GREMLIN Database
MgtC - MgtC family
PFAM: PF02308 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (118)
Sequences: 35594 (22587)
Seq/√Len: 2079.3
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G31_A3.4751.00
85_V108_V3.4301.00
30_V83_L2.9021.00
36_L104_A2.6111.00
11_I86_T2.5881.00
31_A86_T2.5501.00
93_A101_A2.4881.00
37_F88_A2.4231.00
28_A111_V2.3841.00
38_T91_L2.3021.00
7_L105_T2.2301.00
7_L93_A2.1021.00
97_L100_L2.0931.00
52_G55_T1.9151.00
35_A93_A1.8701.00
27_F82_A1.8581.00
4_A35_A1.7741.00
5_L28_A1.6151.00
3_L93_A1.5211.00
27_F86_T1.4431.00
92_A101_A1.4321.00
31_A35_A1.3881.00
9_G28_A1.3731.00
38_T95_A1.3701.00
35_A94_G1.3661.00
26_T81_A1.3661.00
65_I68_Y1.3571.00
33_G84_W1.3541.00
114_L117_P1.3501.00
27_F79_T1.3461.00
82_A112_L1.3401.00
30_V87_A1.3361.00
9_G24_L1.3111.00
38_T42_I1.3101.00
50_A91_L1.3081.00
7_L89_I1.2621.00
57_I87_A1.2471.00
63_G68_Y1.2291.00
5_L32_L1.2151.00
13_L17_R1.2101.00
6_L9_G1.2071.00
38_T94_G1.1721.00
29_L108_V1.1681.00
33_G85_V1.1611.00
110_L114_L1.1361.00
37_F54_V1.1301.00
4_A8_G1.1221.00
66_L69_R1.1171.00
11_I108_V1.1141.00
43_Y46_G1.1131.00
89_I105_T1.1091.00
22_A27_F1.1021.00
48_R52_G1.1011.00
7_L101_A1.0851.00
43_Y97_L1.0781.00
68_Y72_G1.0631.00
24_L28_A1.0601.00
2_L6_L1.0561.00
30_V81_A1.0491.00
36_L88_A1.0451.00
3_L7_L1.0331.00
7_L102_V1.0201.00
40_L92_A1.0151.00
29_L85_V1.0081.00
53_V56_G1.0071.00
3_L98_Y1.0061.00
34_A87_A1.0051.00
4_A31_A1.0011.00
31_A93_A0.9981.00
5_L111_V0.9981.00
14_E18_R0.9951.00
51_A55_T0.9901.00
69_R72_G0.9831.00
36_L92_A0.9711.00
10_L109_L0.9491.00
63_G66_L0.9261.00
98_Y102_V0.9101.00
53_V57_I0.9031.00
40_L95_A0.8951.00
76_G79_T0.8911.00
76_G80_A0.8881.00
115_L119_E0.8811.00
62_A65_I0.8801.00
33_G88_A0.8591.00
14_E113_A0.8531.00
99_L102_V0.8301.00
105_T109_L0.8291.00
64_A68_Y0.8221.00
53_V91_L0.8201.00
68_Y71_G0.8181.00
111_V115_L0.8151.00
108_V112_L0.8081.00
103_A106_V0.8061.00
5_L107_L0.8011.00
48_R51_A0.7891.00
33_G37_F0.7741.00
35_A39_L0.7721.00
62_A66_L0.7701.00
48_R59_F0.7601.00
78_T112_L0.7581.00
21_P77_L0.7571.00
47_S51_A0.7551.00
99_L103_A0.7541.00
51_A54_V0.7531.00
102_V105_T0.7511.00
18_R116_R0.7361.00
50_A54_V0.7341.00
42_I46_G0.7341.00
56_G60_L0.7301.00
24_L115_L0.7231.00
89_I104_A0.7181.00
20_K75_R0.7181.00
47_S52_G0.7121.00
65_I69_R0.7091.00
2_L107_L0.7011.00
40_L91_L0.6961.00
70_R75_R0.6921.00
32_L85_V0.6911.00
27_F83_L0.6861.00
113_A117_P0.6801.00
54_V57_I0.6741.00
11_I82_A0.6691.00
89_I108_V0.6691.00
23_G26_T0.6671.00
70_R73_S0.6491.00
40_L97_L0.6421.00
89_I101_A0.6421.00
44_L95_A0.6351.00
104_A108_V0.6181.00
60_L65_I0.6171.00
27_F31_A0.6161.00
109_L113_A0.6151.00
92_A100_L0.6081.00
58_G61_G0.6081.00
57_I61_G0.6051.00
59_F63_G0.5981.00
39_L43_Y0.5971.00
39_L100_L0.5961.00
53_V87_A0.5921.00
69_R73_S0.5861.00
38_T50_A0.5841.00
8_G28_A0.5801.00
18_R113_A0.5691.00
29_L33_G0.5681.00
37_F91_L0.5651.00
50_A53_V0.5631.00
22_A26_T0.5621.00
51_A59_F0.5621.00
64_A69_R0.5611.00
28_A115_L0.5611.00
24_L118_L0.5591.00
48_R56_G0.5571.00
14_E79_T0.5541.00
42_I95_A0.5511.00
74_V80_A0.5511.00
17_R113_A0.5501.00
26_T78_T0.5491.00
55_T59_F0.5481.00
16_E24_L0.5461.00
14_E17_R0.5461.00
61_G65_I0.5441.00
29_L81_A0.5401.00
103_A107_L0.5401.00
43_Y100_L0.5361.00
101_A105_T0.5331.00
33_G87_A0.5291.00
85_V89_I0.5261.00
37_F87_A0.5191.00
106_V113_A0.5181.00
77_L80_A0.5101.00
52_G56_G0.5061.00
40_L44_L0.5041.00
106_V110_L0.5031.00
41_S49_V0.5011.00
41_S44_L0.5011.00
63_G69_R0.5011.00
55_T58_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.9917 6 0.913 Contact Map
4huqS 1 0.7438 4.5 0.918 Contact Map
3hd6A 3 0.9587 4.4 0.919 Contact Map
1u7gA 3 0.9339 3.6 0.922 Contact Map
2b2hA 3 0.9339 3.5 0.923 Contact Map
4n7wA 2 0.6033 3.4 0.923 Contact Map
4j05A 3 0.8926 3.3 0.924 Contact Map
3l1lA 2 0.6281 3.1 0.925 Contact Map
3iyzA 3 0.9174 2.4 0.929 Contact Map
3wajA 1 0.9835 2 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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