GREMLIN Database
Glucan_synthase - 1,3-beta-glucan synthase component
PFAM: PF02364 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 817 (764)
Sequences: 503 (192)
Seq/√Len: 7.0
META: 0.123

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
746_V749_V4.8380.99
744_A749_V3.9000.95
742_P746_V3.5020.91
742_P749_V3.4550.91
226_D261_R3.4440.91
744_A747_T3.3370.89
743_R749_V3.3170.89
747_T751_F3.1900.87
743_R747_T3.0210.84
743_R746_V2.9130.81
742_P747_T2.9020.81
240_S280_H2.6800.75
5_N76_E2.6730.75
139_G282_I2.6540.74
789_L793_A2.6530.74
133_I143_Y2.6390.74
746_V751_F2.6390.74
791_I803_V2.5810.72
780_A783_T2.5680.72
753_E757_P2.5560.72
756_V761_A2.5550.71
786_L793_A2.5380.71
757_P761_A2.4980.70
784_N788_R2.4430.68
749_V756_V2.4210.67
313_E430_Y2.4160.67
265_P370_Q2.4100.67
773_S776_G2.3660.65
741_V744_A2.3470.65
749_V766_I2.3210.64
749_V752_S2.3200.64
223_A281_A2.2850.62
764_V767_A2.2700.62
292_T429_E2.2660.62
370_Q379_R2.2530.61
765_L799_V2.2470.61
794_L797_I2.2350.61
756_V759_L2.2250.60
787_I791_I2.2030.59
193_V576_L2.1610.58
480_Y612_K2.1540.58
761_A764_V2.1440.57
756_V766_I2.1410.57
354_L444_I2.1360.57
754_I760_S2.1120.56
261_R293_I2.1100.56
757_P760_S2.1040.56
758_L762_V2.0690.54
786_L794_L2.0670.54
39_T192_Y2.0610.54
756_V760_S2.0530.54
800_N804_L2.0480.54
389_D551_I2.0420.53
240_S283_I2.0120.52
749_V764_V2.0080.52
36_S193_V2.0050.52
237_R263_K2.0040.52
746_V750_F1.9920.51
805_L808_F1.9880.51
714_Y794_L1.9720.51
741_V746_V1.9430.50
780_A784_N1.9410.50
745_S749_V1.9390.49
748_N771_I1.9290.49
747_T752_S1.9250.49
751_F801_A1.9150.49
734_S737_R1.9120.48
747_T750_F1.9120.48
780_A789_L1.9100.48
762_V786_L1.9090.48
765_L786_L1.9080.48
281_A553_T1.9020.48
406_I441_F1.8920.48
787_I793_A1.8910.48
784_N791_I1.8890.48
261_R763_V1.8730.47
348_T439_V1.8630.47
744_A748_N1.8560.46
159_L648_L1.8560.46
786_L803_V1.8510.46
760_S764_V1.8510.46
742_P748_N1.8480.46
752_S786_L1.8430.46
750_F764_V1.8400.46
755_L795_G1.8380.46
790_A807_L1.8370.46
158_L254_G1.8340.45
540_V673_F1.8250.45
744_A751_F1.8240.45
788_R791_I1.8240.45
787_I790_A1.8220.45
798_V803_V1.8220.45
742_P751_F1.8200.45
728_K735_E1.8170.45
750_F762_V1.8120.45
478_S526_T1.7960.44
774_Q784_N1.7900.44
290_L560_L1.7800.43
782_P787_I1.7750.43
15_F18_S1.7720.43
254_G262_I1.7640.43
776_G783_T1.7610.43
210_A222_V1.7570.43
784_N795_G1.7560.42
743_R751_F1.7480.42
736_K739_F1.7440.42
73_Y78_D1.7390.42
786_L790_A1.7350.42
745_S751_F1.7320.42
36_S642_G1.7200.41
784_N787_I1.7140.41
779_G790_A1.7110.41
508_S608_H1.7060.41
793_A805_L1.7010.40
198_R202_F1.6970.40
750_F754_I1.6900.40
791_I795_G1.6860.40
754_I790_A1.6820.40
741_V747_T1.6810.40
781_A784_N1.6770.40
280_H284_F1.6770.40
802_A806_V1.6750.39
245_G256_R1.6680.39
743_R748_N1.6590.39
743_R750_F1.6570.39
742_P764_V1.6500.39
758_L766_I1.6480.39
193_V649_L1.6470.38
323_S786_L1.6350.38
776_G780_A1.6340.38
767_A777_V1.6320.38
780_A785_S1.6320.38
762_V791_I1.6290.38
781_A791_I1.6280.38
769_L786_L1.6260.38
172_G176_E1.6200.38
781_A805_L1.6190.37
343_R432_Q1.6180.37
598_Y602_F1.6160.37
39_T265_P1.6050.37
412_I427_H1.6030.37
744_A752_S1.5970.37
43_S213_L1.5960.37
65_L635_A1.5890.36
787_I802_A1.5870.36
753_E761_A1.5800.36
263_K674_A1.5740.36
781_A802_A1.5730.36
409_S452_A1.5700.36
739_F742_P1.5690.36
749_V768_Y1.5690.36
768_Y773_S1.5680.36
744_A757_P1.5670.36
751_F766_I1.5660.36
748_N751_F1.5620.35
742_P745_S1.5590.35
11_R24_P1.5530.35
654_T714_Y1.5490.35
779_G782_P1.5480.35
779_G784_N1.5470.35
174_N293_I1.5410.35
776_G779_G1.5350.35
779_G801_A1.5280.34
745_S750_F1.5000.33
230_P233_G1.4910.33
771_I777_V1.4880.33
310_L505_L1.4870.33
751_F756_V1.4870.33
793_A807_L1.4840.33
280_H283_I1.4700.32
751_F761_A1.4670.32
739_F746_V1.4660.32
758_L803_V1.4610.32
427_H460_L1.4590.32
239_Y263_K1.4580.32
71_Q587_S1.4560.32
181_E677_L1.4560.32
750_F798_V1.4540.32
265_P369_G1.4520.32
714_Y721_R1.4510.32
785_S797_I1.4430.31
762_V777_V1.4380.31
171_F174_N1.4380.31
760_S801_A1.4330.31
761_A772_N1.4200.31
32_M37_V1.4130.30
741_V748_N1.4130.30
674_A685_W1.4110.30
757_P764_V1.3970.30
514_L775_T1.3930.30
752_S767_A1.3890.30
368_L380_L1.3880.30
753_E756_V1.3880.30
364_S470_Q1.3860.30
759_L779_G1.3860.30
754_I757_P1.3860.30
140_Q145_T1.3850.30
214_L222_V1.3840.29
779_G791_I1.3810.29
750_F757_P1.3810.29
781_A787_I1.3800.29
714_Y719_R1.3690.29
755_L804_L1.3680.29
787_I795_G1.3680.29
163_E469_T1.3640.29
768_Y771_I1.3530.29
749_V757_P1.3530.29
756_V764_V1.3510.28
728_K803_V1.3490.28
734_S738_S1.3410.28
748_N763_V1.3410.28
760_S781_A1.3380.28
204_K282_I1.3340.28
752_S759_L1.3340.28
312_E478_S1.3320.28
760_S786_L1.3320.28
793_A802_A1.3310.28
377_G412_I1.3230.28
63_V622_V1.3230.28
783_T787_I1.3180.27
198_R404_K1.3170.27
11_R302_E1.3140.27
750_F768_Y1.3110.27
786_L789_L1.3070.27
414_A569_E1.3020.27
772_N776_G1.3010.27
314_F458_Q1.2970.27
172_G175_T1.2960.27
243_I429_E1.2890.27
768_Y772_N1.2840.26
265_P372_V1.2820.26
281_A606_L1.2820.26
785_S789_L1.2790.26
265_P506_A1.2700.26
755_L769_L1.2700.26
785_S788_R1.2640.26
69_L77_W1.2640.26
245_G258_E1.2630.26
747_T764_V1.2630.26
518_E653_T1.2620.26
715_E719_R1.2560.26
741_V745_S1.2560.26
786_L802_A1.2550.26
781_A803_V1.2550.26
751_F767_A1.2520.25
764_V776_G1.2500.25
756_V768_Y1.2490.25
754_I786_L1.2480.25
240_S282_I1.2470.25
214_L549_L1.2440.25
743_R757_P1.2430.25
747_T756_V1.2390.25
265_P689_V1.2380.25
67_E71_Q1.2380.25
778_R788_R1.2320.25
201_K227_E1.2300.25
767_A774_Q1.2290.25
560_L685_W1.2270.25
211_E215_R1.2270.25
718_S721_R1.2250.25
716_R719_R1.2200.25
542_N563_I1.2180.24
746_V752_S1.2150.24
8_A14_F1.2140.24
743_R752_S1.2140.24
780_A786_L1.2130.24
794_L803_V1.2110.24
45_K268_P1.2100.24
355_A449_T1.2070.24
265_P774_Q1.2010.24
780_A787_I1.2010.24
743_R758_L1.1990.24
752_S756_V1.1980.24
769_L792_V1.1980.24
723_T727_G1.1960.24
756_V777_V1.1930.24
779_G787_I1.1880.24
786_L792_V1.1870.24
292_T399_V1.1860.24
642_G692_Y1.1850.24
792_V795_G1.1830.24
777_V790_A1.1790.23
12_I481_Y1.1790.23
223_A480_Y1.1750.23
778_R791_I1.1740.23
239_Y683_F1.1730.23
745_S752_S1.1700.23
794_L805_L1.1690.23
419_T687_K1.1670.23
175_T750_F1.1670.23
782_P790_A1.1580.23
746_V764_V1.1580.23
781_A790_A1.1580.23
783_T793_A1.1570.23
749_V798_V1.1540.23
247_S738_S1.1540.23
751_F768_Y1.1520.23
262_I314_F1.1500.23
791_I807_L1.1500.23
225_L684_E1.1500.23
76_E584_L1.1470.23
721_R724_G1.1470.23
782_P785_S1.1460.23
265_P595_L1.1450.22
777_V801_A1.1400.22
761_A766_I1.1390.22
781_A786_L1.1370.22
745_S748_N1.1340.22
790_A793_A1.1310.22
774_Q777_V1.1300.22
301_L510_L1.1260.22
781_A801_A1.1260.22
524_N549_L1.1260.22
743_R764_V1.1260.22
452_A486_F1.1240.22
784_N790_A1.1230.22
3_P62_R1.1200.22
752_S766_I1.1180.22
747_T757_P1.1170.22
767_A770_F1.1170.22
745_S768_Y1.1160.22
782_P792_V1.1150.22
776_G800_N1.1140.22
779_G783_T1.1140.22
73_Y89_E1.1130.22
381_H385_P1.1120.22
798_V806_V1.1110.22
751_F758_L1.1110.22
795_G805_L1.1100.22
733_P736_K1.1100.22
740_D743_R1.1090.22
146_V156_L1.1080.22
673_F704_S1.1070.21
282_I758_L1.1050.21
774_Q783_T1.1050.21
745_S801_A1.1040.21
195_S211_E1.1030.21
739_F749_V1.1010.21
304_A433_C1.0990.21
625_I690_I1.0980.21
159_L305_L1.0980.21
673_F677_L1.0960.21
78_D122_S1.0950.21
758_L802_A1.0950.21
631_Y699_L1.0950.21
750_F767_A1.0940.21
764_V777_V1.0930.21
778_R782_P1.0930.21
420_L473_F1.0930.21
771_I774_Q1.0900.21
52_E268_P1.0890.21
715_E721_R1.0870.21
731_G736_K1.0870.21
79_N309_N1.0860.21
750_F765_L1.0830.21
514_L677_L1.0790.21
746_V765_L1.0740.21
281_A310_L1.0740.21
369_G478_S1.0720.21
745_S765_L1.0710.21
795_G801_A1.0700.21
767_A772_N1.0690.21
792_V806_V1.0690.21
429_E622_V1.0670.20
783_T786_L1.0660.20
298_D372_V1.0660.20
770_F773_S1.0660.20
226_D701_R1.0630.20
764_V768_Y1.0630.20
10_R35_F1.0580.20
784_N792_V1.0580.20
750_F755_L1.0530.20
767_A797_I1.0520.20
780_A791_I1.0520.20
24_P261_R1.0510.20
747_T771_I1.0500.20
302_E691_D1.0500.20
739_F743_R1.0470.20
734_S740_D1.0470.20
262_I290_L1.0430.20
750_F753_E1.0430.20
763_V776_G1.0410.20
786_L805_L1.0400.20
241_V261_R1.0350.20
799_V802_A1.0340.20
775_T805_L1.0340.20
255_K282_I1.0340.20
380_L692_Y1.0330.20
751_F759_L1.0320.20
765_L778_R1.0320.20
413_F482_T1.0310.20
453_T510_L1.0300.20
755_L759_L1.0300.20
758_L768_Y1.0290.20
754_I767_A1.0290.20
405_G408_L1.0290.20
269_I304_A1.0270.20
137_L490_N1.0260.19
222_V233_G1.0260.19
459_M602_F1.0240.19
37_V468_G1.0210.19
739_F747_T1.0210.19
449_T614_R1.0190.19
290_L606_L1.0180.19
596_G642_G1.0170.19
794_L809_G1.0170.19
745_S807_L1.0150.19
777_V780_A1.0140.19
76_E275_P1.0140.19
39_T637_S1.0120.19
218_P408_L1.0110.19
764_V769_L1.0110.19
731_G801_A1.0100.19
790_A798_V1.0080.19
780_A801_A1.0070.19
756_V763_V1.0070.19
755_L763_V1.0040.19
798_V805_L1.0030.19
780_A790_A1.0030.19
314_F680_P1.0010.19
596_G681_S1.0010.19
750_F804_L1.0000.19
380_L552_F0.9990.19
773_S786_L0.9990.19
39_T79_N0.9980.19
47_L701_R0.9970.19
767_A771_I0.9950.19
763_V770_F0.9940.19
785_S794_L0.9920.19
218_P288_E0.9900.19
37_V68_Y0.9870.19
787_I794_L0.9870.19
11_R691_D0.9850.19
469_T724_G0.9850.19
743_R753_E0.9850.19
745_S756_V0.9840.18
798_V801_A0.9840.18
68_Y77_W0.9820.18
270_L701_R0.9820.18
784_N805_L0.9820.18
769_L777_V0.9800.18
747_T802_A0.9710.18
759_L762_V0.9700.18
713_S763_V0.9690.18
248_E257_Q0.9690.18
310_L419_T0.9680.18
226_D548_Q0.9670.18
14_F18_S0.9670.18
214_L243_I0.9660.18
146_V754_I0.9640.18
719_R724_G0.9640.18
752_S757_P0.9640.18
764_V775_T0.9630.18
780_A807_L0.9600.18
224_Y429_E0.9600.18
752_S768_Y0.9590.18
3_P8_A0.9590.18
396_R468_G0.9560.18
777_V786_L0.9550.18
742_P752_S0.9520.18
35_F68_Y0.9500.18
756_V767_A0.9500.18
733_P802_A0.9490.18
742_P759_L0.9490.18
782_P799_V0.9460.18
281_A488_F0.9460.18
170_M173_G0.9450.18
617_G679_N0.9440.18
761_A765_L0.9430.18
776_G784_N0.9420.18
320_G512_H0.9420.18
765_L769_L0.9410.18
776_G781_A0.9410.18
741_V750_F0.9370.17
7_E10_R0.9340.17
292_T547_C0.9340.17
228_E261_R0.9330.17
352_S358_M0.9320.17
352_S366_V0.9300.17
377_G456_G0.9300.17
473_F674_A0.9290.17
10_R68_Y0.9280.17
290_L309_N0.9270.17
3_P79_N0.9270.17
793_A806_V0.9270.17
239_Y635_A0.9270.17
759_L764_V0.9260.17
222_V260_Y0.9240.17
778_R794_L0.9230.17
736_K740_D0.9230.17
762_V803_V0.9220.17
775_T783_T0.9220.17
778_R805_L0.9210.17
750_F786_L0.9210.17
497_V620_F0.9200.17
364_S369_G0.9190.17
733_P737_R0.9180.17
762_V779_G0.9170.17
647_L669_L0.9160.17
739_F761_A0.9160.17
199_Y497_V0.9150.17
90_E634_Y0.9140.17
786_L791_I0.9130.17
759_L770_F0.9120.17
801_A808_F0.9100.17
780_A788_R0.9090.17
747_T761_A0.9080.17
215_R669_L0.9080.17
749_V761_A0.9050.17
168_V174_N0.9050.17
293_I750_F0.9040.17
729_L798_V0.9040.17
471_L564_V0.9030.17
267_N719_R0.9020.17
748_N772_N0.9020.17
766_I770_F0.9020.17
572_F677_L0.9010.17
759_L771_I0.9010.17
773_S777_V0.9000.17
241_V258_E0.8970.17
12_I564_V0.8960.17
549_L760_S0.8950.17
797_I800_N0.8950.17
772_N775_T0.8950.17
346_I676_F0.8940.17
199_Y210_A0.8930.16
134_W140_Q0.8920.16
737_R740_D0.8920.16
40_P44_E0.8900.16
354_L396_R0.8900.16
285_T596_G0.8900.16
767_A798_V0.8900.16
739_F751_F0.8880.16
744_A750_F0.8880.16
513_E670_S0.8870.16
732_I735_E0.8870.16
211_E547_C0.8860.16
778_R793_A0.8860.16
766_I793_A0.8860.16
753_E798_V0.8860.16
365_F618_R0.8850.16
775_T780_A0.8850.16
736_K747_T0.8850.16
45_K130_R0.8840.16
154_R599_T0.8830.16
747_T759_L0.8800.16
369_G595_L0.8800.16
753_E759_L0.8800.16
195_S575_A0.8790.16
121_K126_E0.8790.16
262_I599_T0.8760.16
389_D433_C0.8760.16
413_F699_L0.8760.16
519_Y524_N0.8750.16
199_Y270_L0.8750.16
778_R790_A0.8740.16
769_L774_Q0.8740.16
752_S764_V0.8740.16
285_T504_Y0.8710.16
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373_L685_W0.5060.10
745_S760_S0.5050.10
747_T760_S0.5050.10
755_L789_L0.5040.10
303_E306_K0.5040.10
739_F748_N0.5040.10
281_A284_F0.5030.10
779_G802_A0.5030.10
782_P804_L0.5020.10
513_E774_Q0.5020.10
179_E642_G0.5010.10
740_D750_F0.5010.10
396_R444_I0.5010.10
758_L765_L0.5000.10
348_T369_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.7013 91.2 0.985 Contact Map
2nxvA 4 0.2938 83.8 0.987 Contact Map
1qg8A 1 0.2705 61.9 0.989 Contact Map
3ckjA 2 0.3305 42.2 0.99 Contact Map
3bcvA 2 0.2215 38.8 0.99 Contact Map
3f1yA 2 0.3635 34.9 0.99 Contact Map
2z86A 2 0.4321 28.8 0.991 Contact Map
3m66A 1 0.093 13.5 0.992 Contact Map
1l6xB 1 0.0416 11.1 0.992 Contact Map
1otrA 1 0.06 9.7 0.993 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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