T0.6680.51
100_K116_K0.6660.51
70_P118_P0.6660.51
38_P86_P0.6650.50
56_P104_P0.6540.49
46_P78_P0.6500.49
32_P48_P0.6420.48
80_P96_P0.6380.48
53_V101_V0.6200.46
37_V69_V0.6170.45
72_P88_P0.6000.44
36_K44_K0.5950.43
100_K108_K0.5830.42
74_L98_L0.5820.42
39_E87_E0.5800.42
34_T58_T0.5770.41
81_C97_C0.5710.41
30_P78_P0.5670.40
48_P96_P0.5470.38
54_P86_P0.5470.38
46_P70_P0.5470.38
39_E63_E0.5410.38
47_E71_E0.5370.37
81_C113_C0.5240.36
49_C81_C0.5230.36
33_C81_C0.5200.35
62_P110_P0.5200.35
89_C105_C0.5180.35
65_C97_C0.5160.35
88_P104_P0.5160.35
58_T82_T0.5120.35
31_E63_E0.5080.34
91_T99_T0.5010.34
33_C65_C0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ob4A 2 0.4148 0.4 0.951 Contact Map
4po6A 1 0.1778 0.4 0.952 Contact Map
3cqxC 2 0.3704 0.4 0.952 Contact Map
2lboA 1 0.3407 0.3 0.956 Contact Map
3swyA 3 0.1185 0.3 0.957 Contact Map
4kiyR 1 0.1778 0.3 0.958 Contact Map
3iylX 8 0.2741 0.3 0.959 Contact Map
4jnuA 4 0.163 0.2 0.959 Contact Map
4cvdA 1 0.1185 0.2 0.96 Contact Map
3v65B 1 0.3333 0.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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