GREMLIN Database
Transposase_20 - Transposase IS116/IS110/IS902 family
PFAM: PF02371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (84)
Sequences: 63644 (33671)
Seq/√Len: 3673.8
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_I34_L2.9571.00
38_A64_L2.5721.00
46_S51_R2.4801.00
30_S33_Q2.4301.00
17_T67_A2.4161.00
14_T71_A2.2371.00
29_P33_Q2.1941.00
5_M12_P2.1201.00
35_A41_A2.0861.00
70_E73_W2.0021.00
44_E51_R1.8421.00
21_E61_N1.7441.00
21_E63_Y1.7121.00
3_L6_S1.6881.00
73_W76_I1.6831.00
28_F37_Y1.6271.00
75_A82_L1.5641.00
69_V73_W1.5531.00
10_I15_A1.5111.00
14_T67_A1.4921.00
5_M15_A1.4791.00
12_P16_A1.4211.00
45_R50_K1.4171.00
13_V16_A1.4151.00
66_R70_E1.4061.00
5_M11_G1.3931.00
22_I25_I1.3641.00
36_A41_A1.2471.00
80_P84_A1.2371.00
31_A35_A1.2321.00
74_A78_H1.1731.00
13_V17_T1.1641.00
44_E53_R1.1421.00
33_Q36_A1.1051.00
10_I71_A1.0991.00
41_A57_S1.0971.00
10_I14_T1.0911.00
39_G57_S1.0791.00
79_N82_L1.0121.00
80_P83_R1.0051.00
18_L34_L0.9971.00
81_E85_Y0.9961.00
73_W77_R0.9661.00
62_R66_R0.9651.00
45_R52_R0.9461.00
43_R54_G0.9301.00
82_L85_Y0.9231.00
10_I18_L0.9221.00
34_L68_L0.9181.00
28_F34_L0.9041.00
72_A76_I0.9041.00
66_R69_V0.9021.00
81_E84_A0.8901.00
67_A71_A0.8891.00
74_A77_R0.8861.00
4_L15_A0.8821.00
36_A43_R0.8821.00
23_G27_R0.8721.00
17_T63_Y0.8721.00
63_Y67_A0.8711.00
46_S50_K0.8601.00
34_L38_A0.8481.00
24_D27_R0.8361.00
37_Y61_N0.8161.00
44_E54_G0.8091.00
35_A40_L0.8061.00
46_S52_R0.7941.00
4_L10_I0.7901.00
72_A75_A0.7861.00
75_A79_N0.7861.00
17_T66_R0.7861.00
8_P78_H0.7791.00
18_L64_L0.7601.00
40_L65_R0.7591.00
43_R57_S0.7571.00
18_L68_L0.7531.00
44_E50_K0.7381.00
40_L68_L0.7361.00
32_R35_A0.7331.00
2_E5_M0.7191.00
70_E74_A0.7111.00
21_E64_L0.7101.00
49_G52_R0.7051.00
50_K54_G0.7031.00
76_I83_R0.6971.00
16_A20_A0.6761.00
9_G74_A0.6691.00
60_G65_R0.6681.00
35_A42_P0.6661.00
22_I38_A0.6631.00
17_T21_E0.6601.00
36_A57_S0.6591.00
4_L19_L0.6481.00
56_I65_R0.6451.00
43_R58_K0.6251.00
46_S49_G0.6141.00
62_R65_R0.6131.00
46_S53_R0.6121.00
57_S60_G0.6071.00
36_A42_P0.6061.00
14_T74_A0.6021.00
45_R54_G0.6021.00
54_G57_S0.6001.00
17_T20_A0.5991.00
74_A79_N0.5951.00
38_A65_R0.5861.00
71_A75_A0.5791.00
27_R37_Y0.5771.00
14_T70_E0.5721.00
20_A23_G0.5681.00
51_R54_G0.5651.00
52_R55_R0.5601.00
78_H83_R0.5491.00
79_N83_R0.5491.00
8_P79_N0.5401.00
63_Y66_R0.5381.00
18_L71_A0.5371.00
7_I71_A0.5331.00
14_T68_L0.5321.00
72_A82_L0.5281.00
3_L7_I0.5271.00
24_D28_F0.5221.00
76_I82_L0.5141.00
19_L23_G0.5111.00
39_G56_I0.5081.00
46_S54_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5hA 1 0.7586 88.7 0.801 Contact Map
4pj0U 1 0.7586 87.5 0.804 Contact Map
3c65A 1 0 83.7 0.815 Contact Map
2bgwA 2 0.6552 82.7 0.817 Contact Map
1kftA 1 0.6207 81.6 0.819 Contact Map
1pu6A 1 0.8161 81.2 0.82 Contact Map
2duyA 1 0.5747 78.4 0.825 Contact Map
3wu2U 1 0.7586 77.6 0.826 Contact Map
2a1jB 2 0.6782 76.9 0.827 Contact Map
2nrtA 1 0.5862 75.3 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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