GREMLIN Database
Cyt_bd_oxida_II - Cytochrome bd terminal oxidase subunit II
PFAM: PF02322 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 315 (310)
Sequences: 20673 (13131)
Seq/√Len: 745.8
META: 0.789

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_N153_A4.3541.00
287_P291_K3.6021.00
28_I165_A2.9361.00
18_V251_A2.7301.00
186_R190_R2.6301.00
133_G156_T2.6191.00
126_L161_V2.5791.00
39_E183_R2.5721.00
165_A191_L2.5581.00
126_L157_G2.5351.00
26_V43_M2.5041.00
309_A313_R2.4301.00
101_R114_D2.3871.00
43_M172_L2.3111.00
122_L161_V2.2901.00
170_T188_A2.2521.00
80_L139_V2.1771.00
11_V15_G2.1281.00
152_F206_T2.1011.00
225_A229_L2.0921.00
112_F115_W2.0531.00
115_W119_I2.0481.00
68_A293_M1.9841.00
187_L190_R1.9821.00
306_A309_A1.9531.00
130_V157_G1.9491.00
93_L116_A1.9091.00
144_G147_D1.8881.00
185_R189_R1.8791.00
28_I161_V1.8761.00
162_A198_L1.8721.00
163_L254_I1.8541.00
14_A255_A1.7691.00
126_L130_V1.7661.00
118_F122_L1.7521.00
272_S277_S1.7431.00
234_L238_R1.7271.00
224_L228_A1.7171.00
169_A188_A1.7141.00
112_F116_A1.7071.00
41_R45_N1.7041.00
90_G123_L1.6971.00
193_L197_V1.6921.00
46_S175_K1.6841.00
137_Q150_N1.6631.00
179_E182_E1.6611.00
106_S109_W1.6601.00
278_L283_A1.6581.00
181_Q185_R1.6531.00
288_Y291_K1.6491.00
111_R115_W1.6471.00
125_A160_L1.6451.00
87_M128_Q1.6261.00
242_E245_A1.6251.00
227_L231_L1.6241.00
28_I122_L1.6231.00
291_K295_V1.6171.00
199_L257_V1.6121.00
205_A209_A1.6111.00
268_Y277_S1.6051.00
31_P118_F1.5981.00
297_A301_L1.5951.00
295_V299_I1.5651.00
29_L169_A1.5611.00
86_L127_L1.5501.00
2_P284_A1.5471.00
195_A199_L1.5341.00
224_L227_L1.5041.00
167_H251_A1.4991.00
231_L249_A1.4831.00
142_A147_D1.4721.00
125_A164_Y1.4701.00
173_A181_Q1.4621.00
189_R238_R1.4511.00
288_Y292_V1.4371.00
203_S206_T1.4301.00
72_A269_L1.4161.00
223_L226_V1.4151.00
167_H250_S1.4131.00
236_L249_A1.4031.00
241_R244_W1.3961.00
4_I294_L1.3871.00
158_L162_A1.3821.00
77_F84_L1.3811.00
221_P225_A1.3791.00
300_G303_L1.3741.00
268_Y272_S1.3731.00
210_P214_A1.3661.00
9_I64_A1.3651.00
226_V229_L1.3551.00
4_I8_L1.3491.00
185_R240_G1.3401.00
42_V176_T1.3291.00
13_L65_L1.3241.00
279_T282_N1.3191.00
35_T39_E1.3131.00
173_A185_R1.3081.00
120_G124_A1.2981.00
33_A43_M1.2981.00
14_A259_A1.2881.00
199_L203_S1.2821.00
225_A228_A1.2781.00
216_L219_L1.2711.00
226_V230_L1.2671.00
202_F206_T1.2601.00
76_L270_L1.2521.00
220_V223_L1.2511.00
305_L309_A1.2511.00
84_L131_A1.2431.00
235_L239_R1.2301.00
217_L263_I1.2181.00
265_L283_A1.2181.00
182_E186_R1.2151.00
223_L227_L1.2111.00
154_L158_L1.1981.00
212_L215_G1.1911.00
20_D24_L1.1861.00
44_I98_F1.1821.00
12_L15_G1.1781.00
162_A194_A1.1761.00
116_A120_G1.1751.00
181_Q242_E1.1741.00
42_V45_N1.1711.00
186_R189_R1.1641.00
3_T281_W1.1601.00
166_L192_A1.1581.00
134_N153_A1.1571.00
201_A205_A1.1471.00
197_V201_A1.1401.00
162_A191_L1.1401.00
90_G124_A1.1271.00
206_T209_A1.1261.00
71_L75_T1.1181.00
211_P214_A1.1171.00
204_L208_L1.1151.00
45_N102_S1.1061.00
12_L60_L1.1051.00
235_L238_R1.1001.00
45_N48_G1.0931.00
211_P215_G1.0901.00
222_L226_V1.0901.00
187_L191_L1.0881.00
285_S289_T1.0851.00
177_E181_Q1.0831.00
195_A198_L1.0781.00
252_L256_L1.0731.00
180_L184_A1.0661.00
14_A258_L1.0601.00
22_F247_F1.0581.00
205_A210_P1.0581.00
287_P290_L1.0551.00
209_A212_L1.0531.00
268_Y279_T1.0531.00
310_W314_V1.0511.00
46_S171_W1.0501.00
24_L125_A1.0421.00
206_T210_P1.0401.00
87_M127_L1.0381.00
222_L229_L1.0371.00
22_F50_V1.0291.00
223_L229_L1.0271.00
166_L250_S1.0201.00
286_S289_T1.0201.00
3_T266_Y1.0141.00
255_A259_A1.0141.00
108_R111_R1.0131.00
7_V11_V1.0091.00
166_L233_A1.0011.00
136_V265_L0.9981.00
166_L191_L0.9921.00
198_L202_F0.9911.00
115_W118_F0.9851.00
155_L201_A0.9841.00
222_L225_A0.9831.00
26_V172_L0.9821.00
75_T141_V0.9791.00
80_L134_N0.9791.00
71_L283_A0.9791.00
268_Y271_P0.9781.00
208_L211_P0.9771.00
181_Q243_G0.9761.00
170_T250_S0.9701.00
36_D110_R0.9691.00
188_A237_L0.9681.00
234_L237_L0.9671.00
127_L130_V0.9661.00
272_S276_Y0.9631.00
108_R112_F0.9601.00
33_A39_E0.9591.00
221_P228_A0.9421.00
87_M124_A0.9421.00
79_G139_V0.9411.00
20_D128_Q0.9401.00
176_T181_Q0.9311.00
107_P111_R0.9241.00
90_G120_G0.9181.00
294_L298_L0.9151.00
248_L252_L0.9151.00
65_L72_A0.9141.00
194_A198_L0.9091.00
298_L302_P0.9091.00
185_R242_E0.9081.00
189_R193_L0.9081.00
140_P147_D0.9051.00
227_L230_L0.9001.00
233_A236_L0.8991.00
2_P281_W0.8981.00
208_L212_L0.8981.00
22_F312_Y0.8901.00
6_F280_I0.8871.00
182_E240_G0.8851.00
190_R193_L0.8821.00
221_P224_L0.8811.00
236_L244_W0.8811.00
130_V154_L0.8801.00
233_A249_A0.8791.00
198_L201_A0.8781.00
106_S112_F0.8761.00
13_L61_A0.8741.00
192_A234_L0.8711.00
166_L195_A0.8671.00
205_A208_L0.8601.00
42_V180_L0.8601.00
225_A231_L0.8581.00
67_A293_M0.8571.00
225_A256_L0.8551.00
156_T202_F0.8551.00
15_G305_L0.8521.00
182_E185_R0.8521.00
159_L198_L0.8491.00
134_N150_N0.8481.00
166_L170_T0.8481.00
159_L162_A0.8441.00
30_L44_I0.8411.00
135_L270_L0.8371.00
200_A204_L0.8351.00
8_L297_A0.8321.00
31_P115_W0.8311.00
206_T213_I0.8301.00
203_S210_P0.8271.00
83_P130_V0.8271.00
195_A202_F0.8271.00
202_F205_A0.8271.00
155_L205_A0.8251.00
184_A188_A0.8241.00
188_A191_L0.8221.00
141_V276_Y0.8211.00
104_A107_P0.8181.00
218_W221_P0.8181.00
261_L265_L0.8091.00
83_P131_A0.8091.00
79_G83_P0.8051.00
26_V47_I0.8011.00
228_A256_L0.8001.00
149_L153_A0.7981.00
71_L278_L0.7971.00
210_P213_I0.7941.00
102_S110_R0.7861.00
180_L183_R0.7851.00
199_L202_F0.7841.00
233_A237_L0.7781.00
152_F205_A0.7781.00
132_L261_L0.7771.00
18_V255_A0.7761.00
172_L184_A0.7731.00
210_P215_G0.7721.00
34_R39_E0.7711.00
229_L253_A0.7711.00
208_L214_A0.7691.00
104_A109_W0.7671.00
224_L229_L0.7631.00
202_F210_P0.7621.00
5_W8_L0.7591.00
237_L242_E0.7581.00
179_E183_R0.7561.00
44_I117_F0.7541.00
29_L165_A0.7541.00
50_V311_V0.7451.00
123_L127_L0.7421.00
75_T270_L0.7401.00
127_L149_L0.7401.00
37_E42_V0.7371.00
226_V231_L0.7331.00
50_V171_W0.7301.00
198_L206_T0.7301.00
116_A119_I0.7261.00
184_A187_L0.7251.00
6_F10_G0.7251.00
228_A249_A0.7241.00
80_L131_A0.7231.00
41_R44_I0.7221.00
109_W112_F0.7221.00
75_T278_L0.7211.00
40_R114_D0.7181.00
220_V224_L0.7181.00
228_A231_L0.7171.00
64_A67_A0.7091.00
162_A195_A0.7071.00
28_I125_A0.7041.00
166_L188_A0.7031.00
308_T311_V0.7011.00
72_A76_L0.7011.00
61_A65_L0.6991.00
199_L210_P0.6991.00
244_W248_L0.6961.00
113_W116_A0.6951.00
10_G262_G0.6951.00
236_L239_R0.6951.00
43_M180_L0.6941.00
34_R183_R0.6921.00
207_P210_P0.6891.00
8_L12_L0.6871.00
125_A161_V0.6861.00
62_G73_Y0.6861.00
83_P148_L0.6861.00
148_L151_P0.6851.00
89_L93_L0.6831.00
143_G147_D0.6821.00
3_T7_V0.6781.00
178_G182_E0.6771.00
14_A18_V0.6761.00
96_V100_F0.6741.00
211_P268_Y0.6741.00
217_L220_V0.6741.00
236_L241_R0.6741.00
205_A212_L0.6711.00
97_A117_F0.6701.00
189_R237_L0.6701.00
122_L126_L0.6701.00
72_A283_A0.6701.00
198_L205_A0.6651.00
16_Y20_D0.6641.00
9_I65_L0.6601.00
295_V298_L0.6591.00
306_A310_W0.6591.00
249_A252_L0.6551.00
223_L230_L0.6541.00
39_E42_V0.6531.00
265_L268_Y0.6511.00
183_R187_L0.6511.00
206_T211_P0.6511.00
194_A201_A0.6501.00
53_G311_V0.6471.00
137_Q209_A0.6451.00
5_W293_M0.6451.00
225_A230_L0.6441.00
74_A78_S0.6431.00
220_V263_I0.6431.00
224_L231_L0.6421.00
133_G153_A0.6421.00
27_G121_S0.6401.00
203_S207_P0.6391.00
195_A205_A0.6381.00
136_V261_L0.6381.00
52_D99_E0.6381.00
173_A188_A0.6371.00
84_L87_M0.6371.00
138_G141_V0.6371.00
223_L228_A0.6361.00
133_G202_F0.6301.00
44_I102_S0.6291.00
85_M89_L0.6271.00
52_D55_E0.6231.00
166_L169_A0.6231.00
221_P227_L0.6201.00
41_R102_S0.6201.00
173_A242_E0.6191.00
16_Y128_Q0.6181.00
142_A145_F0.6181.00
204_L207_P0.6151.00
236_L240_G0.6141.00
247_F251_A0.6141.00
206_T212_L0.6131.00
122_L125_A0.6121.00
124_A128_Q0.6111.00
204_L209_A0.6111.00
299_I302_P0.6081.00
43_M46_S0.6061.00
12_L64_A0.6061.00
7_V260_G0.6061.00
189_R192_A0.6041.00
237_L240_G0.6041.00
39_E179_E0.6021.00
27_G31_P0.6001.00
8_L301_L0.5941.00
173_A237_L0.5931.00
224_L256_L0.5931.00
174_L247_F0.5911.00
191_L194_A0.5901.00
253_A257_V0.5901.00
107_P110_R0.5871.00
37_E41_R0.5871.00
183_R186_R0.5861.00
42_V177_E0.5841.00
207_P211_P0.5821.00
292_V296_V0.5801.00
174_L244_W0.5791.00
119_I123_L0.5771.00
142_A146_F0.5761.00
231_L236_L0.5751.00
178_G181_Q0.5731.00
105_D109_W0.5711.00
143_G146_F0.5691.00
194_A197_V0.5691.00
110_R114_D0.5681.00
272_S275_A0.5671.00
8_L294_L0.5641.00
60_L64_A0.5641.00
9_I61_A0.5631.00
28_I90_G0.5611.00
259_A263_I0.5591.00
240_G243_G0.5591.00
30_L118_F0.5511.00
245_A248_L0.5511.00
29_L172_L0.5501.00
141_V270_L0.5491.00
291_K294_L0.5461.00
26_V46_S0.5441.00
311_V315_F0.5441.00
284_A287_P0.5431.00
130_V134_N0.5431.00
194_A205_A0.5421.00
185_R241_R0.5411.00
235_L240_G0.5391.00
256_L260_G0.5391.00
23_D26_V0.5381.00
218_W222_L0.5381.00
203_S226_V0.5361.00
172_L176_T0.5351.00
271_P275_A0.5301.00
93_L119_I0.5301.00
222_L227_L0.5291.00
66_F73_Y0.5271.00
80_L83_P0.5261.00
167_H170_T0.5261.00
174_L243_G0.5261.00
22_F54_N0.5251.00
56_V59_V0.5231.00
202_F212_L0.5231.00
95_G100_F0.5211.00
135_L139_V0.5201.00
199_L253_A0.5201.00
127_L131_A0.5191.00
126_L158_L0.5181.00
24_L91_L0.5171.00
311_V314_V0.5151.00
239_R242_E0.5141.00
2_P290_L0.5131.00
170_T233_A0.5111.00
32_F187_L0.5111.00
194_A210_P0.5111.00
93_L120_G0.5091.00
168_G172_L0.5081.00
32_F118_F0.5081.00
271_P277_S0.5081.00
97_A116_A0.5071.00
289_T292_V0.5051.00
33_A36_D0.5051.00
245_A249_A0.5041.00
62_G77_F0.5031.00
171_W314_V0.5031.00
201_A210_P0.5031.00
303_L306_A0.5021.00
137_Q153_A0.5011.00
79_G141_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mgyA 1 0.5143 6.9 0.963 Contact Map
1fftB 1 0.1333 2.6 0.97 Contact Map
3m73A 3 0.5746 2.5 0.97 Contact Map
2a65A 2 0.5333 2.4 0.97 Contact Map
4czbA 2 0.546 2.3 0.971 Contact Map
3pjzA 2 0.4063 2.1 0.971 Contact Map
4tq3A 1 0.4095 1.7 0.973 Contact Map
4p02A 1 0.3556 1.7 0.973 Contact Map
2gfpA 2 0.8508 1.6 0.973 Contact Map
4o6yA 2 0.619 1.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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